Phyllostomus hastatus (greater spear-nosed bat): 123812430
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Entry
123812430 CDS
T07912
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
phas
Phyllostomus hastatus (greater spear-nosed bat)
Pathway
phas05012
Parkinson disease
phas05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
phas00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
123812430 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
123812430 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
phas01001
]
123812430 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
phas04131
]
123812430 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
phas04147
]
123812430 (LRRK2)
Enzymes [BR:
phas01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
123812430 (LRRK2)
Protein kinases [BR:
phas01001
]
Serine/threonine kinases: TKL group
LRRK family
123812430 (LRRK2)
Membrane trafficking [BR:
phas04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
123812430 (LRRK2)
Exosome [BR:
phas04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
123812430 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
Roc
LRR_8
LRR_4
COR
Ras
Arf
LRR_14
LRR_9
WD40_CDC20-Fz
LRR_13
Beta-prop_EML_2
nSTAND3
AAA_22
TsaE
Beta-prop_RSE1_2nd
T2SSE
GTP_EFTU
MMR_HSR1
PduV-EutP
AAA_7
Kdo
AAA_16
ABC_tran
G-alpha
NACHT
TrwB_AAD_bind
WD40_Prp19
Septin
SRPRB
cobW
MobB
AAA_29
Beta-prop_BBS7
FtsK_SpoIIIE
TniB
ResIII
NB-ARC
AAA_33
Arm
AAA_23
Motif
Other DBs
NCBI-GeneID:
123812430
NCBI-ProteinID:
XP_045685094
LinkDB
All DBs
Position
Unknown
AA seq
2528 aa
AA seq
DB search
MASGSCQGCDEEDEETLKKLIVRLNNLQEGKQIETLVQILEDMLVFTYADHASKLFQGKN
VHVPLLIVLDSYMRVTSVQQVGWSLLCKLIEICPNTMQSLLGPQDIGHDWEVLGVHQLII
KMLTVHNASINLSMVGLKALDLLLTSGKITLLILDEESDIFLLIFDAMRTFSTNGEVQKL
GCKALQVLFERVSEEQLTEFVENKDYTILLSAFKNFKDEEEIVLHVLHCLHSLAIPCNNV
EVLMSGNVRCYNIVVEAMKAFPVNEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
KQYSENAALQIAALSCLALLTETIFLNQDLEEKNENQENADDEDEDKLFWLQACYKALTG
HRKNKHVQEAACWALNNLLMYQNNLHEKIGDEDGQFPAHREVMLSMLMHSTSKEVFQASA
NALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDV
MAAVAPNIVTVMKSHVTSSSVQLEALRAILHFIVPGMQGEFTEDTEHQHKLNIVTEQCFR
NDIHKLVLLSLKRFVANPGIQKCGFKVISSVARLPAALEALSLEGALDLVLQTLQMYPDD
QEIQCLGVSLIGCLIMKKTLFLVTGRLLAKVLVSSLQRFKDVAELQIKGFQTVLTVLELS
VSFSKLLVHYSFDSVIFHQMSSSIMEQKDQQFLNLCCKCFAKLAMDEELKSVMLERACDQ
NNSIMAECLLLLGADANRAKEGASLICQVCEKASNPKLVELLLSSGPREQDVRKALTISI
GKGDGQTISLLLRRLALDLANNSICLGGFGIGKIEPSWLGPLFPDKTFNSRKETNIGCTL
ARMVLRYQMKSAAEEGAASGSNGHFSEEVLNKCDEWTFIPESYMDNVFGQSDDLDSEGSE
GSFLEKKKSHSISVGEFCRDPALQRNSPVLQRHPNSLGPIFSHEDLLKRKRKILSSDDSV
RSSKLPSHLRQSDSSSSLASEREYITSLDLSANELREIDALSQKCCISGHLEHLEKLELH
QNALTSFPQRLCETLKCLTHLDLHSNKFTSFPSYLLKMNCIANLDVSRNDIGPSVVLDPA
VKCLTLKQFNLSYNQLTSVPENLGDVVEKLEQLMLEGNKISGMCSPLSLKELKILNLNKN
HISSLSEDFLEACPKVESFSARMNFLAAMPFLPSSMTSIKLSQNRFTCVPEAILNLPHLR
SLDMSSNDIQYLPSPAHWKSLNLRELLFSHNQISILDLSEKAHAWSRVEKLHLSHNKLKE
IPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDII
RFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSELGVQSPTVGIDVKDWPIQ
IKGKRKKDLILNVWDFAGREEFYSTHPHFMTQRSLYLAVYDLSKGQAEVDAMKPWLFNIK
ARASSSPVILVGTHLDVADERQRKACISKINKELLNKRGFPAIRDYHFVNATEESDALAK
LRKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVKE
NQLQLDENELPHAVHFLNESGALLHFQDPALQLSNLYFVEPKWLCKVMAQILTVKVEGYS
KHPKGIISRRDVEKFLSKKKRFPKNYMHQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPV
IELPHCENSEIIIRLYEMPYFPMGFWSRLISRLLEISPYMLSGRERALRPNRMYWRQGIY
LNWSPEAYCLVGSEVLDNHLESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEID
ICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDL
ILADLPRNIMLNSDELEFEQAPEFLLGDGSFGSVYRATYEGEEVAVKIFNKHTSLRLLRQ
ELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKATLTRTLQHRIALHVA
DGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFR
APEVARGNVIYNQQADVYSFGLLLYDIFTSGGRIAEGLKFPNEFDELAIQGKLPDPVKEY
GCAPWPMVEKLIERCLKENPQERPTSAQVFDILNSADLLCLMRHIAIHKNGTVECMVATS
HHSRNASVWLGCGNADRGELSFLDLTTKRLTSEEVTDSRILCLALVHLPSEKESWIVSGA
QSGGLLVIDTEDGNKRHNLERMTDAVTCLYCSSFSKQSKQKNFLLVGTADGKLAIFEDKA
VKCEGAAPLKILTIGNVSTPLMCLSESVNSSERNIMWGGCGTKLFSLSDDFSIQKLIETR
TNQLFSSAAFNDSNIIAVVVDTAVYIAKKNSPVVEVWDKKTDKLCELIDCVHFLKEDMVK
ANKESKQSMYYSGRVKTLCLQKNTALWIGTGGGSVLLLDLSTRRLIRTIHNFYDSVRVMM
PAQLGNLKNAMLVLGYCRKSTEGMQHQKELQSFLSIWDMNLPHEVQNLEKHIEVRKELAE
KMRRISVE
NT seq
7587 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgtcaggggtgcgatgaggaggacgaggaaactttgaagaagttg
atagtcagactgaacaatctccaggaaggaaaacagatagagacgctggtccaaatcctg
gaggacatgctggtgttcacctacgctgaccacgcctccaagttatttcaaggcaaaaat
gtgcacgtgcctctgttgatcgtcttggactcatatatgcgtgtcactagtgtgcagcag
gtgggttggtcacttctatgcaaattaatagaaatctgcccaaatacaatgcaaagcttg
ttgggaccccaggatattggacacgattgggaagtccttggtgttcaccaactgattatt
aaaatgcttacagttcataatgccagtataaacctgtcaatggttggactgaaggcctta
gatctccttctaacttcaggtaaaatcactttgctaatattggatgaagaaagtgatatt
ttcttattaatttttgatgccatgcgaacattttcaaccaatggcgaggtccagaaactt
gggtgcaaagctttacaagtgctgtttgagagagtttccgaggagcaactgactgaattt
gttgagaataaagattatacaatattgctgagtgcatttaaaaactttaaagatgaagag
gaaattgtgcttcacgtactacactgtttacattccctagcaattccttgcaataatgtt
gaagtgctcatgagtggcaatgtgaggtgttacaatattgtggtagaagccatgaaagca
ttccctgtcaacgaaaaaattcaggaagtgagttgctgcttgctccatcggcttacatta
ggtaatttttttaatatcctggtattaaacgaggtgcacgagtttgtggtgaaagccgtg
aagcagtattcggagaatgcggcattgcaaattgcagcgctcagctgtttagcactcctc
actgagaccattttcttaaatcaagacttagaggagaagaatgaaaatcaggaaaacgct
gatgatgaggatgaagataaattgttttggctacaagcctgttacaaagccttaacaggg
cacagaaagaacaagcatgtgcaggaggctgcatgctgggccctaaacaatctccttatg
taccaaaacaatttgcacgagaagattggagatgaagatggccagttcccagctcacaga
gaagtgatgctctccatgctgatgcattctacatcaaaagaagtttttcaggcatctgcg
aacgcattgtcgactctcttagaacaaaatgttaatttcagaaaaatcctgttgtcaaaa
ggaatatacctgaatgtgttggaattaatgcagaagcacatacattctcctgaagtggct
gaaagtggctgcaaaatgctaaatcatctttttgaaggaagtaacacttccctggacgtg
atggcagcagtggcccccaacatagtaacggttatgaaaagtcatgtgacgtcatcatca
gtgcagctagaggcccttagagctattttgcattttatagttccaggcatgcaaggagaa
ttcacggaagatactgaacatcagcacaagctaaatatagttacagaacagtgtttcaga
aatgatattcacaaactggtcctgctatctttaaaaaggttcgttgcaaatcctgggatt
cagaaatgtggatttaaagtaatttcttctgtggcacgtttacctgccgcattagaagca
