KEGG   Pteropus vampyrus (Indian flying fox): 120596984
Entry
120596984         CDS       T07511                                 
Symbol
PIK3CA
Name
(RefSeq) LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pgig  Pteropus vampyrus (Indian flying fox)
Pathway
pgig00562  Inositol phosphate metabolism
pgig01100  Metabolic pathways
pgig01521  EGFR tyrosine kinase inhibitor resistance
pgig01522  Endocrine resistance
pgig01524  Platinum drug resistance
pgig04012  ErbB signaling pathway
pgig04014  Ras signaling pathway
pgig04015  Rap1 signaling pathway
pgig04024  cAMP signaling pathway
pgig04062  Chemokine signaling pathway
pgig04066  HIF-1 signaling pathway
pgig04068  FoxO signaling pathway
pgig04070  Phosphatidylinositol signaling system
pgig04071  Sphingolipid signaling pathway
pgig04072  Phospholipase D signaling pathway
pgig04081  Hormone signaling
pgig04140  Autophagy - animal
pgig04145  Phagocytosis
pgig04150  mTOR signaling pathway
pgig04151  PI3K-Akt signaling pathway
pgig04152  AMPK signaling pathway
pgig04210  Apoptosis
pgig04211  Longevity regulating pathway
pgig04213  Longevity regulating pathway - multiple species
pgig04218  Cellular senescence
pgig04360  Axon guidance
pgig04370  VEGF signaling pathway
pgig04380  Osteoclast differentiation
pgig04510  Focal adhesion
pgig04517  IgSF CAM signaling
pgig04518  Integrin signaling
pgig04550  Signaling pathways regulating pluripotency of stem cells
pgig04611  Platelet activation
pgig04613  Neutrophil extracellular trap formation
pgig04620  Toll-like receptor signaling pathway
pgig04625  C-type lectin receptor signaling pathway
pgig04630  JAK-STAT signaling pathway
pgig04650  Natural killer cell mediated cytotoxicity
pgig04660  T cell receptor signaling pathway
pgig04662  B cell receptor signaling pathway
pgig04664  Fc epsilon RI signaling pathway
pgig04666  Fc gamma R-mediated phagosome formation
pgig04668  TNF signaling pathway
pgig04670  Leukocyte transendothelial migration
pgig04722  Neurotrophin signaling pathway
pgig04725  Cholinergic synapse
pgig04750  Inflammatory mediator regulation of TRP channels
pgig04810  Regulation of actin cytoskeleton
pgig04910  Insulin signaling pathway
pgig04914  Progesterone-mediated oocyte maturation
pgig04915  Estrogen signaling pathway
pgig04917  Prolactin signaling pathway
pgig04919  Thyroid hormone signaling pathway
pgig04923  Regulation of lipolysis in adipocytes
pgig04926  Relaxin signaling pathway
pgig04929  GnRH secretion
pgig04930  Type II diabetes mellitus
pgig04931  Insulin resistance
pgig04932  Non-alcoholic fatty liver disease
pgig04933  AGE-RAGE signaling pathway in diabetic complications
pgig04935  Growth hormone synthesis, secretion and action
pgig04960  Aldosterone-regulated sodium reabsorption
pgig04973  Carbohydrate digestion and absorption
pgig05010  Alzheimer disease
pgig05017  Spinocerebellar ataxia
pgig05020  Prion disease
pgig05100  Bacterial invasion of epithelial cells
pgig05132  Salmonella infection
pgig05135  Yersinia infection
pgig05142  Chagas disease
pgig05146  Amoebiasis
pgig05160  Hepatitis C
pgig05161  Hepatitis B
pgig05162  Measles
pgig05163  Human cytomegalovirus infection
pgig05164  Influenza A
pgig05165  Human papillomavirus infection
pgig05166  Human T-cell leukemia virus 1 infection
pgig05167  Kaposi sarcoma-associated herpesvirus infection
pgig05168  Herpes simplex virus 1 infection
pgig05169  Epstein-Barr virus infection
pgig05170  Human immunodeficiency virus 1 infection
pgig05171  Coronavirus disease
pgig05200  Pathways in cancer
pgig05203  Viral carcinogenesis
pgig05205  Proteoglycans in cancer
pgig05206  MicroRNAs in cancer
pgig05207  Chemical carcinogenesis - receptor activation
pgig05208  Chemical carcinogenesis - reactive oxygen species
pgig05210  Colorectal cancer
pgig05211  Renal cell carcinoma
pgig05212  Pancreatic cancer
pgig05213  Endometrial cancer
pgig05214  Glioma
pgig05215  Prostate cancer
pgig05218  Melanoma
pgig05220  Chronic myeloid leukemia
pgig05221  Acute myeloid leukemia
pgig05222  Small cell lung cancer
pgig05223  Non-small cell lung cancer
pgig05224  Breast cancer
pgig05225  Hepatocellular carcinoma
pgig05226  Gastric cancer
pgig05230  Central carbon metabolism in cancer
pgig05231  Choline metabolism in cancer
pgig05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pgig05415  Diabetic cardiomyopathy
pgig05417  Lipid and atherosclerosis
pgig05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pgig00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    120596984 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    120596984 (PIK3CA)
   04014 Ras signaling pathway
