KEGG   Pipistrellus kuhlii (Kuhl's pipistrelle): 118727615
Entry
118727615         CDS       T07682                                 
Symbol
RYR2
Name
(RefSeq) ryanodine receptor 2 isoform X1
  KO
K04962  ryanodine receptor 2
Organism
pkl  Pipistrellus kuhlii (Kuhl's pipistrelle)
Pathway
pkl04020  Calcium signaling pathway
pkl04024  cAMP signaling pathway
pkl04260  Cardiac muscle contraction
pkl04261  Adrenergic signaling in cardiomyocytes
pkl04371  Apelin signaling pathway
pkl04713  Circadian entrainment
pkl04911  Insulin secretion
pkl04921  Oxytocin signaling pathway
pkl04972  Pancreatic secretion
pkl05020  Prion disease
pkl05022  Pathways of neurodegeneration - multiple diseases
pkl05410  Hypertrophic cardiomyopathy
pkl05412  Arrhythmogenic right ventricular cardiomyopathy
pkl05414  Dilated cardiomyopathy
pkl05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:pkl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    118727615 (RYR2)
   04020 Calcium signaling pathway
    118727615 (RYR2)
   04024 cAMP signaling pathway
    118727615 (RYR2)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    118727615 (RYR2)
   04921 Oxytocin signaling pathway
    118727615 (RYR2)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    118727615 (RYR2)
   04261 Adrenergic signaling in cardiomyocytes
    118727615 (RYR2)
  09154 Digestive system
   04972 Pancreatic secretion
    118727615 (RYR2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    118727615 (RYR2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05020 Prion disease
    118727615 (RYR2)
   05022 Pathways of neurodegeneration - multiple diseases
    118727615 (RYR2)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    118727615 (RYR2)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    118727615 (RYR2)
   05414 Dilated cardiomyopathy
    118727615 (RYR2)
   05415 Diabetic cardiomyopathy
    118727615 (RYR2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:pkl04040]
    118727615 (RYR2)
   04990 Domain-containing proteins not elsewhere classified [BR:pkl04990]
    118727615 (RYR2)
Ion channels [BR:pkl04040]
 Voltage-gated cation channels
  Ryanodine receptor
   118727615 (RYR2)
Domain-containing proteins not elsewhere classified [BR:pkl04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   118727615 (RYR2)
SSDB
Motif
Pfam: RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Tim54
Other DBs
NCBI-GeneID: 118727615
NCBI-ProteinID: XP_036309297
LinkDB
Position
Unknown
AA seq 4971 aa
MADTGEGEDEIQFLRTDDEVVLQCTAAAHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP
DLSICTFVLEQSLSVRALQEMLANTMEKSEGKVDVEKWKFMMKTAQGGGHRTLLYGHAIL
LRHSNSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD
LILVSVSSERYLHLSYGSGSGSLHVDAAFQLTLWSVAPISSGSEAAQGYLIGGDVLRLLH
GHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLR
HVTTGKYLSLLEDKNLLLMDKEKADVKSTAFTFRSSKEKLDAGVRKEVDGMGTSEIKYGD
