Pantherophis guttatus (corn snake): 117671958 Help Entry 117671958         CDS       T07329                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X2   KO K04962   ryanodine receptor 2 Organism pgut  Pantherophis guttatus (corn snake) Pathway pgut04020   Calcium signaling pathway pgut04260   Cardiac muscle contraction pgut04261   Adrenergic signaling in cardiomyocytes pgut04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:pgut00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     117671958 (RYR2)    04020 Calcium signaling pathway     117671958 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     117671958 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     117671958 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pgut04040]     117671958 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:pgut04990]     117671958 (RYR2) Ion channels [BR:pgut04040]  Voltage-gated cation channels   Ryanodine receptor    117671958 (RYR2) Domain-containing proteins not elsewhere classified [BR:pgut04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    117671958 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  117671958 NCBI-ProteinID:  XP_034284173 UniProt:  A0A6P9CIE1 LinkDB All DBs Position Unknown AA seq 4962 aa AA seqDB search MTEVGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRTSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNSSLRVDAAFQQTLWSVAPISSGSEVAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHI TTGKYLNLMDDKSLLLTDKEKADVKSTAFCFRSSKEKLDVGIRKEVDGMGTPEIKYGDSV CFIQHVDTGLWLTYQSVDAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKAKSSIVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGETWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGISEGSAQYRKWYYELMVDYVEPFTTAEATHLRVGWASTEGYSPYPVGGEEWGGNGVGD DLYSYGFDGLHLWSGCVARSVNSPNHHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNTDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPLGYAPCFEAILPKEKLKVEPSREY KQDCNCSRDLLGPNISLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPIRDDNKRQHPCLIEFAKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKLKLPKNYLLSSGYKPAPMDLSCIKLTPSQESMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLINYGYNLEAPDQDHAARPDVFDG MIERFRIFRTEKTYAVKTGKWYFEFEAITAGDMRIGWARPGCQPEQELGSDDQAFVFDGF KAQRWHQGNEHFGRTWLTADIVGCMVDLNEHTMMFTLNGEILLDDSGSELAFKDFEVGDG FIPACSLGLSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLP VPANHEHIEVTRIDGTADSSPCLKLTQKSFGSQNSKTDIMFYRLSMPIECAEVFSKMPGG GMPNSNLFGPKSDLDDYDADSDFEVLMKTAHGHLVPDRVEKEAAKSEFNNHKDYTQEKPS RLKQRFMLKRTKPDYSTSHSARLTEDVLADERDDYDYLMQTSTYYYSVRIFPGQEPANVW VGWITSDFHQYDTNFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGENMSPGQGRNN NGLEIGCLVDVATGILSFTTNGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKN VMPLSAGLFKSEHKNPLPQCPPRLHVQFLTHVLWSRVPNQFLKIDISRINERQGWSIQCL DSLQFMSLHIPEENRSIDILELSEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHVDE SQLLYAIENKYMPGLLRAGYYELLIDIHLNSYATARLMMNNEFIVPMTDETKSITLFPDE HKKHGLPGIGLSTSLRPRIQFSSPSFVRINSECYQYSPEFPLEILKSKTIEMLTEAVQEG SLHVRDPVGGTTEFLFVPLIKLFYTLLIMGVFHNEDLKHILQLIEPSVFKEDNGGEDETR ILVKELVKESLNLETGLDEIRREKVPEEGLLQMKLPEPVKLQMCHLLQYLCDFQIRHRIE AIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTAKKTKEFRSPPQEQINMLLNFKDDK NDCPCPEEIRDHLLDFHEDLMAHCGIQLDEDGILDGNSDLTIKGRLLYLVERVTHLKKKQ AEKLIDDNNKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGVGGLVRALP KTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMR ALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLE NSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQNCPLLISK GYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGL LAAMEEAINISEDPTRDGPSSTNGSTKTSSEVEEEDDTVHMGNAIMTFYAALIDLLGRCA PEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGNVVEPDMSGGFCPD HKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTVALSATDMALALNRYLCTA VLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPS MMQHLLRRLVFDIPLLNEHAKMPLKLLTIHYERCWKYYCLPGGWGNFGAASEEELHLSRK LFWGIFDALSQKKYEQELFKLALPCLSSVAGALPPDYMESNYVGVMEKQASMDSDGNFNP QPVDTSNITIPEKLDYFINKYAEHSHDKWCMEKFANGWIYGETYSESSKVQPLMKQYKLL SEKEKEIYRWPIKESLKTMLAWGWRVERTREGDTMALYNRSRRISQTSQISVDTVHGYTP RAIDMSNVTLSRELHAMAEMMAENYHNIWAKKKKMELEAKVGGGNHPLLVPYDTLTAKEK AKDREKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILE FDGGSRGKGEQFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSSGGHASNKEKE MVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKMALRTFLD NAAEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPVLSSLFDHIGQHQFGEDLI LEDVQISCYRILASLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLNSHNIYS IFNTKTTRAGFSLPNSVQELCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPMLCS YMSHWWEHGPENNHNKSEMCCTALTSDDMNTLLGNILKIIHNNLGIDEGAWMKRLAVFSQ PIISKVKPELLKTHFLPLMEKLKKKAALVIADEEHLRAEGRGDMSEAELLILDEFTTLAR DLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFVVQNE INNMSFLITDTKSKMSKTAVSDPERKKMKRKGDRYSTQTSLIVAALKRLLPIGLNICAPG DQELIALAKNRLSMKDTEDEVRDIICNNLHLQGKLEDPAIRWQVALYKDLPNRTDITSDP EKTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRA VNLFLQGYEKSWVETEDHYFEDTLIEDLAKPGAEPTEEDECIKRVDPLHQLILLFSRTAL TEKCKLDEDYLYMAYADIMAKSCHDEEDNNDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQ QARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDYLKDKKDV GFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLC EGHNSGFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKEVIDEQGQRNFS KAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIEL LKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESFNNVEMILKFFDMFLKLKDLT FSDAFKEYDPDGKGIISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRF HEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELADSVLNYFQPFLGRIEIMGSAKRIER VYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQIS ESDLNERSMNKEENENDKLEDQDPRIGFFSLVTITSALIALRHNIMTLMKMLSMKSIKKQ MKKMKKMTMKDMVMALFSSYWTILMGFMHFLSSVFRGFFQIMYSLLLGGSLVEGAKKIKV AELLANMPDPTQDEVRGDGEEVERKPAEAALPAEDLTDLKALSEDTDLLSDIFGLDLKRE GGQYKLIPHNPNAGLSDLLSSPSLLPLPDVQEKVQDQKMNEGEKDEREDTKFEHEKAEGE DGEKEEKTKEDKGKQKPKQRHKHRHGELELQESAFWKKIIAYQQKVLNYFARNFYNMRML ALFVAFAINFILLFYKVSTSSVTEEKEIQVVNTAEKMKLNSLESPSHRIITVHYVLEESS GYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDD IKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGKDRISELLGMDKAALDFSDAREK KKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMIMSVLGHYNNFFFAAHLLD IAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMK CDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGL IIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYL INKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14889 nt NT seq  +upstreamnt  +downstreamnt atgactgaagtgggcgaaggggaagacgagatacagttcctgcgaactgatgatgaagtc gttctgcagtgtactgctactgttcacaaagaacaacagaaattgtgtcttgctgcagaa ggatttggcaacaggctctgcttcttggaatcaacttctaattccaagaatgttcctccg gatctctccatctgtacttttgttctggagcaatcattgtcagtcagagctctccaagaa atgctggccaacacagaggagaaagcagaagggctagttgatgtggaaaaatggaaattc atgatgaagactgcgcaaggtggtggtcatagaacgctcctctacggacatgcaatatta ctgcgccattcttacagtggcatgtatctgtgttgtctttccacatcacgaacatcaatg gataaattggcttttgatgtaggtttgcaagaagataccacaggagaagcctgctggtgg actatacatcctgcttccaaacagcgttcagaaggagaaaaagtgcgtgttggggatgat ctcatccttgtcagtgtctcttcagaaagatacttgcatttatcttatggcaacagcagc ttgcgtgtggatgcagctttccagcaaacactttggagtgttgccccaatcagttccgga agtgaagtagctcaaggctatctaataggaggtgacgtactgcggttattacatggtcac atggatgaatgcctgacggttccttcaggagaacatggagaagagcagagaagaactgtc cattatgaaggtggtgctgtgtcaattcatgctcgttctctttggcgactggagactttg agggttgcatggagtggaagtcacattagatgggggcagccattcagattaagacatata acaacagggaaatatttaaatctcatggatgacaagagtcttcttctaacagacaaagaa aaagctgatgtgaaatctacagcattttgttttcgatcttccaaggagaaattagatgta gggataagaaaagaagtggatggcatgggaaccccagaaataaagtatggagattcagtc tgctttatacagcatgtagacacaggtttgtggcttacctaccaatcagtggatgcaaag tctgtaaggatgggatctgtgcagcgcaaggccatcatgcaccatgagggccatatggat gatggattgacattatccagatctcagcatgaagaatcacgtacagcacgagtaattcgc agtacagtcttccttttcaacaggttcataaggggccttgatgctctcagcaagaaagct aagtcttccatagttgatttacccattgaatcagtcagccttagccttcaggacttgatt ggttacttccacccaccagatgagcacttagagcatgaagacaaacagaaccgactaaga gctctgaagaatcgacaaaatctcttccaagaagagggtatgatcaatttagtgcttgaa tgtattgatcgcttacatgtgtacagcagtgcagctcattttgctgatgtagctggaaag gaagctggagaaacttggaaatctattctaaattcactgtatgaattattagcggctttg