Pipistrellus kuhlii (Kuhl's pipistrelle): 118729050
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Entry
118729050 CDS
T07682
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
pkl
Pipistrellus kuhlii (Kuhl's pipistrelle)
Pathway
pkl05012
Parkinson disease
pkl05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
pkl00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
118729050 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
118729050 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pkl01001
]
118729050 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
pkl04131
]
118729050 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
pkl04147
]
118729050 (LRRK2)
Enzymes [BR:
pkl01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
118729050 (LRRK2)
Protein kinases [BR:
pkl01001
]
Serine/threonine kinases: TKL group
LRRK family
118729050 (LRRK2)
Membrane trafficking [BR:
pkl04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
118729050 (LRRK2)
Exosome [BR:
pkl04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
118729050 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
LRR_4
COR-B
COR-A
Ras
Beta-prop_EML_2
LRR_14
LRR_9
WDR55
Beta-prop_WDR36-Utp21_1st
WD40_CDC20-Fz
Arf
LRR_13
Beta-prop_ACSF4
LRR_NXF1-5
Beta-prop_THOC3
WD40_Prp19
Ank_2
T2SSE
AAA_22
Beta-prop_WDR3_2nd
nSTAND3
Kdo
Beta-prop_WDR5
Beta-prop_BBS7
AAA_7
PduV-EutP
ABC_tran
Beta-prop_WDR3_1st
G-alpha
MMR_HSR1
TrwB_AAD_bind
WD40_WDHD1_1st
MobB
AAA_16
NB-ARC
Septin
GTP_EFTU
cobW
AAA_29
TsaE
nSTAND_NTPase5
FtsK_SpoIIIE
Beta-prop_RIG_2nd
Beta-prop_WDR19_1st
NACHT
Beta-prop_HPS5
TniB
Motif
Other DBs
NCBI-GeneID:
118729050
NCBI-ProteinID:
XP_036312183
LinkDB
All DBs
Position
Unknown
AA seq
2527 aa
AA seq
DB search
MASGSCQGGEEEDEETLKKLIVRLNNLQEGKQIETLVQILEDMQVFTYADHAAKLFQGKN
VHVPLLIVLDSYVRVACVQQVGWSLLCKLIEICPDTMQSLTGPQDIGCDWEVLGVHQLII
KMLTVHNANMNLSMVGLKALDLLLTSGKITLLILDEESDIFLLIFDAMKRFSANDEVQKL
GCKALHVLFERVSEEQLIEFVENKDYMTLLTALKNFKEEEEIVLYVLCCLHSLASPCNNV
EVLMSGNVRCYNIAVEAMKAFPANEKIQEVSCCLLHRLTLGNFFNILVLNQVQEFVVEAV
QRYSKNAKLQIAGLSCLALLTETIFLNQDLEEKNENQENDDEEEEEKLFWLEACYKALTW
HRKTEHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASA
NALCTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSSEVAESGCKMLNHLFEGSDMPLDV
MAAVAPKIITVMKSHGASLSVQLEALRAILHFMLPGTPEEFTEDTEYRHKLKMVTNQCFK
NDIHKLVLVSLNRFIGNPGIQKCGLKVISSIAHFPDAVEVLSLEGAMESVLQTLKMYPDD
QEIQHLGLSLIGCLITKKNLFLGSVHLLAKILVSSLQRFKDITELQTKGFQTVLTMLELS
