KEGG   Pteropus vampyrus (Indian flying fox): 120604492
Entry
120604492         CDS       T07511                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
pgig  Pteropus vampyrus (Indian flying fox)
Pathway
pgig01521  EGFR tyrosine kinase inhibitor resistance
pgig01522  Endocrine resistance
pgig04010  MAPK signaling pathway
pgig04012  ErbB signaling pathway
pgig04014  Ras signaling pathway
pgig04015  Rap1 signaling pathway
pgig04022  cGMP-PKG signaling pathway
pgig04024  cAMP signaling pathway
pgig04062  Chemokine signaling pathway
pgig04066  HIF-1 signaling pathway
pgig04068  FoxO signaling pathway
pgig04071  Sphingolipid signaling pathway
pgig04072  Phospholipase D signaling pathway
pgig04114  Oocyte meiosis
pgig04140  Autophagy - animal
pgig04148  Efferocytosis
pgig04150  mTOR signaling pathway
pgig04151  PI3K-Akt signaling pathway
pgig04210  Apoptosis
pgig04218  Cellular senescence
pgig04270  Vascular smooth muscle contraction
pgig04370  VEGF signaling pathway
pgig04371  Apelin signaling pathway
pgig04380  Osteoclast differentiation
pgig04510  Focal adhesion
pgig04517  IgSF CAM signaling
pgig04540  Gap junction
pgig04550  Signaling pathways regulating pluripotency of stem cells
pgig04613  Neutrophil extracellular trap formation
pgig04620  Toll-like receptor signaling pathway
pgig04650  Natural killer cell mediated cytotoxicity
pgig04660  T cell receptor signaling pathway
pgig04662  B cell receptor signaling pathway
pgig04664  Fc epsilon RI signaling pathway
pgig04666  Fc gamma R-mediated phagocytosis
pgig04668  TNF signaling pathway
pgig04720  Long-term potentiation
pgig04722  Neurotrophin signaling pathway
pgig04725  Cholinergic synapse
pgig04726  Serotonergic synapse
pgig04730  Long-term depression
pgig04810  Regulation of actin cytoskeleton
pgig04910  Insulin signaling pathway
pgig04912  GnRH signaling pathway
pgig04914  Progesterone-mediated oocyte maturation
pgig04915  Estrogen signaling pathway
pgig04916  Melanogenesis
pgig04917  Prolactin signaling pathway
pgig04919  Thyroid hormone signaling pathway
pgig04921  Oxytocin signaling pathway
pgig04926  Relaxin signaling pathway
pgig04928  Parathyroid hormone synthesis, secretion and action
pgig04929  GnRH secretion
pgig04934  Cushing syndrome
pgig04935  Growth hormone synthesis, secretion and action
pgig05010  Alzheimer disease
pgig05022  Pathways of neurodegeneration - multiple diseases
pgig05034  Alcoholism
pgig05132  Salmonella infection
pgig05135  Yersinia infection
pgig05160  Hepatitis C
pgig05161  Hepatitis B
pgig05163  Human cytomegalovirus infection
pgig05164  Influenza A
pgig05165  Human papillomavirus infection
pgig05166  Human T-cell leukemia virus 1 infection
pgig05167  Kaposi sarcoma-associated herpesvirus infection
pgig05170  Human immunodeficiency virus 1 infection
pgig05200  Pathways in cancer
pgig05205  Proteoglycans in cancer
pgig05206  MicroRNAs in cancer
pgig05207  Chemical carcinogenesis - receptor activation
pgig05208  Chemical carcinogenesis - reactive oxygen species
pgig05210  Colorectal cancer
pgig05211  Renal cell carcinoma
pgig05212  Pancreatic cancer
pgig05213  Endometrial cancer
pgig05214  Glioma
pgig05215  Prostate cancer
pgig05216  Thyroid cancer
pgig05218  Melanoma
pgig05219  Bladder cancer
pgig05220  Chronic myeloid leukemia
pgig05221  Acute myeloid leukemia
pgig05223  Non-small cell lung cancer
pgig05224  Breast cancer
pgig05225  Hepatocellular carcinoma
pgig05226  Gastric cancer
pgig05230  Central carbon metabolism in cancer
pgig05231  Choline metabolism in cancer
pgig05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pgig00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    120604492 (MAP2K1)
   04012 ErbB signaling pathway
    120604492 (MAP2K1)
   04014 Ras signaling pathway
    120604492 (MAP2K1)
   04015 Rap1 signaling pathway
    120604492 (MAP2K1)
   04370 VEGF signaling pathway
    120604492 (MAP2K1)
   04371 Apelin signaling pathway
    120604492 (MAP2K1)
   04668 TNF signaling pathway
    120604492 (MAP2K1)
   04066 HIF-1 signaling pathway
    120604492 (MAP2K1)
   04068 FoxO signaling pathway
    120604492 (MAP2K1)
   04072 Phospholipase D signaling pathway
    120604492 (MAP2K1)
   04071 Sphingolipid signaling pathway
    120604492 (MAP2K1)
   04024 cAMP signaling pathway
    120604492 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    120604492 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    120604492 (MAP2K1)
   04150 mTOR signaling pathway
    120604492 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    120604492 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    120604492 (MAP2K1)
   04148 Efferocytosis
    120604492 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    120604492 (MAP2K1)
   04210 Apoptosis
    120604492 (MAP2K1)
   04218 Cellular senescence
    120604492 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    120604492 (MAP2K1)
   04540 Gap junction
    120604492 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    120604492 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    120604492 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    120604492 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    120604492 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    120604492 (MAP2K1)
   04660 T cell receptor signaling pathway
