KEGG   Phyllostomus hastatus (greater spear-nosed bat): 123808110
Entry
123808110         CDS       T07912                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
phas  Phyllostomus hastatus (greater spear-nosed bat)
Pathway
phas01521  EGFR tyrosine kinase inhibitor resistance
phas01522  Endocrine resistance
phas04010  MAPK signaling pathway
phas04012  ErbB signaling pathway
phas04014  Ras signaling pathway
phas04015  Rap1 signaling pathway
phas04022  cGMP-PKG signaling pathway
phas04024  cAMP signaling pathway
phas04062  Chemokine signaling pathway
phas04066  HIF-1 signaling pathway
phas04068  FoxO signaling pathway
phas04071  Sphingolipid signaling pathway
phas04072  Phospholipase D signaling pathway
phas04114  Oocyte meiosis
phas04140  Autophagy - animal
phas04148  Efferocytosis
phas04150  mTOR signaling pathway
phas04151  PI3K-Akt signaling pathway
phas04210  Apoptosis
phas04218  Cellular senescence
phas04270  Vascular smooth muscle contraction
phas04370  VEGF signaling pathway
phas04371  Apelin signaling pathway
phas04380  Osteoclast differentiation
phas04510  Focal adhesion
phas04517  IgSF CAM signaling
phas04519  Cadherin signaling
phas04540  Gap junction
phas04550  Signaling pathways regulating pluripotency of stem cells
phas04613  Neutrophil extracellular trap formation
phas04620  Toll-like receptor signaling pathway
phas04650  Natural killer cell mediated cytotoxicity
phas04660  T cell receptor signaling pathway
phas04662  B cell receptor signaling pathway
phas04664  Fc epsilon RI signaling pathway
phas04666  Fc gamma R-mediated phagosome formation
phas04668  TNF signaling pathway
phas04720  Long-term potentiation
phas04722  Neurotrophin signaling pathway
phas04725  Cholinergic synapse
phas04726  Serotonergic synapse
phas04730  Long-term depression
phas04810  Regulation of actin cytoskeleton
phas04910  Insulin signaling pathway
phas04912  GnRH signaling pathway
phas04914  Progesterone-mediated oocyte maturation
phas04915  Estrogen signaling pathway
phas04916  Melanogenesis
phas04917  Prolactin signaling pathway
phas04919  Thyroid hormone signaling pathway
phas04921  Oxytocin signaling pathway
phas04926  Relaxin signaling pathway
phas04928  Parathyroid hormone synthesis, secretion and action
phas04929  GnRH secretion
phas04934  Cushing syndrome
phas04935  Growth hormone synthesis, secretion and action
phas05010  Alzheimer disease
phas05022  Pathways of neurodegeneration - multiple diseases
phas05034  Alcoholism
phas05132  Salmonella infection
phas05135  Yersinia infection
phas05160  Hepatitis C
phas05161  Hepatitis B
phas05163  Human cytomegalovirus infection
phas05164  Influenza A
phas05165  Human papillomavirus infection
phas05166  Human T-cell leukemia virus 1 infection
phas05167  Kaposi sarcoma-associated herpesvirus infection
phas05170  Human immunodeficiency virus 1 infection
phas05200  Pathways in cancer
phas05205  Proteoglycans in cancer
phas05206  MicroRNAs in cancer
phas05207  Chemical carcinogenesis - receptor activation
phas05208  Chemical carcinogenesis - reactive oxygen species
phas05210  Colorectal cancer
phas05211  Renal cell carcinoma
phas05212  Pancreatic cancer
phas05213  Endometrial cancer
phas05214  Glioma
phas05215  Prostate cancer
phas05216  Thyroid cancer
phas05218  Melanoma
phas05219  Bladder cancer
phas05220  Chronic myeloid leukemia
phas05221  Acute myeloid leukemia
phas05223  Non-small cell lung cancer
phas05224  Breast cancer
phas05225  Hepatocellular carcinoma
phas05226  Gastric cancer
phas05230  Central carbon metabolism in cancer
phas05231  Choline metabolism in cancer
phas05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:phas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    123808110 (MAP2K1)
   04012 ErbB signaling pathway
    123808110 (MAP2K1)
   04014 Ras signaling pathway
    123808110 (MAP2K1)
   04015 Rap1 signaling pathway
    123808110 (MAP2K1)
   04370 VEGF signaling pathway
    123808110 (MAP2K1)
   04371 Apelin signaling pathway
    123808110 (MAP2K1)
   04668 TNF signaling pathway
    123808110 (MAP2K1)
   04066 HIF-1 signaling pathway
    123808110 (MAP2K1)
   04068 FoxO signaling pathway
    123808110 (MAP2K1)
   04072 Phospholipase D signaling pathway
    123808110 (MAP2K1)
   04071 Sphingolipid signaling pathway
    123808110 (MAP2K1)
   04024 cAMP signaling pathway
    123808110 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    123808110 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    123808110 (MAP2K1)
   04150 mTOR signaling pathway
    123808110 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    123808110 (MAP2K1)
   04519 Cadherin signaling
    123808110 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    123808110 (MAP2K1)
   04148 Efferocytosis
    123808110 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    123808110 (MAP2K1)
   04210 Apoptosis
    123808110 (MAP2K1)
   04218 Cellular senescence
    123808110 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    123808110 (MAP2K1)
   04540 Gap junction
    123808110 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    123808110 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123808110 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    123808110 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    123808110 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    123808110 (MAP2K1)
