Pteropus vampyrus (Indian flying fox): 120592615 Help Entry 120592615         CDS       T07511                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism pgig  Pteropus vampyrus (Indian flying fox) Pathway pgig04020   Calcium signaling pathway pgig04024   cAMP signaling pathway pgig04260   Cardiac muscle contraction pgig04261   Adrenergic signaling in cardiomyocytes pgig04371   Apelin signaling pathway pgig04713   Circadian entrainment pgig04911   Insulin secretion pgig04921   Oxytocin signaling pathway pgig04972   Pancreatic secretion pgig05020   Prion disease pgig05022   Pathways of neurodegeneration - multiple diseases pgig05410   Hypertrophic cardiomyopathy pgig05412   Arrhythmogenic right ventricular cardiomyopathy pgig05414   Dilated cardiomyopathy pgig05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:pgig00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     120592615 (RYR2)    04020 Calcium signaling pathway     120592615 (RYR2)    04024 cAMP signaling pathway     120592615 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     120592615 (RYR2)    04921 Oxytocin signaling pathway     120592615 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     120592615 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     120592615 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     120592615 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     120592615 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     120592615 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     120592615 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     120592615 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     120592615 (RYR2)    05414 Dilated cardiomyopathy     120592615 (RYR2)    05415 Diabetic cardiomyopathy     120592615 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pgig04040]     120592615 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:pgig04990]     120592615 (RYR2) Ion channels [BR:pgig04040]  Voltage-gated cation channels   Ryanodine receptor    120592615 (RYR2) Domain-containing proteins not elsewhere classified [BR:pgig04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    120592615 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  120592615 NCBI-ProteinID:  XP_039706285 LinkDB All DBs Position Unknown AA seq 4893 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTMEKSEGKFMMKTAQGGGHRTLLYGHAILLRHSCSG MYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS SERYLHLSYGDGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTV PSGEHGEEQRRTVHYEGGVVSVHARSLWRLEALRVAWSGSHIRWGQPFRLRHVTTGKYLS LMEDNSLLLMDKEKADVKSTAFTFRSSKEKLDAGVRKEVDGMGTSEIKYGDSVCYIQHVN TGLWLTYQSVDVKSVRMGAIQRKAIMHHEGHMDDGINLSRSQHEESRTARVIRSTVFLFN RFIRGLDALGRKAKAPAADLPIESVSLSLRDLTGYLHPPDEQLEHEDRQNRLRALKNRQN LFQEEGMISLVLECIDRLHIYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKN CAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRN HKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGS AQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGFSPYPGGGEEAGGSGVGDDLFSYGF DGLHLWAGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGL FFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLRVEHSREYKQERVCT RDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPV RDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLP KNYQLTSGYKPAPMDLTFIRLTQAQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNR RNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYSLEAPDQDHAARAAAAGRTGERFRI FRAERTYAVRAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGLKAQRWHQ GNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDTGDGFIPVCSL GVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEH IEVTRIDGTVDSSPCLRVTQKSFGSQNSSTDITFYRLSMPIECAEVFSRTAAGGLPSAGL FGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDRDKEATKPEFNNHKDYAQEKPSRLKQR FLLRRTKPDYSTSHSARLTEDVLAGDRDDHDCLMQTSTYYYSVRIFPGQEPASVWVGWIT SDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRGNNGLEI GCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLS AGLFKSEHRNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRVSERQGWLVQCVDPLQF MSLHIPEENRSVDILELTEQEELLRFHHHTLRLYSAVCALGNHRVAHALCSHVDAPQLLY AIESKYMPGLLRAGYYDLLIDIHLSAYATARLMMNSEFIVPMTEETKSITLFPDEHKEHG LPGIGLSTSLRPRMRFSSPSFVRVNHDCYQDSPEFPLDTLKAKTMQMLTEAVREGGLRAR DPVGGTTEFLFVPLIKLFYTLLIMGVFHGEDLKHILQLIEPRVFTEATPEEECQARPGEP RADDARPEGARGDAAEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDNFVAK LQDNQRFRYNEVMQALNMSAALTARKTREFRSPPQEQINMLLNFKDDKSECPCPEEIRDQ LLDFHEDLMAHCGIELGEDGSLDGNSDLTIKGRLLSLVEKVTYLKKKQTEKPVERDARKS STLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLIRALPKTYTINSVSVED TINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVM VNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMR GSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVCKGYPDIGWNPVEG ERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGAGLLAAIEEANRIAE DPSRDGPSPTSESAKTPDAEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGE AIRIRSILRSLIPLGDLVGVISIAFQMPTVAKDGNVVEPDMSAGFCPDHKAAMVLFLDRV YGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLF AGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFD VPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQK KYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPE KLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPI KESLKTMLAWGWRIERTREGDSMALYSRTRRISQTSQVGSPRAIDMSNVTLSRDLHAMAE MMAENYHNIWAKKKKVELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQISGYV VSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDGAHQYILEFDGGSRGKGEHFPYEQEIKF FAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLF GNDATSIVNCLHILGQTLDARTVMKTGLESVRSALRAFLDSAAEDLEKTLENLRLGQFTH TRSQPRGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGT SKSIYVERQRSALGECLAAVAGAFPVAFLETHLDKHNIYSIYNTKSSRERAALNLPASVE DVCPNIPSLEKLMGEIVEVAESGVRYTQMPHVMEVVLPLLCSYLSRWWEHGPESNPARAA TCCTALSSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPL MEKLKKKAAMVVSEEEHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRA KWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKA AGSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALARNRLSMKDTE EEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTEDSSDPEKTVERVLDIANVLFHLE QVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEH YFEDKLIEDLAKPGAEPAEEEEGTKTVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADI MAKSCHDEEDDDSEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTVSASKGETGPM VAATLKLGIAILNGGNATVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKA EGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIIST VDYLLRVQESVSDFYWFYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQS LAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGT IGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKREFHKVMES HKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTR LQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISKSSRTQWEKPQVKESKRQFIF DVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSASKEESEAEKPEEQGPRMA FFSMLTVATALLALRHNALTLLRMLSLKSLRKQMKKVKKMTVRDMAAALFSSYWGVSRSL LHFAASVLRGFSRIVCGLLLGGSLVEGAKKIRVAELLANMPDPTQDEVRGDGEEAERKPL EAALPSEDLTDLKELAEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPTPE VQDKCQEQKAKEEEKEEKEEKSEPDKAGGENGEKEEKAKEEKGKQKLRPLHTHRYGEPEA PESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSAVEGREPPA RGSGEGEGAAVGGLGGGAPRGAAVHYVLEESSGYMEPALRILAVLHTAISFCCIIGYYCL KPHGEGTSELLAWLRAQSVMDKYGDFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSL SAVLSSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHFNNFFFAAHLLDIAMGFKTLR TILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYM FHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIIILLAIIQGLIIDAFGELR DQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHT GQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14682 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaggacgagatccagttcctgaggactgatgacgaggtg gtcctgcagtgcaccgccactgtccacaaggagcagcagaagctgtgtctggcggcagag ggctttggcaacaggctctgcttcttggagtccacttcaaattccaagaatgtcccccca gacctctccatctgcacctttgtgctggaacagtctctctctgtccgggccctgcaggag atgctggcaaacacgatggagaagtcagaagggaaattcatgatgaagactgctcagggc ggcggccaccggacgctcctctacggacacgccattctgttgcgccattcctgcagcggc atgtatctgtgctgcttgtccacctcccggtcttccactgataaactggccttcgatgtt ggcttacaagaagacacgacaggtgaggcttgttggtggaccatccacccggcctcgaag cagcggtcggaaggagagaaagttcgagtcggagatgacctcatcttagtgagcgtgtcc tcggagaggtacttgcacctgtcctacggtgacggcagcttacacgtggacgctgctttc cagcagaccctgtggagcgtggcccccatcagctcagggagcgaagcagcccaagggtat ctgatcggtggcgacgtcctcaggttgctgcacggacacatggacgaatgcctcactgtc