Phyllostomus hastatus (greater spear-nosed bat): 123805718
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Entry
123805718 CDS
T07912
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
phas
Phyllostomus hastatus (greater spear-nosed bat)
Pathway
phas00562
Inositol phosphate metabolism
phas01100
Metabolic pathways
phas01521
EGFR tyrosine kinase inhibitor resistance
phas04012
ErbB signaling pathway
phas04014
Ras signaling pathway
phas04020
Calcium signaling pathway
phas04062
Chemokine signaling pathway
phas04064
NF-kappa B signaling pathway
phas04066
HIF-1 signaling pathway
phas04070
Phosphatidylinositol signaling system
phas04072
Phospholipase D signaling pathway
phas04360
Axon guidance
phas04370
VEGF signaling pathway
phas04380
Osteoclast differentiation
phas04611
Platelet activation
phas04613
Neutrophil extracellular trap formation
phas04625
C-type lectin receptor signaling pathway
phas04650
Natural killer cell mediated cytotoxicity
phas04662
B cell receptor signaling pathway
phas04664
Fc epsilon RI signaling pathway
phas04666
Fc gamma R-mediated phagocytosis
phas04670
Leukocyte transendothelial migration
phas04722
Neurotrophin signaling pathway
phas04750
Inflammatory mediator regulation of TRP channels
phas04919
Thyroid hormone signaling pathway
phas04933
AGE-RAGE signaling pathway in diabetic complications
phas04935
Growth hormone synthesis, secretion and action
phas05167
Kaposi sarcoma-associated herpesvirus infection
phas05169
Epstein-Barr virus infection
phas05170
Human immunodeficiency virus 1 infection
phas05171
Coronavirus disease - COVID-19
phas05200
Pathways in cancer
phas05205
Proteoglycans in cancer
phas05206
MicroRNAs in cancer
phas05214
Glioma
phas05223
Non-small cell lung cancer
phas05225
Hepatocellular carcinoma
Module
phas_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
phas00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
123805718 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
123805718 (PLCG2)
04064 NF-kappa B signaling pathway
123805718 (PLCG2)
04066 HIF-1 signaling pathway
123805718 (PLCG2)
04070 Phosphatidylinositol signaling system
123805718 (PLCG2)
04072 Phospholipase D signaling pathway
123805718 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
123805718 (PLCG2)
04613 Neutrophil extracellular trap formation
123805718 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
123805718 (PLCG2)
04662 B cell receptor signaling pathway
123805718 (PLCG2)
04664 Fc epsilon RI signaling pathway
123805718 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
123805718 (PLCG2)
04670 Leukocyte transendothelial migration
123805718 (PLCG2)
04062 Chemokine signaling pathway
123805718 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
123805718 (PLCG2)
04919 Thyroid hormone signaling pathway
123805718 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
123805718 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
123805718 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
123805718 (PLCG2)
04380 Osteoclast differentiation
123805718 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
123805718 (PLCG2)
05206 MicroRNAs in cancer
123805718 (PLCG2)
05205 Proteoglycans in cancer
123805718 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
123805718 (PLCG2)
05214 Glioma
123805718 (PLCG2)
05223 Non-small cell lung cancer
123805718 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
123805718 (PLCG2)
05171 Coronavirus disease - COVID-19
123805718 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
123805718 (PLCG2)
05169 Epstein-Barr virus infection
123805718 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
123805718 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
123805718 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
phas04131
]
123805718 (PLCG2)
Enzymes [BR:
phas01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
123805718 (PLCG2)
Membrane trafficking [BR:
phas04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
123805718 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
123805718 (PLCG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF-hand_PLCG2
C2
SH3_1
PH
SH3_9
PH_12
EF-hand_PLCG1
SH2_1
PH_14
SH3_2
Adhesin_E
GDPD
EF-hand_like
Motif
Other DBs
NCBI-GeneID:
123805718
NCBI-ProteinID:
XP_045674372
LinkDB
All DBs
Position
Unknown
AA seq
1265 aa
AA seq
DB search
MTTMVNVDGLPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKCSKDFERAKAVRQKEDCCFTILYGTQFTLSTLSLAADSKEDAT
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRKNSISLRELKTVLPLVNFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VHLHDFQRFLLHEQQELWAQDLNRVRKRMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVVLSIEEHCGVEQQRYMARV
FKEVFGDMLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVDMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDTPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCSEMGGKDGTFLVRESERFPNDYTLSFWRSGRVQHCRIRSTMEDGVMKYY
LTDNLMFPSIYALIQYYRGTHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRKREGSDSYAITFRAKGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
KKHALYRKMKLRYPVTPELLERYSMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKQSDELSFYRGALIHNVSKEPGGWWKGDYGTKIQQYFPSNYVEDISSADVEDLEKQII
EDNPLGSLCRGILDLNAYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIRQITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVVRQKPIDLLKYNQKALTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNQALFSLNGRTGYVLQPESMRTDKYDPMPPESQRKIQMTLTVKVLGARHLPKPGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALIKEFNVNENQLQLYQEKCNRRLREKRVSN
SKFYS
NT seq
3798 nt
NT seq
+upstream
nt +downstream
nt
atgaccaccatggtcaatgtggacggccttccggagtatgagaagagtcagatcaagaga
gccctggagctgggcacagtgatgaccgtgttcagcttccgcaagtccaccccggagcgc
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagtaagacggccgacaag
atcgaaggtttcttggatatcatggaaataaaggaaatccgcccggggaagtgctccaag
gattttgagcgtgcaaaagcagtgcgccagaaggaagactgctgcttcaccatcctgtac
ggcacccagttcaccctcagcacactcagtttagcagctgactctaaggaagatgcaacc
aagtggctctccggcttgaaaatcttacaccaagaagcaatgagtgcgtccacacccacc
attattgagagttggctgagaaagcagatttattcagtggaccaaaccagaaaaaacagc
atcagcctccgagagctgaagaccgtcttgcccctggtcaacttcaaagtgagcagtgcc
aagttcctcaaggacaagtttgtggaaataggcgcgcacaaagacgaactcagctttgag
cagttccatctcttctataaaaaactaatgtttgaacagcaaaaatcgattctcgatgaa
ttcaaaaaagactcctccgtgttcatcttggggaacactgaccggccggacgcctctgct
gttcacctgcacgacttccagcggtttctcttacatgaacagcaggagctctgggctcag
gatctgaacagagtccgcaagaggatgacaaagtttatcgacgacacaatgagggaaact
gcggagccctttctgttcgttgatgagttcctcacgtacctgttttcacgggagaacagc
atttgggatgagaagtatgatgtggtggacatgcaggacatgaacaaccccttgtctcat
tactggatctcctcatcacataacacgtacctcacaggtgaccagctgcggagtgagtcg
tccacggaggcatacatccgctgtctgcgcatgggctgtcgctgcattgagttggactgc
tgggacgggcccgacgggaagcccatcatctaccacggctggacacggaccaccaagatc
aagtttgatgacgtcgtgcaggccatcaaagaccacgcctttgtcacctcgagcttccct
gtggtcctgtccatcgaggagcactgtggcgtggaacagcagcgctacatggccagagtg
ttcaaggaggtgtttggtgacatgctgctgacgaagcccacggaggccagtgccgaccag
ctgccctcacccagccagctgcgggaaaagatcatcatcaagcataagaagctgggcccc
cgaggcgacgtggatgtcgacatggaggacaagaaagatgagcacaagcaacagggtgaa
ctgtacatgtgggactccatcgaccagaaatggactcggcactattgcgccatcgccgat
gccaagctgtccttcagcgatgacattgaacagaccatggaagaagaagtgccccaggat
acaccccctaccgagctgcattttggagagaagtggttccacaagaaggtggagaagagg
acgagtgccgagaagctgctgcaggagtactgctccgagatggggggcaaggacgggacc
ttcttggtgcgggagagcgagaggttccccaatgactacaccctgtccttctggcggtca
ggccgcgtccagcactgccggatccgctccaccatggaggacggggtcatgaagtactac
ctgactgacaacctcatgttccccagcatctacgccctcatccagtactaccgcgggacg
cacctgcgctgtgccgagttcgagctgcgcctcacggaccctgtgcccaaccccaacccc
cacgagtcaaagccgtggtactatgacgggctgagccgtggagaagcggaggacatgctg
atgagagttccccgggacggtgccttcctcatccggaagcgggaaggcagcgactcctat
gccatcaccttcagggccaagggcaaggtgaagcactgtcgcatcaaccgggacggccgg
cacttcgtgctggggacctccgcctacttcgagagcctggtggagctcgtcagttactac
aagaagcacgcgctgtaccggaagatgaaactgcgctaccccgtgactcccgaactcctg
gagcgctacagcatggaaagagacataaactccctgtatgacgtcagcagaatgtatgtg
gaccccagcgaaatcaatccttctatgcctcagagaactgtgaaagctctgtatgactac
aaagccaagcagagtgatgagctgagcttctaccgtggcgccctcattcacaacgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaaaatccagcagtacttcccg
tccaattacgtcgaggacatttcatcggctgatgtggaggatctggagaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatactggatctcaatgcctataatgtt
gtgaaagccccacagggcaaaaaccagaagcctttcgtctttatcctggaacccaagaag
cagggggaccctccggtggagtttgccacagacagggtggaggagctcttcgaatggttc
cagagcatccggcagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtcgatcgccatcgagctgtcagacctggtcgtctactgcaagccaacc
agcaagaccaaagacaacttagaaaatcctgacttccgagaaatccgctcctttgtggag
acgaaggctgacagcgtcgtcaggcagaagcccatcgatctcctgaagtacaatcagaag
gccctgacccgcgtgtacccgaagggacagagggtggactcctccaactacgatcccttc
cgcctctggctgtgtggctcccaaatggtggcactcaatttccagactgcagacaagtac
atgcagatgaatcaggccttgttctcgctcaatgggaggaccggctacgtcctacagcct
gagagcatgaggacggataagtatgaccccatgccacccgagtcccagaggaagattcag
atgaccttgacggtcaaggttctcggggctcgccatcttcccaagcctggacgaagcatc
gcatgtccctttgtggaggtggaaatatgtggagctgaatatgacaacaacaagtttaag
acgacggttgtgaatgacaatggcctaagccccgtttgggctccaacacaggagaaggtg
acattcgaaatttatgatccaaacctcgcgttcctgcgctttgtggtgtacgaggaagat
atgttcagcgatcccaactttcttgctcatgccacttaccctattaaaggaatcaaatca
ggatttagatctgttcctctgaagaatgggtacagcgaagacattgagctggcttccctc
ctggttttctgtgagatgcggccagtcctggagagcgaagaggaactctactcctcctgt
cgccagctgcggaggcggcaagaagagctgaacaaccagctctttctctacgacacacac
cagaacttgcgcaatgccaaccgggatgccctcattaaagaattcaatgtcaacgagaac
cagctccagctgtaccaggagaagtgcaaccggaggttaagagagaagagagtcagcaac
agcaagttttactcatag
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integrated database retrieval system
