KEGG   Pipistrellus kuhlii (Kuhl's pipistrelle): 118731984
Entry
118731984         CDS       T07682                                 
Symbol
PIK3CD
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pkl  Pipistrellus kuhlii (Kuhl's pipistrelle)
Pathway
pkl00562  Inositol phosphate metabolism
pkl01100  Metabolic pathways
pkl01521  EGFR tyrosine kinase inhibitor resistance
pkl01522  Endocrine resistance
pkl01524  Platinum drug resistance
pkl04012  ErbB signaling pathway
pkl04014  Ras signaling pathway
pkl04015  Rap1 signaling pathway
pkl04024  cAMP signaling pathway
pkl04062  Chemokine signaling pathway
pkl04066  HIF-1 signaling pathway
pkl04068  FoxO signaling pathway
pkl04070  Phosphatidylinositol signaling system
pkl04071  Sphingolipid signaling pathway
pkl04072  Phospholipase D signaling pathway
pkl04081  Hormone signaling
pkl04140  Autophagy - animal
pkl04150  mTOR signaling pathway
pkl04151  PI3K-Akt signaling pathway
pkl04152  AMPK signaling pathway
pkl04210  Apoptosis
pkl04211  Longevity regulating pathway
pkl04213  Longevity regulating pathway - multiple species
pkl04218  Cellular senescence
pkl04360  Axon guidance
pkl04370  VEGF signaling pathway
pkl04380  Osteoclast differentiation
pkl04510  Focal adhesion
pkl04550  Signaling pathways regulating pluripotency of stem cells
pkl04611  Platelet activation
pkl04613  Neutrophil extracellular trap formation
pkl04620  Toll-like receptor signaling pathway
pkl04625  C-type lectin receptor signaling pathway
pkl04630  JAK-STAT signaling pathway
pkl04650  Natural killer cell mediated cytotoxicity
pkl04660  T cell receptor signaling pathway
pkl04662  B cell receptor signaling pathway
pkl04664  Fc epsilon RI signaling pathway
pkl04666  Fc gamma R-mediated phagocytosis
pkl04668  TNF signaling pathway
pkl04670  Leukocyte transendothelial migration
pkl04722  Neurotrophin signaling pathway
pkl04725  Cholinergic synapse
pkl04750  Inflammatory mediator regulation of TRP channels
pkl04810  Regulation of actin cytoskeleton
pkl04910  Insulin signaling pathway
pkl04914  Progesterone-mediated oocyte maturation
pkl04915  Estrogen signaling pathway
pkl04917  Prolactin signaling pathway
pkl04919  Thyroid hormone signaling pathway
pkl04923  Regulation of lipolysis in adipocytes
pkl04926  Relaxin signaling pathway
pkl04929  GnRH secretion
pkl04930  Type II diabetes mellitus
pkl04931  Insulin resistance
pkl04932  Non-alcoholic fatty liver disease
pkl04933  AGE-RAGE signaling pathway in diabetic complications
pkl04935  Growth hormone synthesis, secretion and action
pkl04960  Aldosterone-regulated sodium reabsorption
pkl04973  Carbohydrate digestion and absorption
pkl05010  Alzheimer disease
pkl05017  Spinocerebellar ataxia
pkl05020  Prion disease
pkl05100  Bacterial invasion of epithelial cells
pkl05132  Salmonella infection
pkl05135  Yersinia infection
pkl05142  Chagas disease
pkl05146  Amoebiasis
pkl05160  Hepatitis C
pkl05161  Hepatitis B
pkl05162  Measles
pkl05163  Human cytomegalovirus infection
pkl05164  Influenza A
pkl05165  Human papillomavirus infection
pkl05166  Human T-cell leukemia virus 1 infection
pkl05167  Kaposi sarcoma-associated herpesvirus infection
pkl05168  Herpes simplex virus 1 infection
pkl05169  Epstein-Barr virus infection
pkl05170  Human immunodeficiency virus 1 infection
pkl05171  Coronavirus disease - COVID-19
pkl05200  Pathways in cancer
pkl05203  Viral carcinogenesis
pkl05205  Proteoglycans in cancer
pkl05206  MicroRNAs in cancer
pkl05207  Chemical carcinogenesis - receptor activation
pkl05208  Chemical carcinogenesis - reactive oxygen species
pkl05210  Colorectal cancer
pkl05211  Renal cell carcinoma
pkl05212  Pancreatic cancer
pkl05213  Endometrial cancer
pkl05214  Glioma
pkl05215  Prostate cancer
pkl05218  Melanoma
pkl05220  Chronic myeloid leukemia
pkl05221  Acute myeloid leukemia
pkl05222  Small cell lung cancer
pkl05223  Non-small cell lung cancer
pkl05224  Breast cancer
pkl05225  Hepatocellular carcinoma
