Entry |
|
Symbol |
PLCB1
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
|
KO |
|
Organism |
pkl Pipistrellus kuhlii (Kuhl's pipistrelle)
|
Pathway |
pkl04070 | Phosphatidylinositol signaling system |
pkl04072 | Phospholipase D signaling pathway |
pkl04261 | Adrenergic signaling in cardiomyocytes |
pkl04270 | Vascular smooth muscle contraction |
pkl04613 | Neutrophil extracellular trap formation |
pkl04621 | NOD-like receptor signaling pathway |
pkl04723 | Retrograde endocannabinoid signaling |
pkl04750 | Inflammatory mediator regulation of TRP channels |
pkl04919 | Thyroid hormone signaling pathway |
pkl04925 | Aldosterone synthesis and secretion |
pkl04927 | Cortisol synthesis and secretion |
pkl04928 | Parathyroid hormone synthesis, secretion and action |
pkl04933 | AGE-RAGE signaling pathway in diabetic complications |
pkl04935 | Growth hormone synthesis, secretion and action |
pkl04961 | Endocrine and other factor-regulated calcium reabsorption |
pkl04973 | Carbohydrate digestion and absorption |
pkl05022 | Pathways of neurodegeneration - multiple diseases |
pkl05163 | Human cytomegalovirus infection |
|
Module |
pkl_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:pkl00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
118708478 (PLCB1)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
118708478 (PLCB1)
04310 Wnt signaling pathway
118708478 (PLCB1)
04070 Phosphatidylinositol signaling system
118708478 (PLCB1)
04072 Phospholipase D signaling pathway
118708478 (PLCB1)
04071 Sphingolipid signaling pathway
118708478 (PLCB1)
04022 cGMP-PKG signaling pathway
118708478 (PLCB1)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
118708478 (PLCB1)
04081 Hormone signaling
118708478 (PLCB1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
118708478 (PLCB1)
04613 Neutrophil extracellular trap formation
118708478 (PLCB1)
04062 Chemokine signaling pathway
118708478 (PLCB1)
09152 Endocrine system
04911 Insulin secretion
118708478 (PLCB1)
04922 Glucagon signaling pathway
118708478 (PLCB1)
04929 GnRH secretion
118708478 (PLCB1)
04915 Estrogen signaling pathway
118708478 (PLCB1)
04921 Oxytocin signaling pathway
118708478 (PLCB1)
04926 Relaxin signaling pathway
118708478 (PLCB1)
04935 Growth hormone synthesis, secretion and action
118708478 (PLCB1)
04918 Thyroid hormone synthesis
118708478 (PLCB1)
04919 Thyroid hormone signaling pathway
118708478 (PLCB1)
04928 Parathyroid hormone synthesis, secretion and action
118708478 (PLCB1)
04924 Renin secretion
118708478 (PLCB1)
04925 Aldosterone synthesis and secretion
118708478 (PLCB1)
04927 Cortisol synthesis and secretion
118708478 (PLCB1)
09154 Digestive system
04970 Salivary secretion
118708478 (PLCB1)
04971 Gastric acid secretion
118708478 (PLCB1)
04972 Pancreatic secretion
118708478 (PLCB1)
04973 Carbohydrate digestion and absorption
118708478 (PLCB1)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
118708478 (PLCB1)
09156 Nervous system
04724 Glutamatergic synapse
118708478 (PLCB1)
04725 Cholinergic synapse
118708478 (PLCB1)
04728 Dopaminergic synapse
118708478 (PLCB1)
04726 Serotonergic synapse
118708478 (PLCB1)
04720 Long-term potentiation
118708478 (PLCB1)
04730 Long-term depression
118708478 (PLCB1)
04723 Retrograde endocannabinoid signaling