SVCYIQHVSTGLWLTYQAVDVKSVRMGAIQRKAIMHHEGHMDDGINLSRSQHEESRTARV
IRSTVFLFNRFIRGLDALGRKAKAPPVDLPIESVSLSLRDLISYLHPPAEHLEHEDRQNR
LRALKNRQNLFQEEGMISLVLQCVDRLHVYSSAAHFAEVAGREAGESWKSILNSLYELLA
ALIRGNRKNCAQFSGSLDWLVSRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSII
SLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPN
IFLGVSEGSAQYKKWYYELMVDHTQPFVTAEATHLRVGWASTEGHSPYPGGGEEWGGNGV
GDDLFSYGFDGLHLWAGCIASTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGM
FENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSR
EYKQERTYTRDLLGPTVALTQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKI
ELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAE
EKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTY
GIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYSLEAPDQDHAARAEVC
SSPGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGCDEHAFAFD
GFKAQRWHQGNEHYGRSWQTGDVVGCMVDMTERTMMFTLNGEILLDDSGSELAFKDFDVG
DGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQF
LQVPSNHEHIEVTRIDGTADTSPCLKITQKSFSSQNSSTDIMFYRLSMPIECAEVFSRTA
AGGLPGAGLFGPKSDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQ
EKPSRLKQRFLLRKTKPDYSTSHSARLTEDVLADDRDDYEYLMQTSTYYYSVRIFPGQEP
ASVWVGWVTADFHQYDTCFDLDRVRTVTVTLGDEKGKVHESLAIDSLCGFGIKRSNCYMV
CAGESMSPGQVRNNNGLEIGCMVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQAT
SPNVFQFELGRIKNVMPLSAGLFKSEHRNPMPQCPPRLHVQFLSHVLWSRMPNQFLKVDV
SRVSERQGWLVQCVDPLQFMSLHIPEENRSVDILELTEQEELLHFHSHTLRLYSAVCALG
NHRVAHALCSHVDEAQLLYAIESKYMPGLLRTGYYDLLIDIHLSAYATARLMMNNEYIVP
MTEETKSITLFPDQHKEHGLPGIGLSTSLRPRMRFSSPSFVGLNHDCYQYSPEFPLDTLK
TKTMQMLTEVVQEGGLRARDPVGGTTEFLFVPLIKLFYTLLTMGVFQGEDLKHILQLIEP
RVFREAFPEEEDQAPSKEPHPEDARPEGMRGDAAEGLLQMKLPEPVKLQMCLLLQYLCDC
QVRHRIEAIVAFSDDFVARLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINML
LNFKDDKNECPCPEEIRDQLLDFHEDLMAHCGIELDDDGSLDGHSDLTIRGRLLSLVEKV
TSLKKKQADKPAESDSDKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIG
GLVQALPKTYTISAVSVEDTINLLASLGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFY
QHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFD
HLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQS
CPMLVAKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALR
GEGGNGLLAAMEEAIKIAEDPSRDGPSPASGSSKTPDTAEEDNTIHMGNAIMTFYAALID
LLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISITFQLPTIAKDGNVAEPDMS
AGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALH
RYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSIC
GQLRPSMMQHLLRRFVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGSFGAASEEE
LHLSRKLFWGMFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNHVGMMEKQSSMDS
EGNFNPQPVETSNITIPEKLEYFINKYAEHSHDRWSMDKLANGWIYGETYSDSSKVQPLM
KPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALCHRTRRISQTSQVSVDA
AHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTL
TAKEKAKDREKAQDILKFLQINGYVVSRGFKDLELDTPTIEKRFAYSFLQQLIRYVDEAH
QYILEFDGGCRGKGQRFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGAHAS
NKEKEMVTSLFCKLGVLVRHRISLFGNDAASIVNCLHILGQTLDARTVMKTGLESVKGAL
SAFLDSAAEDLDRTLENLKEGQFTHTRTQPRGVTQIINYTTVALLPVLSSLFEHIGQHQF
GEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSAVGECLAAFAGAFPVAFLETHLNK
HNSCSIYNTSSSRERAALNLPANVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEV
ILPMLCSYMSRWWEQGPESSPARARLCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMK
RLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVAEEDHLKAEARGDMSEAELLILD
EFTTLARDLYAFYPLLIRFVDYNRAKWLKEPSPEAEDLFRMVAEVFIFWSKSHNFKREEQ
NFVVQNEINNMSFLISDTKSKMSKAAVSDQERKKMRRKGDRYSVQTSLIVAALRRLLPIG
LNICAPGDQELIALAKNRLSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNR
PEDSADPEKTVERVLDIASVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLY
NLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKRVDPLHQLIL
LFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEDDDDSEEEVKSFEVTGSQRSKEKEMEK
QKLLYQQARLHERGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYL
KEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFR
FLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQ
GQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQD
SSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFL
KLKDLTSSDTFKEYDPDGKGVVSKRDFHKAMESHKHYTPSETEFLLSCAETDENETLDYE
EFVKRFHEPAKDISFNVAVLLTNLSEHMPNDSRLQTFLELAESVLRYFQPFLGRIEIMGS
AKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQ
LAAQISESDLTERSASKEEGEKEKPEEQSPRTGFFSLLTVRSALLALRSNLLALLRMLSL
KSLKKQMKKVKKMTVRDMATALFASYWGALASLLHVVASVLRGFSRIVGSLLLGGSLVEG
AKKIRVAELLADMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFG
LDLKREGGQYKLIPHNPNAGLSDLMSNPDPVPEAPEKVQEQETKEEEKEEKEENKSEPEK
AEGEDGEKEEKAKDEKGRQKLRLIHTHRYGEPEAPESVFWKKIIAYQQKLLNYFARNFYN
MRMLALFVAFAINFILLFYKVSTSSVVEGKELPPRSASESAKVSIPDEGGGGEDAPGVLA
VHYVLEESSGYMEPTLRILAVLHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLY
ITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAA
LDFSDAREKKKPKKDSSLAAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNN
FFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKS
EDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIV
ILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLA
NYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN
NT seq 14916 nt   +upstreamnt  +downstreamnt
atggccgatacgggcgagggcgaggacgagatccagttcctgcggaccgacgacgaggtg
gtgctgcagtgcacggcggccgcccacaaggagcagcagaaactgtgcctggcggccgaa
gggtttggcaacagactctgcttcctggagtccacctccaactccaagaatgtcccccca
gacctctccatctgcacctttgtgctggagcagtccctctctgtccgggccctccaggag
atgctggccaacacgatggagaagtcagaagggaaagttgatgtggaaaaatggaaattc
atgatgaagacggctcaagggggtggccaccggacactcctctacggacacgccatcctg
ctgcgccactccaacagcggcatgtatctgtgctgcctgtccacctcccggtcttcaacg
gacaagctggcctttgacgttggcttgcaagaggacacaacaggcgaggcttgctggtgg
accatacaccccgcctccaagcagcggtctgagggggagaaggtgcgcgttggcgatgac
ctcatcttagtgagcgtgtcctccgaaaggtacctgcacctgtcctatggcagcggcagc
ggcagcctgcacgtggacgccgctttccagctgacgctctggagcgtggcccccatcagc
tctggaagtgaagcggcccaagggtacctgattggcggggacgtcctgcggctgctgcac