attagagggaatcgtaaaaattgtgctcagttctccggatctcttgattggctcataagt agactggagagattggaggcatcttctggaattcttgaagtattacactgtgtgttggtg gaaagtccagaagcattgaatattattaaagaaggacatattaaatcaatcatttgtctt ttggacaaacatggcagaaaccataaggtattagatgttctttgttcattgtgtgtatgt catggagtagctgtgcgatccaatcaacatttgatctgtgataatcttctgccagggaga gaccttcttcttcaaactcgccttgtcaatcatgtgagcagcatgcgaccaaatattttc cttggaatcagcgagggctctgctcaatacaggaaatggtattatgaattaatggttgat tatgtggagccatttacaacagcagaagctactcaccttcgtgtaggttgggcatcaaca gaaggctattcaccatatccagtgggtggagaagaatggggtggcaatggtgttggtgat gacttatattcctatggttttgatggacttcatctatggtcaggttgtgtagcaagatca gtcaattctcctaatcatcatctactcaggactgatgatgtgatcagctgttgccttgac ctgagtgctccaagcatttcattccgaataaatgggcagccagtgcagggaatgtttgag aatttcaacacagatggtcttttctttccggttgtcagcttttcagcagggataaaagta cgatttttgctcggaggccgccatggggaatttaaattccttccccctctaggatatgct ccatgttttgaagctattctgccgaaagaaaagttaaaagtggaacccagtagggaatat aaacaagattgcaattgctcaagggatctcttgggaccaaatatctctttgtcacaagca gcattcactccagtacctgtagataccagtcagattgtattacctccacatctggaaaga attagagaaaaactagctgagaatatccatgaactttgggtgatgaataaaattgaactt ggatggcagtatggaccaattagagatgacaacaagcggcagcatccctgtttgatagag tttgctaaactgcctgaacaagaacggaattataatcttcagatgtcactagaaacatta aaaacattgctggcattaggttgtcatgttggaattgctgatgagcatgctgaagaaaag gtgaaaaaactaaaacttcccaaaaattatctattatcaagcggatataaacctgctcct atggatctaagttgtatcaagttgactccatctcaggaatccatggttgataaactcgca gagaatgctcacaatgtatgggcaagagatcgtataaggcagggatggacatatggaatt caacaggatgtgaagaaccgtcgaaatcctcgccttgtcccctatacacttctagatgat cgcactaagaaatcaaacaaagatagtcttcgagaagcagttcgtactctcatcaattac ggatataaccttgaagctccagatcaagaccatgctgcaaggcctgatgtgtttgatggc atgatagaaaggttcaggatattccgaacagaaaaaacatatgctgtaaaaactgggaaa tggtactttgaatttgaagcaataaccgctggagatatgagaattggctgggccaggcca ggttgtcagcccgagcaagagcttggctcagatgatcaagcatttgtatttgatggtttc aaggcccagcgatggcaccagggaaatgagcattttggccgtacttggttaacagcagat attgtgggatgcatggtggatctgaatgagcacaccatgatgtttacgctaaatggtgaa atccttcttgatgactcaggttctgaacttgcatttaaagattttgaggttggtgatggc tttatacctgcctgtagcctgggattgtcacaggtgggcagaatgaacttcggcaaagat gttagcactttgaaatatttcactatttgtggcttacaagaaggctatgaaccttttgct gtgaatacaaatcgtgacattactatatggctgagcaaaagattacctcagtttcttcca gtaccagcaaatcatgaacatattgaggttacaaggattgatggaactgcagatagttct ccatgtttgaaactcacacagaagtcctttggatctcaaaacagcaaaacagacatcatg ttttatcgtctaagcatgcccattgaatgtgcagaagtgttttctaaaatgcctggagga ggaatgccaaattctaatctttttggcccaaagagtgatttggatgattatgatgcagat tctgattttgaagtcctcatgaagactgctcatggtcatcttgtacctgaccgtgtagaa aaagaagccgcaaaatcagagttcaataaccataaagattatacacaagagaaaccttca cgcctcaaacaaagatttatgctgaaaaggacgaagccagactacagcacaagccattct gcaagactaactgaagatgtcctagcagatgaacgagatgattatgattatctaatgcaa