118708478 (PLCB1)
09157 Sensory system
04742 Taste transduction
118708478 (PLCB1)
04750 Inflammatory mediator regulation of TRP channels
118708478 (PLCB1)
09159 Environmental adaptation
04713 Circadian entrainment
118708478 (PLCB1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
118708478 (PLCB1)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
118708478 (PLCB1)
09174 Infectious disease: parasitic
05146 Amoebiasis
118708478 (PLCB1)
05142 Chagas disease
118708478 (PLCB1)
05143 African trypanosomiasis
118708478 (PLCB1)
09164 Neurodegenerative disease
05010 Alzheimer disease
118708478 (PLCB1)
05016 Huntington disease
118708478 (PLCB1)
05017 Spinocerebellar ataxia
118708478 (PLCB1)
05022 Pathways of neurodegeneration - multiple diseases
118708478 (PLCB1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
118708478 (PLCB1)
05415 Diabetic cardiomyopathy
118708478 (PLCB1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
118708478 (PLCB1)
04934 Cushing syndrome
118708478 (PLCB1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:pkl04131]
118708478 (PLCB1)
Enzymes [BR:pkl01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
118708478 (PLCB1)
Membrane trafficking [BR:pkl04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
118708478 (PLCB1)
Endocytosis
Macropinocytosis
Phospholipase C
118708478 (PLCB1)
|
SSDB |
|
Motif |
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Other DBs |
|
LinkDB |
|
Position |
Unknown
|
AA seq |
1226 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDTTIVTPIILRSDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISYLNLV
AFQEEVAKEWTNEVFNLATNLLAHNMSRDAFLEKAYTKLKLQVTPEGRIPLKNLYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEMYRVFLNHLCPRPEIDNIFSEFGAKSRPYL
TVDQMMDFINIKQRDPRLNEILYPPLKQEQVQVLIEKYEPNTSLATKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPNDLMYKILVKNKKKSHKSSEGSSKK
KLSEQASNTCSDSSSVFEPSSPGAGEGLGASGLAGEAETESDDDDDDDDCKKSSMDEGTA
GSEAMATEEMSNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYN
KMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRL
KPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRR
KAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPG
YHYISLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAAL
TLEDEEDLKKEHDPGETPSEAPSEAGTTPAENGVNHTTSLVPKLPSQALHSQPAPGSLKA
PAKTEDLIHSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKELVKRHHKKTTDLIKEHTT
KYNEIQNDYLRRRAALEKTARKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKD
KQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKK
KMDKKRQEKITEAKSKDKSQMEEEKTEMIRLYIQEVVQNIKRLEEAQSKRQEKLVEKHKE
IRQQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQDAMKGKISEDSNHSSALSSLASDA
GKLNHRPSSSEELEGEHPGKEFDTPL |
NT seq |
3681 nt +upstreamnt +downstreamnt
atggccggggctcagcccggggtgcacgctctgcaactcaagcccgtgtgtgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgacaccactattgtcactcca
attattttgaggtctgaccctcagggatttttcttttactggacagatcaaaacaaggag
acggagctgttagatctcagccttgtcaaggatgccagatgtgggaaacacgccaaagcg
cccaaggaccccaagttacgggaacttttggatgtggggaacatcggacgtctggaacat
cgtatgataacggtggtgtatgggcctgacttagtgaacatctcctatttgaacctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcaatttggcaacaaac
ctgctggcccacaacatgtccagggacgcatttctggaaaaagcctatactaaacttaag