ccttcgggagagcacggggaggagcagcggagaaccgtccattatgaaggtggtgttgtg tccgtccacgcacggtccctgtggagactggaggcgctaagggtggcgtggagtggaagc cacatcaggtggggccagcctttccgactccgccacgtcacaaccgggaaatacttgagt ctcatggaggacaacagccttctgctcatggacaaagaaaaagcagacgtaaagtcgacg gcgtttaccttccggtcttccaaggaaaaattggatgcaggggtgaggaaagaagtcgat ggcatggggacatccgagataaagtacggggactccgtgtgctacatacaacacgtgaac acaggcctgtggctgacttaccagtccgtggacgtgaaatctgtgaggatgggagccata caacgtaaggctattatgcaccatgaaggccacatggatgatggcataaatttatctaga tctcagcatgaagaatctcggacagcgcgagtcatccggagcaccgtcttcctttttaat agatttataaggggccttgacgctctcggcagaaaggcgaaggcgcccgcagcggacttg cccatagagtccgtcagcctgagtctgcgggacctgacgggctacctgcacccaccggac gagcagctggagcacgaggaccggcagaacaggctgcgggccctgaagaaccggcagaac ctcttccaggaggaggggatgatcagcctcgtgctcgagtgcatagacaggctgcacatc tacagcagcgccgcccacttcgccgacgtggccgggagagaagccggggagtcctggaag tcgatcctgaattctctgtatgagttgctggcggctctaattagaggaaatcgtaaaaac tgtgctcagttttctggctccctcgactggctgatcagccgattggaaaggctggaagct tcttctggaattcttgaagttttgcactgtgtgttagtagaaagtccagaagctctaaat attattaaagaaggacacattaaatccattatttcacttttagacaagcacggaagaaat cacaaggttctggacgtcttatgctctctctgcgtttgccacggagtagcagtccgttcc aaccagcatctcatctgtgacaatctcctgccaggaagagatctgttactgcagacacgc ctggtgaaccacgtcagcagcatgaggcccaatatttttctgggcgtgagcgaagggtct gcccagtataagaaatggtactatgaactgatggtggaccacaccgagccgttcgtgaca gccgaagcgactcacctgcgcgtgggctgggcgtccacggagggcttctcgccctacccc ggaggcggcgaggaggcgggcggcagcggcgtgggagacgacctcttttcctacgggttc gacggcctgcacctctgggcaggttgtattgctcggactgtaagctcgccaaaccaacat ctgctgagaaccgatgatgtcatcagttgctgtttagacctaagtgccccaagcatctcc ttccgaattaacggacaacctgttcaaggcatgtttgagaatttcaacatcgatggcctc ttctttccggttgttagtttctctgcaggaataaaggtacgctttctgcttggggggcga catggagaatttaagttccttcctccgccgggctacgcgccgtgttatgaagccgttctg ccgaaggagaagctgagagtggagcacagccgggagtacaagcaggaaagggtgtgcacc cgggaccttctgggccccacggtgtcgctgacacaagccgccttcacaccgatccccgtg gacaccagccagattgtgttgccaccccacctggagaggataagagaaaaattggcagag aatatccatgagctctgggttatgaataagattgaacttggctggcagtatgggccggtg cgtgatgacaacaagaggcagcacccgtgtctggtggagttctccaagctgcccgagcag gagcgcaattacaacttacagatgtcccttgagaccctgaagacgctgctggcattaggg tgccacgtgggcatcgcagacgagcatgccgaagaaaaggtgaagaagatgaagctgccc aagaactaccagctgacaagtggctacaaacctgccccgatggacctgacctttatcaga ctcacccaggctcaggaggcaatggtggacaagttggcagaaaacgcccataacgtgtgg gcccgggatcggatccggcagggctggacctacggcatccagcaggatgtaaagaacaga agaaaccctcgccttgttccctacacgctcctcgatgacagaaccaagaaatccaataag gacagcctccgggaggctgtgcgcacgctgctggggtacggctacagcctggaggcgccg gatcaggatcacgctgcgcgcgccgcggcggccggccgcaccggggagaggttccgcatc ttccgcgccgagaggacgtacgcggtgcgcgccgggcgctggtacttcgagttcgaggcc gtcaccgccggggacatgcgtgtgggctggagcaggccgggctgtcagccggaccaggag ctgggctcggacgagcgcgccttcgccttcgacggcctcaaggcccagcgatggcaccag ggcaatgagcactatggccgctcttggcaagccggcgacgttgtggggtgtatggttgac atgacagagcacaccatgatgttcacgctgaatggtgaaatcctcctcgatgattcgggc