VSFSRLLVHYSLDSVIFHQMSSSLMEQKDQQFLNLCCKCFAKLAMDDELKGVMLERACDK
NNSVMVECLLLLGADANRAKDETSLICQVCEKASSPKLVELLLNSGSREQDVRKALAISI
GKGDSQIISLLLKRLGLDLANNSICLGGFGIGKIEPSWLGPLFPDKTCNSKKEINIGSTL
ARMVLRYQMKSAVAEGAASGSDGSFSEQILDKFDQWTFIPESYVDSVFGQSDDLDSEGSE
GSFLMKKNSSSISVGEFYRDPALQRCCSPNLQKHSDSLRPIFDQEDLLKQKRKILSSDDS
FRSSKLPSHMRHSESASSLASEREHITSLDLSANELRDIDALSQKSCISGHLEHLERLEL
HQNALTGFPRRLSEVLKCLTHLDLHSNKFTAFPSYLLKMNCIANLDVSRNDIKPSVVLDP
AVKCPTLKQFNLSYNQLSSVPENLGSVAEKLELLTLEGNKISGMCSPLSLKELKILNLSK
NHISSLSEDFFEACPKVENFSARMNSLAAMPFLPSSMTIIKLSQNRFTCVPEAILNLPHL
RSLDMSSNKIKHLPSPAHWKSLNLRELLFSHNQISILDLSEKAHAWSRVEKLHLSHNKLK
EIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDI
IRFLQQRLKKAVPYNRIKLMIVGNTGSGKTTLLQQLMKTKKSDLGMPSATVGIDVNDWPI
QIRGKRKKDLILNVWDFAGREEFYSTHPHFMTPRSLYLAVYDLSKGQAEVDAMKPWLFNI
KARASSSPVILVGTHLDVSDEKQRKACISKINKELLNKRGFPAIRDYHFVNATEESDALA
KLRKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVK
ENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSNLYFVEPKWLCKVMAQIFTEKVEGC
PKHPEGIISRRSVEKFLSKKKRFPKNYTQQYFKLLEKFQIALPIGEEYLLVPSSLSDHRP
VIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRIYWRQGI
YLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGWVLLGQVVDHIDSLMEEWFPGLLEI
DICGEGETLLKKWALYSFNDGEEHKKILLDDLMKKAEEGDLLVNPDQPRLTLPISQIAPD
LILADLPRNIMLNNDGLKFEQAPEFLLGDGSFGSVYRATYEGDEVAVKIFNKHTSLRLLR
QELVVLCHHHHPSLISLLAAGIRPRMLVMELAPKGSLDRLLQQDKASLTRTLQHRIALHV
ADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGF
RAPEVARGNVIYNQQADVYSFGLLLYDILTIGGRIAEGLKFPNEFDELAIQGKLPDPVKE
YGCAPWPMVEKLIKRCLRENPQERPTSAQVFDILNSAELICLMRHISIPKNFAAECMVAA
NQSCKNASVWLGCGLRDRGQLSFLDLTTERLTSQEVTNSRILCLALVHLPMEKESWVVSG
TQSGELLVINTEDGKKMHTLQKMTDSVTCLHCNSKQSRQKNFLLVGTADGNLAIFEDNSV
KYKGAAPLKILNIGNISTPLMCLSESVNSAEKNIMWGGCGTKLFSFSDDFTIQKLIETRT
NQLFTYAALSDSNIIAVVVDRVLYVAKKNSPFVEVWDKKTEKLCELIDCAHFLKEEMVRV
NKESKNNMSYSGRVKTLCLQKNTALWIGTGGGYMLLLDLSTLRLIRVIDDFCDSVRVMMT
AQLGSLKNAMLVLGYIWKGTEDMQHQKELQSCLSIWDINLPHEVQNLGKHIEVRQELAER
MRRITVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgtcaggggggcgaggaggaggacgaggaaactttgaagaagttg
atagtcaggctgaacaatctccaggaaggaaagcagatagagacgctggtccagattctg
gaggacatgcaggtgttcacctacgcggaccacgccgccaagttatttcaaggcaaaaat
gtccacgtgcctctgttgatcgtcctggactcctacgtgcgagtggcgtgtgtgcagcag
gtgggttggtcactgctatgcaaattaatagaaatctgtccagatacaatgcaaagctta
acgggaccccaggatattggatgcgattgggaagtccttggtgttcaccaactgattatt
aaaatgcttacagttcataatgccaatatgaatctgtcaatggttggactgaaggcctta
gatctccttctaacttcaggtaaaatcactttgctaatattggatgaagaaagcgatatt
