Poecilia latipinna (sailfin molly): 106934571 Help Entry 106934571         CDS       T08005                                  Name (RefSeq) ryanodine receptor 2-like   KO K04962   ryanodine receptor 2 Organism plai  Poecilia latipinna (sailfin molly) Pathway plai04020   Calcium signaling pathway plai04260   Cardiac muscle contraction plai04261   Adrenergic signaling in cardiomyocytes plai04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:plai00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     106934571    04020 Calcium signaling pathway     106934571  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     106934571    04261 Adrenergic signaling in cardiomyocytes     106934571  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:plai04040]     106934571    04990 Domain-containing proteins not elsewhere classified [BR:plai04990]     106934571 Ion channels [BR:plai04040]  Voltage-gated cation channels   Ryanodine receptor    106934571 Domain-containing proteins not elsewhere classified [BR:plai04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    106934571 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 DDHD EF-hand_6 EF-hand_1 Motif Other DBs NCBI-GeneID:  106934571 NCBI-ProteinID:  XP_014870046 Ensembl:  ENSPLAG00000010133 LinkDB All DBs Position Unknown AA seq 4950 aa AA seqDB search MTATGEAEDEGQFLRTGDEVVLQSTFTSHNEHLKLCLAAEGFGSRLCRLEPTSNCKNVPP DLSVCGFILAQCLSVRALQEMLAHSEQLAAEAKAGVAHRTLLYGQAVMFTHSFSGMYLSC LSSSQTSPDKLAFDVGLQEDKAGEACWWTVHPASRQRSEGEKVRVGDDLILVSVSSERYL HLSFAPVSDNKSLSDSLIVSASFQQTLWSVAPICSGGAIAQGYLKGGETLRLLHSHSDAC LTIPCSEQGEELQRVMHYEIGSVSGHGRSLWRLEILHVAWSGRHTCWGEPFRLCHVTTGR YLCLTEENGLHLVDRDKADINTTSFCFRSSKEKLDAGKNTNSDCMGIPEIKYGDSMCYLQ HLYSGLWLTYQATDAKCRLGGNVRKAILHSEGHMDDGLTLSRSQREESHTAGLIRNTVSL FTRFIRKLDCFSHEGSLSSLCLPMKTVTCSLQDLIKYFQSPLDGQSHEDKQKKMAALRKR QNMFKEEGVIDLVLDCIDHLHHYSSDSSITDPAQWEAVVHLFYELLAALIRGNRVNCAHF SSSVDWLIGRLDHLEASSGVLEVLHCVLVESPEAINVIKDGHIQSIISFLEKHGHDNKVL EVLCSLCVCHGVAVRSNQNLICDSLLPDRDLLLQTRLTNQVTSMRANIFLAMGEASAQHR RWYYELVVDHADPFLTAEPTHLRVGWAFTKGYLPRPTGGERWGGNGVGDDLYSFGFDGLH LWSGCVGRKVSSPFSHLLKDNDVVSCCLDLTVPCISFRVNGLPVQGMLENFNANGLLYPV VSFSAGVRVRFLFGGGHGEFRFLPPPGYASCSEALLPKVKLRVEPCQKYISDCEEGKKEL IGPSVPVTPLTFIPTPVDISKVVLPPQLEDIREKMAEHFHELWVKDRIDLGWTNGPVKDE GKQHDPCLVEFSKLPEQERNQNLHMAEDILKTVLALGFHIGLADDHAEERVKYTRLHTKY ELPCGYRPAPIDLRQITLSSADKDVVTLLAENHHNIWARERIKQGWTYGPEQDIKGKRSP HLVPYSLVDERMRKAGMESVREAVRLLLAFGYSLESLSQEQTPLSKPCLFSVEKSRVFRP DKSYAVTMGKWYFEFEVLTAGNMRVGWARPGCAPDKELGSDDQAYVFDGFEAQWCHQGGE PLGRRWLRGDVVGCLVDMFEGTMMVTLNGELLFNDRGSELAAKDLDVRDGLLPVVSVGVN QVGRMNLGRQVETLQYFNVCGQQEGYKPFAFNMTRDPSLWMSWKLPQFTSVLPDDHSLQV TRRRGSMDSLSSLRVSQRALVRHGGGSEMGFYRLSMPIQCAATLRSPAEGGLQVPSSSLT