   04660 T cell receptor signaling pathway
    123808110 (MAP2K1)
   04662 B cell receptor signaling pathway
    123808110 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    123808110 (MAP2K1)
   04666 Fc gamma R-mediated phagosome formation
    123808110 (MAP2K1)
   04062 Chemokine signaling pathway
    123808110 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123808110 (MAP2K1)
   04929 GnRH secretion
    123808110 (MAP2K1)
   04912 GnRH signaling pathway
    123808110 (MAP2K1)
   04915 Estrogen signaling pathway
    123808110 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    123808110 (MAP2K1)
   04917 Prolactin signaling pathway
    123808110 (MAP2K1)
   04921 Oxytocin signaling pathway
    123808110 (MAP2K1)
   04926 Relaxin signaling pathway
    123808110 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    123808110 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    123808110 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    123808110 (MAP2K1)
   04916 Melanogenesis
    123808110 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    123808110 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    123808110 (MAP2K1)
   04726 Serotonergic synapse
    123808110 (MAP2K1)
   04720 Long-term potentiation
    123808110 (MAP2K1)
   04730 Long-term depression
    123808110 (MAP2K1)
   04722 Neurotrophin signaling pathway
    123808110 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    123808110 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123808110 (MAP2K1)
   05206 MicroRNAs in cancer
    123808110 (MAP2K1)
   05205 Proteoglycans in cancer
    123808110 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    123808110 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    123808110 (MAP2K1)
   05230 Central carbon metabolism in cancer
    123808110 (MAP2K1)
   05231 Choline metabolism in cancer
    123808110 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123808110 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    123808110 (MAP2K1)
   05212 Pancreatic cancer
    123808110 (MAP2K1)
   05225 Hepatocellular carcinoma
    123808110 (MAP2K1)
   05226 Gastric cancer
    123808110 (MAP2K1)
   05214 Glioma
    123808110 (MAP2K1)
   05216 Thyroid cancer
    123808110 (MAP2K1)
   05221 Acute myeloid leukemia
    123808110 (MAP2K1)
   05220 Chronic myeloid leukemia
    123808110 (MAP2K1)
   05218 Melanoma
    123808110 (MAP2K1)
   05211 Renal cell carcinoma
    123808110 (MAP2K1)
   05219 Bladder cancer
    123808110 (MAP2K1)
   05215 Prostate cancer
    123808110 (MAP2K1)
   05213 Endometrial cancer
    123808110 (MAP2K1)
   05224 Breast cancer
    123808110 (MAP2K1)
   05223 Non-small cell lung cancer
    123808110 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    123808110 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    123808110 (MAP2K1)
   05161 Hepatitis B
    123808110 (MAP2K1)
   05160 Hepatitis C
    123808110 (MAP2K1)
   05164 Influenza A
    123808110 (MAP2K1)
   05163 Human cytomegalovirus infection
    123808110 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123808110 (MAP2K1)
   05165 Human papillomavirus infection
    123808110 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123808110 (MAP2K1)
   05135 Yersinia infection
    123808110 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123808110 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    123808110 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    123808110 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    123808110 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123808110 (MAP2K1)
   01522 Endocrine resistance
    123808110 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:phas01001]
    123808110 (MAP2K1)
Enzymes [BR:phas01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     123808110 (MAP2K1)
Protein kinases [BR:phas01001]
 Serine/threonine kinases: STE group
  STE7 family
   123808110 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 123808110
NCBI-ProteinID: XP_045678406
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAIGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHVAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgccgaagaagaagccgacgcccatccagctgaacccggccccagacggctccgcggtt
aacgggaccagctcggcagagaccaacctggaggctttgcagaagaagctggaggagctg
gagctcgatgagcagcagcggaagcgccttgaggcctttcttacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgctggcaatggtggt
gtggtgttcaaggtctcccacaagccgtccggcctggttatggccagaaagctaattcac
ctggagatcaaacctgcgatccggaaccagatcataagggagctgcaggttctacatgag
tgtaactccccatacattgtgggcttctatggtgcattttacagtgatggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgagcaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagattatgcatagagatgtcaagccttccaacatcctggtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aattcctttgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tcggtgcagtcggacatctggagcatggggctctctctggttgagatggcgattgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagacaccacccaggccaaggacccctgggagaccccttagctcttat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtgaacgag
cctcctccgaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaattaaaaaccctgcagagcgagcagatttgaagcaactcatggttcatgctttc
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacaccgacccatgtggctggtgtctaa

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