KEGG   Pteropus vampyrus (Indian flying fox): 120605013
Entry
120605013         CDS       T07511                                 
Symbol
TBK1
Name
(RefSeq) serine/threonine-protein kinase TBK1
  KO
K05410  TANK-binding kinase 1 [EC:2.7.11.10]
Organism
pgig  Pteropus vampyrus (Indian flying fox)
Pathway
pgig04014  Ras signaling pathway
pgig04137  Mitophagy - animal
pgig04140  Autophagy - animal
pgig04620  Toll-like receptor signaling pathway
pgig04621  NOD-like receptor signaling pathway
pgig04622  RIG-I-like receptor signaling pathway
pgig04623  Cytosolic DNA-sensing pathway
pgig04657  IL-17 signaling pathway
pgig04936  Alcoholic liver disease
pgig05014  Amyotrophic lateral sclerosis
pgig05022  Pathways of neurodegeneration - multiple diseases
pgig05135  Yersinia infection
pgig05160  Hepatitis C
pgig05161  Hepatitis B
pgig05162  Measles
pgig05163  Human cytomegalovirus infection
pgig05164  Influenza A
pgig05165  Human papillomavirus infection
pgig05167  Kaposi sarcoma-associated herpesvirus infection
pgig05168  Herpes simplex virus 1 infection
pgig05169  Epstein-Barr virus infection
pgig05170  Human immunodeficiency virus 1 infection
pgig05171  Coronavirus disease - COVID-19
pgig05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pgig00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    120605013 (TBK1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    120605013 (TBK1)
   04137 Mitophagy - animal
    120605013 (TBK1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    120605013 (TBK1)
   04621 NOD-like receptor signaling pathway
    120605013 (TBK1)
   04622 RIG-I-like receptor signaling pathway
    120605013 (TBK1)
   04623 Cytosolic DNA-sensing pathway
    120605013 (TBK1)
   04657 IL-17 signaling pathway
    120605013 (TBK1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    120605013 (TBK1)
   05161 Hepatitis B
    120605013 (TBK1)
   05160 Hepatitis C
    120605013 (TBK1)
   05171 Coronavirus disease - COVID-19
    120605013 (TBK1)
   05164 Influenza A
    120605013 (TBK1)
   05162 Measles
    120605013 (TBK1)
   05168 Herpes simplex virus 1 infection
    120605013 (TBK1)
   05163 Human cytomegalovirus infection
    120605013 (TBK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    120605013 (TBK1)
   05169 Epstein-Barr virus infection
    120605013 (TBK1)
   05165 Human papillomavirus infection
    120605013 (TBK1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    120605013 (TBK1)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    120605013 (TBK1)
   05022 Pathways of neurodegeneration - multiple diseases
    120605013 (TBK1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    120605013 (TBK1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    120605013 (TBK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pgig01001]
    120605013 (TBK1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pgig04131]
    120605013 (TBK1)
Enzymes [BR:pgig01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     120605013 (TBK1)
Protein kinases [BR:pgig01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   120605013 (TBK1)
Membrane trafficking [BR:pgig04131]