PSSVRKELEDTDSDFEVLMKSARSFAGSRDELDHKDHSQDKTSKLKQRFMMKRTKPGLVS SNSSARLLEDVIVEKDNYDHLIQSSRYYYAVRILPGQEPFSVWIGWVTSDFHHHGSTFDT DSVGTVTVTLGDDSGKVQESVKRSNCFVVCAGEATGLSQSRRSAGLEIGCLIDTATGLLT FTSNGIEMSTFFQLEAGTKLFPAVFVKPTTTNMFQFELESIQNAMPLSSAFLRGQRRNPS PQCPPRFQVQYLKPVTWTRVPDGGLKVFVDWPDEHHGWRVQCFDPQQVMTLQIPEESRCV DILELSELDDLLSFHQNVLLLYCSLCALGNTRVCHALCSHVDQSQILYAIQNPHLAGPLR LAYYQLFIQVYLSSHTTACLTMNHEYIIPMTDQTAQASFYLGPVVGVSDGGNGQTPEGTC RSTCLKPQMCFSSPCFVRGDGMEAEGAVEIACPDSPEIPLDTLRNLTADMLTAGVVAVGQ AVRDPAGGSVELLLVPLLRLFYNLLVMGVFEDEDLVRVLRLIEPNVFSKNVKTVEEAKDG KQRGESINIKDDAIKQGLLQMELPEPVQLELCHLLSYLCDCQVRHRVEAVTAFSGNFVRQ LQENQRFRYTQVMQALNMSAALTARKTKEFRLPPQEQINLLLSFREDEQQENCPCPVELQ QLLRDFHHLLNTHCGTKTVPDSEEEDDTKMSLKDRLFSRAAKAVGLKKKPDEVEKYKSPK LKSLRRLISDMTVCWAQEREIEDPELVRAIFTLLHRQYQGLEGQMEGSLSKAYAISQSSV EDTMALLSSLGQIRSLLSVRMGKEEEKLMIRKLGDIMNNKVFYQHPNLMRSLGMHETVME VMVHVLGEGESKEITFPKMVASCCRFLCYFCRISRHNQGALFDRLSYLLENSRVGLASPS MRGSTPLDVAAASVMDNNELALSLKEADLEKVVQYLAGCGLQSCSLLLAKGYTDIGWNPV EGERYVDFLRFAVFCNGESVEENAYVVLRLLIRRPECFGPALRGDGGDGLLAAMKEAISI SQDPSMDGPFPTQHPSKTTDGVHSNEDDLIHMGHAIMTFYSALIDLLGRCAPEMHLIQGG KGEAIRIRAILRSLIPVQDLEGVISICFRLPSVSEDGVLVEPDLSTAFCPDHKAAMVLFL DRVYGVESQRFLLHLLEVGFLPDLHAAVSLDTTDLGSTDMALALNRYLCTAVLPLLTKCS ALFHDLEDHVLLVDSLIQAIYRLSRALSLTRAQRDTTEDCLLALCSKLQPSTMQPLLQRL VFDVLHLSHHSKLPLKMLTSHYEQMWKYYSYSGSQDKQKLASEGELQLSRKLFWGVFKAL TKKSFIPQLLSLGVQCLVAVAKALPPDYVEPGCLSQVDRITSVDTDGYFEPHPVDTSNVS VPERLDFVVNKYAEHTHEKWSLEKFASGWVHGDQLCENAKVHPLLKPYRALAEKEKDSYR WAIKETIKSMLAFGWTIERTKEGDAFGILACARRVSQAGQLSFEGASTFSPKPLDMSSIT LSWEQCAMAEQLAENYHNVWAKTKKLELESRGGGHSMLVPYDALTAKEKTKFREKAQEIL KFLLLHGYTVWRDRKSMEIDFPATANCFGHIFLQHMLYYTEETQENMLKLEVIQARGQMP KGERAQDQQPIIFFQKVVLPLLEQYVKSHRLYFLSSSLKSSENRSHASKREKEMVLCLFC KLAALVRHRISLIGDEASAVTSCLRILAQALDARILTAAASESLQTSLHSFFEAAAADLE MTVGKISETLPHSRGQLSKGVVNTLNYTTSILIPTLTSLFHHLANQNYGVDVLVGGIQVS CYKILNSLYSLGTSKSFYMEGQRSAAGACVAALTGAFPVCFLEPTLDHSNPHSIYNVMSP TEIKDQGLPDRMENACRPLPSLGEALEKVEELAGAGSVAHQMQYIHVAEVTLPMLCSYIS HWCRWGPEGHPEGPVLSSVVAQHASDLIGHILRIIHNHVGASQGDWMKQLAVFSQPIVCK ADSELLRSHFLPLMEKLKKRAECVQSEEEVMKAEDCCTSEAELQIQEKYRVLVQDLYAFY PLLIQFVDFNRARWLKETIPEAEQLFSMVAEVFVFWAKSHHFKWEEQGYVVQNRINTLAF LLSSNNLLEFDHKNKGMKRKGDRYSAHTSLIVAAIKKMVPVGLRVCFPCDQNLIMLVKNC YSQNNLEDEIREQILRYLKHFFGQASNSVSCGILSADLPAQLEAPADTQRTVDRVLEIAR VLYYLDQVEHPQRSKKPAWKIFLSKRRKRAVVACLRMTPLYNLPRHRAVNLFLQGYNRSW ISTEGNDLVEMLVEDLAKGRVTKPWEGEKGEVKEVEEGAKAIDPLLQLIMLFSRSALTES SNLDNDNLYKDYAAIMAKSCRRESHDDAEQEVESFEEKEMEKQKLLYQQARLHCRGASEM VLQAISASNGTMGFMIGPTLKLGIALLNGGNATVQQKMLDYLREKRNVGFFQSMAGLMRS CSVLDLNAFERQNKAEGLGVATDESSGEKVMPDKDLTCDLLRFLQLLCEGHNSDFQNYLR TQTGNNTTVNIVISTVDYLLRVQESISDFYWYYSGKDVIDPLGQHNFSKAIEVAKQVFNT LTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSRQIKLLKELMDLLKDMV VFLLSMLEGNVINGTIGKQMVDMLVESSSNVEMVLKFFDMFLKLKDLTSSEGFREYDSDC