KEGG   Phyllostomus hastatus (greater spear-nosed bat): 123823743
Entry
123823743         CDS       T07912                                 
Symbol
AKT2
Name
(RefSeq) RAC-beta serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
phas  Phyllostomus hastatus (greater spear-nosed bat)
Pathway
phas01521  EGFR tyrosine kinase inhibitor resistance
phas01522  Endocrine resistance
phas01524  Platinum drug resistance
phas04010  MAPK signaling pathway
phas04012  ErbB signaling pathway
phas04014  Ras signaling pathway
phas04015  Rap1 signaling pathway
phas04022  cGMP-PKG signaling pathway
phas04024  cAMP signaling pathway
phas04062  Chemokine signaling pathway
phas04066  HIF-1 signaling pathway
phas04068  FoxO signaling pathway
phas04071  Sphingolipid signaling pathway
phas04072  Phospholipase D signaling pathway
phas04140  Autophagy - animal
phas04150  mTOR signaling pathway
phas04151  PI3K-Akt signaling pathway
phas04152  AMPK signaling pathway
phas04210  Apoptosis
phas04211  Longevity regulating pathway
phas04213  Longevity regulating pathway - multiple species
phas04218  Cellular senescence
phas04261  Adrenergic signaling in cardiomyocytes
phas04370  VEGF signaling pathway
phas04371  Apelin signaling pathway
phas04380  Osteoclast differentiation
phas04510  Focal adhesion
phas04550  Signaling pathways regulating pluripotency of stem cells
phas04611  Platelet activation
phas04613  Neutrophil extracellular trap formation
phas04620  Toll-like receptor signaling pathway
phas04625  C-type lectin receptor signaling pathway
phas04630  JAK-STAT signaling pathway
phas04660  T cell receptor signaling pathway
phas04662  B cell receptor signaling pathway
phas04664  Fc epsilon RI signaling pathway
phas04666  Fc gamma R-mediated phagocytosis
phas04668  TNF signaling pathway
phas04722  Neurotrophin signaling pathway
phas04725  Cholinergic synapse
phas04728  Dopaminergic synapse
phas04810  Regulation of actin cytoskeleton
phas04910  Insulin signaling pathway
phas04914  Progesterone-mediated oocyte maturation
phas04915  Estrogen signaling pathway
phas04917  Prolactin signaling pathway
phas04919  Thyroid hormone signaling pathway
phas04920  Adipocytokine signaling pathway
phas04922  Glucagon signaling pathway
phas04923  Regulation of lipolysis in adipocytes
phas04926  Relaxin signaling pathway
phas04929  GnRH secretion
phas04931  Insulin resistance
phas04932  Non-alcoholic fatty liver disease
phas04933  AGE-RAGE signaling pathway in diabetic complications
phas04935  Growth hormone synthesis, secretion and action
phas04936  Alcoholic liver disease
phas04973  Carbohydrate digestion and absorption
phas05010  Alzheimer disease
phas05017  Spinocerebellar ataxia
phas05132  Salmonella infection
phas05135  Yersinia infection
phas05142  Chagas disease
phas05145  Toxoplasmosis
phas05152  Tuberculosis
phas05160  Hepatitis C
phas05161  Hepatitis B
phas05162  Measles
phas05163  Human cytomegalovirus infection
phas05164  Influenza A
phas05165  Human papillomavirus infection
phas05166  Human T-cell leukemia virus 1 infection
phas05167  Kaposi sarcoma-associated herpesvirus infection
phas05168  Herpes simplex virus 1 infection
phas05169  Epstein-Barr virus infection
phas05170  Human immunodeficiency virus 1 infection
phas05200  Pathways in cancer
phas05205  Proteoglycans in cancer
phas05207  Chemical carcinogenesis - receptor activation
phas05208  Chemical carcinogenesis - reactive oxygen species
phas05210  Colorectal cancer
phas05211  Renal cell carcinoma
phas05212  Pancreatic cancer
phas05213  Endometrial cancer
phas05214  Glioma
phas05215  Prostate cancer
phas05218  Melanoma
phas05220  Chronic myeloid leukemia
phas05221  Acute myeloid leukemia
phas05222  Small cell lung cancer
phas05223  Non-small cell lung cancer
phas05224  Breast cancer
phas05225  Hepatocellular carcinoma
phas05226  Gastric cancer
phas05230  Central carbon metabolism in cancer
phas05231  Choline metabolism in cancer
phas05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
phas05415  Diabetic cardiomyopathy
phas05417  Lipid and atherosclerosis