 Autophagy
  Xenophagy
   Other xenophagy associated proteins
    120605013 (TBK1)
SSDB
Motif
Pfam: TBK1_CCD1 Pkinase TBK1_ULD PK_Tyr_Ser-Thr Pkinase_fungal ABC1 Kinase-like DUF713 CEP63 COG6_N ubiquitin
Other DBs
NCBI-GeneID: 120605013
NCBI-ProteinID: XP_039721842
UniProt: A0A6P3R621
LinkDB
Position
Unknown
AA seq 729 aa
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMIIHVFSLQQMTAHKIYIHSYNTATVFHELVYKQTKIISSNQELIYEGRRLV
LEPGRLAQHFPKTTEENPIFVVSQEPMSTIGLTYEKISLPKVHPRYDLDGDASMAKAITG
VVCYACRIASTLLLYQELMRKGIRWLIELVKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKINLEAAELDEISDIHTKLLRLSSSQGTIETSLQDIESRLSPGGLLADTWAHQE
GTHPKDRHVEKLQVLLNYITEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWVRKMLHLRKQLLSLANQCFDIEEEVSKYQDYTNELQETLPQ
KMIAASSGIKHAMTPIYPCSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
NT seq 2190 nt   +upstreamnt  +downstreamnt
atgcagagcacttctaatcatctgtggcttttatctgatattttaggccaaggagctact
gcaaatgtctttcgtggaagacataagaaaactggtgacttatttgctatcaaagtattt
aataacataagcttccttcgtccagtagatgttcaaatgagagaatttgaagtgttaaaa
aaactcaatcacaaaaatattgtcaaattatttgcaattgaggaggagacaacaacaaga
cataaagtccttattatggaattttgtccatgtgggagtttatacactgttttagaagag
ccatctaatgcctatggactaccagagtctgaatttttaattgttttgcgagatgtggtg
ggtggaatgaatcatctccgagagaacggcatagtgcatcgtgatatcaagccaggaaat
atcatgcgtgttataggggaagatggacagtctgtttacaaactcacagattttggtgca
gctagagaattagaagatgatgagcagttcgtttctctgtatggcacagaagaatatttg
catcctgatatgtatgagagagcagtgctaagaaaagatcaccagaagaaatatggagca
acagttgatctttggagcattggggtaacgttttaccacgcagctactggatcactgcca
tttagaccatttgaagggccacgtaggaataaggaagtgatgtataaaataattactgga
aagccgtctggtgcaatatctggagtacagaaagcagaaaatggaccaatcgactggagt
ggagacatgcctgtttcttgtagtctttctcggggtcttcaagttctacttactcctgtt
cttgcaaacatccttgaggcagatcaggaaaagtgttggggttttgaccagttttttgca
gaaactagtgatatacttcaccgaatgataattcatgttttttcgctacaacaaatgaca
gctcataagatttatattcatagttataatactgctactgtatttcatgaactggtgtat
aaacaaaccaaaattatttcttcaaatcaagaacttatatatgaaggacgacgcttagtt
ctcgaacctggaagactggcacagcatttccctaaaactactgaggaaaaccctatcttt
gtagtaagccaggaacccatgagtaccataggactgacatatgaaaaaatttccctccct
aaagtacatccacgttatgatttagatggagatgctagcatggctaaggcaataacagga
gttgtgtgttatgcctgtagaattgccagtaccctgctgctttatcaggaattaatgcga
aaggggatacgatggttgatagaattagttaaagatgattataatgaaactgttcacaaa
aagacagaagttgtgatcacactggatttctgcatcagaaacattgaaaaaactgtgaaa
gtatatgaaaagttgatgaaaatcaacctagaagcagcagagttagatgaaatttcagac
atacacaccaaattgttgagactttccagttctcagggaacaatagaaaccagtcttcag
gatatcgaaagcagattatctccaggtggattgctggcggatacgtgggcccatcaagaa
ggcactcatccaaaagataggcatgtggaaaagctacaagtcctgttaaattacatcaca
gagatttactatcagttcaaaaaagacaaagcagaacgtagactggcttataatgaagaa
cagatccacaaatttgataagcaaaaactctattaccatgcaacaaaagccatgacccac
tttacagatgaatgtgttaaaaagtatgaggcatttttgaataagtcagaagaatgggtg
agaaagatgcttcatcttaggaaacagttattgtccctagctaatcaatgttttgatatt
gaagaagaagtatcaaagtatcaagactatactaatgagttacaagaaactttgcctcag
aaaatgattgcagcctccagtggaatcaaacatgccatgactccaatttatccatgttct
aacacattagtagaaatgactcttggtatgaagaaattaaaggaagaaatggaaggggtt
gttaaagaacttgctgaaaataatcatattttagaaaggtttggctctctaaccatggat
ggtggccttcgcaatgttgactgcctttag

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