KGSICRKDFQKAMENCKYFSQAEIHFLLSCIETNDGEILEYQTFVDRFHEPAKDIGFSIA VLLTNLSEHMPKESRLKAFTELAECALTYFQPSLGRIEILGSGKRFERVYFEISEYSRTQ WEKPQVKESKRQFIFDVVNKGGDKEKMEMFVNFCEDTIFEMQLAAQISGSNSGEKCNGKT EVETRELEEYSPPDCKRWTLIYYWWLMLTCALSVKNLKTLMKTTPKDFLLAAVQFIRFIC ALQIRCISAVICRIMYLLYITFVNSGLIEAAKRMKVSDLLGGILEPTLDEVMEVSSNVDQ LRKYSASFSSQKELREIGQMASLTFPKEVDILSDIFGLKLKKEGDQYRLVTQDLSDSLTH LFSSTSRTIIDTDVSEEHHTLQFTDYLDKEKTQDKKKENLQEKEWKKTEKERRNAKEETK HGAKRGCNGSKEPQRQHSALWETISSHSKSLLNYFARNFYNIRLLALFVAFAINFILLFY KVAFLPASKEQQATTSAHGKEQLSAKTNASNGRVYFVLEESSGYMELCLHFLSIAHTIIS FCCIIGYYCLKVPLVIFKREKEVARKLEFDGLYVTRQPPEEDVKGQWDRLVINTLSFPSN YWDKFVKRKVMDKYGEFYGRKKISELLGLDQAALDFSTERKEKKLRRDSAWSVLSAVCSR FNSLDAKYQVWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTIL SSVTHNGKQLVLTVGLLAVVVYLYTVIAFNFFRKFYNHSRGKETEDMKCNDMLTCYMFHM YVGVRAGGGIGDEIEDPAGDEFEVERIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQ EQVKEDMETKCFICGIGSEYFDKIPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQE SYVWKMYQERCWEFFPVGDCFRKQHEDQLG NT seq 14853 nt NT seq  +upstreamnt  +downstreamnt atgaccgccacaggagaggctgaagatgagggacaatttttacgaacgggagacgaggtg gttttgcagagcacctttacctcccataatgaacatttgaagctctgtcttgctgctgaa ggatttggcagcaggctttgcaggcttgagcccacttcaaactgcaagaatgttcctcca gacttgtctgtgtgtggcttcatcctggctcagtgtctctctgttcgagccctgcaggag atgctggcccacagcgaacaactggcagcagaggcaaaagctggagttgctcatcgcact ctgctgtacggccaggcagtgatgttcacacactccttcagcggcatgtatcttagttgc ttgtcttcgtctcagacttcacctgacaagttggcgtttgacgtgggtctgcaagaggat aaagcaggagaggcatgttggtggactgtccatccggcttccaggcagaggtcagagggc gagaaggtgcgtgtcggagatgacctcatactggtcagtgtctcctctgagagatatctg catctgtcctttgcccctgtatctgacaacaaaagcctgagcgacagtctgattgtcagt gcctccttccagcagactctttggagtgttgctcccatctgctctggaggtgccattgct caaggctatctaaaggggggagaaacgttgcgtctgctccacagccatagtgatgcttgt ctgactattccttgttcagagcagggagaggagcttcagagagtgatgcattatgagatt ggatccgtgtctggtcatggacggtccctctggaggctggaaattctgcatgtcgcgtgg agtgggaggcacacatgttggggcgagccttttcgcctgtgccatgtaacaacggggagg tacctgtgtctgacggaggaaaacggattgcacctagtcgatcgggacaaggccgacatc aacacgacctccttctgcttccgatcatcaaaggagaaactcgatgctggcaaaaacaca aatagtgattgcatgggaatcccagaaatcaaatatggagactcgatgtgttaccttcag catctgtactcaggactgtggctaacctatcaagctacagatgccaaatgccgcctgggt ggaaatgtgcgcaaggccattttgcacagcgagggtcacatggacgatggactgacgtta tctcgctctcagagagaagaatctcacaccgccggactcatccgaaacactgtctctttg tttactcgctttataaggaaactcgactgttttagtcatgaaggaagcctctcctcactc tgtctgccaatgaagacggtaacctgcagcctccaggatctcatcaagtacttccagtct ccacttgatgggcaaagccatgaagataaacagaaaaagatggctgcccttaggaaacgc cagaatatgtttaaagaagagggtgtaatagatctggtcttagattgcattgatcatctg caccactacagcagtgattcttctataaccgatcctgctcagtgggaggccgtcgtccat ttgttctatgagttacttgctgctttgatccgtgggaaccgtgtaaactgtgctcatttc