KEGG   Pteropus vampyrus (Indian flying fox): 120587190
Entry
120587190         CDS       T07511                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pgig  Pteropus vampyrus (Indian flying fox)
Pathway
pgig00562  Inositol phosphate metabolism
pgig01100  Metabolic pathways
pgig04015  Rap1 signaling pathway
pgig04020  Calcium signaling pathway
pgig04022  cGMP-PKG signaling pathway
pgig04062  Chemokine signaling pathway
pgig04070  Phosphatidylinositol signaling system
pgig04071  Sphingolipid signaling pathway
pgig04072  Phospholipase D signaling pathway
pgig04081  Hormone signaling
pgig04082  Neuroactive ligand signaling
pgig04261  Adrenergic signaling in cardiomyocytes
pgig04270  Vascular smooth muscle contraction
pgig04310  Wnt signaling pathway
pgig04371  Apelin signaling pathway
pgig04540  Gap junction
pgig04611  Platelet activation
pgig04613  Neutrophil extracellular trap formation
pgig04621  NOD-like receptor signaling pathway
pgig04713  Circadian entrainment
pgig04720  Long-term potentiation
pgig04723  Retrograde endocannabinoid signaling
pgig04724  Glutamatergic synapse
pgig04725  Cholinergic synapse
pgig04726  Serotonergic synapse
pgig04728  Dopaminergic synapse
pgig04730  Long-term depression
pgig04742  Taste transduction
pgig04750  Inflammatory mediator regulation of TRP channels
pgig04911  Insulin secretion
pgig04912  GnRH signaling pathway
pgig04915  Estrogen signaling pathway
pgig04916  Melanogenesis
pgig04918  Thyroid hormone synthesis
pgig04919  Thyroid hormone signaling pathway
pgig04921  Oxytocin signaling pathway
pgig04922  Glucagon signaling pathway
pgig04924  Renin secretion
pgig04925  Aldosterone synthesis and secretion
pgig04926  Relaxin signaling pathway
pgig04927  Cortisol synthesis and secretion
pgig04928  Parathyroid hormone synthesis, secretion and action
pgig04929  GnRH secretion
pgig04933  AGE-RAGE signaling pathway in diabetic complications
pgig04934  Cushing syndrome
pgig04935  Growth hormone synthesis, secretion and action
pgig04961  Endocrine and other factor-regulated calcium reabsorption
pgig04970  Salivary secretion
pgig04971  Gastric acid secretion
pgig04972  Pancreatic secretion
pgig04973  Carbohydrate digestion and absorption
pgig05010  Alzheimer disease
pgig05016  Huntington disease
pgig05017  Spinocerebellar ataxia
pgig05022  Pathways of neurodegeneration - multiple diseases
pgig05142  Chagas disease
pgig05143  African trypanosomiasis
pgig05146  Amoebiasis
pgig05163  Human cytomegalovirus infection
pgig05200  Pathways in cancer
pgig05415  Diabetic cardiomyopathy
pgig05417  Lipid and atherosclerosis
Module
pgig_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pgig00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    120587190 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    120587190 (PLCB2)
   04310 Wnt signaling pathway
    120587190 (PLCB2)
   04371 Apelin signaling pathway
    120587190 (PLCB2)
   04020 Calcium signaling pathway
    120587190 (PLCB2)
   04070 Phosphatidylinositol signaling system
    120587190 (PLCB2)
   04072 Phospholipase D signaling pathway
    120587190 (PLCB2)
   04071 Sphingolipid signaling pathway
    120587190 (PLCB2)
   04022 cGMP-PKG signaling pathway
    120587190 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    120587190 (PLCB2)
   04081 Hormone signaling
    120587190 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    120587190 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    120587190 (PLCB2)
   04613 Neutrophil extracellular trap formation
    120587190 (PLCB2)
   04621 NOD-like receptor signaling pathway
    120587190 (PLCB2)
   04062 Chemokine signaling pathway
    120587190 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    120587190 (PLCB2)
   04922 Glucagon signaling pathway
    120587190 (PLCB2)
   04929 GnRH secretion
    120587190 (PLCB2)