pkl05226  Gastric cancer
pkl05230  Central carbon metabolism in cancer
pkl05231  Choline metabolism in cancer
pkl05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pkl05415  Diabetic cardiomyopathy
pkl05417  Lipid and atherosclerosis
pkl05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pkl00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    118731984 (PIK3CD)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    118731984 (PIK3CD)
   04014 Ras signaling pathway
    118731984 (PIK3CD)
   04015 Rap1 signaling pathway
    118731984 (PIK3CD)
   04370 VEGF signaling pathway
    118731984 (PIK3CD)
   04630 JAK-STAT signaling pathway
    118731984 (PIK3CD)
   04668 TNF signaling pathway
    118731984 (PIK3CD)
   04066 HIF-1 signaling pathway
    118731984 (PIK3CD)
   04068 FoxO signaling pathway
    118731984 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    118731984 (PIK3CD)
   04072 Phospholipase D signaling pathway
    118731984 (PIK3CD)
   04071 Sphingolipid signaling pathway
    118731984 (PIK3CD)
   04024 cAMP signaling pathway
    118731984 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    118731984 (PIK3CD)
   04152 AMPK signaling pathway
    118731984 (PIK3CD)
   04150 mTOR signaling pathway
    118731984 (PIK3CD)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    118731984 (PIK3CD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    118731984 (PIK3CD)
  09143 Cell growth and death
   04210 Apoptosis
    118731984 (PIK3CD)
   04218 Cellular senescence
    118731984 (PIK3CD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    118731984 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    118731984 (PIK3CD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    118731984 (PIK3CD)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    118731984 (PIK3CD)
   04613 Neutrophil extracellular trap formation
    118731984 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    118731984 (PIK3CD)
   04625 C-type lectin receptor signaling pathway
    118731984 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    118731984 (PIK3CD)
   04660 T cell receptor signaling pathway
    118731984 (PIK3CD)
   04662 B cell receptor signaling pathway
    118731984 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    118731984 (PIK3CD)
   04666 Fc gamma R-mediated phagocytosis
    118731984 (PIK3CD)
   04670 Leukocyte transendothelial migration
    118731984 (PIK3CD)
   04062 Chemokine signaling pathway
    118731984 (PIK3CD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    118731984 (PIK3CD)
   04923 Regulation of lipolysis in adipocytes
    118731984 (PIK3CD)
   04929 GnRH secretion
    118731984 (PIK3CD)
   04915 Estrogen signaling pathway
    118731984 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    118731984 (PIK3CD)
   04917 Prolactin signaling pathway
    118731984 (PIK3CD)
   04926 Relaxin signaling pathway
    118731984 (PIK3CD)
   04935 Growth hormone synthesis, secretion and action
    118731984 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    118731984 (PIK3CD)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    118731984 (PIK3CD)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    118731984 (PIK3CD)
  09156 Nervous system
   04725 Cholinergic synapse
    118731984 (PIK3CD)
   04722 Neurotrophin signaling pathway
    118731984 (PIK3CD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    118731984 (PIK3CD)
  09158 Development and regeneration
   04360 Axon guidance
    118731984 (PIK3CD)
   04380 Osteoclast differentiation
    118731984 (PIK3CD)
  09149 Aging
   04211 Longevity regulating pathway
    118731984 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    118731984 (PIK3CD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118731984 (PIK3CD)
   05206 MicroRNAs in cancer
    118731984 (PIK3CD)
   05205 Proteoglycans in cancer
    118731984 (PIK3CD)
   05207 Chemical carcinogenesis - receptor activation