tcaagctccgtggactggctcataggcagactggaccatctagaagcatcttctggagtc ttggaggttctgcactgtgttcttgtagagagtcctgaggcaattaatgtcataaaagat ggacacattcaatctattatctcttttctggaaaagcatggacacgacaacaaggtgctg gaggttctgtgctcgctgtgtgtgtgccatggtgtggcggtgcgctccaatcagaacctc atctgcgacagcttgctgccagacagagatttgctacttcagacgcgactgactaatcag gtcaccagcatgagagcaaacatcttcctggccatgggagaggcctcggctcagcatcgg aggtggtactacgagttggtcgttgatcatgctgacccgtttctcacagctgaaccgaca cacctgcgtgttggctgggccttcaccaaaggctacctgcccaggcccacaggaggagag cgatgggggggcaatggagttggagacgacctctattcgtttggcttcgatgggctacac ctgtggtcaggttgtgtgggccgtaaagtcagttcccccttctcgcatctgctgaaagat aatgatgtggttagctgctgtctcgacctcacggttccatgcatctccttccgggtcaac ggtctgccagtgcagggcatgctggagaacttcaatgctaatggacttctgtatcctgtg gtcagcttctcagctggagtcagggttcgttttctgtttggcgggggacatggagagttt cgcttcctgcccccaccaggctatgcttcatgctctgaggctttgctccccaaagtcaaa ctgagggtggagccgtgtcagaaatacatctcggactgtgaagagggaaaaaaagagctc attggcccctcggtgccagtcactccacttaccttcatccccactccagtagacatcagc aaggttgtgttacctccacaacttgaagacatccgagaaaaaatggcagaacattttcat gaactctgggtaaaggacagaattgacctcggatggacaaatggaccagtgaaagacgaa ggtaaacaacacgacccttgtctcgtggagttctccaagcttccagagcaagagagaaac cagaaccttcacatggctgaggacatacttaagacggtgcttgcccttggtttccacatt ggtttggcagatgaccacgctgaagaacgcgtcaaatacacgagactacacacaaagtat gagttgccctgcggctacaggcctgcaccaatagatttaagacaaattactctgagttca gctgacaaggatgtggttaccctcttggccgaaaaccatcataatatctgggccagagag cgcatcaaacagggatggacctatggacctgagcaggatataaagggtaaacggagtcct catctcgtgccttacagccttgttgatgaaaggatgaggaaagcaggcatggagagcgtg agagaggccgtccgtctcctgctggcatttggctacagcctggagtccctaagccaggaa cagactcctttatcaaagccatgcctcttttctgtggagaagagcagagtgttcagacca gataaatcctacgcggtgaccatggggaagtggtattttgaatttgaagtactgacagcc gggaatatgagagtgggctgggcccgaccgggctgtgctccagataaagagctcggctca gatgaccaggcctatgtctttgatgggtttgaggctcagtggtgccatcagggtggcgag cccctgggacggcgctggctcagaggcgatgtggtgggttgcttggtggacatgttcgaa ggcaccatgatggtcacgctcaatggagagctgctgtttaatgacagaggatcagagctg gctgccaaggatttggatgtcagagatggcctgttgcctgtggtcagtgttggggttaac caggtggggaggatgaatctgggccgccaggtggagactctgcagtactttaacgtgtgt gggcagcaagaaggttacaaaccctttgcctttaatatgaccagagacccgtctctgtgg atgagttggaaactgccccagtttacttcagttctgcctgatgatcacagcttacaggtt actcgacgtaggggctcaatggattccttatccagcctgagggtctctcagcgggcgttg gtgcgacatggtggaggaagtgagatgggcttttaccggctcagcatgcccatccaatgt gctgccacactcagaagccctgcagaggggggccttcaagtcccctccagctctctaact ccaagttcagtgaggaaggagctggaggacacagactctgactttgaagttctgatgaag tcagcacgcagcttcgccggctcaagagatgagctggaccacaaggatcacagtcaggac aaaacatctaaactgaaacagcggttcatgatgaaaaggactaaaccaggcttagtcagc agcaactcctctgcacggcttctagaagacgttattgttgaaaaggataactacgatcac cttatccagagctccagatattattatgcagtgaggattcttcctggccaggagccgttc