Peromyscus leucopus (white-footed mouse): 114693051
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Entry
114693051 CDS
T07241
Symbol
Lrrk2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
pleu
Peromyscus leucopus (white-footed mouse)
Pathway
pleu05012
Parkinson disease
pleu05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
pleu00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
114693051 (Lrrk2)
05022 Pathways of neurodegeneration - multiple diseases
114693051 (Lrrk2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pleu01001
]
114693051 (Lrrk2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
pleu04131
]
114693051 (Lrrk2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
pleu04147
]
114693051 (Lrrk2)
Enzymes [BR:
pleu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
114693051 (Lrrk2)
Protein kinases [BR:
pleu01001
]
Serine/threonine kinases: TKL group
LRRK family
114693051 (Lrrk2)
Membrane trafficking [BR:
pleu04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
114693051 (Lrrk2)
Exosome [BR:
pleu04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
114693051 (Lrrk2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
LRR_4
Roc
COR
Ras
WDR55
WD40_CDC20-Fz
Beta-prop_EML_2
Beta-prop_RSE1_2nd
LRR_9
Arf
Ank_2
LRR_6
nSTAND3
Beta-prop_BBS7
AAA_22
T2SSE
Beta-prop_WDR19_1st
PduV-EutP
ABC_tran
LRR_13
GTP_EFTU
Beta-prop_RIG_2nd
MMR_HSR1
Kdo
AAA_7
G-alpha
Ank_3
Arm
AAA_16
NACHT
MobB
cobW
SRPRB
TniB
AAA_29
HEAT_EZ
TrwB_AAD_bind
FtsK_SpoIIIE
Gtr1_RagA
Ank_5
TsaE
LRR_NXF1-5
Septin
AAA_18
AAA_23
WD40_like
AAA_15
SRP54
Motif
Other DBs
NCBI-GeneID:
114693051
NCBI-ProteinID:
XP_028725092
LinkDB
All DBs
Position
20:complement(12625947..12770571)
Genome browser
AA seq
2524 aa
AA seq
DB search
MASGGSQGCEEEEEEEALKKLIVRLNNVQEGKQIETLLQLLEDMLVFTYSDRASKLFEGK
NFHVPLLIVLDSYMRVACVQQVGWSLLCKLIEVCPGTLPSLIGPQDIGNDWEVLGIHQLI
LKMLTVHHANVNVSTVGLKALDLLLDSGKITLLILEEECDVFLLIFDAMHTYSANDEVQK
LGCKALHVLFERVSEEHLMEFVESKDYMVLLTTLSNFKGDRDIVFHVLSCLHSLAVPCNN
VEVLMSGNVRCYNIVVEAMKAFPANEKIQEVSCSLLHRLTLGNFYNILVLNEVHVFVVKA
VQRYPENAALQISALSCLALLTETIFLNQDLEERSEPQENNDEEDTEKLFWLEPCYKALM
RHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKDVFQAA
SHALSTLLEQNVNFRKILLAKGVYLNVLELMQKHAHVPEVAESGCKMLSHLFEGSNASLD
TMAAVVPRIITVMKAHETSLPVQLEALRAILHFVVPGIPEESRDDSQCKLNMLKRQYLRT
DIHKLVLAALNRFIGNPGIQKCGLKVLSSLTHLPDALEMLSLHGAVDSTLHTLQMYPDDQ
EIQCLGLHLTGCLITKKNFCIRTGHLLAKILVSSLQRFKDVAELQTTGLQTILAILELSV
SFSKLLLHYSFDLVIFHQMSSSVMEQKDEQFLNLCCKCFAKLAVDEELKSTMLERACDQN
NSIMVECLLLLGADANQTKGATSLIYQVCEKESSPKLVELLLNGGCREQDVRKALTVSIQ
KGDSQVISLLLRRLALDLANNSICLGGFCIRKIDPSWLGPLFPDKSSNLRKQTNTGSLLA
RKVFRYQMKNTLQEGATSGSDGNFPEDALAKFGEWTFVPDSSMDSVFGHSDDLDSEGSES
SFLVKRKSNSIGVGEFSRDPVLQRCSPNSQRQSNSLGPIFDHEDLLRRKRKILSSDESLR
SSKLQSHMRHSDSSSSLASEREYITSLDLSANELKDIDALSQKCLGGYLEHLTKLELHQN
ALTGFPQQLCETLKCLTHLDLHSNKFTSFPSFLLKMACITHLDASRNDIGPTIGFDPLVK
CPSLRHFNLSYNQLSSIPENLAQVVEKLEQLLLEGNKISAICSPLSLKELKILNLSKNHI
PSLPEDFLEACPKVESFSARMNSLAAMPALPFSITSLKLSQNCFTCIPEAIFILPHLRSL
DMSHNNIEYLPGPAHWTSQNLRELFFSHNQINVLDLSEKPHVWSRVEKVHLSHNKLKEIP
PEIGCLENLTSLDVSHNSELRSFPNEMGKLSKLWDLPLDGLQLNFDFKHVGCKAKDIIRF
LQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKMKKSDLGMQSTTVGIDVRDWPIQIR
GKRKKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKAR
ASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPTIRDYHFVNATEESDALAKLR
KTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKAVPVEFPVINRKRLLQLVKEHQ
LQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGCLKH
PKGIISRRDVEKFLSKKKRFPKNYMTQYFKLLEKFQIALPLGEEYLLVPSSLSDHRPVIE
LPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPFMLSGRERALRPNRMYWRQGIYLN
WSPEAYCLVGSEVLDNRPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDIC
GEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLINPDQPRLTIPISQIAPDLIL
ADLPRNIMLNNDELEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQEL
VVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADG
LRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAP
EVARGNVIYNQQADVYSFGLLLHDIWTTGGRITEGLKFPNEFDELALQGKLPDPVKEYGC
APWPMVEKLIGKCLKENPQERPTSAQVFDILNSAELICLMRHILIPENIIVECMVATIPN
SKSATLWLGCGNTEKGQLSFFDLNTERYSYEEVTDSRILCLALVHLPDEKESWIVCGTQS
GDLLVINAEDETKRHTLEKMTDSVTCLYCNSFAKQSKQSNFLLVGTADGNLMIFEDKTIK
FKGAAPLKTLHIGDVSTPLMCLSVSMNSSERHITWGGCGTKIFSFSNDFTIQKLIETRTN
QLFSYAAFSDSNIIAVAVDTVLYIAKKNSPVVEVWDKKTEKLCELIDCVHFLKEMMVNKE
SKHKLCYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDSVRALAMAQL
GSLKNVMLVLGYKRKSTDDTQEQKEIQSCLSIWDINLPHEVQNLEKHIEVRAELADKMRR
TSVE
NT seq
7575 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcggctcgcagggctgcgaggaggaagaggaggaggaggctctgaagaag
ttgatagtcaggctgaacaatgtccaggaaggcaagcagatcgagacgttgctccagctc
ctggaggacatgcttgtttttacctattccgacagagcctccaagttatttgaagggaaa
aatttccacgtgcctctgttgatcgtcctggactcctacatgagagtcgcctgtgtgcag
caggtgggatggtcacttctgtgcaaattaatagaagtctgcccagggacattgccgagc
ttaataggaccccaggatattggaaatgattgggaggtccttggtattcatcagctgatt
cttaagatgttaactgtccaccatgccaatgtgaatgtgtcaacagttggactaaaagcc
ttagatctcctgttagattcaggtaaaatcactttgctgatactggaagaagaatgtgat
gttttcttgttaatttttgatgccatgcacacatattcagccaatgatgaagttcagaaa
cttggatgcaaggctttacatgtgctgtttgagagagtctccgaggaacacctgatggag
ttcgttgagagcaaagactacatggtgctgctgaccacactcagcaacttcaaaggggac
agggacattgtgtttcatgtgctctcctgcttgcattccctggcggttccttgcaacaat
gttgaagtcctcatgagtgggaatgtcaggtgttacaatattgtggtggaagccatgaaa
gcattccctgccaatgaaaaaattcaagaagtgagctgttccttgctccataggcttacc
ttaggtaatttctacaacatcctggtgttaaacgaagtacatgtctttgtggtgaaagct
gtccagcggtatccagagaatgcagccttacagatctctgccctcagctgcctagcgctc
ctcactgagaccatcttcttaaaccaagacttggaggaaagaagtgagcctcaggagaac
aatgacgaggaggacactgagaagctattctggttggaaccctgctataaagccctgatg
cgccatcggaagaacaaacatgtacaggaggctgcatgctgggcactaaataatctcctt
atgtaccagaacagtttacatgagaagattggagacgaagatggccagttccccgcacac
agggaagtgatgctgtccatgctgatgcactcttcttccaaagatgtcttccaagcagct
tcgcatgcactgtccactctcttggaacaaaatgttaatttcaggaaaatcctgctggca
aaaggagtgtacctgaatgtcttagaattgatgcagaagcatgcccacgttcctgaggtg
gcagagagtggctgcaagatgctgagtcatctgtttgaaggaagtaacgcctccctggat
accatggcagcagtggtccctagaataataacagtgatgaaagcccacgagacatctctg
ccagtgcagctggaggcgctgcgagcgattctccattttgtagtgccaggaataccagaa
gaatccagggatgactctcaatgcaaactaaacatgctcaaaagacagtatctcaggacg