tcagaactggcattcaaggactttgacaccggcgatggatttatacctgtgtgcagcctc ggggtggctcaagtgggcaggatgaacttcggaaaggacgtgagcaccttgaaatatttc accatctgtggcttgcaggagggctacgaaccattcgccgttaacacaaacagggacatt accatgtggctgagcaagcggctgcctcagtttctccaagttccatcaaatcatgaacat atcgaggtgaccaggatagacggcaccgtggacagttccccgtgcttaagggtcacgcag aagtccttcggctctcagaacagcagcacggacatcacgttctaccgcctgagcatgccc atcgagtgcgccgaggtcttctccaggacggcggccggggggctgcccagtgccggcctc tttgggcccaagaacgatttagaggattatgatgcggattctgacttcgaggttctgatg aagacagctcacgggcatctggtgcctgatcgagtcgacagagacaaagaagctacgaag ccagagtttaataaccacaaagattatgctcaggagaagccttctcgcctgaaacaaagg tttttgctgaggagaacgaagccagattacagcacaagccactccgcgaggctcacggag gacgtcctcgcgggggaccgggacgaccacgactgcctgatgcagacgtccacgtactat tactcagtgagaatctttcctggacaagagccggccagcgtctgggtgggctggatcacg tccgacttccaccagtatgacacgggcttcgacttggacagagttcgcacagtaaccgtt actctgggcgacgaaaaaggaaaagtgcacgaaagcatcaaacgcagcaactgctacatg gtgtgtgcaggcgagagcatgagccccgggcaaggacgcggcaacaacgggctggagatc ggctgcgtggtggacgcggccagcgggctgctcacgttcacggccaatggcaaggagctg agcacgtactaccaggtggagccgagcaccaaattatttcctgcggtttttgcacaagct acaagtcccaatgtttttcagtttgagttgggaaggattaagaacgtgatgccgctgtcc gcggggctgttcaagagcgagcacaggaaccccgtgccgcagtgcccgccgcgcctgcac gtgcagttcctgtcgcacgtgctgtggagcaggatgcccaaccagttcctgaaggtggac gtgtcgcgggtcagcgagcgccagggctggctggtgcagtgcgtggaccccctgcagttc atgtccctgcacatcccggaggagaacaggtccgtggacatcctggagctgacggagcag gaggagctgctgcgcttccaccaccacacgctgcgcctctactcggccgtgtgcgcgctg ggcaaccaccgcgtggcgcacgcgctctgcagccacgtggacgcgccgcagctgctctac gccatcgagagcaagtacatgccgggcctgctgcgcgccggctactacgacctgctcatc gacatccacctgagcgcctacgccaccgcgcggctcatgatgaacagcgagttcatcgtg cccatgaccgaggagaccaagagcatcacgctcttcccggacgagcacaaggagcacggg ctgccgggcatcggcctcagcacctcgctgcgcccgcgcatgcgcttctcctcgcccagc ttcgtgcgcgtcaaccacgactgctaccaggacagccccgagttcccgctggacacgctc aaggccaagaccatgcagatgctgaccgaggcggtgcgagagggcggtctgcgcgcgcgg gacccggtcgggggcaccaccgagttcctcttcgtgccgctcatcaagctcttctacacg ctgctcatcatgggcgtcttccacggcgaggacctgaagcacatcctgcagctgatcgag ccccgggtcttcacggaggccaccccggaggaggagtgccaggcgcggcccggggagccg cgcgccgacgacgccaggcccgagggcgcgcgtggggacgcggcggaggggctgctgcag atgaagctgccggagcccgtaaagctgcagatgtgcctgctgctccagtacctctgtgac tgccaggtccggcaccggatagaagccatcgtggccttttcggataacttcgtagctaag ctccaagacaaccagcgcttccgatacaatgaagttatgcaagccttgaacatgtcggct gcactcacagccaggaaaacgagggaatttaggtcaccacctcaagaacagatcaatatg cttcttaattttaaggatgacaaaagcgaatgtccgtgtcctgaagaaatccgggaccaa ctcttggattttcacgaagatctgatggcacattgtggaattgagctgggcgaggacggg tctctggatggaaacagcgatttgacaattaaaggacgcctgctgtccctggtagaaaag gtgacatacctgaagaagaaacaaactgaaaagccagttgagcgtgacgccaggaagtcc tccacccttcagcagctgatctctgacaccatggttcgatgggctcaagagtctgtcatt gaagaccctgagctggtgagggccatgttcgtgttgctccatcgacagtatgatggcatt gggggcctgatccgggccctgccaaaaacctacactataaacagtgtttctgtggaggac accatcaacctgctggcatctctcggtcagatccgttctctgctgagcgtgaggatgggc