ggacacatggatgagtgcctcaccgtcccctctggggagcatggggaggagcagcggagg
actgtacattatgaaggtggggccgtgtctgtccacgcccgctccctgtggagactggag
acgctgagagttgcgtggagcgggagccacatacggtggggccagcctttccgactgcgg
cacgtcaccacgggcaagtacctgagtctcctggaagacaagaaccttctgctcatggac
aaagagaaggccgacgtgaagtccacggccttcaccttccgctcttccaaggaaaaattg
gatgcaggggtgagaaaagaagttgatggcatgggaacctctgagatcaagtacggagac
tcggtctgctacatacaacatgtgagcacaggcctgtggctgacgtaccaggctgtggac
gtgaagtctgtgaggatgggagccatacaacgcaaggccatcatgcatcacgaaggccac
atggacgacggcatcaacttgtccaggtcgcagcatgaggagtcccggaccgcacgggtc
atccggagcactgtcttccttttcaacaggtttataaggggcctggatgctctgggcagg
aaggcgaaggcgccccccgtggacttgcccatcgagtcggtcagcctgagcctgcgggac
ctcatcagctacctgcacccgccggctgagcacctggagcacgaggacaggcagaaccgg
ctgcgggccctgaagaaccggcagaacctcttccaggaggaggggatgatcagcctcgtg
ctccagtgcgtggaccggctgcacgtctacagcagcgccgcccactttgccgaggtcgct
ggccgagaggcgggggagtcctggaagtccattctgaattccctgtatgagttactagcg
gctctcattagaggaaatcggaaaaactgcgcccagttttctggctccctcgactggctg
gtcagccgactggaaagactggaagcttcttctggtattcttgaagttttgcactgtgtg
ctagtagaaagtccagaagcgctaaatattatcaaagaagggcatattaaatccatcatt
tcacttttagacaaacatggaagaaatcacaaggttctggacgtcctgtgctctctctgt
gtttgccacggggtggcagtccgctccaatcagcatctcatctgtgacaatctcctgcct
ggaagggacctgttactgcagacacgcctcgtgaaccacgtcagcagcatgagacccaac
atttttctgggcgtcagcgaaggctctgctcagtataagaagtggtactatgagctgatg
gtggaccacacccagcccttcgtgaccgccgaggccacccacttgcgtgtgggctgggcg
tccacggaagggcactctccgtaccccggcggcggtgaggagtggggcgggaacggcgtc
ggggacgacctcttttcctacggattcgacggcctgcacctgtgggcaggctgtatcgcc
agcaccgtgagctcgccaaaccagcacctgctgaggaccgatgacgtcatcagctgctgc
ttagatctcagtgccccgagcatctcattccgaatcaatgggcagcccgtccagggaatg
tttgagaatttcaacatcgatggcctcttcttccccgttgtcagtttctctgcaggaatc
aaggtccgctttctgctcggagggagacacggagaatttaaattccttccccctccgggc
tatgctccttgctatgaagcggtgctgccaaaagaaaagctgaaggtggaacacagccgg
gagtacaagcaggagagaacgtacacccgggacctgctgggccccacagttgccctgacc
caagccgccttcacgccggtccccgtggacaccagccagattgtgttgcccccccacctg
gagaggataagagaaaagctggcagagaacatccatgagctctgggttatgaataaaatt
gaacttggctggcagtatggcccggtcagagacgacaacaagaggcagcacccctgcctg
gtggagttctccaagctgccggagcaggagcgcaactacaacctgcagatgtcgctggag
accctgaagaccttgttggcattaggatgccatgtgggcatatcagatgaacacgctgag
gaaaaggtgaaaaagatgaagctacccaagaattaccagctgacaagtggctacaagccg
gcaccgatggacctgagctttatcaaactcaccccgtctcaggaagcaatggtggacaaa
ctggcagaaaatgctcacaacgtgtgggcccgggaccggatccggcagggctggacctac
ggcatccagcaggacgtcaagaacaggagaaacccgcgcctggtgccctacacccttctg
gatgacaggaccaagaagtccaacaaggacagcctccgggaggcggtgcgcacgctgctg
gggtacggctacagcctggaggcgcccgaccaggaccacgctgcccgagccgaagtgtgc
agcagccccggggagcggttccggatcttccgggctgagaaaacctacgccgtgaaggcg
ggaaggtggtactttgagttcgagactgtcaccgctggggacatgcgcgttggctggagc
aggccgggctgccagcctgatcaggagctgggctgcgacgaacacgccttcgcctttgac
ggcttcaaggcccagcggtggcaccagggcaatgagcactacgggcgctcctggcaaacg
ggcgatgtcgtgggatgcatggtggacatgacagagcgcaccatgatgttcacgctgaac