ctgcaagtcactccagaagggcgcattcctctcaaaaacttataccgcttgttttcagca
gaccggaaacgagttgaaactgcgttagaggcttgtagtcttccatcatcaaggaatgat
tcaatacctcaagaagatttcactccagaaatgtacagagtattcctgaaccatctttgt
cctcgacctgaaattgataacatcttttctgaatttggtgccaaaagcagaccatacctt
actgttgaccagatgatggattttatcaacattaagcagcgagatccccggctaaatgaa
atactttacccacctttaaagcaagagcaagtccaagtattgattgagaaatatgaaccc
aacactagcctcgccacaaaaggacagatatccgtggacgggtttatgcgctacctgagt
ggagaagagaatggcgttgtgtcacctgagaaactggatctgaatgaagatatgtctcag
cccctctctcactatttcatcaattcctcgcacaacacctacctcacagctggccagctg
gctggaaactcctccgtcgagatgtaccgtcaagtgctcctgtctggttgtcgctgtgtg
gagttggactgctggaaaggacggactgcagaggaagaaccagtcatcacccatgggttc
accatgacaacagaaatatccttcaaggaagtgatagaagcaatcgctgagtgtgcattt
aagacttcaccttttccaattctcctttcatttgagaatcacgtggactccccgaagcag
caggccaagatggcagagtattgccggctgatctttggggatgcccttctcatggagccc
ctggaaaaatacccactggagtctggagttcctcttccaagccctaatgatttaatgtac
aaaattttggtgaaaaataagaagaagtcacacaagtcgtcggaaggaagcagcaaaaag
aaactctcagaacaagcctccaacacgtgcagcgactcctccagtgtgttcgaaccctcg
tctcccggagccggtgaggggctgggggcctcagggctggcaggggaagctgaaacggag
agtgacgatgacgatgatgatgatgactgtaaaaagtcttcaatggatgaggggactgct
gggagcgaggccatggctacagaagagatgtctaacctggtgaactatatccagccagtc
aagtttgagtcatttgaaatttcaaaaaaaagaaatagaagttttgaaatgtcttccttc
gtggaaaccaaaggactggagcagctgacgaagtctccggtggaatttgtagaatataac
aaaatgcagcttagcaggatatatccgaaaggaacacgtgtagattcatccaactatatg
cctcagctcttctggaatgcaggctgtcaaatggttgcccttaatttccaaacagtggac
ctggctatgcagataaatatggggatgtatgaatacaatgggaagagtggctacagatta
aagccagagtttatgaggagacctgacaagcattttgatccattcaccgaaggcatcgta
gatgggatagtggccaacactttgtctgttaagatcatttcgggtcagtttctttctgat
aagaaagtcgggacttatgtggaagtggatatgtttggtttgcctgtggacacgaggagg
aaagcatttaagaccaagacatcccaaggaaatgctgtaaatcccgtctgggaagaagaa
cccattgtgttcaaaaaggtggttcttccttcactcgcctgtctgagaatagcagcttat
gaagaaggagggaaatttattggtcaccggatcttgccagtacaagcaattcggccaggc
taccactacatcagtctgaggaatgagaggaaccagcctctgatgctaccagctgtcttt
gtctacatagaggtgaaagactacgttccagacacctatgcagatgtgattgaagctttg
tcaaatccaattcgatatgtgaatctgatggagcagagagctaagcaactggctgctttg
acactagaagatgaagaagacttaaagaaagagcatgatcctggggaaacaccgtcagaa
gctccgagtgaagccgggacgactccagcagaaaatggagtaaatcacactacatccctg
gtacccaaacttccctcccaggcccttcacagccaacctgctccaggttctttaaaggca
cctgccaaaacagaagatcttattcacagtgttctaacagaagtggaagcgcagaccatt
gaagagctaaagcaacagaagtcgtttgtcaagcttcagaagaagcactacaaagaaatg
aaagagctggttaagagacaccacaagaaaaccactgaccttatcaaggagcacactaca
aaatacaatgagattcagaatgactacttaagaaggagagcggctttggagaagacagcc
agaaaggatagtaagaaaaaatcggaacccagcagccctgaccacggctcatcaaccatt
gagcaagatctggctgccctggatgccgaaatgacccagaagttaatcgacttgaaggac
aagcaacagcagcaactgcttaatcttcgacaagaacagtattatagtgaaaaataccag
aagcgagaacatattaaactgcttatccaaaaattgacggatgttgctgaagaatgtcag
aacaatcagttgaagaagctcaaagaaatctgtgagaaagagaagaaggaattaaagaag
aaaatggataaaaagagacaggagaagataacagaagctaaatccaaagacaagagccag
atggaagaggaaaagacagagatgatccggttatacatccaggaggtggtgcagaacatc
aagaggttagaagaggcacaaagtaaacggcaagaaaaactcgtagagaaacataaggag
atacgtcagcagatcctggacgaaaagcccaagctgcaggtggagctggagcaagagtac
caagacaagttcaaaagactgcccctggagattctggagttcgtacaggacgccatgaaa
gggaagatcagcgaggacagcaatcacagctctgccctttcctcccttgcctctgacgct
ggaaaactaaaccacaggccttcctccagtgaggagctggaaggagagcacccgggaaaa
gagtttgatactcctctgtga |