agtgtgtggataggctgggtgacctctgactttcatcaccacggctcaacgtttgacacg gacagcgttggcacagtaactgtcacccttggcgatgacagtggcaaagttcaagaaagt gtgaagcgaagcaactgtttcgtggtttgtgctggagaagctacaggcttgtctcagagc cgtcggagtgcggggttggaaattggctgcttgattgacacagcgaccggacttctcact ttcacttctaacggcattgagatgtcgactttcttccaactggaggctggtaccaagctg tttccggctgtttttgtcaagcccaccaccaccaacatgttccagttcgaactggaaagc atccagaatgccatgcccttgtcatcagctttccttcgcggtcagagaaggaatccgagt cctcagtgccctccaaggtttcaggttcagtatttgaaaccagtgacctggacaagagta ccagacggtggattaaaggtgtttgttgattggcctgatgaacaccatggttggagagtc cagtgctttgacccccaacaagtgatgacccttcagattcctgaagaaagcagatgtgtt gacattttggagctgtccgagctcgacgacctcctctcttttcatcaaaatgtcctcttg ctctactgctctctctgtgccctgggtaacaccagagtttgccacgctctctgcagtcat gttgaccagtcgcagatcctttatgctattcagaatcctcacctcgcagggccgctccgc ttggcatattatcagctctttattcaggtctatctaagcagtcacaccacagcatgcctc acgatgaaccatgaatacatcatcccaatgacggaccagaccgcacaagcctcattttat ctcggccctgtcgttggcgtttcagacggagggaatggtcaaacaccagagggcacttgt agaagcacatgccttaaaccacagatgtgtttttcatctccttgttttgtcaggggtgat gggatggaagcagaaggtgcggttgaaatagcctgcccagacagcccagaaatccctctg gacactctgaggaatttgacagcggacatgctgactgccggggttgtggctgtcggtcaa gcagtgagggatcctgcgggaggcagtgttgaactgttgctcgtaccccttttaagattg ttttacaaccttctggtcatgggggtgtttgaggacgaagaccttgtgagggtgcttagg ctaattgaaccgaatgtcttctccaaaaatgtcaaaaccgttgaggaagccaaggatgga aaacaaagaggagaaagcatcaacataaaagatgatgccattaaacaaggacttcttcaa atggagcttccagagcctgtccaactagagctctgtcatctgctgtcctacctgtgtgac tgccaggtgcgacacagagtcgaagcagtgactgcattctctggaaactttgtgcgtcag ctgcaggagaaccagcgatttcgctacactcaggtcatgcaggcactcaacatgtctgca gcactgaccgctcgcaaaaccaaggagttccgacttcctccgcaagagcagatcaatttg ctgctgagcttcagagaagatgagcaacaggagaactgtccgtgtccggtcgaactccag cagctcctgcgcgactttcatcacctcctcaacacacactgtggcactaaaacggtccca gactctgaggaggaagatgataccaagatgtctttgaaagatcgactattcagtcgagca gcgaaagcagttggacttaaaaagaaacctgatgaagtggagaaatataaatcacccaaa ctcaagtccctcagaaggctaatttctgatatgacagtgtgctgggctcaggagagagag atagaagaccctgaactggtcagggctatcttcaccttgctacaccgccagtatcagggc ctcgagggccaaatggaagggtcgctctcaaaggcatacgctatcagccagtcgtccgtg gaggacaccatggcactcctgtcctctctgggccaaattcgttctctcctgagtgtccgc atggggaaagaagaagagaagctgatgattagaaaactaggagatattatgaataataaa gttttctaccaacatcccaatttaatgagatctttgggcatgcatgagacggtgatggag gtgatggttcatgttctgggagaaggggagtctaaggagattaccttccccaagatggta gccagttgctgtcgattcctctgttacttttgtcgtatcagtcgtcacaatcagggagcg ctgttcgaccggctctcatacttactggaaaacagcagagttgggctagcttcaccgtcc atgcgtggctccactcctcttgatgtggcagcagcctctgttatggataataacgagctg gctttatcgctgaaggaagctgacctagagaaggttgttcagtaccttgctgggtgtggt ctccagagctgttcgctgctactggctaaaggctacactgatattggatggaaccctgtg gagggagaacgctatgtggattttttacggtttgctgtgttctgcaatggcgagagtgta