ggcgaaatccttcttgacgactcagggtcagagctggctttcaaggactttgatgttggc
gatggattcatacccgtgtgcagccttggggtggctcaggtgggaaggatgaactttgga
aaggacgtgagcaccttgaagtatttcaccatttgtggcttacaggagggctacgagccg
ttcgccgttaacaccaacagggacattaccatgtggctaagcaagcgacttcctcagttc
ctccaggttccttcaaaccacgaacatattgaggtgaccagaatagacggcaccgcggac
acctccccatgtttaaagatcactcagaagtccttcagttcccagaacagcagcacggac
atcatgttctaccggctgagcatgcccatcgagtgcgcagaggtcttctccaggacggcg
gccggcgggctcccgggggccggcctcttcgggcccaagagtgacctggaggattacgac
gcggattctgatttcgaggttctgatgaagacagctcacggccatctggtgcccgatcgg
gtggacaaggacaaagaagctacaaagccagagtttaacaaccacaaggattacgcgcag
gagaagccctctcgtctgaaacagagattcttgctgagaaagacaaagccggattacagc
acgagccactccgcgaggctcactgaggacgtcctagcggatgaccgggacgactacgaa
tacctgatgcagacgtccacgtactattactcggtgaggatcttccctggacaagagccg
gccagtgtctgggtgggctgggtcacggccgacttccaccagtacgacacgtgcttcgac
ctggacagagttcgcacagtgaccgtgactctgggagatgagaaagggaaggtgcacgaa
agcctggccattgactcgctgtgtggctttggcatcaaacgcagcaactgctacatggtg
tgcgcgggcgagagcatgagccccgggcaggtccgcaacaacaacgggctggagatcggc
tgcatggtggacgccgccagcgggctgctcaccttcacggccaacggcaaggagctgagc
acctactaccaggtggagccaagcaccaaattatttcctgcagtttttgcacaagccaca
agtcccaatgtcttccagtttgagttgggaagaataaagaacgtgatgcctctctcggcg
ggcctcttcaagagcgagcacaggaaccccatgcctcagtgtcccccgcgcctccacgtg
cagttcctgtcccacgttctgtggagccggatgcccaaccagttcctgaaggtggacgtg
tcgcgggtcagcgagcgccagggctggctggtgcagtgcgtggacccgctgcagttcatg
tccctgcacatccccgaggagaacaggtccgtggacatcctggagctgacggagcaggag
gagctgctgcacttccactcgcacacgctgcggctctactcggccgtgtgtgccctgggc
aaccaccgcgtggcgcacgcgctctgcagccacgtggacgaggcgcagctgctgtacgcc
atcgagagcaagtacatgcccggcctgctgcgcacgggctactacgacctgctcatcgac
atccacctgagcgcctacgccaccgcgcggctcatgatgaacaacgagtacatcgtgccc
atgaccgaggagaccaagagcatcacgctcttccccgaccagcacaaggagcacgggctg
ccgggcatcggcctcagcacctcgctgcggccgcgcatgcgcttctcctcgcccagcttc
gtgggcctcaaccacgactgctaccagtacagccccgagttccccctggacacgctcaag
accaagaccatgcagatgctgacggaggtggtgcaggagggcggcctgcgcgccagggac
ccggtagggggcaccaccgagttcctcttcgtgccgctcatcaagctcttctacacgctg
ctcaccatgggcgtcttccaaggggaggacctgaagcacatcctgcagctcattgagccc
cgggtgttcagggaggccttcccggaggaggaggaccaggcgccctccaaggagccccac
cccgaggatgccaggcccgagggcatgcgtggggacgctgcagaggggctgctgcagatg
aaactgcccgagcccgtgaagctccagatgtgcctgctcctccagtacctctgcgactgc
caggtccggcaccgcatcgaagccatcgtggccttttccgatgactttgtcgccaggctc
caggacaaccagcgcttccgctacaacgaagtcatgcaggccctgaacatgtcagccgcg
ctcacagcccggaagacgaaggagttcaggtcgcccccacaagagcagatcaatatgctt
ctcaattttaaggatgacaaaaacgagtgtccatgtccagaggaaatccgagaccaactc
ttagatttccatgaagatctgatggcacattgtggcatcgagctggatgacgatgggtct
ctggatggacacagtgacctaaccatcagagggcgcctgctgtccctggtggagaaggtg
acgtccctgaagaagaaacaagctgacaagccagcggagagcgactctgacaagtcctcc
actcttcagcagctgatctctgagacgatggtgcggtgggctcaggagtctgtcatcgag
gaccccgagctggtgagggccatgttcgtgctgctgcaccggcagtatgacggcattggg
gggctggtccaggccctgcccaagacctacaccatcagcgccgtctccgtggaggacacc
atcaacctgctggcctccctgggccagatccgctctctgctgagcgtgaggatgggcaga