ttcttattaatttttgatgccatgaaaaggttttcagccaatgatgaggtccagaaactt
ggatgcaaagctttacacgtgctatttgagagagtttcagaggagcaactgattgaattt
gtggagaataaagattatatgacattgctaactgcattaaaaaactttaaagaggaggag
gaaattgtgctttatgtactgtgctgtttacattctctagcaagtccttgcaacaatgtt
gaagtcctcatgagtggcaatgtcaggtgttacaacattgcggtcgaagccatgaaagca
ttccctgccaatgaaaaaattcaagaagtgagttgctgcttgctccataggcttacatta
ggtaatttttttaatatcctggtattaaaccaggtacaggagtttgtggtggaagctgtg
cagcggtattcaaagaatgcaaagttgcaaattgcagggctcagctgtttagcgcttctc
actgagaccatttttttaaatcaagacttagaggaaaaaaatgaaaatcaggagaatgat
gatgaagaagaagaagaaaaattgttttggctagaagcctgttacaaagccctaacgtgg
catagaaagacagagcatgtacaggaggctgcctgctgggccctaaataatctccttatg
taccaaaacagtttgcacgagaagattggagatgaagatggccagttcccagctcaccgg
gaagtgatgctctccatgctgatgcattcttcatcaaaagaagtcttccaggcatctgcg
aatgctttgtgcactcttctagaacaaaatgttaatttcagaaaaatcctgttgtcaaaa
ggaatctacctgaacgtgctggagttgatgcagaagcatatacactcctctgaagtggct
gaaagtggctgcaaaatgctcaatcatcttttcgaaggaagtgacatgcccctggatgta
atggcagcagtggcccccaaaataataacagtgatgaagagtcatggggcctcattgtca
gtgcagctggaggcacttcgagccattttacattttatgcttccaggcacgccagaagaa
ttcacagaagataccgaatatcgacacaagctaaaaatggtaacaaatcagtgtttcaag
aatgatattcacaagctggtcctggtatctttaaacaggttcattggaaatcctgggatt
cagaagtgtggattaaaagtaatttcttcaatagcacattttcctgatgccgtagaggtc
ttatctctggaaggtgctatggaatcagtgcttcaaacactgaagatgtatccggacgac
caagaaattcagcatctgggtttaagtcttatcggatgcttgattaccaagaagaattta
ttcctaggaagtgtgcatctgctggcaaaaatcctggtttccagtttacaacgatttaag
gatattactgaattacagactaaaggatttcagacagtcctgaccatgctggaactgtca
gtgtctttttccaggctgttggtacattattccttggactcagtaatattccatcagatg
tcctccagtctcatggaacagaaggatcaacagtttctaaacctttgttgcaagtgcttt
gcaaaattagccatggatgatgagttaaaaggtgtgatgctcgagagagcatgcgataag
aataacagcgtcatggttgaatgcttgcttctgttgggagcggacgccaatcgagcaaag
gatgaaacatctttaatctgtcaggtgtgtgaaaaagcaagcagtcctaaactggtggag
ctgttactgaatagtgggtcgcgtgaacaagatgtacggaaagcgctggcaatcagcatc
gggaaaggcgacagccagatcatcagtttgctcttaaagagactgggcctggatctggcc
aataacagcatatgcctcggaggatttggtatcgggaaaatcgaaccttcttggcttggt
cctttatttccagataagacatgcaattcaaaaaaagaaataaatataggatctacccta
gcaagaatggtcctcagataccagatgaaaagtgctgtggcagagggagcagcctcaggc
agcgatgggagtttttctgagcaaattctggataaatttgaccaatggacctttattcct
gagtcctacgtggacagtgtgtttggccaaagcgatgacctagatagcgaaggaagtgaa
ggttcatttcttatgaaaaagaattcaagttccattagcgtaggagaattttaccgagat
cctgccttgcaacgttgttgctcaccaaatttgcaaaagcattccgattcattgagaccc