gacatccacaagctggttctagcagctctgaacaggttcattgggaatcctgggattcag
aaatgtggattgaaagtgctatcttctctgacacatcttcctgatgccttagagatgttg
tccctgcatggggcagttgactccacgcttcacactttgcagatgtatccagatgaccaa
gaaattcaatgcctgggtttacacctgacaggatgcttgattacaaagaagaatttctgc
atacggacaggccacctcctggcaaaaattctggtttccagtttgcagcgctttaaagat
gttgctgaattgcaaactacaggattacagacaatcttggcaatacttgaattgtcagtc
tctttctccaagctgctactgcactactcttttgatctggtaatattccaccagatgtct
tccagcgtcatggaacaaaaggatgagcagtttctcaatctatgctgcaaatgctttgca
aaactggctgtggatgaggagttaaaaagcacaatgctggagagagcctgtgatcagaac
aacagcatcatggttgagtgtttgcttctgttgggagctgatgccaatcaaacgaagggg
gccacgtctttaatttatcaggtatgcgagaaagagagcagtccaaaattggtggaactg
ttgcttaacggtggatgtcgtgaacaagatgtacggaaagcgctgacagtaagcatccaa
aagggcgacagccaggtcatcagcttgctcctgaggaggcttgcccttgacctggccaac
aacagcatttgccttggaggattttgcataaggaaaattgatccttcttggcttggtcct
ttatttcctgataagtcatctaatttaaggaaacaaacaaacacaggatctctcctagcg
agaaaagtattccgatatcagatgaagaacactctccaagaaggagcgacctcaggcagt
gatggcaactttcctgaagatgccctggcgaagtttggtgaatggaccttcgttcctgac
tcttccatggacagtgtgtttggtcacagtgatgatttggatagtgaaggcagtgagagc
tcatttctcgtgaaaaggaagtcgaattcgattggtgtaggagaattttccagagatccg
gttctgcagcgttgctcaccaaactcacagaggcaatccaattccttgggtcccattttt
gatcatgaagatttactgagaagaaaaagaaaaatactgtcttcagatgagtctctcagg
tcatcgaagcttcagtcccatatgaggcattccgatagttcttcttccctggcttccgag
agagagtacatcacatccttagacctttctgccaatgagctgaaagatattgatgccctg
agccagaagtgcctaggtggctacctggagcatctcaccaagctggaacttcaccagaat
gcactcactggctttcctcagcagctgtgtgagactctgaagtgtttgacacatttggat
ttgcacagtaacaaattcacatcctttccctccttcttgttgaaaatggcatgcatcacc
catctagatgcctctcgaaatgacattggaccgacaataggttttgaccccctggtgaag
tgtccaagcctcagacactttaacctgtcatacaaccagctctcttccatcccggagaac
cttgcccaagtggtggagaaactggagcagctcctattggaaggaaataaaatatcagca
atttgttctcccctgagcctgaaggaactgaagattttaaatcttagtaaaaaccacatt
ccatccctacctgaagactttcttgaggcttgccccaaagtggagagtttcagtgcccgg
atgaattctcttgctgcgatgcctgccttacctttttccataacaagcctaaaattatcc
caaaactgtttcacatgcattccagaagcgattttcattcttccacacttgcggtccttg
gatatgagccacaacaacattgagtatctgccagggcctgcacactggacatctcagaac
ttgagggaactcttctttagccataatcagatcaacgtcttggacttgagtgaaaagccg
catgtgtggtcgagagtagagaaagtccatctttctcataataagctgaaagagattcct
cctgaaattggctgtctggaaaatctgacatctcttgatgtcagtcacaactcggaactg
aggtcctttccgaatgaaatggggaaattgagcaagctatgggaccttcctctggatggg
ctgcagctgaactttgactttaagcacgtaggatgcaaagcaaaggacatcatcaggttt
ctccaacaacggctgaaaaaggctgtgccctacaaccgaatgaagctaatgattgtggga
aatactgggagtgggaagaccactctcctgcagcaactcatgaaaatgaagaaatcagat
cttggcatgcaaagcaccacggttggcatagacgtcagagactggcctatccaaatccga
ggcaaaaggaaaaaggaccttgttctaaatgtgtgggactttgcaggtcgggaggaattc
tacagcactcatccccacttcatgacccagagagctctgtaccttgctgtctatgatctc
agcaaagggcaggcagaggtggatgccatgaagccctggctcttcaatattaaggctcgt
gcctcttcttccccggtgattctggtgggcacgcatttggatgtttctgatgagaagcag
cgcaaagcctgcataagcaaaatcactaaggaactcctaaataagcgaggattccccacc
atccgggactaccacttcgtgaatgccaccgaggagtcagatgcacttgcaaagcttcgg
aaaaccatcataaatgagagtcttaatttcaagatccgagatcagcctgtggttgggcag
ctcattccagactgctacgtggaactggagaaaatcattttgtcagagcgcaaggccgtg