   04912 GnRH signaling pathway
    120587190 (PLCB2)
   04915 Estrogen signaling pathway
    120587190 (PLCB2)
   04921 Oxytocin signaling pathway
    120587190 (PLCB2)
   04926 Relaxin signaling pathway
    120587190 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    120587190 (PLCB2)
   04918 Thyroid hormone synthesis
    120587190 (PLCB2)
   04919 Thyroid hormone signaling pathway
    120587190 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    120587190 (PLCB2)
   04916 Melanogenesis
    120587190 (PLCB2)
   04924 Renin secretion
    120587190 (PLCB2)
   04925 Aldosterone synthesis and secretion
    120587190 (PLCB2)
   04927 Cortisol synthesis and secretion
    120587190 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    120587190 (PLCB2)
   04270 Vascular smooth muscle contraction
    120587190 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    120587190 (PLCB2)
   04971 Gastric acid secretion
    120587190 (PLCB2)
   04972 Pancreatic secretion
    120587190 (PLCB2)
   04973 Carbohydrate digestion and absorption
    120587190 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    120587190 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    120587190 (PLCB2)
   04725 Cholinergic synapse
    120587190 (PLCB2)
   04728 Dopaminergic synapse
    120587190 (PLCB2)
   04726 Serotonergic synapse
    120587190 (PLCB2)
   04720 Long-term potentiation
    120587190 (PLCB2)
   04730 Long-term depression
    120587190 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    120587190 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    120587190 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    120587190 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    120587190 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    120587190 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    120587190 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    120587190 (PLCB2)
   05142 Chagas disease
    120587190 (PLCB2)
   05143 African trypanosomiasis
    120587190 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    120587190 (PLCB2)
   05016 Huntington disease
    120587190 (PLCB2)
   05017 Spinocerebellar ataxia
    120587190 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    120587190 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    120587190 (PLCB2)
   05415 Diabetic cardiomyopathy
    120587190 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    120587190 (PLCB2)
   04934 Cushing syndrome
    120587190 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pgig04131]
    120587190 (PLCB2)
Enzymes [BR:pgig01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     120587190 (PLCB2)
Membrane trafficking [BR:pgig04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    120587190 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    120587190 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 Gp58
Other DBs
NCBI-GeneID: 120587190
NCBI-ProteinID: XP_039699842
LinkDB
Position
Unknown
AA seq 1169 aa
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKIPKSQKLRDVFNMDFPDNNFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKNWAEDVLALVKHPLTANAPRITFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEH
LTTFINQKQRDSRLNSVLFPKARSDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRVMFGDMLLTEPLEKFPLKPGTPLPSPEDLRGKILIKNKKNQFSGPASPSTEQPGG
EAEGSCPPSAPVGGDTVWTGEEGAELEEEVEEEEESGSLDEEEIKKLQSDEGTAGLEVTA
YEEMSSLVNYIQPAKFISFEFSAQKNRSYVISSFTELKAYDLLSKATVQFVDYNKRQMSR
IYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMR
RPDKQYNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKL
SPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCL
HSESNMPLTMPSLFVFLELKDYVPDRWADLTVALTNPIKFFSAQDKKSVKLKEATGGLPE
KPFPLGSPVASQVNGAAAPTSNGSAELRTTSPEELRESKGVVKLQRRHEKELRELERRGA
RRWEELLQRGTAQLAELGPLGAEVGCGGRRLGPGKGSRKKRTLPCEENAGAAPGEGPEGT
DLRVRELRDRLELELLQQGEEQYECILKRKEQHVAEQITKMMELAREKQAAELKTLKETS