    118731984 (PIK3CD)
   05208 Chemical carcinogenesis - reactive oxygen species
    118731984 (PIK3CD)
   05203 Viral carcinogenesis
    118731984 (PIK3CD)
   05230 Central carbon metabolism in cancer
    118731984 (PIK3CD)
   05231 Choline metabolism in cancer
    118731984 (PIK3CD)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118731984 (PIK3CD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    118731984 (PIK3CD)
   05212 Pancreatic cancer
    118731984 (PIK3CD)
   05225 Hepatocellular carcinoma
    118731984 (PIK3CD)
   05226 Gastric cancer
    118731984 (PIK3CD)
   05214 Glioma
    118731984 (PIK3CD)
   05221 Acute myeloid leukemia
    118731984 (PIK3CD)
   05220 Chronic myeloid leukemia
    118731984 (PIK3CD)
   05218 Melanoma
    118731984 (PIK3CD)
   05211 Renal cell carcinoma
    118731984 (PIK3CD)
   05215 Prostate cancer
    118731984 (PIK3CD)
   05213 Endometrial cancer
    118731984 (PIK3CD)
   05224 Breast cancer
    118731984 (PIK3CD)
   05222 Small cell lung cancer
    118731984 (PIK3CD)
   05223 Non-small cell lung cancer
    118731984 (PIK3CD)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118731984 (PIK3CD)
   05170 Human immunodeficiency virus 1 infection
    118731984 (PIK3CD)
   05161 Hepatitis B
    118731984 (PIK3CD)
   05160 Hepatitis C
    118731984 (PIK3CD)
   05171 Coronavirus disease - COVID-19
    118731984 (PIK3CD)
   05164 Influenza A
    118731984 (PIK3CD)
   05162 Measles
    118731984 (PIK3CD)
   05168 Herpes simplex virus 1 infection
    118731984 (PIK3CD)
   05163 Human cytomegalovirus infection
    118731984 (PIK3CD)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118731984 (PIK3CD)
   05169 Epstein-Barr virus infection
    118731984 (PIK3CD)
   05165 Human papillomavirus infection
    118731984 (PIK3CD)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    118731984 (PIK3CD)
   05135 Yersinia infection
    118731984 (PIK3CD)
   05100 Bacterial invasion of epithelial cells
    118731984 (PIK3CD)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    118731984 (PIK3CD)
   05142 Chagas disease
    118731984 (PIK3CD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118731984 (PIK3CD)
   05017 Spinocerebellar ataxia
    118731984 (PIK3CD)
   05020 Prion disease
    118731984 (PIK3CD)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    118731984 (PIK3CD)
   05418 Fluid shear stress and atherosclerosis
    118731984 (PIK3CD)
   05415 Diabetic cardiomyopathy
    118731984 (PIK3CD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    118731984 (PIK3CD)
   04932 Non-alcoholic fatty liver disease
    118731984 (PIK3CD)
   04931 Insulin resistance
    118731984 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    118731984 (PIK3CD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118731984 (PIK3CD)
   01524 Platinum drug resistance
    118731984 (PIK3CD)
   01522 Endocrine resistance
    118731984 (PIK3CD)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pkl04131]
    118731984 (PIK3CD)
Enzymes [BR:pkl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     118731984 (PIK3CD)
Membrane trafficking [BR:pkl04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    118731984 (PIK3CD)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2
Other DBs
NCBI-GeneID: 118731984
NCBI-ProteinID: XP_036316804
LinkDB
Position
Unknown
AA seq 1065 aa
MPPGVDCPMEFWANEENQSVAVDFLLPTGVYLNFPVSRNASLSTIKKVLWHRAQYEPLFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLRDPEVNDFRAKMRQLCEEAAARRQQLGWEAWLQYSFPLQLEPAARAWGP
GLRAPGRALLVNVKFEGSEESFTFQVSTKDLPLALMACALRKKATVFRQPLVEQPEDYTL
QVNGKQEFLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKSRT
KPPPIPMKKPSSLSLWALERPFCVELIQGSKVNADERMKLVVQAGLFHGNETLCKTVSSS
EVSVCSEPVWKQRLEFDIHVCDLPRMARLCFALYAVIEKAKKARSTKKKAKKADCPIAWA
NLTLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVCNNPNTESAAALVICLPEVAPH
PVYYPALDKILELGRHGEHGRATEEEQLQLREILERRGAGELYEHEKDLVWKLRHEVQER