acctctacatattattattctgtacgtatatttcctggacaagaacctgctaatgtttgg gtaggctggattacatctgatttccatcaatatgacacaaactttgatttggacagagtc cgtactgttacagtaaccttaggagatgaaaaagggaaagttcatgagagtatcaaacga agcaactgctatatggtgtgtgctggagaaaacatgagtccagggcaaggacgcaataat aatggattagagattggctgcttggttgatgttgcaactggtatcctatccttcactacc aatggcaaagaattaagcacttattatcaggtagaaccaagtactaaattatttcctgca gtatttgcacaagccacaagccctaatgttttccaatttgagttgggacgaataaagaat gtaatgccattgtcagctggcttgttcaaaagtgagcacaaaaatccacttcctcagtgc ccaccccgtctccatgttcagtttctgacacatgttctttggagcagagtgccaaatcag tttctgaaaatagatatatcacgaatcaatgaacggcagggctggtcaattcagtgcctg gattctttgcagttcatgtcccttcacattccagaggaaaacaggtctatagatatttta gaactgtcagaacaagaagaactgctaaagtttcattatcatactctcagactatactca gcagtgtgtgctcttgggaataacagagttgcacatgctatgtgcagccatgttgatgaa tctcagcttctctatgcaattgagaacaaatacatgccaggcttgttacgtgcgggctat tatgaacttctcattgatattcaccttaatagctatgccactgcaaggttgatgatgaac aatgaattcattgtcccaatgacagatgagactaaaagcattactttgtttcctgatgaa cacaaaaaacatggcctaccaggtatcgggcttagtacatctttacgacccagaatacag ttttcttctcccagttttgtaagaattaatagtgaatgctaccaatatagtcctgaattt cctctagaaattttgaagtctaaaaccatagagatgttgacagaagcagttcaggagggt agccttcatgtcagagatccagtaggtggtactacagaatttctcttcgttcctttgatc aaacttttttatactctccttataatgggagtcttccacaatgaagatctgaagcatatc ttgcagctcattgagcccagtgtgtttaaagaagataacggcggtgaagatgaaacccga atattagtgaaggaactagttaaagaaagtctaaatttagagacaggtttggatgaaatc agaagggagaaggttccagaagaaggacttcttcaaatgaagcttcctgagcccgtcaaa ttacagatgtgccatttactccaatatctatgtgacttccagatacgccatagaatagaa gccattgtagcattttcagatgattttgtagcaaaactccaggaaaatcagcgtttccga tataatgaagttatgcaagctttaaatatgtcagcagctctgacagccaagaaaacgaaa gaatttcgatccccaccacaggagcagatcaacatgctactgaattttaaggatgataaa aatgattgtccttgtcctgaagaaataagggatcatctcctggattttcatgaagatctg atggcacattgcggtattcagctagatgaagatggaattctagatggaaacagtgattta actattaaaggtcgcctgctatatcttgtagaaagagtcacacacttgaaaaaaaaacaa gcagagaagctaattgatgataataacaagaaaccatcaactctccaacagctgatatca gaaactatggtacgttgggctcaagaatctgtaatagaagacccagagttggtgagggcc atgtttgttttgctacatcgccaatatgatggggttggtggcctggtccgagccttgccc aagacatacacaataaatggtgtatcagtggaagataccatcaacttgcttgcatctctt ggccagatccgttctctcctcagtgttaggatgggcaaggaagaagaaaagcttatgatt cgtggattaggggacattatgaacaataaagttttttatcagcatcctaatcttatgagg gcgttggggatgcatgagactgtaatggaagtaatggtgaatgtacttggaggaggagaa tcaaaggaaatcacctttcctaagatggtggcaaactgctgtcgttttctatgttatttt tgccgcatcagcagacagaatcagaaagccatgttcgaccatctaagctatcttttggaa aacagcagtgttggacttgcttctccttccatgcggggatcaacccctttagatgttgca gcagcatcagtaatggataataatgagcttgcactggctttaagagaacctgacttagag aaggtagtccgctacttggctggctgtggtttgcagaactgtcctttactaatttctaaa ggctatccagatattggatggaacccagttgaaggagaacgatacctggatttccttcgt tttgctgttttttgcaatggagagagtgttgaagaaaatgctaatgtggtagtcagactg