KEGG   Peromyscus leucopus (white-footed mouse): 114693019
Entry
114693019         CDS       T07241                                 
Symbol
Mapk12
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
pleu  Peromyscus leucopus (white-footed mouse)
Pathway
pleu01522  Endocrine resistance
pleu04010  MAPK signaling pathway
pleu04015  Rap1 signaling pathway
pleu04068  FoxO signaling pathway
pleu04071  Sphingolipid signaling pathway
pleu04114  Oocyte meiosis
pleu04148  Efferocytosis
pleu04218  Cellular senescence
pleu04261  Adrenergic signaling in cardiomyocytes
pleu04370  VEGF signaling pathway
pleu04380  Osteoclast differentiation
pleu04517  IgSF CAM signaling
pleu04550  Signaling pathways regulating pluripotency of stem cells
pleu04611  Platelet activation
pleu04613  Neutrophil extracellular trap formation
pleu04620  Toll-like receptor signaling pathway
pleu04621  NOD-like receptor signaling pathway
pleu04622  RIG-I-like receptor signaling pathway
pleu04625  C-type lectin receptor signaling pathway
pleu04657  IL-17 signaling pathway
pleu04658  Th1 and Th2 cell differentiation
pleu04659  Th17 cell differentiation
pleu04660  T cell receptor signaling pathway
pleu04664  Fc epsilon RI signaling pathway
pleu04668  TNF signaling pathway
pleu04670  Leukocyte transendothelial migration
pleu04714  Thermogenesis
pleu04722  Neurotrophin signaling pathway
pleu04723  Retrograde endocannabinoid signaling
pleu04728  Dopaminergic synapse
pleu04750  Inflammatory mediator regulation of TRP channels
pleu04912  GnRH signaling pathway
pleu04914  Progesterone-mediated oocyte maturation
pleu04917  Prolactin signaling pathway
pleu04926  Relaxin signaling pathway
pleu04932  Non-alcoholic fatty liver disease
pleu04933  AGE-RAGE signaling pathway in diabetic complications
pleu04935  Growth hormone synthesis, secretion and action
pleu04936  Alcoholic liver disease
pleu05014  Amyotrophic lateral sclerosis
pleu05020  Prion disease
pleu05022  Pathways of neurodegeneration - multiple diseases
pleu05132  Salmonella infection
pleu05133  Pertussis
pleu05135  Yersinia infection
pleu05140  Leishmaniasis
pleu05142  Chagas disease
pleu05145  Toxoplasmosis
pleu05152  Tuberculosis
pleu05161  Hepatitis B
pleu05163  Human cytomegalovirus infection
pleu05167  Kaposi sarcoma-associated herpesvirus infection
pleu05169  Epstein-Barr virus infection
pleu05170  Human immunodeficiency virus 1 infection
pleu05171  Coronavirus disease - COVID-19
pleu05205  Proteoglycans in cancer
pleu05208  Chemical carcinogenesis - reactive oxygen species
pleu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pleu05415  Diabetic cardiomyopathy
pleu05417  Lipid and atherosclerosis
pleu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pleu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    114693019 (Mapk12)
   04015 Rap1 signaling pathway
    114693019 (Mapk12)
   04370 VEGF signaling pathway
    114693019 (Mapk12)
   04668 TNF signaling pathway
    114693019 (Mapk12)
   04068 FoxO signaling pathway
    114693019 (Mapk12)
   04071 Sphingolipid signaling pathway
    114693019 (Mapk12)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    114693019 (Mapk12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    114693019 (Mapk12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    114693019 (Mapk12)
   04218 Cellular senescence
    114693019 (Mapk12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    114693019 (Mapk12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    114693019 (Mapk12)
   04613 Neutrophil extracellular trap formation
    114693019 (Mapk12)
   04620 Toll-like receptor signaling pathway
    114693019 (Mapk12)
   04621 NOD-like receptor signaling pathway
    114693019 (Mapk12)
   04622 RIG-I-like receptor signaling pathway
    114693019 (Mapk12)
   04625 C-type lectin receptor signaling pathway
    114693019 (Mapk12)
   04660 T cell receptor signaling pathway
    114693019 (Mapk12)
   04658 Th1 and Th2 cell differentiation
    114693019 (Mapk12)
   04659 Th17 cell differentiation
    114693019 (Mapk12)
   04657 IL-17 signaling pathway
    114693019 (Mapk12)
   04664 Fc epsilon RI signaling pathway
    114693019 (Mapk12)
   04670 Leukocyte transendothelial migration
    114693019 (Mapk12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    114693019 (Mapk12)