    120604492 (MAP2K1)
   04662 B cell receptor signaling pathway
    120604492 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    120604492 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    120604492 (MAP2K1)
   04062 Chemokine signaling pathway
    120604492 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    120604492 (MAP2K1)
   04929 GnRH secretion
    120604492 (MAP2K1)
   04912 GnRH signaling pathway
    120604492 (MAP2K1)
   04915 Estrogen signaling pathway
    120604492 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    120604492 (MAP2K1)
   04917 Prolactin signaling pathway
    120604492 (MAP2K1)
   04921 Oxytocin signaling pathway
    120604492 (MAP2K1)
   04926 Relaxin signaling pathway
    120604492 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    120604492 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    120604492 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    120604492 (MAP2K1)
   04916 Melanogenesis
    120604492 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    120604492 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    120604492 (MAP2K1)
   04726 Serotonergic synapse
    120604492 (MAP2K1)
   04720 Long-term potentiation
    120604492 (MAP2K1)
   04730 Long-term depression
    120604492 (MAP2K1)
   04722 Neurotrophin signaling pathway
    120604492 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    120604492 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    120604492 (MAP2K1)
   05206 MicroRNAs in cancer
    120604492 (MAP2K1)
   05205 Proteoglycans in cancer
    120604492 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    120604492 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    120604492 (MAP2K1)
   05230 Central carbon metabolism in cancer
    120604492 (MAP2K1)
   05231 Choline metabolism in cancer
    120604492 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    120604492 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    120604492 (MAP2K1)
   05212 Pancreatic cancer
    120604492 (MAP2K1)
   05225 Hepatocellular carcinoma
    120604492 (MAP2K1)
   05226 Gastric cancer
    120604492 (MAP2K1)
   05214 Glioma
    120604492 (MAP2K1)
   05216 Thyroid cancer
    120604492 (MAP2K1)
   05221 Acute myeloid leukemia
    120604492 (MAP2K1)
   05220 Chronic myeloid leukemia
    120604492 (MAP2K1)
   05218 Melanoma
    120604492 (MAP2K1)
   05211 Renal cell carcinoma
    120604492 (MAP2K1)
   05219 Bladder cancer
    120604492 (MAP2K1)
   05215 Prostate cancer
    120604492 (MAP2K1)
   05213 Endometrial cancer
    120604492 (MAP2K1)
   05224 Breast cancer
    120604492 (MAP2K1)
   05223 Non-small cell lung cancer
    120604492 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    120604492 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    120604492 (MAP2K1)
   05161 Hepatitis B
    120604492 (MAP2K1)
   05160 Hepatitis C
    120604492 (MAP2K1)
   05164 Influenza A
    120604492 (MAP2K1)
   05163 Human cytomegalovirus infection
    120604492 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    120604492 (MAP2K1)
   05165 Human papillomavirus infection
    120604492 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    120604492 (MAP2K1)
   05135 Yersinia infection
    120604492 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    120604492 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    120604492 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    120604492 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    120604492 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    120604492 (MAP2K1)
   01522 Endocrine resistance
    120604492 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pgig01001]
    120604492 (MAP2K1)
Enzymes [BR:pgig01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     120604492 (MAP2K1)
Protein kinases [BR:pgig01001]
 Serine/threonine kinases: STE group
  STE7 family
   120604492 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 120604492
NCBI-ProteinID: XP_039721175
UniProt: A0A6P3S323
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaatccagccccagacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctggatgagcagcagcggaagcgccttgaggcctttcttacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgctggcaatggtggt
gtggtgttcaaggtctcccacaagccatccggcctggtcatggctagaaagttaattcac
ctggaaatcaaacctgcaatccggaaccagatcataagagagctgcaagttctacatgaa
tgtaactctccgtatatcgtgggcttctatggtgcattttacagtgatggcgagatcagc
atctgcatggaacatatggatgggggttccttggatcaagtgctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtgattaaaggtctgacgtatctg
agggagaagcacaagattatgcatagagatgtcaagccttctaacatcctagtgaactct
cgtggggagatcaagctttgtgactttggggtcagcgggcagctcatcgactccatggcc
aattccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcactac
tcggtgcagtcggacatctggagtatggggctctctctggttgagatggcagttgggagg
tatcccatccctcctccagatgccaaggagctggaactgatgtttgggtgccaagtggag
ggagatgcagctgagacaccgcctaggccaaggacccctgggaggcccctcagctcttat
ggaatggatagccgacctcccatggcaattttcgaattgttggattatatagtcaatgag
cctcctccaaaactacccagtggagtattcagtctggaatttcaagactttgtgaataaa
tgcttaataaaaaaccccgcagaaagagctgatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtagattttgcaggttggctctgctctaccattggc
cttaaccagcccagcacaccaacccatgcagctggtgtctaa

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