    120596984 (PIK3CA)
   04015 Rap1 signaling pathway
    120596984 (PIK3CA)
   04370 VEGF signaling pathway
    120596984 (PIK3CA)
   04630 JAK-STAT signaling pathway
    120596984 (PIK3CA)
   04668 TNF signaling pathway
    120596984 (PIK3CA)
   04066 HIF-1 signaling pathway
    120596984 (PIK3CA)
   04068 FoxO signaling pathway
    120596984 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    120596984 (PIK3CA)
   04072 Phospholipase D signaling pathway
    120596984 (PIK3CA)
   04071 Sphingolipid signaling pathway
    120596984 (PIK3CA)
   04024 cAMP signaling pathway
    120596984 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    120596984 (PIK3CA)
   04152 AMPK signaling pathway
    120596984 (PIK3CA)
   04150 mTOR signaling pathway
    120596984 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    120596984 (PIK3CA)
   04517 IgSF CAM signaling
    120596984 (PIK3CA)
   04518 Integrin signaling
    120596984 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    120596984 (PIK3CA)
   04140 Autophagy - animal
    120596984 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    120596984 (PIK3CA)
   04218 Cellular senescence
    120596984 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    120596984 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    120596984 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    120596984 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    120596984 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    120596984 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    120596984 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    120596984 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    120596984 (PIK3CA)
   04660 T cell receptor signaling pathway
    120596984 (PIK3CA)
   04662 B cell receptor signaling pathway
    120596984 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    120596984 (PIK3CA)
   04666 Fc gamma R-mediated phagosome formation
    120596984 (PIK3CA)
   04670 Leukocyte transendothelial migration
    120596984 (PIK3CA)
   04062 Chemokine signaling pathway
    120596984 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    120596984 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    120596984 (PIK3CA)
   04929 GnRH secretion
    120596984 (PIK3CA)
   04915 Estrogen signaling pathway
    120596984 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    120596984 (PIK3CA)
   04917 Prolactin signaling pathway
    120596984 (PIK3CA)
   04926 Relaxin signaling pathway
    120596984 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    120596984 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    120596984 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    120596984 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    120596984 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    120596984 (PIK3CA)
   04722 Neurotrophin signaling pathway
    120596984 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    120596984 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    120596984 (PIK3CA)
   04380 Osteoclast differentiation
    120596984 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    120596984 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    120596984 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    120596984 (PIK3CA)
   05206 MicroRNAs in cancer
    120596984 (PIK3CA)
   05205 Proteoglycans in cancer
    120596984 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    120596984 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    120596984 (PIK3CA)
   05203 Viral carcinogenesis
    120596984 (PIK3CA)
   05230 Central carbon metabolism in cancer
    120596984 (PIK3CA)
   05231 Choline metabolism in cancer
    120596984 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    120596984 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    120596984 (PIK3CA)
   05212 Pancreatic cancer
    120596984 (PIK3CA)
   05225 Hepatocellular carcinoma
    120596984 (PIK3CA)
   05226 Gastric cancer
    120596984 (PIK3CA)
   05214 Glioma
    120596984 (PIK3CA)
   05221 Acute myeloid leukemia
    120596984 (PIK3CA)
   05220 Chronic myeloid leukemia
    120596984 (PIK3CA)
   05218 Melanoma
    120596984 (PIK3CA)
   05211 Renal cell carcinoma
    120596984 (PIK3CA)
   05215 Prostate cancer
    120596984 (PIK3CA)
   05213 Endometrial cancer
    120596984 (PIK3CA)
   05224 Breast cancer
    120596984 (PIK3CA)
   05222 Small cell lung cancer
    120596984 (PIK3CA)
   05223 Non-small cell lung cancer
    120596984 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    120596984 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    120596984 (PIK3CA)