gaagaggaaaagctcatgattcggggattaggggacattatgaataataaagtgttttac
cagcacccgaatctcatgagggcactggggatgcatgagacggtgatggaggtcatggtg
aacgtccttggtggtggggagtccaaggagatcacctttcctaagatggtagccaactgt
tgccgtttcctctgttacttctgtcggatcagccggcagaaccaaaaggctatgtttgac
catctcagctacttactggaaaatagcagtgttggtctagcttcgccagcgatgagaggt
tcaacgcccctggatgtggcggcagcttcagtgatggacaacaatgagctggccttagct
ctgcgtgagccggacctggagaaggtcgtccggtatttggccggctgtggactgcagagc
tgcccgatgctagtggccaagggctacccagacatcggctggaacccagtcgaaggggag
agatacctcgactttctcagatttgctgttttctgcaacggggagagcgtggaggagaac
gcgaatgtggtggtgcggctgctcatccgcaggcccgagtgcttcggccccgcgctgcgc
ggcgagggcgggaacgggctcctcgcagccatggaagaggccatcaaaatagccgaggac
ccttctcgagatggcccctccccagccagcgggtccagcaaaacccctgacacagcggag
gaggacaacaccatccacatggggaacgccatcatgaccttttacgcagctttgatcgac
ctgttaggacgctgtgcccctgagatgcatttgattcacgccggcaagggggaagccatc
aggatcaggtccattttgaggtccctgattccactgggcgatttggtgggtgtgatcagc
atcaccttccagctgcccacgatagccaaagatgggaatgtggcggagcctgacatgtcc
gcggggttttgcccagatcacaaggcagccatggttttgttccttgacagggtctatgga
attgaggttcaggatttcctccttcaccttctggaggttggctttctgccagatctccgg
gctgctgcctccttagacacggctgccctgagtgctactgacatggccttggccctccat
cggtacctctgcacagccgtgctgcctttgttaacaagatgtgcccctctgtttgctggc
acagagcaccacgcgtccctcatcgactcgttgcttcacaccgtgtacagactttccaag
ggctgctccctgaccaaagctcagcgggattccatagaagtttgtttgctctctatctgt
ggccaactgagaccttctatgatgcagcacttactcagaagatttgtgtttgatgtcccg
ctgttaaatgagcatgcaaagatgccccttaagctgctgacaaaccactatgaaaggtgt
tggaaatactactgtttgcctggcgggtggggcagcttcggagccgcctctgaggaagag
ctgcatttatccaggaaattgttctggggcatgtttgatgccttgtctcaaaagaaatat
gaacaagagcttttcaagctggctctgccgtgcctgagtgcggtggcgggcgcactgccc
ccggattacatggagtcaaaccatgtgggcatgatggagaagcagtcatccatggactcc
gagggcaacttcaacccccagcctgtggaaacctccaacatcacgattcctgagaagctg
gaatacttcattaacaaatatgctgagcactcccacgacaggtggtccatggacaagttg
gccaatgggtggatttatggagaaacatattcagactcatctaaagttcaaccattaatg
aagccatataaactattatctgaaaaggaaaaagaaatctatcgctggcccatcaaagag
tctctgaagacgatgctggcctggggctggcgaattgagcgcacgcgggagggggacagc
atggccctctgccaccggacccggcgcatctcccagaccagccaggtttctgtggacgct
gcacatgggtacagccctcgggccattgacatgagcaatgtcacactgtccagggacctg
catgccatggcagaaatgatggctgaaaactaccataatatatgggcaaagaagaagaaa
atggaactggagtccaaagggggcgggaaccatcccctgctggtgccttacgatacgctg
accgccaaagagaaagccaaggaccgggagaaagcacaggatatcctcaagttcttgcag
atcaacggctatgttgtgtccagaggcttcaaggacctggagctggacacgcctacgatt
gagaagcggtttgcctacagcttcctccagcagctcatccgctacgtggacgaagcgcat
cagtatatcttggagttcgatggcggctgcagaggcaaaggacagcgcttcccttacgag
caagagatcaagttctttgctaaagttgtgctgcctctcatcgatcagtatttcaaaaac
caccgtttgtacttcctgtctgcagcgagcagaccactgtgctccggggcacacgcgtca
aacaaggagaaggaaatggtgacgagcctgttctgcaaactcggagttcttgtcaggcat
aggatctcactgtttggaaacgatgcagcttccattgtcaactgccttcacattctgggc
cagactctggatgcaaggaccgtcatgaagaccggcctggagagcgtcaagggcgcgctc
agtgcgtttctggacagcgcggccgaggacctggacaggaccctggaaaacctgaaggag