gaggaaaatgcatatgtggttttgaggttgctgatccgtcggcctgagtgcttcggccct gcgctcagaggagacgggggagacgggctgctagccgccatgaaggaagccatcagcatc tctcaggacccatctatggacggaccgttccccactcagcaccccagcaaaacaacggat ggagtccacagcaacgaggacgaccttattcacatggggcacgccatcatgaccttctac tcggcacttattgacttactgggacgctgtgctccagagatgcatttaattcagggcggc aaaggagaagccattcgcatcagggccatcctgagatctctcatcccagttcaggatctt gaaggagtcatcagcatctgctttcgactcccatctgtgtcagaagatggtgtgttggtg gagcctgacctgtccacagctttctgtcctgaccacaaggcagccatggttttattcctg gatcgtgtttatggggtggagagtcaacgttttcttctgcaccttctggaagttggcttt ctgcccgaccttcacgcagctgtttctctggacactactgacctgggatctactgacatg gctcttgccctcaatagatacttgtgcacagctgtccttcccctgctcaccaaatgttca gccctctttcacgatttagaggatcatgtcttgctggtagattctctcatccaggcaatc taccggctctcaagggctctaagcttgaccagggctcagagagacactacggaggattgt ttgctggctttgtgcagtaaactccagccatctacgatgcagcctctcctccaaaggctt gtgtttgatgttctccatctctcacatcacagcaaattgcccctgaaaatgttgaccagt cattatgagcagatgtggaagtattactcctactctggaagtcaggataaacaaaagtta gcctctgaaggggagctccagctgtctaggaagttattctggggtgtgtttaaggccttg acgaaaaagtccttcattcctcagctgcttagtttgggtgtgcagtgtcttgttgcagtt gccaaagccttgcctcctgactatgtggagcctggctgtttgtctcaagtggacagaata acctcggtggacacggacggatattttgagccgcatcctgtagatacatcaaatgtttct gtgcctgagcgactggactttgtagttaacaagtatgcagagcacactcatgagaagtgg tctctagaaaagtttgccagtggctgggtgcacggtgatcagctgtgtgaaaacgccaag gtccaccctctcttgaagccatacagggctctggctgagaaggagaaggattcatatcgc tgggccatcaaagagacaataaagagcatgttggcctttggatggaccatagaacgtacc aaagaaggagatgcatttggcattctcgcctgtgcccgcagggtctctcaggccggtcag ctctcatttgaaggagcatccacctttagccctaaacctttggacatgagcagcatcacc ttatcatgggaacagtgtgcaatggccgaacagttggctgaaaactatcataatgtctgg gccaagacaaagaagttggaacttgagagcagagggggaggccattcgatgctggttcca tacgatgctctgactgccaaggagaagaccaagttcagagaaaaagctcaggagatactg aagttccttttgctccatggctacactgtgtggagggatcgaaaatccatggaaattgac ttccctgctactgcaaactgctttggacacatttttctccaacacatgctgtattacacc gaggagactcaggagaacatgctaaagctcgaggtgattcaagccagaggacagatgcct aaaggagaaagggctcaagatcagcagccaattattttttttcagaaggtcgttcttcca ctattggagcagtatgtaaaaagccaccgtctgtattttttgtcctcttctctgaagtca agtgaaaacagaagtcatgcctccaaaagggaaaaggagatggttctgtgtctcttctgt aagcttgctgctttggtaagacacagaatctcactaattggagacgaagcctctgctgtt acaagctgcctccgcattctggctcaggcgcttgatgcaagaatattgacagcagcagct tcggagtccctacagacgtctctgcattcatttttcgaagcagccgcagcagatttggag atgactgtggggaaaatatcggagaccttgcctcacagtagaggtcagctgtctaaagga gttgtcaacactcttaactacacaacgtccatcctaataccaacacttacctccctcttc catcatcttgccaatcaaaactatggagtggatgttctggtcggtggtatccaggtgtcg tgttacaagattttaaacagcctctactctctggggaccagtaaaagcttctacatggag gggcagcggtcagccgcaggcgcctgtgtagcagctctgaccggagcttttcctgtatgc ttcctggagccaactctagaccacagcaatccacattctatctacaatgtcatgagtccc actgagattaaagatcagggactgccggaccggatggagaacgcgtgtcgccctcttcct