   05161 Hepatitis B
    120596984 (PIK3CA)
   05160 Hepatitis C
    120596984 (PIK3CA)
   05171 Coronavirus disease
    120596984 (PIK3CA)
   05164 Influenza A
    120596984 (PIK3CA)
   05162 Measles
    120596984 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    120596984 (PIK3CA)
   05163 Human cytomegalovirus infection
    120596984 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    120596984 (PIK3CA)
   05169 Epstein-Barr virus infection
    120596984 (PIK3CA)
   05165 Human papillomavirus infection
    120596984 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    120596984 (PIK3CA)
   05135 Yersinia infection
    120596984 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    120596984 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    120596984 (PIK3CA)
   05142 Chagas disease
    120596984 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    120596984 (PIK3CA)
   05017 Spinocerebellar ataxia
    120596984 (PIK3CA)
   05020 Prion disease
    120596984 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    120596984 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    120596984 (PIK3CA)
   05415 Diabetic cardiomyopathy
    120596984 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    120596984 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    120596984 (PIK3CA)
   04931 Insulin resistance
    120596984 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    120596984 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    120596984 (PIK3CA)
   01524 Platinum drug resistance
    120596984 (PIK3CA)
   01522 Endocrine resistance
    120596984 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pgig04131]
    120596984 (PIK3CA)
Enzymes [BR:pgig01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     120596984 (PIK3CA)
Membrane trafficking [BR:pgig04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    120596984 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 120596984
NCBI-ProteinID: XP_039711513
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPXAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYAHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactttttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaggcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctctttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggctttgct
attggcatgccagtgtgtgaattcgatatggttaaagatccagaagttcaggacttccga
aggaatattctgaatgtttgtaaagaagctgtggatcttagggatcttaactcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcacctgaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaatcatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgttatcatctgaacaactaaaa
ctttgtgttttagaatatcagggcaaatatattttaaaagtatgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactctcaactgccaatggac
tgttttacaatgccgtcttattccagacgtatctccacagctacaccgtatatgaatgga
gaaacatctacaaaatccctttgggttataaatagcgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctacgttagaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgagtggctgaattatgatatatacattcctgatcttcccngtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacattgc
ccattggcctggggaaatataaatttgtttgattacacagatactctagtatctggaaaa
atggctctgaatctttggccagtacctcatggattagaagatttactgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaattggtctgtg
tcccgagaagcaggatttagttatgcccacgcaggactgagtaacagactagccagagac
aacgagttaagggaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacctaaattgcttctctccgttaaatggaattctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaaacctgaacaggctatggag
cttctagactgcaactacccagatcctatggttcgaggctttgctgttcgatgcttggaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacttgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagagatttggcctacttttggagtcctattgtcgtgcatgtggaatgtatttgaag
cacctgaataggcaagtcgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctgcagggctttctatctcctctaaaccctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
ttcaaaaatggggatgatttacggcaagatatgctaacacttcagattatccgcattatg
gaaaatatctggcaaaaccaaggtcttgatcttcgaatgttaccatatggatgtctgtca
attggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcaaatt
cagtgcaaaggcggcctgaaaggtgcactgcagttcaacagccacacactacatcagtgg
ctcaaagacaagaacaaaggagaaatatacgatgcagccattgatctgtttacacgttca
tgtgctggatattgtgttgctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggctataaacgagagcgcgtgccatttgttttgactcaagatttc
ttgatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgaaaggttt
caggaaatgtgttacaaagcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaagctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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