atttttgatcaagaagacttactgaagcaaaaaagaaaaatattgtcttcagatgattca
ttcaggtcatcaaaacttccatcccatatgaggcattcagagagcgcttcttccctggct
tctgagagggaacatattacatcgctagatctttcagccaacgagctcagggacattgat
gccctgagccagaagagctgcatcagtggccatctggagcacctggagaggctggagctt
caccagaatgcactcacgggcttcccacggcggctaagcgaagtgctgaagtgtttgacg
cacttggacttgcacagtaataagttcacggcgtttccctcctacttgttgaaaatgaac
tgtattgccaaccttgatgtctctcgaaatgacatcaagccctcggtagttttggatcct
gcagtgaagtgtccgaccttgaaacagttcaacctgtcatataaccagctgtcttctgtt
cccgagaaccttggcagtgtggcagaaaaactggagctgctgactttagaaggaaataaa
atatcaggaatgtgttcccccctgagtctgaaggagctgaagattttaaatcttagtaaa
aatcacatttcatccctgtcagaggacttttttgaggcttgtcctaaagtggagaatttc
agtgccagaatgaactctcttgctgcaatgccttttttaccatcttctatgacaatcatc
aaattatctcaaaacagatttacatgtgttccagaagcaattttaaatcttccacacttg
cgatcactagacatgagcagcaacaaaattaaacacctaccaagtcctgcccactggaaa
tcgctgaacttaagggaactcttgtttagccataatcagatcagcatcttggatttgagc
gaaaaagcacacgcatggtccagagtagagaaactacatctttctcataataaactgaaa
gagattcctccagagattggctgtcttgaaaatctgacatctcttgatgttagttacaac
ttggaactgagatcctttcccaatgaaatggggaaattgagcaaaatatgggatcttcct
ttggatgaactgcgtcttaattttgattttaagcatataggatgtaaagccaaagacatc
ataaggtttctccaacagcggttaaagaaggccgtgccctataaccgaattaaacttatg
attgtgggaaacactgggagtggtaaaaccaccttattgcagcaattaatgaaaaccaag
aaatcagatcttgggatgccaagtgccacagttggcatagacgtgaacgactggcctatc
caaatcagaggcaaaaggaagaaagacctgattctaaatgtgtgggattttgcaggccgg
gaggaattctacagcacgcatccgcacttcatgaccccgcggtcactgtacctcgctgtc
tatgacctcagtaaagggcaggctgaagttgatgctatgaagccttggctattcaatata
aaggctcgagcttcctcttcccctgtgattctcgtgggcacacatttggatgtttctgac
gagaagcagcgcaaagcctgcataagtaaaatcaacaaggagctcttgaacaagcgaggg
tttcccgcaataagggattaccactttgtgaatgccaccgaggagtctgatgctttggca
aaacttcggaaaaccatcataaatgagagcctcaatttcaagatcagagatcagcctgtt
gttgggcagctgattccagactgctatgtggaacttgagaaaatcattttatcagagcgt
aaaaatgtgccaattgaatttcctgtaattgaccggaaacgattattacaactggtgaaa
gaaaatcagctgcagctagatgaaaatgagcttcctcatgcagtgcacttcctaaatgaa
tcaggggttcttcttcattttcaagacccagcactgcagttaagtaacttgtattttgtg
gaacccaagtggctttgtaaagtcatggcacagatttttacagagaaagtagaaggctgt
ccaaaacatcccgaaggaattatttcacgtagaagtgtggaaaaatttctttcaaagaaa
aagagatttccaaagaactacacacaacagtacttcaaactcctagaaaaatttcagatc
gccttgccaataggagaagagtatttgctggttccaagcagtctatctgaccacaggcct
gtgatagagctcccccattgtgagaactctgaaattatcattcgactatatgaaatgcct
tattttccaatgggattttggtcaagattaatcaatcgattacttgaaatttcaccttac
atgctttcaggtagagaacgagcacttcgcccaaacaggatatattggcgacaaggcatc