ccagttgagtttcctgtaattaaccggaagcgtttattacaactcgtgaaagaacaccag
ctgcagctggatgagaacgagctcccacacgctgttcatttcctaaacgagtcaggcgtc
cttctgcattttcaagaccccgcgctgcagctaagtgacctgtattttgtggaacccaag
tggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctgtctgaagcac
ccgaagggcatcatttcacggagagatgtagaaaaatttctttcaaagaaaaagcgattc
ccaaagaactacatgacacagtactttaaactattagaaaaattccagattgccttgcca
ttgggagaagaatatctgctggttccaagcagcttatctgaccacaggcctgtgatagag
cttccccactgtgagaactctgagatcatcattcggttatatgaaatgccatactttcca
atgggattttggtcaagactgattaatcgattacttgaaatctcacctttcatgctttct
ggaagagagagagcacttcgcccgaacagaatgtattggcgacagggcatctacttgaac
tggtccccagaagcatattgtctggtaggatccgaagtattagacaatcgtcctgagagt
ttcttgaaaattacagttccatcttgtagaaaaggttgtattcttttgggccaagttgtg
gatcacattgactccctcatggaagaatggtttcctgggttgctggagattgacatttgt
ggggaaggagaaactctgttgaagaaatgggcactgtacagttttaatgatggtgaagaa
catcagaagatcttacttgatgacttaatgaagaaagcagaagagggagacctgctaata
aatccagatcaaccaaggctcactattccaatatctcagattgctcctgacttgattttg
gctgacctgcctagaaatattatgttgaacaatgatgagttggaatttgaggaagcacct
gagtttctcttaggtgatggaagttttggatcagtttatcgggctgcctatgaaggagag
gaagtggctgtgaagatttttaataaacatacatcacttaggctgttaagacaagagttg
gtggtactttgccacctccaccacccaagcttgatatctttgctggcagctgggatccgt
cctcggatgttggtcatggaattggcctccaagggttccttggatcgtttgctgcagcag
gacaaagccagcctcaccagaaccctccaacataggatcgcgttgcatgtggctgatggc
ctgagatacctccactcagccatgattatttaccgtgatctgaaaccccacaacgtgttg
ctctttaccctctatcccaacgctgctatcatcgcgaagattgcggattacgggattgca
cagtactgctgtagaatgggaataaagacatcagagggcaccccagggttccgggcaccc
gaagttgccagaggaaatgtcatttataaccaacaggctgatgtttattcgttcggctta
ctgcttcatgacatttggacaactgggggtagaatcacagagggcttgaagtttccaaat
gagtttgatgaactagcactccaagggaaattgccagatccagttaaagaatatggctgt
gccccatggcctatggttgagaagttgattggaaagtgcttgaaagaaaaccctcaagaa
aggcccacttctgcccaggtctttgacattttgaattcggctgaattaatttgtctcatg
cgacacattttgatacctgagaacattattgttgaatgtatggttgctacaattcccaat
agcaagagcgcgaccctctggttgggctgtgggaacactgagaaaggacagctctccttc
tttgacttaaacacagaaagatacagctatgaggaagttactgatagtagaattctgtgc
ttggctttggtgcatcttcctgatgagaaagagagctggattgtgtgtggcacacaatct
ggggatctcctggtcatcaatgctgaagatgagacaaagaggcacacccttgaaaagatg
actgactccgttacttgtttgtattgcaattcctttgccaagcagagcaagcaaagtaat
tttcttttggtgggaaccgctgatggtaatttaatgatatttgaagataagaccattaag
tttaaaggagctgcccccttgaagacactacacataggtgatgtcagtacccccctgatg
tgcttgagtgtgtccatgaattcatctgaaagacatatcacatggggaggatgtggcaca
aagatcttctccttttccaatgatttcaccattcagaaactcattgagacaagaaccaac
caactgttttcttatgcagctttcagcgattctaacatcatagcagtggcagtagacacg
gttctctacattgccaagaaaaacagccctgtggtagaggtgtgggacaagaaaacagaa
aaactctgtgaattaatagactgtgtgcacttcttaaaggagatgatggtaaacaaggaa
tcgaaacacaagctatgctactctggaagggtgaaagctctctgcctgcagaagaacaca
gctctctggataggaactggaggaggccacattttactcctggatctttccactcgacga
gtgatacgtaccattcacaacttctgtgattctgtgagagccctggccatggcacagtta
ggaagccttaaaaatgtcatgctggttttggggtacaagcggaagagtacagatgatacc
caagagcaaaaagagatacagtcttgcttgtctatttgggacatcaatcttccacatgaa
gtacaaaatttagaaaaacacattgaagtaagagcagaattagctgataagatgagaaga
acgtctgttgaatag
DBGET
integrated database retrieval system
