| Entry |
|
| Symbol |
Plcb1
|
| Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
|
| KO |
|
| Organism |
pleu Peromyscus leucopus (white-footed mouse)
|
| Pathway |
| pleu04070 | Phosphatidylinositol signaling system |
| pleu04261 | Adrenergic signaling in cardiomyocytes |
| pleu04613 | Neutrophil extracellular trap formation |
| pleu04621 | NOD-like receptor signaling pathway |
| pleu04723 | Retrograde endocannabinoid signaling |
| pleu04750 | Inflammatory mediator regulation of TRP channels |
| pleu04925 | Aldosterone synthesis and secretion |
| pleu04928 | Parathyroid hormone synthesis, secretion and action |
| pleu04933 | AGE-RAGE signaling pathway in diabetic complications |
| pleu04935 | Growth hormone synthesis, secretion and action |
| pleu04961 | Endocrine and other factor-regulated calcium reabsorption |
| pleu04973 | Carbohydrate digestion and absorption |
| pleu05022 | Pathways of neurodegeneration - multiple diseases |
|
| Module |
| pleu_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
| Brite |
KEGG Orthology (KO) [BR:pleu00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
114703672 (Plcb1)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
114703672 (Plcb1)
04310 Wnt signaling pathway
114703672 (Plcb1)
04371 Apelin signaling pathway
114703672 (Plcb1)
04020 Calcium signaling pathway
114703672 (Plcb1)
04070 Phosphatidylinositol signaling system
114703672 (Plcb1)
04072 Phospholipase D signaling pathway
114703672 (Plcb1)
04071 Sphingolipid signaling pathway
114703672 (Plcb1)
04022 cGMP-PKG signaling pathway
114703672 (Plcb1)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
114703672 (Plcb1)
04081 Hormone signaling
114703672 (Plcb1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
114703672 (Plcb1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
114703672 (Plcb1)
04613 Neutrophil extracellular trap formation
114703672 (Plcb1)
04621 NOD-like receptor signaling pathway
114703672 (Plcb1)
04062 Chemokine signaling pathway
114703672 (Plcb1)
09152 Endocrine system
04911 Insulin secretion
114703672 (Plcb1)
04922 Glucagon signaling pathway
114703672 (Plcb1)
04929 GnRH secretion
114703672 (Plcb1)
04912 GnRH signaling pathway
114703672 (Plcb1)
04915 Estrogen signaling pathway
114703672 (Plcb1)
04921 Oxytocin signaling pathway
114703672 (Plcb1)
04926 Relaxin signaling pathway
114703672 (Plcb1)
04935 Growth hormone synthesis, secretion and action
114703672 (Plcb1)
04918 Thyroid hormone synthesis
114703672 (Plcb1)
04919 Thyroid hormone signaling pathway
114703672 (Plcb1)
04928 Parathyroid hormone synthesis, secretion and action
114703672 (Plcb1)
04916 Melanogenesis
114703672 (Plcb1)
04924 Renin secretion
114703672 (Plcb1)
04925 Aldosterone synthesis and secretion
114703672 (Plcb1)
04927 Cortisol synthesis and secretion
114703672 (Plcb1)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
114703672 (Plcb1)
04270 Vascular smooth muscle contraction
114703672 (Plcb1)
09154 Digestive system
04970 Salivary secretion
114703672 (Plcb1)
04971 Gastric acid secretion
114703672 (Plcb1)
04972 Pancreatic secretion
114703672 (Plcb1)
04973 Carbohydrate digestion and absorption
114703672 (Plcb1)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
114703672 (Plcb1)
09156 Nervous system
04724 Glutamatergic synapse
114703672 (Plcb1)
04725 Cholinergic synapse
114703672 (Plcb1)
04728 Dopaminergic synapse
114703672 (Plcb1)
04726 Serotonergic synapse
114703672 (Plcb1)
04720 Long-term potentiation
114703672 (Plcb1)
04730 Long-term depression
114703672 (Plcb1)
04723 Retrograde endocannabinoid signaling
114703672 (Plcb1)
09157 Sensory system
04742 Taste transduction
114703672 (Plcb1)
04750 Inflammatory mediator regulation of TRP channels
114703672 (Plcb1)
09159 Environmental adaptation
04713 Circadian entrainment
114703672 (Plcb1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
114703672 (Plcb1)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
114703672 (Plcb1)
09174 Infectious disease: parasitic
05146 Amoebiasis
114703672 (Plcb1)
05142 Chagas disease
114703672 (Plcb1)
05143 African trypanosomiasis
114703672 (Plcb1)
09164 Neurodegenerative disease
05010 Alzheimer disease
114703672 (Plcb1)
05016 Huntington disease
114703672 (Plcb1)
05017 Spinocerebellar ataxia
114703672 (Plcb1)
05022 Pathways of neurodegeneration - multiple diseases
114703672 (Plcb1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
114703672 (Plcb1)
05415 Diabetic cardiomyopathy