tcactgggagaggcgctggagaaagtggaggagctggctggtgctggttctgtagctcat caaatgcagtacatccatgtggcagaggtcactttgcccatgttgtgcagctatatttca cactggtgtcgctggggccctgagggccacccagagggcccagtcctcagctctgttgtt gctcagcatgcgagcgacctgattggccacatccttcgcatcatccacaaccatgtgggc gctagccagggtgactggatgaagcagcttgcagttttttcgcagccgatcgtatgcaaa gccgacagcgagctgctgagaagtcactttctccccctgatggagaagctgaagaagcgg gcagagtgtgtccagtcagaagaggaagtgatgaaagcggaagactgctgtacttctgaa gcagagctacagatacaggagaagtacagagttctggtccaggatctctacgccttttat cctcttctcatccagtttgttgattttaatcgagccagatggctgaaagagacgatcccc gaggctgagcagctgttcagcatggtggcagaggtctttgtattctgggccaaatctcat catttcaaatgggaagagcagggttacgtggtccagaatcgaatcaacactttggctttt ttgctctccagtaacaacctgctggagtttgaccataaaaacaaagggatgaagaggaag ggggatcgttactctgcacacacttctctcatagtggctgccataaagaagatggtgcct gtgggactcagagtttgttttccatgtgaccagaaccttatcatgttggtgaagaactgc tattctcagaataaccttgaagatgagattcgggagcaaattttgagatacctcaagcat ttttttggtcaggcatcaaacagcgtcagctgtgggattctgtctgctgatctcccagca cagcttgaggccccagctgacacacaaaggacggtggacagggttctagaaatagctcgg gtgctttattacctggatcaggtagagcacccacagaggagcaaaaaacctgcttggaaa atttttttatccaaacgtaggaaacgtgcggtggtggcttgcctgaggatgactcccctc tacaatctgccacggcaccgagctgtcaaccttttcctgcaaggctacaacagatcttgg atatcaacagagggaaatgacttagtagaaatgcttgtggaggatttagctaaggggcga gtgacgaaaccgtgggaaggtgagaaaggggaagtaaaggaggtggaagaaggcgccaag gcaattgatcctctccttcagctcattatgctcttcagtcgaagtgcgctgacggaaagc agcaaccttgataatgacaacctctacaaagattatgctgctattatggccaagagctgc cgcagagagagccatgatgacgcggagcaggaagtagaaagctttgaagagaaggagatg gaaaagcaaaagctgttgtaccaacaggccaggctgcattgtcgtggagcctctgaaatg gtcctgcaagccattagcgccagcaatggcaccatgggattcatgattggtcctactctg aaattaggtattgctcttcttaatggagggaatgcaacagttcagcagaaaatgctggat tatctgagagagaagcgcaatgttggcttttttcagagcatggctggactcatgcggtca tgtagcgttctggatttgaatgcatttgagaggcagaacaaagcagaaggattaggcgtg gccacggatgagagctcaggagagaaggtaatgcccgacaaggacctgacttgtgaccta ctccgtttcctgcagctgctctgcgaaggacacaattcagatttccagaactatttaaga actcaaactgggaacaacaccaccgtcaacattgttatatcaacggttgactatttacta agggtacaggaatcgatcagtgatttctactggtactactcagggaaagacgtcattgat cctctgggtcaacacaacttctccaaggccattgaagttgccaagcaggtcttcaacaca ctcaccgagtatatacagggtccgtgtattgggaaccagcagagtctggctcacagtcgt ctgtgggatgccgtcgtgggattcctccatgtctttgctcacatgcagatgaagctctct caggattcaaggcagataaaactcctaaaggaactcatggacttactgaaggacatggtt gtattcctcctttccatgttagaaggcaatgttatcaatggaacaattggtaagcagatg gtggatatgttggtggaatcatcaagcaatgtggaaatggtcctcaagtttttcgacatg ttcctcaaactaaaagacctgacttcatctgagggcttcagagagtacgactctgactgt aagggcagcatatgcaggaaggacttccagaaagccatggaaaactgcaaatacttctca caagccgagatccacttcctgctctcctgcattgaaacaaacgacggcgaaatcttggaa taccaaacgtttgtggatcgcttccacgagccggcgaaagacatcggcttcagcatcgct