   04914 Progesterone-mediated oocyte maturation
    114693019 (Mapk12)
   04917 Prolactin signaling pathway
    114693019 (Mapk12)
   04926 Relaxin signaling pathway
    114693019 (Mapk12)
   04935 Growth hormone synthesis, secretion and action
    114693019 (Mapk12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    114693019 (Mapk12)
  09156 Nervous system
   04728 Dopaminergic synapse
    114693019 (Mapk12)
   04723 Retrograde endocannabinoid signaling
    114693019 (Mapk12)
   04722 Neurotrophin signaling pathway
    114693019 (Mapk12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    114693019 (Mapk12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    114693019 (Mapk12)
  09159 Environmental adaptation
   04714 Thermogenesis
    114693019 (Mapk12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    114693019 (Mapk12)
   05208 Chemical carcinogenesis - reactive oxygen species
    114693019 (Mapk12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    114693019 (Mapk12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    114693019 (Mapk12)
   05161 Hepatitis B
    114693019 (Mapk12)
   05171 Coronavirus disease - COVID-19
    114693019 (Mapk12)
   05163 Human cytomegalovirus infection
    114693019 (Mapk12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    114693019 (Mapk12)
   05169 Epstein-Barr virus infection
    114693019 (Mapk12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    114693019 (Mapk12)
   05135 Yersinia infection
    114693019 (Mapk12)
   05133 Pertussis
    114693019 (Mapk12)
   05152 Tuberculosis
    114693019 (Mapk12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    114693019 (Mapk12)
   05140 Leishmaniasis
    114693019 (Mapk12)
   05142 Chagas disease
    114693019 (Mapk12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    114693019 (Mapk12)
   05020 Prion disease
    114693019 (Mapk12)
   05022 Pathways of neurodegeneration - multiple diseases
    114693019 (Mapk12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114693019 (Mapk12)
   05418 Fluid shear stress and atherosclerosis
    114693019 (Mapk12)
   05415 Diabetic cardiomyopathy
    114693019 (Mapk12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    114693019 (Mapk12)
   04932 Non-alcoholic fatty liver disease
    114693019 (Mapk12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    114693019 (Mapk12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    114693019 (Mapk12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pleu01001]
    114693019 (Mapk12)
Enzymes [BR:pleu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     114693019 (Mapk12)
Protein kinases [BR:pleu01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   114693019 (Mapk12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 114693019
NCBI-ProteinID: XP_028724984
LinkDB
Position
20:15234988..15245675
AA seq 367 aa
MSSPPPARKGFYRQEVTKTAWEVRVVYQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMK
VTGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLEKMLVLDAEQRV
TAAEALAHPYFESLQDTEDEPKAQKYDDSFDDVDRTLEEWKRVTYKEVLSFRPPRQPGAR
VPKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctccccgccacccgcccgcaagggcttttaccgccaggaggtgaccaaaacggcc
tgggaggtccgcgtcgtgtaccaggacctgcagcccgtgggctctggtgcctatggtgca
gtgtgctctgcagtagacagccgcactggtaacaaggtggcaatcaagaagttgtaccgg
cccttccagtccgagctgtttgccaagcgcgcctacagagaactgcggctcctcaaacac
atgcgccacgagaacgtgattgggctactggatgtattcacgcctgatgagactctggat
gacttcacagacttttacctggtgatgccgttcatgggcactgatctgggcaagctcatg
aagcatgagacgctgagtgaagacagaatccagtttcttgtgtaccagatgctgaagggg
ctgaagtacatccatgctgccggcgtcatccacagagacttgaagcctggcaacctggct
gtgaatgaggattgtgagctgaagatcctagacttcggcctagccagacaagcagacagt
gagatgacgggttacgtggtgacccggtggtacagggcaccggaggtcatcttgaattgg
atgcgctacacacagacagtggacatttggtctgttggctgcatcatggcagagatgatt
acgggaaagattctgttcaaaggcaatgaccacctggaccagctgaaggagatcatgaag
gtcacagggacaccccctccggagtttgtgcagaagctacagagtgctgaggccaagaac
tacatggaaggcctccctgagctggaaaagaaggattttgcctctgtcctgaccaatgca
agccctcaggccgtgaaccttctggaaaagatgctggtgctggatgcagagcagcgggtg
acggcagctgaggcactggcccatccatactttgagtccctgcaggacactgaggatgag
cccaaggcccagaaatacgatgactcctttgatgatgtagaccgcacccttgaggaatgg
aagcgtgttacctacaaggaagtgctcagcttcaggcctcccaggcagccaggagccaga
gtcccaaaggagacagctctatga

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