ctcattcgacggcctgaatgttttggaccagcactgagaggtgaaggtggaaatggctta cttgctgccatggaagaagccataaacatatcagaagatcctacaagagatggtccttca tcaactaatggatctactaaaacatcaagtgaagtagaagaagaggatgatactgttcac atgggaaatgccatcatgactttttatgctgctctgattgatctcttgggccgctgtgct ccagaaatgcatctcatccatgctggcaaaggggaagccattagaatcagatctattctg aggtccttgattcctttggaggacttggtgggtgtaattagcattccttttcacatgcca acaatagcaaaagatggcaatgttgtagaaccagatatgtcaggggggttttgccctgat cacaaggcagcgatggtattgtttcttgacagggtctatggaattgaagaccaagatttt cttctacacctactagaagttggctttctgccagatcttcgtgcagctgcttctttagat acggttgccctgagtgccacagatatggccctggctcttaatcggtacctctgcactgct gttttgcctttattaacaagatgtgctcctctttttgctggaacagaacatcatgcttcc cttatagattccttgctacatactgtatatcggctttccaaaggctgttctcttaccaaa gctcagcgggattctattgaagaatgcctactctccatttgtggtcagctaagaccttca atgatgcaacatttgttgagaagattagtatttgatatccctcttctaaatgaacatgcc aaaatgcctcttaagttgctgacaattcattatgaaagatgttggaaatactactgttta ccaggagggtggggcaactttggtgctgcatcagaagaagaacttcatttgtccagaaag ctgttctggggtatttttgatgccttatctcaaaagaaatatgaacaagaactattcaaa ttagcactgccatgcttgagttctgtagctggggctttacctcctgattacatggaatca aattatgttggtgttatggaaaaacaagcttccatggattcagatgggaacttcaatcca cagcctgttgatacttcaaacattacaattcctgaaaaactagactactttataaacaaa tatgctgaacattctcacgataaatggtgcatggaaaagtttgcaaatgggtggatatat ggtgaaacatattcagaatcttccaaagtgcagccattaatgaaacaatataaactatta tcagaaaaggaaaaagaaatttatagatggccaattaaagaatctctgaaaaccatgctt gcttggggatggcgggttgaaagaacgagggaaggagatactatggctctttataatcgt tcacgtcggatatcacagacaagtcagatttctgtagatacagtccatggctatactccc cgtgcaattgacatgagtaatgtaaccctgtccagagagttacatgcaatggctgagatg atggctgaaaattatcataacatatgggcgaaaaaaaagaaaatggagcttgaagccaaa gtgggaggaggaaatcatcccctacttgtaccctatgatacattgacagccaaagaaaaa gctaaggatagagagaaagcccaagatattctgaagttcctccagatcaatggctatgtt gtgtccagaggcttaaaggatttagaattagacacaccatccattgaaaaaaggtttgct tacagttttctccaacaattgatacgatacgtagatgaagcccatcagtatattctggaa ttcgatggtggcagcagagggaaaggagaacagtttccttatgaacaagaaatcaaattc tttgctaaagttgtacttcctttaattgatcagtatttcaaaaatcaccgcctgtatttc ctatctgcagcaagcagacctctgagcagcgggggtcatgcttctaacaaggagaaagaa atggtaaccagcctattctgcaaacttggagttcttgtcaggcataggatttcactgttt ggaaatgatgcaacttcaatagtcaattgtcttcatatcttgggtcagaccttggatgca aggacagtgatgaagacaggtttagaatcggttaagatggctttgaggacatttttggat aatgctgcagaggacctggaaaaaacaatggaaaatcttaagcaggggcaattcacgcac accaggagtcagccaaaaggagtaacacaaattattaactacacaacagtggctctcctg ccagtattgtcttcattatttgatcacattggacagcatcagtttggcgaagatttgata ttggaagatgttcaaatctcttgttatagaatattggccagcttatatgctttgggaacc agcaagagtatctatgtggaacgtcaacgttcagctctaggtgaatgtttagcagctttt gcaggtgcctttcctgtggcatttttagaaactcatctgaatagccacaatatttattct atattcaataccaagacaacaagagcaggtttcagtttaccaaacagcgtacaggaactt