ggccagttcacgcacacccgcacccagccgcggggcgtcacgcagatcatcaactacacg
accgtggcgctgctgcccgtgctgtcctccctgttcgagcacatcggccagcaccagttc
ggggaggacctgatcctggaagatgtgcaggtgtcctgttatcgaatcctgaccagctta
tatgctctgggaacgagcaagagtatttatgtggaaaggcagcgatcggcggtgggcgag
tgtctggcagcctttgctggtgctttcccggtggcatttctggaaactcatctcaacaaa
cacaacagctgctccatctacaataccagctcctcgcgggagagagcagctctcaatctg
ccagccaacgtggaagacgtctgccccaatatcccgtctctggagaagctgatggaggag
atcgtggagctggctgagtccgggatccgctacacgcagatgccgcacgtgatggaagtg
atcctgcccatgctctgcagctacatgtcccgctggtgggagcagggcccggagagcagc
cccgcgcgggccaggctatgctgcaccgcgctgaactcggagcacatgaacaccctgctg
ggcaacatcctgaagatcatctacaacaacctgggcatcgacgagggcgcctggatgaag
aggctggcagtgttttcccagccgattataaacaaagtgaagccgcagctcctgaaaacg
cacttcctgccgctcatggagaagctgaagaagaaggcggccatggtggtggcggaggag
gaccacctgaaagccgaggccaggggggacatgtccgaggccgagctgctcatcctggac
gagttcaccacgctggccagggacctctatgccttctacccgctcctcatccgattcgtg
gactacaacagggccaagtggctcaaagaacccagcccggaagccgaggacctgttccgc
atggtggccgaggtgttcatcttctggtccaagtcccacaatttcaagagagaggagcag
aacttcgtggtccagaatgaaatcaacaacatgtccttcctcatctccgacaccaagtcc
aagatgtcaaaggccgctgtttccgaccaggagaggaagaagatgaggcggaaaggggac
cgctactccgtgcagacctccctcatcgtggctgcgctgcggcggctgctgcccatcggg
ctgaacatctgtgcccccggagaccaggagctcattgctctggccaagaaccggctgagt
ctgaaagacaccgaggatgaagtccgagatataatccgcagtaatattcatttacaaggc
aagttggaggatcctgctattagatggcagatggctctttacaaagacctgccgaacagg
cccgaggacagcgccgatcccgagaagacggtggagagagtcctggacatagcgagcgtg
ctcttccacctggagcaggtggagcatcctcagaggtccaagaaggccgtgtggcacaag
ctgctgtccaagcagcggaaacgggcggtggtggcctgcttccgcatggcccctctctac
aatctgcccaggcatcgggccgtcaatctctttcttcaggggtacgagaagtcctggatt
gagacagaagagcattactttgaggataaactgatagaagacttagcgaaacctggagca
gaacctccggaggaagacgaaggcaccaagagagttgatcctctgcatcagctgatcctt
ctgttcagccgaacggccttaacggagaaatgcaaactggaggaagattttttatacatg
gcatatgcagatattatggcaaagagttgtcatgacgaagatgacgatgacagtgaagaa
gaggtgaagagttttgaagtcacgggatcccagcgcagcaaggaaaaggaaatggagaag
cagaagcttctgtaccagcaagcccggctgcatgagcgtggcgccgccgagatggtgctg
cagaccatcagcgccagcaaaggtgaaactggaccgatggtggctgcgactttgaaactt
ggaattgcgatcctcaatggcgggaactccacagtgcagcagaaaatgctcgactacctc
aaggagaagaaggacgtgggcttcttccagagcctcgcaggcctgatgcagtcatgcagc
gtcctcgacctgaacgcctttgagcggcagaacaaagctgaagggctggggatggtgacc
gaggagggatcaggcgagaaggttcttcaggacgatgagttcacctgcgacctcttccgc
ttcctgcagctgctctgtgagggacacaactcagatttccagaattacctgaggacgcag
actggcaacaacaccaccgtgaacatcatcatctccaccgtggactacctgctgcgggtg
caggagtccatcagtgatttctattggtactactccgggaaagacgtgattgatgagcaa
ggacagcggaacttctccaaagcgattcaagtagcaaagcaagtctttaacactctcaca
gagtacatccagggcccgtgcacggggaaccagcagagcctggcccacagccggctctgg
gatgcggtcgtgggcttcctgcacgtgttcgcccacatgcagatgaagctgtcccaggac
tccagtcagatcgagctcctgaaagaactgatggacctgcagaaggacatggtggtcatg
ctgctgtccatgctggaaggtaacgtcgtgaacgggaccatcggcaagcagatggtcgac
atgctcgtggagtcgtccaacaacgtggagatgatcctcaagttcttcgacatgttccta
aagctcaaggacctgacgtcctccgacacgttcaaggaatacgaccccgacggcaagggc