ESDTKEMKKKLEAKRLERIQAMVKVTTDKMAQERLKREINNSHIQDVVQVVKQMTENLER
HQEKLEEKQAACLEQIREMEKQFQQEALTEYEARMKGLEAEVKESLKTCFRACFPSETED
KPETPCGASGELCEQDPLTAKIDTQESHF
NT seq 3510 nt   +upstreamnt  +downstreamnt
atgtctctgctcaaccctgtcctgttgccccccaaggtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggatgatgaaacaacgatagcctccccagttatcctccgtgtg
gaccccaagggctattacttatactggacatatcagagtaaggagatggagtttctggat
atcaccagcatccgtgacacccgctttgggaagtttgccaagattcccaagagccagaag
ctccgggatgtcttcaacatggactttcctgacaacaacttcctgctgaagacacttact
gtggtgtctggccccgacatggtggacctcaccttccacaactttgtctcctacaaggag
aacgtgggcaagaactgggctgaagatgtactggctctggtcaagcatccgctgacagct
aatgccccccgcattaccttcctggacaagatcctggtgaagctcaagatgcagctcaac
cctgaagggaagattcctgtgaagaattttttccagatgtttcctgctgaccgcaagcgg
gtagaagctgccctcagtgcctgccacctccccaaagggaagaatgatgccatcaatcct
gaggacttcccagagtctgtctacaagagtttcctcatgagcctctgtcctcggccagaa
atagatgagatcttcacttcctaccattccaaggccaaaccctacatgaccaaggagcac
ttgaccacattcatcaaccagaaacagagggactcccgcctcaactccgtactgtttccg
aaagcgcggtctgaccaggtgcagggcctcattgacaagtatgagcccagtggtatcaac
gtgcagaggggccagctgtcacctgagggcatggtatggtttctctgtgggcctgagaat
agtgtgctggcccaggacaagctgctgctccaccatgacatgacacagccactcaatcat
tacttcatcaactcctcacacaacacctacctgacagctggccagttctcaggcctttcc
tcggctgagatgtatcgccaggtgctgctagctggctgccgctgtgtggagctggactgc
tggaaggggaagccccccgatgaggagcctattatcacccatggcttcaccatgaccaca
gatatttacttcaaggaagcaattgaagcgattgcagaaagtgcctttaagacctcccca
tatcctgtcattctgtcatttgaaaaccacgtggactcaccccgccaacaagccaagatg
gccgagtactgccgggtgatgtttggcgatatgctgctcacagagcccctggaaaagttc
cctctgaaaccaggcacccccctgcccagcccagaggatctccgtggcaagatcctcatc
aagaataagaagaatcagttttctggcccagcatcccccagcacagagcagccaggtgga
gaggctgagggcagctgcccacccagtgcccctgtgggtggagacacagtgtggaccggt
gaggaaggggctgagctggaggaggaggtggaagaggaagaggagtcgggaagcctggat
gaagaagagataaagaagttgcagtcagatgagggcacagcgggcctggaggtgacagct
tatgaggagatgtccagcctagtcaactacattcagcccgccaagttcatctccttcgag
ttctctgcccagaagaaccgaagttatgtcatctcctcattcaccgagctcaaggcttat
gatctgctctccaaggccacagtgcagtttgtggactacaacaagcgccagatgagccgc
atttatcccaagggaacccgcatggactcctccaactacatgccccagatgttttggaat
gctggttgccagatggtcgccctcaacttccagacgatggacctgcctatgcagcagaac
atggcgctgtttgagttcaatgggcagagcggctacctcctcaagcatgagtttatgcgt
cggccggacaagcagtacaacccattctcggtggaccgcattgacgtggtggtagccacc
accctttccattacggtaatctctgggcagttcctgtcagaacgcagtgtgcgcacctat
gtggaagtggagctgtttggccttcctggggaccccaagcggcgctatcgcaccaagctg
tcgcccagtaccaactccatcaaccctgtctggaaggaggagccctttgtctttgagaag
atcttgatgcctgagttggcctccctcagggtggctgtgatggaggaaggcaacaagttt
ctcggacaccgcatcatccccatcaacgccttgaattctggataccaccatctgtgcctg
cacagtgagagcaacatgcccctcaccatgccttcactctttgtcttcctggaattgaag
gactatgtacctgacaggtgggcagatctcaccgtggcccttaccaatcccatcaagttc
ttcagtgcccaagataagaagtctgtgaagctcaaggaagccacgggaggtctgcctgag
aagcctttccctctggggagtccagttgccagccaggtcaatggggcagctgccccaaca
agcaatggatcagcagagctgcggactaccagcccggaggagctacgagagtcgaagggc
gtcgtgaagctgcagcggcggcatgagaaggaactgcgagagcttgagcggcgcggtgcg
cggcgctgggaggagctgctgcagaggggcaccgcgcagctggcggagcttgggccactg
ggcgcggaggtcggctgcgggggccgtaggctcggtccgggcaagggctcccgcaagaaa
aggactctgccctgcgaggagaacgctggggcagcaccgggtgagggtcccgagggcacg
gacctgcgtgtgcgcgagctgagggacaggctggagctggagctgctgcagcagggcgag
gagcaatacgagtgtatcctgaagcgcaaggagcagcacgtggctgagcaaatcaccaag
atgatggagctggctagagagaaacaggctgcagagcttaagactctcaaggagacctca
gagagtgacactaaagagatgaagaaaaagctggaggccaagaggctggagcggatccag
gccatggtcaaggttaccacggacaagatggcccaggagaggttgaaaagagagattaac
aactcccatatccaggacgtggtgcaggtcgtcaaacagatgacagagaacctggagagg
catcaggagaagctggaggagaagcaggcagcttgcctggaacagatccgggagatggaa
aagcagttccagcaggaggcactgacagaatatgaggccaggatgaagggcctggaggct
gaggtgaaggagtcattgaagacctgcttcagggcgtgcttcccttctgagactgaggac
aagcctgagaccccctgtggggcctctggggagctgtgtgaacaggacccacttacagca
aaaatagacacccaagagagccatttctga

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