KEGG   Peromyscus leucopus (white-footed mouse): 114685999
Entry
114685999         CDS       T07241                                 
Symbol
Rps6kb2
Name
(RefSeq) ribosomal protein S6 kinase beta-2 isoform X1
  KO
K04688  ribosomal protein S6 kinase beta [EC:2.7.11.1]
Organism
pleu  Peromyscus leucopus (white-footed mouse)
Pathway
pleu01521  EGFR tyrosine kinase inhibitor resistance
pleu01522  Endocrine resistance
pleu04012  ErbB signaling pathway
pleu04066  HIF-1 signaling pathway
pleu04140  Autophagy - animal
pleu04150  mTOR signaling pathway
pleu04151  PI3K-Akt signaling pathway
pleu04152  AMPK signaling pathway
pleu04211  Longevity regulating pathway
pleu04213  Longevity regulating pathway - multiple species
pleu04350  TGF-beta signaling pathway
pleu04371  Apelin signaling pathway
pleu04666  Fc gamma R-mediated phagosome formation
pleu04714  Thermogenesis
pleu04910  Insulin signaling pathway
pleu04931  Insulin resistance
pleu05163  Human cytomegalovirus infection
pleu05165  Human papillomavirus infection
pleu05170  Human immunodeficiency virus 1 infection
pleu05200  Pathways in cancer
pleu05205  Proteoglycans in cancer
pleu05207  Chemical carcinogenesis - receptor activation
pleu05210  Colorectal cancer
pleu05212  Pancreatic cancer
pleu05221  Acute myeloid leukemia
pleu05224  Breast cancer
pleu05225  Hepatocellular carcinoma
pleu05226  Gastric cancer
pleu05231  Choline metabolism in cancer
pleu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pleu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    114685999 (Rps6kb2)
   04350 TGF-beta signaling pathway
    114685999 (Rps6kb2)
   04371 Apelin signaling pathway
    114685999 (Rps6kb2)
   04066 HIF-1 signaling pathway
    114685999 (Rps6kb2)
   04151 PI3K-Akt signaling pathway
    114685999 (Rps6kb2)
   04152 AMPK signaling pathway
    114685999 (Rps6kb2)
   04150 mTOR signaling pathway
    114685999 (Rps6kb2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    114685999 (Rps6kb2)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagosome formation
    114685999 (Rps6kb2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    114685999 (Rps6kb2)
  09149 Aging
   04211 Longevity regulating pathway
    114685999 (Rps6kb2)
   04213 Longevity regulating pathway - multiple species
    114685999 (Rps6kb2)
  09159 Environmental adaptation
   04714 Thermogenesis
    114685999 (Rps6kb2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114685999 (Rps6kb2)
   05205 Proteoglycans in cancer
    114685999 (Rps6kb2)
   05207 Chemical carcinogenesis - receptor activation
    114685999 (Rps6kb2)
   05231 Choline metabolism in cancer
    114685999 (Rps6kb2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    114685999 (Rps6kb2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    114685999 (Rps6kb2)
   05212 Pancreatic cancer
    114685999 (Rps6kb2)
   05225 Hepatocellular carcinoma
    114685999 (Rps6kb2)
   05226 Gastric cancer
    114685999 (Rps6kb2)
   05221 Acute myeloid leukemia
    114685999 (Rps6kb2)
   05224 Breast cancer
    114685999 (Rps6kb2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    114685999 (Rps6kb2)
   05163 Human cytomegalovirus infection
    114685999 (Rps6kb2)
   05165 Human papillomavirus infection
    114685999 (Rps6kb2)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    114685999 (Rps6kb2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    114685999 (Rps6kb2)
   01522 Endocrine resistance
    114685999 (Rps6kb2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pleu01001]
    114685999 (Rps6kb2)
Enzymes [BR:pleu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     114685999 (Rps6kb2)
Protein kinases [BR:pleu01001]
 Serine/threonine kinases: AGC group
  RSK family [OT]
   114685999 (Rps6kb2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_C Kinase-like Pkinase_fungal ABC1 Seadorna_VP7
Other DBs
NCBI-GeneID: 114685999
NCBI-ProteinID: XP_028716481
LinkDB
Position
1:58139710..58146477
AA seq 485 aa
MAAVFDIDLETEEGSEGEGEPEFSPAEVCPLGELRAAGLETVGHYEEVELTESSVNLSPE
RIGPHCFELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAER
NILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITL
ALGHLHSQGIIYRDLKPENIMLNSQGHIKLTDFGLCKESIHEGAITHTFCGTIEYMAPEI
LVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIMKGKLVLPPYLTPDARDLA
KKFLKRNPVQRIGGGPGDAAEVQRHPFFRHINWDDLLARRVDPPFRPSLQSEEDVSQFDT
RFTRQTPVDSPDDTTLSESADQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRT
PISPLKFSPFEGFRPSPGPPEPMEPSLPPLLPPPSPPPPTSTAPLPIRPPSGTKKSKKGR
GRPGR
NT seq 1458 nt   +upstreamnt  +downstreamnt
atggccgccgtgtttgatatagacttggagaccgaggaaggcagcgagggcgagggcgaa
ccagagttcagccctgcggaggtgtgtccccttggcgagttgagggctgctggcctggag
acggtgggacactatgaggaggtggagctgacagagagcagcgtgaacctgagccctgaa
cgcatcggcccccactgctttgagcttctgagtgtgctgggcaaggggggctatggcaag
gtgttccaggtgagaaaagtgcaaggcaccaacttgggcaaaatatatgccatgaaagtc
ttgagaaaggccaagattgtacgcaatgccaaggacacagcacatacccgggctgagcgg
aacattctagaatccgtgaagcatcccttcattgtggaactggcctacgctttccagaca
ggtggcaaactctacctcatcctggagtgcctcagtggtggtgagctcttcacacatctt
gagcgagaaggcatcttcttggaagacacagcctgcttctacctggctgagatcacactg
gccctgggccatctccattcccaaggcatcatctaccgggatctcaagcctgagaacatc
atgcttaacagccagggccacatcaaactgacagactttggactctgcaaagagtccatt
catgagggtgctatcactcacactttctgtggcaccattgagtacatggccccagagatt
ctagtgcgcagtggccacaaccgggcagtggactggtggagcctgggggccctgatgtac
gacatgctcactggatcgccgcccttcaccgcggagaaccgaaagaaaaccatggataaa
atcatgaaagggaagctggtgctgcccccctacctcaccccggatgctcgggatcttgcc
aaaaagtttctgaagcggaatcccgttcaacgaattgggggtggcccaggagatgctgct
gaggtgcagaggcaccccttcttccggcacatcaattgggatgacctcctggcccgccgt
gtggaccctcccttcaggccgagtctgcagtcagaagaggatgtgagtcagtttgacaca
cgcttcacacggcagacgccggtagacagccccgacgacacaaccctcagcgagagtgct
gaccaggccttcctgggcttcacatacgtggcaccttctgtcctggacagcatcaaggag
ggcttctcgttccagcccaagctgcggtcccccaggcgtcttaacagcagcccccgcacc
cccatcagccccctcaagttctctccctttgaggggttccggcccagccctggcccgcca
gagcccatggaaccgtctctacctccgctcctgccaccaccgtcgccgccgccgcccaca
agcacggcccctcttcccatccgtcccccctcagggaccaagaaatccaagaagggccgc
gggcgcccagggcgctaa

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