aaagaagaagagaagcttatgatccgtggattaggggatatcatgaataacaaagtgttt taccagcaccctaatctcatgagggcactgggcatgcacgagacagtgatggaggtcatg gtgaacgtcctcggaggtggggagtccaaggagatcacttttcccaagatggtggccaac tgttgccgttttctctgttacttctgtcggataagccggcagaatcagaaagccatgttt gaccatctcagttatttattggaaaacagtagtgttggtctcgcctcgccagctatgaga ggttcaacaccgctggatgtggcagcagcctcggtgatggataacaacgaactggcctta gctttgcgtgagcccgacctggaaaaggtcgtccggtatctggctggctgtggactgcag agttgccagatgctggtgtgtaaggggtacccagatattggctggaacccagttgaaggg gagcggtacctcgacttcctcagatttgctgtcttctgtaatggggagagtgtggaggaa aacgccaacgtcgtggtgaggctgctcatccggaggcctgagtgcttcggcccggctctg agaggggagggcggggccggccttctcgccgccatagaggaagccaaccggatagccgag gacccttctcgagacggaccctcgccaaccagcgaatccgcgaaaacccctgacgcagag gaggaggaggacgacactatccacatggggaacgccatcatgaccttctacgcagctctc atcgacctgctgggacgctgcgctcccgagatgcacctgattcatgctggtaagggagaa gccatcaggatcagatctattttgagatccctgattccactgggagatttggtgggcgta atcagcatcgctttccagatgcccacggtagccaaggatgggaatgtggtggagcctgac atgtccgcggggttttgcccagatcacaaggcagccatggttttgttccttgacagggtc tatgggattgaggttcaggatttcctcctgcatcttctagaggttggctttctgccagat ctccgggctgctgcttctttagatacggccgcgttgagtgccacagacatggccttggcc ctgaatcggtacttgtgcacggccgtgctgcctctgttgacgagatgtgcccctcttttt gctggcacagagcaccacgcttccctcatcgactcgttacttcataccgtgtacaggctt tctaagggctgctcgctgaccaaagctcagcgggattccatagaagtttgtttgctgtct atttgtggccagttgagaccttctatgatgcagcacttactcagaagattagtgtttgat gtcccgttactaaacgagcacgcgaagatgccacttaagctgctgactaatcattatgaa agatgctggaaatattactgcctgcctggagggtggggaaactttggagctgcctcagaa gaagaacttcatttatcaagaaagttgttctggggcatttttgatgccctgtctcaaaag aaatatgaacaagaacttttcaaactggcactgccgtgcctgagcgcagttgcgggagct ttgcctccagactacatggagtcaaattatgtcagtatgatggaaaaacagtcatcaatg gattctgaagggaactttaacccacagcccgttgatacctcaaatattacaattcccgag aagctggagtacttcattaacaagtacgcggaacactcccacgacaagtggtccatggac aagttggcaaatggatggatttatggagaaatatattcagactcgtctaaagttcagcca ttaatgaagccatataaattattatctgaaaaggaaaaagaaatctatcgctggccaatc aaagaatctctgaaaacgatgctggcttggggctggagaatcgagcggacgcgggaggga gacagcatggcgctctacagcaggacccgccgcatctcgcagacgagccaggtcggcagt ccccgggccatcgacatgagcaacgtcacactgtctagagatctgcatgcgatggcagaa atgatggccgaaaactaccataacatatgggcaaagaaaaagaaagtggagctggagtcc aaaggaggcggaaaccatcccctgctcgtgccctacgacacgctgacagccaaagagaaa gccaaggacagggaaaaagcccaggacatcctcaagttcctgcagatcagtggatatgtt gtgtccagagggttcaaggacctggaactggacacgccttccattgaaaagcgatttgcc tacagcttcctgcagcagctcatacgctacgtggacggagcccatcagtacatcctggag ttcgatgggggcagcagaggcaaaggagagcatttcccctacgagcaagaaatcaagttc ttcgctaaggtcgttctgcctttaatcgatcagtatttcaaaaaccatcgtctgtacttc ctgtctgcggcgagcagacctctctgttccggaggacacgcctcgaacaaggagaaggaa atggtgacgagcctattctgcaaactcggagttcttgtcaggcataggatttcactattt ggaaatgatgcgacatcgattgtcaactgtctccatattttgggtcagactttggatgcg aggacggtcatgaagacgggcctggagagcgtgagaagcgcgctgcgagcgtttctggac