gttctcctcaccaatttgtcggagcacatgcccaaagagtccaggctgaaggcattcacg gagctcgcagaatgcgccctgacctactttcagcccagtcttggacgcattgagattctt ggcagcgggaagcgctttgaacgggtctactttgagatcagcgaatacagtcgcacacag tgggagaagccacaggtgaaggaatccaagaggcagttcatctttgatgtggtcaataag ggaggagacaaagagaaaatggagatgttcgtcaacttctgtgaggacaccatatttgag atgcaacttgcagcccagatatccggatccaactctggagagaagtgcaacgggaaaaca gaggtggagacgagagagcttgaagaatattcgcccccagattgcaagaggtggactttg atctactattggtggctgatgttgacttgtgccctctctgtgaaaaacctgaaaacactg atgaagacgacgccaaaggatttcctcttggcagcagttcaattcatcagattcatttgc gcgcttcagatccgctgcatttctgccgtcatctgccgcatcatgtatttactgtacatc acatttgtcaacagtggtctcatagaggcagcaaaaagaatgaaggtgtcagacttgctc gggggtatacttgagccaactcttgatgaggtcatggaggtgtcgagcaatgtggatcaa ctgagaaagtactctgccagtttctcttcccagaaagaattgagggagatcgggcagatg gcttcattgacttttcccaaggaggtggacatattgtcagacatatttggtctcaagctg aagaaggagggagatcagtacagacttgtaacgcaagatctctctgacagtctgactcat ctgttcagttcaacttccagaacaataatcgacacggatgtttctgaggagcaccacacg ttgcagtttacagactacttggacaaagagaaaacacaagataagaaaaaggagaacttg caggaaaaagaatggaagaaaactgaaaaggagcgtaggaatgcaaaagaagagacaaaa cacggagccaagagaggctgtaatgggtcaaaggaaccacagagacaacattctgctcta tgggaaacgataagctcacatagcaagagtcttctgaactactttgcaagaaatttttat aacatccgtctgctggcgttgtttgttgcttttgcaatcaacttcatcctcctgttctat aaggtagcatttttgcctgcatccaaagagcaacaggcgactacatcggcacatggaaaa gaacagctctctgctaagacaaacgccagcaatggcagagtttattttgtgcttgaagaa agcagtggttacatggagctgtgtctccatttcctttccatcgcacacacaatcatctca ttctgctgcattattggttactactgcctcaaggtgccgttggtgatcttcaaacgggaa aaggaggtggccagaaaactggagtttgacggactgtacgtgactcggcagcctcctgag gaagacgttaaagggcaatgggaccgcctggtcatcaacacactatcatttccaagtaat tactgggataaatttgtgaaaaggaaggtgatggataagtatggagagttttatggccgc aagaagatcagtgaactgctaggcctggaccaagctgctttagacttcagcaccgagcgg aaagaaaagaagctcagaagagacagtgcctggagtgtcctttctgctgtttgttccaga ttcaactccctcgacgcaaagtaccaggtctggaagctaggagtcgtgttcactgacaac tccttcttgtacttggcgtggtacatgaccatgtcagttttgggtcattataacaacttc ttctttgctgcccaccttttggacatcgccatgggctttaagacactccgtaccatcctt tcctccgtcacacacaatggaaaacagctggtgctgactgtgggtctgttggcggtcgtg gtgtatctctacaccgtcatagccttcaatttcttcagaaagttttacaaccacagccgt ggcaaggaaactgaagatatgaagtgcaatgatatgcttacttgttacatgttccacatg tacgtgggagtgcgagcaggtggcgggattggtgacgagatcgaggatcctgctggagac gagttcgaagtcgaacggatcgtctttgatattacttttttctttttcgtcatcgtcatc ctgctcgccattatccagggcttaataattgatgcctttggtgagcttcgagaccagcag gagcaggtgaaggaggacatggagaccaaatgtttcatatgtggaataggaagcgagtac tttgacaagattcctcacggcttcgagacgcacactctgcaggagcacaacttggccaac tatctatttttcctgatgtatctcattaacaaggatgaaactgagcacacgggacaggaa tcctatgtgtggaaaatgtaccaggagcgttgctgggaattctttcctgtgggagactgt ttccgtaagcagcatgaggatcaactcggctga

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