Peromyscus leucopus (white-footed mouse): 114685253
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Entry
114685253 CDS
T07241
Symbol
Gclc
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
pleu
Peromyscus leucopus (white-footed mouse)
Pathway
pleu00270
Cysteine and methionine metabolism
pleu00480
Glutathione metabolism
pleu01100
Metabolic pathways
pleu01240
Biosynthesis of cofactors
pleu04216
Ferroptosis
Module
pleu_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
pleu00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
114685253 (Gclc)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
114685253 (Gclc)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
114685253 (Gclc)
Enzymes [BR:
pleu01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
114685253 (Gclc)
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Motif
Pfam:
GCS
Motif
Other DBs
NCBI-GeneID:
114685253
NCBI-ProteinID:
XP_028715665
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Position
7:66883208..66926098
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AA seq
636 aa
AA seq
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MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKKVQLVLSGEDVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSVLGENRALCTITSFPRLGCPGFTLPEHKPNPEEGGASKSLFFPDEAI
NKHPRFGTLTRNIRHRRGEKVVINVPIFKDKNTPSPFVETFPEDEEAAKASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQPTVCPHVMALSAAAPFYRGYVSDIDCRWGVIS
ASVDDRTREERGLEPLKNNRFRISKSRYDSIDSYLSKCGEKYNDIDLTIDNEIYEQLLRE
GIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIG
WRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKMAQKRDAVLQ
GMFYFRKDICKGGNAVVDGCSKAQSSAEPAAEEYALMSIDTIINGKEGVFPGLIPILNSY
LENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSIITDEINYSL
VLKCNQIANELCECPELLGSGFRKAKYSGDKSDSSN
NT seq
1911 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctcgccgctgagctgggaagagacccagcggcacgccgac
cacgtgcggcggcacggcatcctccagttcctgcacatctaccacgccgtcaaggaccgg
cacaaggacgtgctcaaatggggtgacgaggtggaatacatgttggtgtcctttgatcat
gaaaataaaaaagtccagttggtgctgtctggagaagatgttcttgaaactctgcaggag
aagggggagaggacaaaccccaaccacccaaccctctggagaccagagtacggaagttac
atgattgaagggacacctggccagccctacggaggaacgatgtccgagttcaacacagtg
gaggacaacatgaggaaacgccggaaggaggctacttctgtgttaggggaaaaccgggct
ctctgcacgataacttcttttcccagactaggctgccctggattcacattgcccgagcac
aaacccaatccagaggaaggaggtgcatccaagtccctcttctttccagatgaagccata
aacaaacacccccgctttggaactctaacaagaaacatccggcacaggagaggggaaaag
gtcgttatcaatgttccaatatttaaggacaagaacacaccatctccatttgtagaaaca
tttcctgaagatgaggaggcagcaaaggcttctaagccagaccatatttacatggatgcc
atgggatttgggatgggaaactgctgtcttcaggtgacattccaagcctgcagcatatct
gaggccagatacctttatgatcagccaactgtatgtcctcatgttatggctttgagtgct
gcagctccgttttaccgaggctacgtgtcagacattgactgtcgctggggagtgatttcc
gcgtctgtagatgatagaacacgggaggagagaggactggagcctctgaagaacaaccga
tttaggattagtaaatctcggtatgactcaatagatagctacctatctaagtgtggtgag
aaatacaatgacatcgacctgaccattgataacgaaatctatgagcagctcttgcgggaa
ggcattgatcaccttttggcacagcacgttgctcatctctttattagagacccactcacc
ctatttgaagagaaaatacacctggatgatgccaacgagtctgaccattttgagaatatt
cagtccacaaactggcagacaatgagatttaagcctcctcctccaaactcagatattgga
tggagagtagagttcagacccatggaggtgcagctgacagactttgagaactccgcctat
gtggtgtttgtggttctgctcaccagggtgatcctctcctacaaactggatttcctcatt
ccactatccaaggttgatgaaaacatgaaaatggcacagaagcgagatgctgtcttgcag
gggatgttttatttcaggaaagacatttgcaaaggtggcaatgctgtggtggatggatgt
agcaaggcccagagcagcgctgagccagcagcagaggagtacgctctcatgagcatagac
accatcatcaacgggaaggaaggggtgtttcctggactcatccccattctgaactcctat
cttgaaaacatggaagtagatgtggacaccagatgcagtattctgaactacctaaagcta
attaagaagagagcatctggagaactaatgacagttgccagatggatgagagagtttatt
gcaaaccaccctgactacaagcaagacagtataataactgatgagataaattatagcctc
gttttgaagtgtaaccaaattgcaaatgaattatgtgaatgtccagagttacttggatca
ggatttagaaaagcaaagtatagtggagataaaagcgactcttcaaactag
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