agcgccgcggaggacctggagaagaccctggagaacctgcggctcggccagttcacgcac acgcggagccagcccaggggcgtcacgcagatcatcaactacaccacggtggccctgctg cccatgctgtcgtcgctgttcgagcacatcggccagcaccagttcggagaagatttaatc ctggaagatgtacaggtgtcatgttatagaattctgaccagcttatatgctttgggaacg agcaagagcatttatgtggaaaggcagcgttctgcgttaggagagtgtctggctgccgtt gctggtgcctttcccgtggcgtttctggaaactcatctcgacaaacataatatttactct atctacaacactaagtcctcacgagagagagcagctctcaacctgccggccagcgtggaa gatgtctgcccgaacatcccgtccttggagaagctcatgggcgagatcgtggaggtggcc gagtccggcgtccgctacacgcagatgccacacgtgatggaagtcgtcctgcccctgctg tgcagctacctgtcgcgctggtgggagcacggccccgagagcaacccggcccgagccgcg acgtgctgcacggcgctcagctccgagcacatgaacaccctgctgggcaacatcctgaag atcatatacaacaacctgggcatcgacgagggcgcctggatgaagagactggcagtattt tcccagcctattataaacaaagtgaaacctcagctcttgaaaactcacttcttgccactg atggagaaactcaagaaaaaggcagcgatggtggtgtccgaggaggagcatctgaaagcc gaggccaggggggacatgtccgaggccgagctgctcatcctggacgagttcaccacgctg gcccgagacctctacgccttctaccctctcttgattagattcgtggactataacagggcc aagtggctcaaagagccgaacccagaagccgaggaccttttccgcatggtggccgaagtc ttcatctactggtcgaaatcccacaatttcaaaagagaagagcagaactttgttgtccag aacgaaatcaacaacatgtctttcctcattacagacaccaagtcgaagatgtccaaggcg gccgggtctgaccaggagcggaagaagatgaagcgcaagggagaccgctactccatgcag acgtccctcatcgtggccgcgctgaagcggctgctgcccatcggcctgaacatctgcgcc ccgggcgaccaggagctcatcgccctggccaggaaccggctcagcatgaaagacactgag gaagaagtacgcgacatcatccgcagtaatattcacctacagggcaagttggaggaccct gccatcagatggcagatggctctttacaaagacttgccgaacaggactgaggacagttcg gatcccgagaagacagtagaaagagtgctggacatagcaaatgtgcttttccatcttgaa caggtggagcatccgcagaggtccaagaaggccgtctggcacaagctgctctccaagcag aggaaaagggccgtggtggcctgcttccgcatggcaccgttgtataacctgccaaggcat cgggccgttaatctctttcttcagggatatgaaaagtcctggattgaaacagaagaacat tactttgaagataaactgatagaagatttagcaaaacctggagcggagcctgcagaggaa gaggaaggcaccaagacagtcgaccctctgcaccagctgatccttctgttcagtcggacg gctctgacggagaaatgcaaactggaggaagattttttatacatggcgtatgcagatatt atggcaaagagttgtcatgacgaggaagatgatgatagtgaagaagaagtgaagagtttc gaggaaaaagaaatggaaaagcaaaagcttctgtaccagcaagcccgtctgcacgaccgc ggggccgctgagatggtgctgcagaccgtcagcgccagcaaaggtgagaccggcccgatg gtcgccgccacgctgaagctcggaatcgccatcctcaacggcgggaacgccacggtgcag cagaaaatgctcgactacctcaaggagaagaaagacgtgggcttcttccagagcctggcc ggcctcatgcagtcctgcagtgtcctcgacctgaatgcctttgagcgacagaacaaagct gaaggactcggaatggtgacagaggaaggatcaggagaaaaggtcctgcaggatgatgag ttcacctgtgacctcttccgcttcctgcagctgctttgtgagggacacaactcagatttt cagaattacctgagaacgcagactggcaacaacacaactgttaacatcatcatctccacc gtcgattacctgctgagagtccaggagtcggtcagcgatttctactggttttactccgga aaagatgtcatcgacgagcaaggacagaggaatttctccaaagcgattcaagtcgcaaag caagtcttcaacacgctcacggagtacattcagggcccgtgcactggcaaccagcagagt ctggcccacagccggctctgggacgcggtggtgggctttctgcacgtgtttgcccacatg cagatgaagctgtctcaggattccagtcaaatcgagctgctaaaggagctgatggacctg cagaaggacatggtggtgatgctgctgtccatgctggaaggtaacgtcgtgaacgggacc atcggcaagcagatggtcgacatgcttgtggagtcttccaacaacgtggagatgattctc