FPEALARLLLVTKWNKHEDVAQVGAGRPGGGAAREAPPDCRPPQMLYLLCSWPELPVLSA
LELLDSSFPDRHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALA
NRKIGHFLFWHLRSEMHVPSVSLRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFV
KVSSQKSPKPQTKELMHLCMRQETYLEALSHLQSPLDPSILLAEVCVEQCTFMDSKMKPL
WVVYSNEEAGGDGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLSTG
DRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSC
AGYCVATYVLGIGDRHSDNIMIRENGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFV
HVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLK
DSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ
NT seq 3198 nt   +upstreamnt  +downstreamnt
atgcccccgggggtggactgccccatggaattctgggccaacgaggagaaccagagcgtg
gcggtcgacttcctgctgcccacgggggtctacctgaacttccccgtgtcccgcaatgcc
agcctcagcaccatcaagaaggtgctgtggcaccgagcccagtatgagccgctgttccac
atgctcagcgaccccgaggcctacgtgttcacctgcgtcaaccagacggcggagcagcag
gagctggaggacgagcagcggcggctgtgcgacatccagcccttcctgccggtgctgcgc
ctggtggcccgcgagggcgaccgcgtcaagaagctcatcaactcgcagatcagcctcctc
atcggcaaaggcctgcacgagttcgattccctgcgggaccccgaggtgaacgacttccgg
gcgaagatgcggcagctgtgcgaggaggcggcggcgcggcggcagcagctgggctgggag
gcctggctgcagtacagcttcccgctgcagctggagcccgcggcgcgggcctggggcccc
ggcctgcgcgcccccggccgggccctcctggtcaacgtcaagttcgagggcagcgaggag
agcttcaccttccaggtgtccaccaaggacctgccgctggcgctgatggcctgcgccctg
cgcaagaaggccaccgtgttccggcagccgctggtggagcagcccgaggactacacgctg
caggtgaacgggaagcaggagttcctgtacggcagctacccgctctgccagttccagtac
atctgcagctgcctgcacagcgggctgaccccccacctgaccatggtccactcctcctcc
atccttgccatgcgggacgagcagagcaaccctgccccccaggtccagaaatcgcgcacc
aagccgccccccatccccatgaagaagccctcgtccctgtccctgtgggccctggagcgg
cccttctgcgtggagctgatccagggcagcaaagtgaacgccgacgagcggatgaagctg
gtggtgcaggccgggctcttccacggcaacgagacgctgtgcaagacggtgtccagctcg
gaggtgagcgtgtgctcggagcccgtgtggaagcagcgcctggagttcgacatccacgtg
tgcgacctgccgcgcatggcccggctgtgcttcgcgctctacgccgtcatcgagaaggcc
aagaaggcgcgctccaccaagaagaaggccaagaaggcggactgccccatcgcctgggcc
aacctcaccctcttcgactacaaggaccagctgaagacgggcgagcgctgcctctacatg
tggccctccgtcccagacgagaaaggggagctgctgaaccccacgggaaccgtgtgcaac
aaccccaacaccgagagcgccgccgccctggtcatctgtctccccgaggtggcgccccac
cccgtgtactaccccgccctggacaagatcctggagctggggcggcacggggagcacggg
cgcgccacggaggaggagcagctgcagctgcgggagatcctggagcggcgcggggcgggg
gagctgtacgagcacgagaaggacctggtgtggaagctgcggcatgaggtgcaggagcgc
ttccccgaggcgctggcccggctgctgctggtcaccaagtggaacaagcacgaggacgtg
gcccaggtgggcgcggggcggccgggggggggggcggcccgagaggcaccccctgactgc
cggcccccccagatgctctacctgctgtgctcctggccggagctgcccgtgctgagcgcc
ctggagctgctggactccagcttccccgaccgccacgtgggctccttcgccatcaagtcc
ctgcggaagctgacggacgacgagctgttccagtacctgctgcagctggtgcaggtgctc
aagtacgagtcctacctggactgcgagctgaccaagttcctgctggaccgggcgctggcc
aaccgcaagatcggccacttcctcttctggcacctccgctccgagatgcacgtgccctct
gtgtccctgcgcttcggcctcatcatggaggcgtactgccggggcagcacccaccacatg
aaggtgctgatgaagcagggggaggcgctgagcaagctgaaggcgctgaacgactttgtc
aaggtgagctcgcagaagagccccaagccgcagaccaaggagctgatgcacctgtgcatg
cgccaggagacctacctggaggcgctgtcccacctgcagtccccgctggaccccagcatc
ctgctggcggaagtctgcgtggagcagtgcaccttcatggactccaagatgaagccgctg
tgggtcgtgtacagcaacgaggaggcgggcggtgacggcagcgtgggcatcatcttcaag
aacggggacgacctccgccaggacatgctgacgctgcagatgatccagctcatggacgtc
ctgtggaagcaggaggggctggacctgaggatgaccccctacggctgcctctccaccggg
gaccgcacgggcctcatcgaggtggtgctgcactcggacaccatcgccaacatccagctg
aacaagagcaacatggcagccacggccgccttcaacaaggatgccctgctcaactggctc
aagtccaagaaccctggggaggccctggacagggccatcgaggagttcaccctctcctgc
gccggctactgtgtggccacctatgtgctgggcatcggcgaccggcacagcgacaacatc
atgatccgcgagaacgggcagctgttccacattgattttggccacttcctggggaatttc
aagaccaagtttgggatcaaccgcgagcgggtccccttcatcctcacctatgactttgtg
cacgtgatccagcagggcaagaccaacaacagcgagaagtttgagaggttccgcggctac
tgcgagagggcctacaccatcctgcggcgccacgggctgctcttcctccacctcttcgcc
ctgatgcgggcggcgggcctgccggagctcagctgctccaaagacatccagtatctgaag
gactcgctggcgctggggaagacggaggaggaggcgctgaagcacttccgcgtcaagttc
aacgaggcgctgcgggagagctggaagaccaaagtgaactggctggcccacaacgtgtcc
aaagacaaccggcaatag

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