tgtccaaatattccatctctggaaaaactaatggaagaaattgtagaattagctgaatca ggcattcgctatacacaaatgcctcatgtaatggaagttatattgcccatgctttgtagt tatatgtcgcattggtgggaacatggaccagaaaacaatcataacaagagtgaaatgtgc tgcacagcattgacttcagatgatatgaatactcttctgggaaacattctaaaaatcata cataacaatttgggcatagatgaaggagcctggatgaagagattagcagtgttttctcag cctatcataagcaaagtgaagccggaacttctgaaaacacattttcttccactgatggaa aaactaaagaaaaaagcagctctggtgattgctgatgaagaacacttacgagcagaaggc aggggtgatatgtctgaggcggaacttctcattctagatgaattcactacacttgcccgg gacctttatgccttctatccattgttgatcagatttgtggactacaacagagcaaaatgg ctcaaagagcccaaccctgaagctgaagatttgtttcgtatggttgcagaagttttcatt tactggtcaaaatcccataattttaaaagggaagaacagaactttgtggtgcaaaatgag atcaacaatatgtctttccttattactgacactaaatcgaagatgtctaagacagctgtt tctgatccggaaagaaaaaaaatgaaacggaaaggggatcgttactcaactcaaacgtct ctaattgtggctgcattaaaaagattgcttcctattgggttaaatatttgtgcacctggt gaccaagaattaattgctctggcaaaaaatcgattgagcatgaaggacaccgaggatgaa gttcgagatattatttgcaacaacctccatttacagggcaagcttgaagatcctgcaatt agatggcaggtggccctttacaaagatctaccgaacagaactgatatcacttcagatcca gaaaagactgtggaacgggttttggatatagctaatgtacttttccatctggaacaggtt gagcatcctcaaagatcaaaaaaggcagtatggcataaactcttgtccaaacagagaaaa agagctgtggtggcttgcttcagaatggcgccactatataatcttccacggcaccgagct gtcaatctttttcttcagggatatgaaaagtcctgggtggaaacagaagaccattatttt gaagatacgttgatagaagacttagcaaaacctggagcagaaccaacagaagaggatgaa tgtattaagcgagttgatcctttgcatcaacttattttattattcagccgaactgcttta actgaaaaatgtaaattggacgaagattacttgtatatggcatatgctgatattatggca aagagctgccatgatgaagaagataacaatgatggagaagaggaagtgaagagctttgaa gtcacaggatcccaacgcagcaaggaaaaagaaatggaaaagcaaaaactcctctaccag caagcaagactccatgatcgaggggctgctgaaatggtcctgcagacaattagtgccagc aaaggtgaaatgggaccaatggttgcagccaccctcaaacttggaattgctatcttgaat ggaggaaattcaactgttcagcagaaaatgctggactatctcaaagacaaaaaagacgta ggattctttcagagccttgctggtcttatgcagtcttgcagtgtccttgacctaaatgct ttcgaacgtcagaataaagcagaaggccttggaatggtaacagaagaaggatcaggggaa aaggtgatgcaggatgatgaatttacctgtgacctcttccggttccttcagttgctttgt gaaggtcataattcaggttttcagaattacttgagaactcagactggtaataatacaact gtcaacattatcatatcaactgtggattatttattgagagttcaggaatcaattagtgat ttctattggtattattctggaaaggaagttatcgatgaacaaggacaacgtaatttctct aaagctattcaagttgcaaagcaagtcttcaatactcttacagaatatattcagggtccg tgtacaggtaatcaacagagtcttgcacacagcaggctttgggatgctgtggttggtttt cttcatgtctttgcccacatgcagatgaagctctctcaggattctagtcaaattgaatta ctgaaagaattaatggaccttcagaaagacatggtggtcatgctgctatctatgttggaa ggtaatgttgtgaatggaacaatcggcaagcaaatggttgacatgctggtggaatcgttc aacaatgtagaaatgattctaaagttttttgatatgtttctaaaactgaaggatttaact ttctctgatgcattcaaagaatatgatccagatggtaagggcattatttccaagagagat ttccacaaagcgatggagagccacaaacattatactcaatcggaaactgagtttctgctc tcctgtgctgaaacagatgagaatgaaactttggactatgaggaatttgtgaaacgattt catgagccagctaaagacattggcttcaacgttgctgttttgctgacaaacttatccgag