ttatctctggaaggcgctcttgatttggtgcttcagaccctgcagatgtatccggacgac
caagaaattcagtgtctgggtgtaagtcttataggatgcttgattatgaagaagacttta
ttcttggtaactgggcgtctgttggcaaaagttctggtttccagtttacagcgatttaag
gatgttgctgaattacagattaaaggatttcagacagtcttgacagtgctggaattgtca
gtgtcgttttccaagctgttggtgcattactcctttgattcagtaatattccatcagatg
tcttctagtatcatggaacagaaggatcagcagttcctaaacctctgttgcaagtgcttt
gcaaaattagctatggatgaggagttaaaaagtgtgatgctggagagagcatgcgatcag
aacaacagcatcatggctgaatgcttgcttctgttgggagcggatgccaatcgagcgaag
gagggagcttctttaatttgtcaggtgtgcgaaaaagccagcaaccccaaactggtggaa
ctgttactgagtagtgggccccgtgaacaagatgtgcgtaaagcgctgacaataagcatt
gggaaaggggatggccagaccatcagtttgctcttaaggaggcttgccctggacctggct
aacaacagcatctgccttggaggatttggtataggaaaaattgaaccttcttggctcggt
cctttatttccagataagacatttaattcaagaaaagaaacaaatataggatgtacctta
gcaagaatggtcctcagataccagatgaaaagtgctgcggaagaaggagcagcctcaggc
agcaatgggcacttttctgaagaagtacttaataaatgtgatgaatggaccttcattcct
gagtcttacatggacaatgtatttggtcaaagtgatgatctagatagcgaaggaagtgaa
ggttcatttcttgagaaaaagaagtcacattcaattagcgtaggagaattttgccgagat
cctgccttgcagcgcaactcaccagttttgcaaaggcatcccaattcattgggacccatt
ttcagtcatgaagatttactgaagcggaaaagaaaaatattgtcttcagatgattcagtc
aggtcatcgaaacttccatcccacctgaggcagtcagacagcagttcttccctggcttct
gagagagaatatattacatcattagatctttcagcaaatgaactcagagagattgacgcc
ctgagccagaagtgctgcataagtgggcacttggagcatcttgaaaagctggagcttcac
cagaatgcactcacgagctttccacaacgactctgtgaaactctgaagtgtttgacacat
ttggacttgcacagtaataaatttacatcatttccctcctacttgttgaaaatgaattgt
atcgccaaccttgatgtctctcggaatgacatcggaccctcagtagttttggatcctgcg
gtgaagtgtctgaccctgaaacagtttaacctgtcatataatcagctgacttctgttcct
gagaacctcggtgatgtggtggagaagctggaacagctcatgttagaaggaaataaaata
tcaggaatgtgttcccccctgagcctgaaagagttgaagattttgaacctcaataaaaac
cacatttcatccctatcagaggactttcttgaggcttgtcctaaagtggaaagtttcagt
gctagaatgaattttcttgctgctatgccttttttgccttcttcgatgacgagcataaaa
ttatctcaaaacagatttacatgtgttccagaggcaattttaaatcttccacatttgcga
tccttagatatgagcagcaatgatattcagtatctaccaagccctgcacattggaaatct
ctgaacttaagggagctcttgtttagtcataatcagatcagcatcttggacttgagtgaa
aaagcacatgcatggtctagagtagagaaactacatctttctcataataagctcaaagag
attcctcctgagattggctgtcttgaaaacctgacatctcttgatgttagttacaacttg
gaactgagatcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttg
gatgaactgcgtcttaattttgattttaaacatataggatgtaaagccaaagacatcata
aggtttcttcaacagaggttgaaaaaggctgtgccctacaaccgcatgaaactcatgatt
gtgggaaatactgggagtggtaaaaccaccttgttgcagcaattaatgaaaaccaagaaa
tcagaacttggcgtgcaaagtcccacagttggcatagatgtgaaagactggcctatccaa
ataaaaggcaaaaggaagaaagacctcattctgaatgtgtgggattttgcaggtcgtgag
gaattctacagcactcacccccacttcatgacccagcggtctctgtacctggccgtctat
gacctcagcaaagggcaagctgaggttgatgcgatgaagccttggctcttcaatataaag
gctcgtgcttcttcctccccggtgattcttgtcggcacgcatttggatgttgctgatgag
aggcagcgcaaagcctgtatcagtaaaataaacaaggaactcttgaacaagcgagggttt
cccgcaatacgtgattaccactttgtgaacgccactgaggaatccgacgctttggcaaaa
cttcggaaaaccatcataaatgagagccttaatttcaagattcgagatcagcctgttgtt
gggcagctcattccagactgctatgtggaacttgagaaaatcattttatcagagcgtaaa
aacgtgccaattgaatttcctgtaattgaccggaaacgattattacaacttgtgaaagaa
