KEGG   Pipistrellus kuhlii (Kuhl's pipistrelle): 118731760
Entry
118731760         CDS       T07682                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pkl  Pipistrellus kuhlii (Kuhl's pipistrelle)
Pathway
pkl01521  EGFR tyrosine kinase inhibitor resistance
pkl01522  Endocrine resistance
pkl04010  MAPK signaling pathway
pkl04012  ErbB signaling pathway
pkl04068  FoxO signaling pathway
pkl04270  Vascular smooth muscle contraction
pkl04650  Natural killer cell mediated cytotoxicity
pkl04720  Long-term potentiation
pkl04726  Serotonergic synapse
pkl04730  Long-term depression
pkl04810  Regulation of actin cytoskeleton
pkl04910  Insulin signaling pathway
pkl04914  Progesterone-mediated oocyte maturation
pkl04928  Parathyroid hormone synthesis, secretion and action
pkl05010  Alzheimer disease
pkl05022  Pathways of neurodegeneration - multiple diseases
pkl05034  Alcoholism
pkl05160  Hepatitis C
pkl05161  Hepatitis B
pkl05200  Pathways in cancer
pkl05205  Proteoglycans in cancer
pkl05208  Chemical carcinogenesis - reactive oxygen species
pkl05210  Colorectal cancer
pkl05211  Renal cell carcinoma
pkl05212  Pancreatic cancer
pkl05213  Endometrial cancer
pkl05214  Glioma
pkl05215  Prostate cancer
pkl05218  Melanoma
pkl05219  Bladder cancer
pkl05220  Chronic myeloid leukemia
pkl05221  Acute myeloid leukemia
pkl05223  Non-small cell lung cancer
pkl05224  Breast cancer
pkl05225  Hepatocellular carcinoma
pkl05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:pkl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    118731760 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    118731760 (ARAF)
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    118731760 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    118731760 (ARAF)
   04720 Long-term potentiation
    118731760 (ARAF)
   04730 Long-term depression
    118731760 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118731760 (ARAF)
   05205 Proteoglycans in cancer
    118731760 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    118731760 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    118731760 (ARAF)
   05212 Pancreatic cancer
    118731760 (ARAF)
   05225 Hepatocellular carcinoma
    118731760 (ARAF)
   05226 Gastric cancer
    118731760 (ARAF)
   05214 Glioma
    118731760 (ARAF)
   05221 Acute myeloid leukemia
    118731760 (ARAF)
   05220 Chronic myeloid leukemia
    118731760 (ARAF)
   05218 Melanoma
    118731760 (ARAF)
   05211 Renal cell carcinoma
    118731760 (ARAF)
   05219 Bladder cancer
    118731760 (ARAF)
   05215 Prostate cancer
    118731760 (ARAF)
   05213 Endometrial cancer
    118731760 (ARAF)
   05224 Breast cancer
    118731760 (ARAF)
   05223 Non-small cell lung cancer
    118731760 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    118731760 (ARAF)
   05160 Hepatitis C
    118731760 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118731760 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    118731760 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    118731760 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118731760 (ARAF)
   01522 Endocrine resistance
    118731760 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pkl01001]
    118731760 (ARAF)
Enzymes [BR:pkl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     118731760 (ARAF)
Protein kinases [BR:pkl01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   118731760 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 Pkinase_fungal zf-RING-like TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 118731760
NCBI-ProteinID: XP_036316471
LinkDB
Position
Unknown
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQYYHSIQDLSGGYRQHEAPSNRPLNEPL
TPQGSSSSSQHRDPEHFPFPATANAPLQRIRSTSTPNVHMVSTTTPLDSSVFQLAAQSFN
ADAAGSRGGNDGVPRGSPSPASVSSGRKSPHSKSPSEQRERKSVGDDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccccgccaacggggccgagccgtcccgggcagtgggcact
gtcaaagtgtacctgcccaacaagcaacgcacagtggtgactgtccgggatggcatgagt
gtctatgactctctagacaaggctctcaaggtgcggggtctcaatcaggattgctgcgtg
gtctaccggctcatcaaagggcgaaagacagtcactgcctgggacacagccattgccccc
ctggatggcgaggagctcattgttgaggtccttgaagacgtcccactgactatgcacaat
ttcgtacggaagacgttcttcagcctggccttctgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctctaaggtc
cccacagtctgtgttgacatgagtaccaactgccgacagtactaccacagtatccaggat
ttgtccggaggctacagacagcatgaggctccttccaaccggcctttgaatgagccgctc
acccctcagggttccagctccagctcccagcaccgagaccctgagcacttcccctttcct
gccacggccaacgcccccctgcagcgcatccgctccacgtctactcccaatgtccatatg
gtcagcaccaccacccccctggactccagtgtcttccagcttgctgcccagagtttcaac
gccgatgctgctggtagtagaggtggcaatgatggagtgccccgggggagccccagcccg
gctagtgtgtcctcggggaggaagtccccacattccaagtccccatcagaacagcgggag
aggaagtccgtgggtgatgacaagaagaaagtgaagaatctggggtaccgggactcgggc
tattactgggaggtgccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgcgggcggtggcatggcgatgtggctgtgaaggtgctcaaggtg
gcgcaacccacagctgagcaggcgcaggccttcaagaacgagatgcaggtgctcagaaag
acacgtcatgtcaacatcttgctgttcatgggcttcatgacccggccggggttcgccatc
atcacacagtggtgtgagggctccagcctctaccaccacctgcacgtggccgacacacgc
ttcgacatggtccagctcattgacgtggcccggcagacggcccagggcatggactacctc
catgccaagaacatcatccaccgggatctcaagtctaacaacatcttcctacatgagggg
ctcacagtgaagatcggtgacttcggcctggccacggtgaagacgagatggagcggggct
cagcccttggagcagccctcaggctctgtgctgtggatggcggctgaggtgatccgtatg
caggacccaaacccctacagcttccagtcagatgtctacgcctatggggttgtgctctat
gagctcatgaccggctccttgccttatagccacattggcagccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgattgcctcaagtttcagcgagaggagcggcccctcttc
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcatcgcacccaggctgatgagttgcccgcctgcctactcagc
gcagcccgccttgtgccttag

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