Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1: PFREUD_20070
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Entry
PFREUD_20070 CDS
T01252
Symbol
hemD
Name
(GenBank) Uroporphyrinogen-III synthase HemD
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
pfr
Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1
Pathway
pfr00860
Porphyrin metabolism
pfr01100
Metabolic pathways
pfr01110
Biosynthesis of secondary metabolites
pfr01120
Microbial metabolism in diverse environments
pfr01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
pfr00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
PFREUD_20070 (hemD)
Enzymes [BR:
pfr01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
PFREUD_20070 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
PFREUD_20070 (hemD)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
CBL57500
UniProt:
D7GG39
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Position
complement(2164545..2166161)
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AA seq
538 aa
AA seq
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MSQRVDVEAPDNAGPDDVAGRLCHGRVVFVGSGLSSADQLTRAGLRALSSATMLVTTPEL
REMLDEAGVEVPDKDATRFVGDLPDVARFVVEAAGDDQSVARFVRGDPLLEGNIADEVSA
YIDADLMLDIVPGVPSLTSVTTLAGVSFPGQSVQLISLPYRAKTAEIPAAGSLAVGCYSS
QAAMVARAAVEAARTPDEDVLITFHGGTLRQHSEMSTIGTLMGKKSPIEPGDDRVSIVFG
KASHRPEGMNWYESKPLFGWQVLVPLTRDRNEELIERLSLHGAHCTEVPTIDVEPPRNAA
QLDRAIRGLVDGHYQWVIFTSVNAVRAVAAKVAEYGLDARSLSGLQIAAVGDGTREYLST
WGLIPDLAPTDVHTVAGLAAEFPAYDDIVDPMNSVLVPRAEIATEPLSEGLAELGWEVDD
VTAYRTVRASPPPAPIREAIKSGDFDAVVFTSSTTVRNLIGIAGKPHAATMVAAIGPATA
VTCEEHGLDVAVISDAPGQIELADSLAYGARRRAKALVEAGKPVKRPSQRRRRRTNKS
NT seq
1617 nt
NT seq
+upstream
nt +downstream
nt
atgagtcagcgagtcgatgtcgaagcccccgacaatgcggggccggacgatgtggcaggc
aggttgtgccatgggcgtgtggtctttgtcggtagcgggctctcgtcggctgatcagttg
acccgtgccggcctgcgggcgctcagcagcgccaccatgctggtgaccacgccggagctt
cgcgagatgctcgacgaggccggcgtggaggtgcccgacaaggacgcgacgcgttttgtc
ggcgaccttcccgatgtggcccgattcgtggtcgaggccgccggcgacgaccagtcggtc
gcccgcttcgtgcgtggcgatcccctgctcgagggcaatatcgccgacgaggtcagcgcc
tacatcgacgccgacctgatgcttgacatcgtgccgggcgtgccctcgctcacctcggtg
accaccctggccggggtcagctttcccgggcagtcggtgcaactcatctccctgccctat
cgcgccaagaccgctgagatcccggctgcgggttcgctggcggtcggctgctattcctcg
caggccgccatggtggcccgggcggccgtcgaggccgcacgcacccccgacgaggacgtg
ctcatcaccttccacggtggcaccctgcgccagcactccgagatgtcgaccatcggcacc
ctgatgggcaagaagagccccattgaacccggcgatgaccgggtctcgatcgtcttcggc
aaggcctcccaccgccccgagggcatgaactggtacgagtcgaagccgttgttcggctgg
caggtgctcgtgcccctcacccgcgatcgcaatgaggaactcatcgagcgcctcagcctg
cacggcgcccactgcaccgaggtgcccaccatcgacgtggagccgccgcgcaacgccgcc
cagctcgaccgcgccatccgtggcctggtcgacgggcactaccagtgggtgatcttcacc
agcgtcaatgcggtgcgtgccgtggcggcgaaggtggccgagtacggactcgatgcccgc
tcgctgtcgggcctgcagatcgccgcagtgggcgacggaacccgcgaatatctttcgacg
tggggcctgattcccgacctggcgcccactgatgtgcacaccgtggccggtttggccgca
gaatttcctgcctacgacgacatcgtcgatccgatgaactccgtgctcgtgccgcgcgcc
gagatcgccacggagccgttgtcggagggcctggccgagttgggctgggaggtcgacgac
gtgaccgcctaccgcacggtgcgcgcctcgccgccgccggccccgatccgcgaggccatc
aagtcgggcgatttcgatgcggtggtgttcacctcgagcaccacggtgcgcaatctgatc
ggcattgccggcaaaccgcacgccgccaccatggtggccgcgatcggcccggccaccgcc
gtcacctgcgaggagcacggcctggacgtcgccgtgatctccgacgcgcccggccagatc
gaactggccgattccctggcctacggggcgcgacgccgcgccaaggcactcgtcgaggcc
ggcaagcccgtgaagcgtccctcgcagcgacgtcgtcgccgcacgaacaagtcatag
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