Phyllostomus hastatus (greater spear-nosed bat): 123832643
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Entry
123832643 CDS
T07912
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
phas
Phyllostomus hastatus (greater spear-nosed bat)
Pathway
phas01521
EGFR tyrosine kinase inhibitor resistance
phas01522
Endocrine resistance
phas04010
MAPK signaling pathway
phas04012
ErbB signaling pathway
phas04068
FoxO signaling pathway
phas04270
Vascular smooth muscle contraction
phas04650
Natural killer cell mediated cytotoxicity
phas04720
Long-term potentiation
phas04726
Serotonergic synapse
phas04730
Long-term depression
phas04810
Regulation of actin cytoskeleton
phas04910
Insulin signaling pathway
phas04914
Progesterone-mediated oocyte maturation
phas04928
Parathyroid hormone synthesis, secretion and action
phas05010
Alzheimer disease
phas05022
Pathways of neurodegeneration - multiple diseases
phas05034
Alcoholism
phas05160
Hepatitis C
phas05161
Hepatitis B
phas05200
Pathways in cancer
phas05205
Proteoglycans in cancer
phas05208
Chemical carcinogenesis - reactive oxygen species
phas05210
Colorectal cancer
phas05211
Renal cell carcinoma
phas05212
Pancreatic cancer
phas05213
Endometrial cancer
phas05214
Glioma
phas05215
Prostate cancer
phas05218
Melanoma
phas05219
Bladder cancer
phas05220
Chronic myeloid leukemia
phas05221
Acute myeloid leukemia
phas05223
Non-small cell lung cancer
phas05224
Breast cancer
phas05225
Hepatocellular carcinoma
phas05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
phas00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
123832643 (ARAF)
04012 ErbB signaling pathway
123832643 (ARAF)
04068 FoxO signaling pathway
123832643 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
123832643 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
123832643 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
123832643 (ARAF)
04914 Progesterone-mediated oocyte maturation
123832643 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
123832643 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
123832643 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
123832643 (ARAF)
04720 Long-term potentiation
123832643 (ARAF)
04730 Long-term depression
123832643 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
123832643 (ARAF)
05205 Proteoglycans in cancer
123832643 (ARAF)
05208 Chemical carcinogenesis - reactive oxygen species
123832643 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
123832643 (ARAF)
05212 Pancreatic cancer
123832643 (ARAF)
05225 Hepatocellular carcinoma
123832643 (ARAF)
05226 Gastric cancer
123832643 (ARAF)
05214 Glioma
123832643 (ARAF)
05221 Acute myeloid leukemia
123832643 (ARAF)
05220 Chronic myeloid leukemia
123832643 (ARAF)
05218 Melanoma
123832643 (ARAF)
05211 Renal cell carcinoma
123832643 (ARAF)
05219 Bladder cancer
123832643 (ARAF)
05215 Prostate cancer
123832643 (ARAF)
05213 Endometrial cancer
123832643 (ARAF)
05224 Breast cancer
123832643 (ARAF)
05223 Non-small cell lung cancer
123832643 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
123832643 (ARAF)
05160 Hepatitis C
123832643 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
123832643 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
123832643 (ARAF)
09165 Substance dependence
05034 Alcoholism
123832643 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
123832643 (ARAF)
01522 Endocrine resistance
123832643 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
phas01001
]
123832643 (ARAF)
Enzymes [BR:
phas01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
123832643 (ARAF)
Protein kinases [BR:
phas01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
123832643 (ARAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
ABC1
Pkinase_fungal
zf-RING-like
TUG-UBL1
Kdo
Motif
Other DBs
NCBI-GeneID:
123832643
NCBI-ProteinID:
XP_045716354
LinkDB
All DBs
Position
Unknown
AA seq
612 aa
AA seq
DB search
MEPPRGPPANGAEPSRGVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFQVRKTFFSLVFCDFCLKFL
FHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQFYHSVQDLSGGSRQHEAPSNRPPNEP
LTPQGSSLSPGSSCTQHRDPERFPFPAPTNAPLQRIRSTSTPNVHMVSTTTPMDSSLIQL
TAQSFSTDAAGSRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDKKKVKNL
GYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNE
MQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVAETRFDMVQLIDVARQTA
QGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMA
AEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKI
SSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADEL
PACLLSAARLVP
NT seq
1839 nt
NT seq
+upstream
nt +downstream
nt
atggagccaccacggggcccccctgccaacggggctgagccatcccggggagtgggcact
gttaaagtatacctacccaacaagcaacgcacagtggtgactgtccgggatggcatgagc
gtctatgactctctagacaaggctctcaaagttcggggtctcaatcaggattgctgcgtg
gtctaccggctcatcaaggggcgaaagacagtcactgcctgggacacagccattgccccc
ctggatggcgaggagctcattgtggaggtcctcgaagatgtcccactgaccatgcacaat
tttcaggtacggaagacgttcttcagcttggtgttctgtgacttctgccttaagtttctg
ttccatggctttcgctgccaaacctgtggctacaagttccaccagcattgttcctctaag
gtccccacagtctgtgttgacatgagtaccaactgccgacagttctaccacagtgtccag
gatttgtccggaggctccagacagcatgaggctccctcaaaccgccctccaaatgagccg
ctaacccctcaaggttccagcctttcccctggcagctcctgcactcagcaccgagaccct
gagcgcttcccctttcctgccccgaccaatgcccccctccagcgcattcgctctacgtct
acccccaacgtccatatggtcagcaccacaacccccatggactccagcctcattcagctc
actgcccagagtttcagcactgatgctgctggtagtagaggtggtggtgatggagctccc
cgggggagccccagcccagccagtgtgtcctcagggagaaagtccccacattccaagtcc
ccatcagaacagcgggagaggaagtcgttggctgatgacaagaagaaagtgaagaatctg
gggtaccgggactcaggctattactgggaggtgccacccagtgaggtgcagctgctgaag
aggatcgggacgggctcgtttggcaccgtgtttcgcgggcggtggcatggcgatgtggct
gtgaaggtgctcaaggtggcccaacccacagctgagcaggcccaggccttcaagaacgag
atgcaggtgctcaggaagacacgtcatgtcaacatcttgctgttcatgggcttcatgacc
cgtccagggttcgccatcatcacacagtggtgcgagggctccagcctctaccaccatctg
catgtggctgaaacacgctttgacatggtccagctcattgatgtggcccggcagactgcc
cagggcatggactacctccatgccaagaacatcatccaccgagatctcaaatctaacaac
atcttcctacacgagggactcacagtgaagatcggtgactttggcctggccacagtgaag
acacggtggagcggggctcagcccttagagcaaccctcaggctctgtgctgtggatggct
gctgaggtgatccgtatgcaggacccgaacccctacagcttccagtcagatgtctacgcc
tatggggttgtgctatacgagctcatgaccggctccttgccttatagccacattggcagt
cgtgaccagattatctttatggtgggccgtggctatctgtctccagacctcagcaaaatc
tccagcaactgccccaaggccatgcggcgcctgctgtccgactgtctcaagttccagcgg
gaggagcggcccctcttcccccagatcctggccacgattgagctgctgcagcggtcactc
cccaagattgagcggagtgcctctgaaccctccttgcaccgcacccaggctgatgagtta
cctgcctgtctactcagcgcagcccgccttgtgccttag
DBGET
integrated database retrieval system