tatttgaattggtctcctgaagcttattgcctggtaggatctgaagtcttagataatcac
ccagagagtttcctaaaaattacagttccttcttgtagaaaaggctgggttcttttggga
caagttgtggaccacattgattctctcatggaagaatggtttcctgggttattggagatt
gatatttgtggtgaaggagaaactttgttgaagaaatgggcattatatagtttcaatgat
ggtgaagaacataaaaaaatcttacttgatgacttgatgaagaaagcagaagaaggagac
ctcctagtaaatccagatcaaccaaggctcacccttccaatatcccagattgctcctgat
ttgattttggctgacctccctagaaatattatgttgaacaatgatggattaaaatttgaa
caagctccggaatttctcttaggtgacggcagttttggatcagtttatcgagcaacctat
gaaggagatgaagtggctgtaaagatatttaacaaacatacatcacttagactcttaaga
caagagctggtggtgctttgccaccaccaccaccccagcttaatatcgctgctggcggct
gggattcgtccccggatgctggtgatggagctggcccccaagggctccctggaccgcctg
ctgcagcaggacaaagccagtctcacgaggactctgcagcacaggatcgcactccatgtg
gctgatggcttgaggtacctccactcggccatgatcatataccgggatttgaagccccac
aatgtgctgctcttcaccctgtatcccaatgccgccatcatcgccaagattgctgactac
gggattgctcagtactgctgcagaatgggcatcaaaacatcagagggcacaccaggcttt
cgtgcacctgaagttgctagaggaaatgtaatttataaccaacaggctgatgtttattca
tttggtttactactgtatgacattttgacaattggaggtaggatagcagagggtttgaag
tttccaaatgagtttgatgaattggcaatacaaggcaaattaccagatccagttaaagaa
tatggttgtgccccgtggcctatggttgagaagttaattaaaaggtgtttaagagaaaat
cctcaagaaaggcctacatctgcccaggtctttgacattttgaactcggcagagttgatc
tgtctgatgagacacatatccatccccaaaaacttcgctgcggagtgcatggtggctgca
aatcagagctgcaagaatgccagcgtctggctgggctgcgggctcagggacagaggccag
ctctcctttcttgacctaactactgaaagactgacttcacaggaagttaccaacagcaga
atactgtgcctcgccctggtgcacctgcccatggaaaaagaaagctgggttgtgtctggg
acacagtctggcgagctcctcgtcattaatactgaagatgggaagaagatgcataccctt
cagaagatgactgattctgttacttgcttgcattgcaattccaaacaaagcaggcaaaaa
aattttcttttggtgggaactgctgatggaaacttagcaatttttgaagataatagtgtt
aagtataaaggagctgctcctttgaagatactcaacataggaaatatcagcactccactc
atgtgtctgagtgaatctgtgaattcagctgaaaaaaacattatgtggggaggatgtggc
acaaaacttttctcgttttctgatgatttcaccattcagaaactcattgagacccggaca
aaccagctgtttacttatgcagctctcagtgactccaacatcatagcagtggtggtggac
agagttctctacgttgctaagaaaaacagcccgtttgtggaagtgtgggataagaaaacg
gaaaaactctgtgaactaatagactgtgcgcactttttaaaggaggaaatggtgagagtg
aacaaggagtccaaaaacaatatgtcttactcggggagggtgaaaactctctgcctgcag
aagaacacggctctctggattggaaccgggggaggctacatgctgctccttgacctttcg
actctcaggcttatccgtgtaattgacgacttctgtgactctgtccgagtcatgatgaca
gcacagttaggaagccttaaaaatgccatgttggttttgggatatatctggaaaggtact
gaagatatgcaacaccaaaaagaattacaatcttgcttgtctatttgggacatcaatctt
ccacacgaagtgcaaaatttaggaaaacatattgaagtgagacaagaattagctgaaaga
atgagaagaataactgttgaataa
DBGET
integrated database retrieval system