cacatgccccatgatacgcgactgcaaactttccttgaattggcagacagtgttctcaac tacttccagccgtttttaggacgcatagaaataatgggcagcgcaaagcgcattgaacga gtttactttgagatcagtgaatcaagtcggacgcagtgggagaaacctcaggttaaagag tcaaagaggcagtttatttttgatgtagtaaacgaaggaggggaaaaggaaaaaatggaa ctttttgttaatttttgtgaagataccatctttgaaatgcagttggctgctcagatctca gaatcagatctgaacgagcggtctatgaataaagaagaaaatgaaaatgacaagctggaa gatcaagacccccgaataggattcttctctctagtgacaatcacatcagcattaatagcc ctcaggcataacataatgactctcatgaaaatgttaagcatgaaaagtataaagaagcaa atgaagaagatgaaaaaaatgaccatgaaggacatggtcatggctttgttttcttcctat tggaccattttaatgggtttcatgcattttttatcgagcgtcttcagaggcttctttcaa atcatgtacagcttgctgcttggagggagccttgttgaaggagccaagaaaattaaagta gctgaacttttagctaacatgcctgaccctactcaggatgaggtccgtggtgatggagaa gaagtagaaaggaagccagccgaagcagctttgcctgcagaagacctgactgacctcaaa gctctatctgaagatactgacctcctctcagatatttttggcttagatttgaaacgagaa ggaggacagtataaactaattccacataatccaaatgcagggttgagcgatttgttgagc agtccttctttactccctttacctgatgtgcaagaaaaagtacaggaccagaagatgaat gaaggtgaaaaagatgaaagagaagatactaaattcgaacatgaaaaagcagagggagaa gatggagaaaaggaagagaaaacaaaagaagataagggaaagcagaaaccaaagcagcgt cacaaacataggcatggtgaactagaattgcaagaatctgccttctggaaaaaaattatt gcatatcaacagaaagtccttaattattttgctcggaatttttacaatatgaggatgctg gctttatttgttgcatttgccattaatttcattcttttgttctacaaggtatctacatct tcagtgacagaagaaaaggaaatacaagtagttaatactgctgagaaaatgaagctaaac agcctagaaagtccttctcatagaatcatcacagtacactatgtccttgaagaaagcagt ggctacatggaacctacactccgcattttagcaattttacacactgtcatttcctttttc tgcatcattgggtattactgtctgaaagttccattggtaatatttaagcgagaaaaagaa gttgcaaggaaattggaatttgacgggctatatattacagaacagccttcagaggatgat attaagggacaatgggacagacttgtcatcaatacacagtcttttcctaataactattgg gacaagtttgtgaaaagaaaggttatggataaatatggagagttttatggcaaagaccga atcagtgaattgctgggaatggacaaggctgctctagatttcagtgatgctcgagaaaaa aagaaacccaaaaaggatagttctttatcagctgtgctgaattctattgatgtaaagtat caaatgtggaaactaggtgttgttttcactgataattcttttctgtacctggcctggtat atgatcatgtcagtccttggtcattacaacaactttttctttgctgcacacctccttgac atagcaatgggatttaaaacattacgaacgattctatcatcagtgacccacaatgggaaa cagcttgtactaactgtgggattactggcagtggtagtttatctatacacagtagttgct ttcaatttcttccgaaaattctacaataagagtgaagatggagatatgccagatatgaaa tgtgatgatatgctaacgtgctatatgtttcacatgtatgtgggagtacgcgctggtggt ggaattggtgatgaaatcgaagatcctgcaggcgatgaatatgaaatatatcgaatcatc tttgatattacatttttcttttttgtaattgttattctactagctatcatacaaggcttg attattgatgcatttggagaattaagagatcagcaagaacaagttaaagaagacatggag actaaatgttttatctgtggaataggtaatgattattttgatacagtgccacatggcttt gaaacacatactctacaggagcacaacttagctaattatctattttttctgatgtatctc attaataaagatgaaaccgaacacactggtcaagagtcgtatgtgtggaaaatgtatcaa gaacgatgctgggaattttttcctgccggtgattgttttcgaaagcagtatgaagatcag cttaattaa

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