phas05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:phas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    123823743 (AKT2)
   04012 ErbB signaling pathway
    123823743 (AKT2)
   04014 Ras signaling pathway
    123823743 (AKT2)
   04015 Rap1 signaling pathway
    123823743 (AKT2)
   04370 VEGF signaling pathway
    123823743 (AKT2)
   04371 Apelin signaling pathway
    123823743 (AKT2)
   04630 JAK-STAT signaling pathway
    123823743 (AKT2)
   04668 TNF signaling pathway
    123823743 (AKT2)
   04066 HIF-1 signaling pathway
    123823743 (AKT2)
   04068 FoxO signaling pathway
    123823743 (AKT2)
   04072 Phospholipase D signaling pathway
    123823743 (AKT2)
   04071 Sphingolipid signaling pathway
    123823743 (AKT2)
   04024 cAMP signaling pathway
    123823743 (AKT2)
   04022 cGMP-PKG signaling pathway
    123823743 (AKT2)
   04151 PI3K-Akt signaling pathway
    123823743 (AKT2)
   04152 AMPK signaling pathway
    123823743 (AKT2)
   04150 mTOR signaling pathway
    123823743 (AKT2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    123823743 (AKT2)
  09143 Cell growth and death
   04210 Apoptosis
    123823743 (AKT2)
   04218 Cellular senescence
    123823743 (AKT2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    123823743 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    123823743 (AKT2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123823743 (AKT2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123823743 (AKT2)
   04613 Neutrophil extracellular trap formation
    123823743 (AKT2)
   04620 Toll-like receptor signaling pathway
    123823743 (AKT2)
   04625 C-type lectin receptor signaling pathway
    123823743 (AKT2)
   04660 T cell receptor signaling pathway
    123823743 (AKT2)
   04662 B cell receptor signaling pathway
    123823743 (AKT2)
   04664 Fc epsilon RI signaling pathway
    123823743 (AKT2)
   04666 Fc gamma R-mediated phagocytosis
    123823743 (AKT2)
   04062 Chemokine signaling pathway
    123823743 (AKT2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123823743 (AKT2)
   04922 Glucagon signaling pathway
    123823743 (AKT2)
   04923 Regulation of lipolysis in adipocytes
    123823743 (AKT2)
   04920 Adipocytokine signaling pathway
    123823743 (AKT2)
   04929 GnRH secretion
    123823743 (AKT2)
   04915 Estrogen signaling pathway
    123823743 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    123823743 (AKT2)
   04917 Prolactin signaling pathway
    123823743 (AKT2)
   04926 Relaxin signaling pathway
    123823743 (AKT2)
   04935 Growth hormone synthesis, secretion and action
    123823743 (AKT2)
   04919 Thyroid hormone signaling pathway
    123823743 (AKT2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    123823743 (AKT2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    123823743 (AKT2)
  09156 Nervous system
   04725 Cholinergic synapse
    123823743 (AKT2)
   04728 Dopaminergic synapse
    123823743 (AKT2)
   04722 Neurotrophin signaling pathway
    123823743 (AKT2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    123823743 (AKT2)
  09149 Aging
   04211 Longevity regulating pathway
    123823743 (AKT2)
   04213 Longevity regulating pathway - multiple species
    123823743 (AKT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123823743 (AKT2)
   05205 Proteoglycans in cancer
    123823743 (AKT2)
   05207 Chemical carcinogenesis - receptor activation
    123823743 (AKT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    123823743 (AKT2)
   05230 Central carbon metabolism in cancer
    123823743 (AKT2)
   05231 Choline metabolism in cancer
    123823743 (AKT2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123823743 (AKT2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    123823743 (AKT2)
   05212 Pancreatic cancer
    123823743 (AKT2)
   05225 Hepatocellular carcinoma
    123823743 (AKT2)
   05226 Gastric cancer
    123823743 (AKT2)
   05214 Glioma
    123823743 (AKT2)
   05221 Acute myeloid leukemia
    123823743 (AKT2)
   05220 Chronic myeloid leukemia
    123823743 (AKT2)
   05218 Melanoma
    123823743 (AKT2)
   05211 Renal cell carcinoma
    123823743 (AKT2)
   05215 Prostate cancer
    123823743 (AKT2)