aagttcttcgacatgttcttaaaactgaaggacttgacatcctctgacacatttaaggaa tatgaccccgatggcaagggcgtcatttccaagagggagttccacaaagtgatggaaagc cacaagcactacacgcagtcagagaccgagttcctcctgtcctgcgcggagacggacgag aacgagaccctcgactacgaggaattcgtcaaacgtttccacgagcccgcgaaggacatc ggcttcaacgtcgccgtgctcctgacgaacctttccgagcacatgcccaacgacacgcgg ctgcagaccttcctggagctggccgagagcgtgctcaactacttccagcccttcctgggc cgcatcgagatcatgggcagcgccaagcgcatcgagagggtttacttcgaaatcagcaag tccagccggacgcagtgggagaagccgcaggtcaaggagtccaagaggcagttcatcttc gatgtggtcaacgagggcggcgagaaggagaagatggagctcttcgtgaacttctgcgag gacaccatcttcgagatgcagctggcggcccagatctcggagtcggacttgaacgagcgc tcggccagcaaagaggagagcgaggcggagaagcccgaggagcaggggccgcgcatggcc ttcttctccatgctgaccgtcgcgaccgccttgctcgccctcaggcacaacgccctgacc cttctgcgcatgctcagcctgaagagcctgcggaagcagatgaagaaggtgaagaagatg acggtgagggacatggctgctgccctcttctcctcctactggggcgtgtcgcggagcctc ctgcacttcgcggccagcgtgctcagaggcttctcccgcatcgtctgcggcctgctcctg ggaggcagcctcgtggaaggcgccaagaagatccgagtggccgagctcctggccaacatg ccggaccccacgcaggacgaggtgaggggagacggcgaggaggccgagaggaagccgctg gaggccgccctgccctcggaggacctcacggacctgaaggagctggcggaggaaagcgac ctcctctcagacatatttggcttggatctgaagagagaaggaggacagtacaagctcatc cctcataacccgaacgccggcctcagcgacctcatgagcaaccccgtccccacccccgag gtgcaagacaagtgtcaggaacagaaggcaaaagaggaggaaaaggaagaaaaagaagag aaatcggagcctgacaaagccgggggagaaaatggggaaaaagaagaaaaagccaaggaa gagaaaggcaaacagaagctccggccgctgcacacacacagatacggggagccagaggcc cccgagtcagcattctggaagaaaatcatagcttatcaacagaagctgctaaactatttt gctcgcaacttttacaacatgagaatgttagccttatttgtcgcgtttgcgatcaatttc atcttgctcttctacaaggtctccacttcttctgcggtggaaggaagggagccccccgcg cgcggctccggggaaggcgaaggcgccgcggtgggcggcctgggcggcggggcgccgcgc ggcgcggccgtgcactacgtcctggaggagagcagcggctacatggagcccgcgctgcgc atcctggccgtgctgcacaccgccatctccttctgctgcatcatcggctactactgcctg aagccacacggggaaggcacgtcagagctcttagcgtggttgcgggcgcaaagtgtcatg gacaagtacggggacttctacggccgggacaggatcagcgagctgctcggcatggacaag gccgctctggacttcagcgacgcccgggagaagaagaagcccaagaaagacagctccctg tcggccgtgctgagctccatcgacgtgaagtaccagatgtggaagctcggagtcgtcttc accgacaactccttcctctaccttgcctggtacatgaccatgtctgttctcggacacttt aacaactttttttttgctgctcatcttctcgacatcgctatggggttcaagacgctgaga accatcttgtcatcagtaactcacaatggcaaacagctggtattaaccgtgggcttgtta gctgtggtcgtgtacctgtatactgttgtggcattcaattttttccgaaaattctacaat aaaagtgaagatggagatacgccagacatgaaatgtgacgatatgctaacgtgctacatg ttccacatgtacgtcggggttcgtgccggagggggcatcggggacgaaatcgaggaccct gcgggcgacgagtacgagatctaccgcatcatcttcgacatcacctttttcttcttcgtg atcatcatcctcttggccataatacaaggtttaattatcgatgctttcggagagctcaga gaccagcaggagcaagtcaaagaggacatggagaccaaatgcttcatctgcggcataggc aacgattacttcgatacggtgccgcacggcttcgaaacccacaccttacaggagcacaac ttggccaattacctgtttttcctgatgtatctcataaacaaggatgaaaccgagcacaca ggacaggagtcttatgtctggaagatgtatcaagaaagatgctgggagtttttcccagcg ggggactgtttccggaaacagtatgaagaccagctcaattaa

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