aatcaactgcagttagatgaaaatgagcttcctcatgcagttcacttcctaaatgaatca
ggggcccttcttcattttcaagacccagcactacagttaagtaacttatattttgtggaa
cccaagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctattca
aagcatcctaaaggaattatttcacgtagagatgtggaaaaatttctttcaaagaaaaag
agattcccaaagaactacatgcaccagtactttaaactcctagaaaaatttcagattgcc
ttgccaataggagaagaatatttgttggttccaagcagtttgtctgaccacaggcctgtg
atagagcttccccattgtgagaactctgaaattattattcgactgtatgaaatgccttat
tttccaatgggattttggtcaagattaatcagtcgattacttgaaatatcaccttacatg
ctttcaggaagagaacgagcacttcgcccaaatagaatgtactggcgacaaggcatctac
ttgaattggtctcctgaagcttattgtctggtaggatctgaagtcttagataatcacctg
gagagtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttctgggccaa
gttgtggaccacatagattctctcatggaagaatggtttcctgggttattggagattgat
atttgtggtgaaggagaaactttgttgaagaaatgggcattatatagctttaatgatggg
gaagaacatcaaaaaatcttacttgatgacttgatgaagaaagcagaagaaggagacctc
ctggtaaatccagatcaaccaaggctcaccattcccatatctcagattgctcctgacctg
attttggctgaccttcctagaaatattatgttgaatagtgatgaattggaatttgaacaa
gctccagagtttctcttaggtgatggcagttttggatcagtttatcgagctacctatgaa
ggggaagaagtggctgtgaagatttttaataaacatacatcacttagactgttaagacaa
gagctggtggtgctttgccacctccaccaccccagcttaatatctttgctggcagctggg
attcgtcctcggatgttggtgatggagctggcctccaagggctccctggaccgcctgctg
cagcaggacaaagccactctcaccagaactctgcagcacaggatcgcactacatgtggct
gatggcttgagatacctccactcagctatgatcatataccgtgatttgaagccacacaat
gtattgcttttcacactgtatcccaatgctgccatcattgccaagattgctgactatgga
atcgctcagtattgctgcagaatggggataaaaacatcagaaggcacaccagggtttcgt
gcacctgaagttgctagaggaaatgtaatttataaccaacaggctgatgtttattcattt
ggcttactactgtatgacattttcacatctggaggtagaatagcagagggtttgaagttt
ccaaatgagtttgatgaattggcaatacaaggaaaattaccagatccagttaaagaatat
ggatgtgcaccatggcctatggttgagaagttaattgaaaggtgtttaaaagaaaatcct
caagaaagacctacttctgcacaggtgtttgacattttgaattcagctgatttactctgc
ctgatgagacatatagcgatccataaaaatggtaccgtagaatgcatggtcgctacgagc
catcacagcaggaacgccagtgtctggctgggctgcgggaatgcagacagaggagagctt
tcctttcttgacttaaccaccaaaagactcacttctgaggaagtgactgatagtagaata
ctgtgccttgccttggtgcatctccctagcgaaaaggaaagctggattgtgtctggggca
cagtccggtgggctgctcgtcattgacactgaagatggaaataagaggcacaaccttgaa
aggatgactgatgctgttacttgcttgtattgcagttccttttccaagcagagcaagcaa
aagaattttcttttggtgggaactgctgatggaaagttagcaatttttgaagataaagct
gttaagtgtgaaggagctgctcctttgaagatactcactataggaaatgttagcactcca
ctcatgtgtttgagtgaatccgtgaattcaagtgaaagaaacattatgtggggaggatgt
ggcacaaaacttttctcgctttctgatgatttctccattcagaaactcattgagaccagg
acaaatcagctgttttcttctgcagctttcaatgattccaacatcatagccgtggtggta
gacacagctgtctacattgcgaagaaaaatagcccagttgtggaagtgtgggataagaaa
actgataaactgtgtgaactaatagactgtgtgcactttttaaaggaggacatggtaaaa
gcaaacaaagaatcaaaacaaagtatgtattattctgggagagtgaaaactctctgcctc
cagaagaacacagctctctggatcgggactggaggaggctcagtgttactcctggatctc
tcgactcgccgactgatacgtacaattcacaacttttatgattctgtcagagtcatgatg
ccagcacagttaggaaaccttaaaaatgccatgttggttttggggtattgccggaaaagt
actgaaggtatgcaacaccagaaagaattacagtctttcttgtctatttgggacatgaat
cttccacatgaagtgcaaaatttagaaaaacatattgaagtgagaaaagaattagctgaa
aaaatgagaagaatatctgttgagtaa
DBGET
integrated database retrieval system