   05213 Endometrial cancer
    123823743 (AKT2)
   05224 Breast cancer
    123823743 (AKT2)
   05222 Small cell lung cancer
    123823743 (AKT2)
   05223 Non-small cell lung cancer
    123823743 (AKT2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    123823743 (AKT2)
   05170 Human immunodeficiency virus 1 infection
    123823743 (AKT2)
   05161 Hepatitis B
    123823743 (AKT2)
   05160 Hepatitis C
    123823743 (AKT2)
   05164 Influenza A
    123823743 (AKT2)
   05162 Measles
    123823743 (AKT2)
   05168 Herpes simplex virus 1 infection
    123823743 (AKT2)
   05163 Human cytomegalovirus infection
    123823743 (AKT2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123823743 (AKT2)
   05169 Epstein-Barr virus infection
    123823743 (AKT2)
   05165 Human papillomavirus infection
    123823743 (AKT2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123823743 (AKT2)
   05135 Yersinia infection
    123823743 (AKT2)
   05152 Tuberculosis
    123823743 (AKT2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    123823743 (AKT2)
   05142 Chagas disease
    123823743 (AKT2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123823743 (AKT2)
   05017 Spinocerebellar ataxia
    123823743 (AKT2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123823743 (AKT2)
   05418 Fluid shear stress and atherosclerosis
    123823743 (AKT2)
   05415 Diabetic cardiomyopathy
    123823743 (AKT2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    123823743 (AKT2)
   04932 Non-alcoholic fatty liver disease
    123823743 (AKT2)
   04931 Insulin resistance
    123823743 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    123823743 (AKT2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123823743 (AKT2)
   01524 Platinum drug resistance
    123823743 (AKT2)
   01522 Endocrine resistance
    123823743 (AKT2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:phas01001]
    123823743 (AKT2)
Enzymes [BR:phas01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     123823743 (AKT2)
Protein kinases [BR:phas01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   123823743 (AKT2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Kinase-like Pkinase_C PH_20 PH_11 ABC1 Seadorna_VP7
Other DBs
NCBI-GeneID: 123823743
NCBI-ProteinID: XP_045702657
LinkDB
Position
Unknown
AA seq 481 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMQAIQMVANSLKQRGLGEDPM
DYKCGSPSDSSAAEEMEVSVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLPPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGSLDLDQRTHFPQFSYSASIR
E
NT seq 1446 nt   +upstreamnt  +downstreamnt
atgaacgaggtgtctgtcatcaaagaaggctggcttcacaagcgtggtgaatacatcaag
acctggaggccccggtacttcctgctgaagagtgatggctccttcattggctataaggag
cgtcctgaggcacctgaccagaccctgccccccctgaacaacttctctgttgcagaatgc
cagctgatgaagaccgagagaccacggcccaacacgtttgtcatacgctgcctgcagtgg
accacagtcatcgagaggaccttccatgtggactctccagatgagagggaggagtggatg
caggccatccagatggtcgccaacagcctcaagcagcggggcctgggggaggaccccatg
gactacaagtgtggctcccctagtgactcttcggcagctgaggagatggaagtgtcggtt
agcaaggcacgggccaaggtgaccatgaatgactttgactatctcaagctcctcggcaag
ggcacctttggcaaagtcatcctggtgcgggagaaggccactggccgctactacgccatg
aagatcctgcggaaggaggtgatcatcgccaaggatgaagtcgcccacacggtcaccgag
agccgggtcctccagaacaccaggcacccgttcctcaccgcgctgaagtatgccttccag
acccacgaccgcctgtgctttgtgatggagtacgccaatggtggggagctgttcttccac
ctgtcccgggagcgggtcttcacagaggagagggcccgcttctatggcgcagagatcgtc
tcggccctggagtacctgcactcaagggacgtggtgtaccgggacatcaagctggaaaac
ctcatgttggacaaagatggccacatcaagatcactgactttggcctgtgcaaagagggc
atcagtgacggggccaccatgaaaaccttctgtgggactcccgagtatctggcgcctgag
gtgctggaggacaacgactatggccgggccgtggactggtgggggctgggcgtggtcatg
tacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgaa
ctcatcctcatggaggagatccgcttcccacgcacgctcagccccgaggccaagtccctg
cttgctgggctgcttaagaaggaccccaagcagaggctcggcggggggcccagtgatgcc
aaggaggtcatggagcacaggttcttcctcagcatcaactggcaggacgtggtacagaag
aagctcccgccgcccttcaaacctcaggtcacgtctgaggttgacacaaggtacttcgac
gacgagttcactgcccagtccatcaccatcacacccccggaccgctatgacagcttgggc
tcgctcgacctggaccagcggactcacttcccccagttctcctactcagccagcatccga
gagtga

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