gtcgtttccaagcgggacttccacaaagccatggagagccacaagcactacacgccgtcg
gagaccgagttcctgctgtcctgcgcggagacggacgagaacgagaccctggactacgag
gagttcgtgaagcgcttccacgagccggccaaggacatcagcttcaacgtggccgtgctg
ctgaccaacctgtcggagcacatgcccaacgactcgcggctgcagaccttcctggagctg
gcagagagcgtgctgcgctacttccagcccttcctgggccgcatcgagatcatgggcagc
gccaagcgcatcgagcgcgtgtacttcgagatcagcgagtccagccgcacgcagtgggag
aagccgcaggtcaaggagtccaagcgccagttcatcttcgacgtggtcaacgagggcggc
gagaaggagaagatggagctcttcgtgaacttctgcgaggacaccatcttcgagatgcag
ctggccgcccagatctccgagtccgacctcaccgagcgctcggccagcaaggaggagggc
gagaaggagaagccggaggagcagagcccgaggacgggcttcttctcgctcctgaccgtg
cgctcggccctgctggccctccgctccaacctgctggccctcctgcgcatgctcagcctc
aagagcctcaagaagcagatgaagaaggtgaagaagatgacggtgcgggacatggccacg
gcactcttcgcctcctactggggcgcgctggccagcctgctgcacgtcgtggccagcgtc
ctgcgcggcttctcccgcatcgtgggcagcctgctgctggggggcagcctggtggagggc
gccaagaagatccgggtggccgagctgctggccgacatgccggaccccacgcaggacgag
gtgcggggcgacggggaggagggcgagcggaagccgctggaggccgccctgccctcggag
gacctcaccgacctgaaggagctgacagaggagagcgacctgctgtccgacatcttcggc
ttggacctcaagcgggaaggggggcagtacaagctcatcccgcacaaccccaacgccggc
ctcagcgacctcatgagcaacccggaccccgttcccgaggcgccagagaaagtgcaggaa
caggagacaaaagaggaagaaaaggaagaaaaagaagaaaacaagtcggaacccgagaaa
gccgagggagaagacggagagaaagaagagaaggccaaagacgagaagggccggcagaag
ctgcggctgatccacacgcaccgctacggggagcccgaggcccccgagtccgtgttctgg
aagaagatcatcgcttatcagcagaagctcctgaactattttgctcgcaacttttacaac
atgagaatgctggccttatttgtcgcctttgcgatcaacttcatcttgctcttctataag
gtctccacttcttctgtggttgaaggcaaggagctgccccctcgcagcgcaagcgaaagc
gccaaggtcagcatcccggacgagggcggtggcggggaggacgcgcccggcgtgctggcg
gtgcactacgtgctggaggagagcagcggctacatggagcccacgctgcgcatcctggcc
gtgctgcacaccatcatctccttcttctgcatcatcggctactactgcctgaaggtcccg
ctggttatttttaagcgcgaaaaggaagtggctcggaaattggaatttgacgggctttac
atcacagagcagccttcggaagacgatatcaaaggccagtgggaccggctggtaatcaac
actcagtcatttcccaacaactactgggacaaatttgtcaaaagaaaggtgatggacaaa
tacggcgagttctacggtcgggacaggatcagtgagctgctgggcatggacaaggccgcc
ctggacttcagcgacgcccgcgagaaaaagaagcccaagaaagacagctcgctggccgcg
gtactgaactccatcgatgtgaagtatcagatgtggaaactcggagtcgttttcacggac
aactctttcctgtacctggcctggtacatgaccatgtccgtgctggggcactacaacaac
ttcttcttcgcggctcatcttctcgacatcgccatgggcttcaagacgctgaggaccatc
ttgtcgtcagtcacgcacaacggcaagcagctggtattaaccgtgggcttattggctgtg
gtcgtatacctgtacacggtggtggcattcaatttcttccggaaattctacaacaaaagt
gaagatggagacacgccggatatgaagtgtgacgacatgctaacgtgctacatgttccac
atgtacgtgggcgtgcgggctggagggggcatcggcgacgagattgaggacccggcaggt
gacgagtatgagatctaccggatcatcttcgacatcaccttcttcttcttcgtcatcgtc
atcctcctggcgatcatacaaggtttgatcattgatgcgtttggagaactccgagaccag
caggaacaggtcaaggaggacatggagaccaagtgcttcatctgcgggataggcaacgac
tactttgacacggtgccccacggcttcgagacacacacgctgcaggagcacaacctggcc
aactacctgtttttcctgatgtatctcatcaacaaggacgagacagagcacacggggcag
gaatcttacgtgtggaagatgtaccaggaaaggtgctgggagttcttccccgctggggac
tgtttccggaagcagtatgaagaccagctgaactaa

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