114703672 (Plcb1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
114703672 (Plcb1)
04934 Cushing syndrome
114703672 (Plcb1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:pleu04131]
114703672 (Plcb1)
Enzymes [BR:pleu01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
114703672 (Plcb1)
Membrane trafficking [BR:pleu04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
114703672 (Plcb1)
Endocytosis
Macropinocytosis
Phospholipase C
114703672 (Plcb1)
|
| SSDB |
|
| Motif |
|
| Other DBs |
|
| LinkDB |
|
| Position |
4:111005219..111706472
|
| AA seq |
1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTSEVFSLATNLLAQNMSRDASLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVEQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLS
GEENGVISPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLAVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYISLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETSSEAPSESRTTPAENGVTHTTSLAPKPPSQAPHSQPAPGSVKAPAKTEDLVQS
VLTEVEAQTIEELKQQKAFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEVRQQILDEKP
KLQMELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPPSLASEPGKVNHKSPSS
EEVEGENPGREFDTPL |
| NT seq |
3651 nt +upstreamnt +downstreamnt
atggctggggctcagcccggagtgcacgctttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactattgtaactcca
atcattttgaggactgatcctcagggatttttcttttactggacagatcaaaataaggag
acagagctgttagatctcagcctcgtcaaggatgccaggtgtgggaagcatgccaaagct
cccaaggaccccaagttacgtgaacttctggatgttgggaacatcgggcacttggagcag
cgtatgataacagtggtgtatgggcctgacctggtgaacatctctcacttgaatcttgtg
gctttccaagaggaagtcgccaaggaatggacaagtgaggttttcagcttggccacaaat
ctactggctcagaacatgtccagggatgcatctctggagaaagcatatactaagctcaag
cttcaggtcactccagaagggcgcattcctcttaaaaacatctatcgattgttttcagca
gaccgaaagcgagttgaaactgcactagaggcttgtagtcttccatcttcacggaatgat
tccatacctcaagaggatttcactccagatgtatacagagtgttcctgaacaatctttgt
ccccgtcctgaaattgataacatcttttctgaatttggtgccaaaagcaaaccgtacctt
actgttgagcagatgatggattttatcaaccttaagcagagagatccccgactcaatgaa
atactttacccacctctgaagcaagagcaggtccaagtattgattgagaagtatgagccc
aacagcagcctcgccaagaaagggcagatgtcagtggatggattcatgcgctacctgagc
ggagaagaaaacggagtcatttctcctgagaaactggatctgaatgaagacatgtcacag
cccctgtcccactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctgggaactcctctgtagagatgtatcgccaggtgcttctgtctggatgtcgctgtgtg
gagctggactgctggaagggaaggactgcagaggaagagcctgtcatcacccatggattc
accatgacaacagaaatatccttcaaggaagtcatagaagccatcgcagaatgtgcgttc
aagacctcgccttttcccatcctcctgtcctttgagaaccatgtggactccccgaagcag
caagccaagatggccgagtattgccgattaatctttggtgatgccttgcttatggagcca
ctggaaaaatacccactggaatctggggtacctcttccgagccctatggatttaatgtat
aaaatcttggtgaaaaacaagaagaaatcacacaagtcatcagaaggaagtggtaaaaag
aagctctctgagcaagcctccaacacatacagcgactcctccagtgtgttcgagccctcg
tctccgggagctggggaggcagacacagagagtgacgatgacgacgatgatgacgactgt
aaaaagtcttccatggatgaggggactgccggcagcgaggccatggccacagaagagatg
tctaacctagtgaactatattcaacctgtcaagtttgagtcctttgaaatttcaaaaaaa
agaaataaaagctttgaaatgtcttccttcgtggaaaccaagggacttgaacaacttacc
aagtctccagtggaatttgtagaatacaacaagatgcaacttagcaggatatatcccaaa
ggcacacgtgtggactcctccaactacatgccccagctcttctggaacgctggctgtcag
atggtggcactcaatttccagacagtggatctagctatgcagataaacatgggcatgtat
gagtacaatgggaagagtggctacaggctgaagccagagttcatgaggaggccggacaag
catttcgacccatttaccgagggaatcgtagatgggatagtggccaacactctagccgtt
aagattatttcaggtcagtttctttctgataagaaggttggaacttacgtggaagtggat
atgtttggtttgcctgtggacacaaggaggaaggcatttaaaactaagacatcccaagga
aatgctgtaaatcctgtctgggaagaagaacctattgtgttcaaaaaggtagttctgcct
tctctggcctgtttgaggatagcagcatatgaagaaggaggtaaatttattggccaccgg
atcttgcctgtgcaggctatacggccaggctatcactacatctccctgcggaatgagagg
aaccagcccctgatgctgccagctgtctttgtctacatagaagtcaaagactacgtgcca
gatacatatgcagatgtgatcgaagctctgtccaacccgatccgatatgtcaatctgatg
gagcagagagctaagcagctggctgcactgaccctggaggacgaggaggaagtgaagaaa
gaggctgaccctggggaaacatcatcggaggcaccaagtgaaagcaggaccacgccagca
gaaaatggggtgactcacacaacatcccttgcacccaaaccaccttcccaggctccacac
agccagccagctccaggttctgtaaaggcgcccgccaaaacagaagacctggtccagagt
gttttaacagaagtggaggcgcagaccattgaagagctcaagcaacagaaagcgttcgtg
aagcttcagaagaagcactacaaagaaatgaaagacctggtcaagagacaccacaagaaa
accaccgagctcatcaaggagcacaccaccaagtacaacgagatccagaacgactacctg
agaaggagggcagccttggaaaagtccgccaagaaggacagcaagaaaaaatctgaaccc
agtagccctgaccatggctcatctgccattgagcaagacctcgctgccctggatgcagag
atgacccagaagttaatagacttgaaggacaagcagcaacagcagctgcttaatcttcgg
caagagcagtattacagtgagaagtaccagaagcgagagcacattaaactgcttatccag
aagttgacagatgttgccgaggagtgtcagaacaatcagttaaagaagctcaaggaaatc
tgtgagaaagagaagaaggaattaaagaagaagatggataaaaagaggcaggagaagata
acagaagccaaatcgaaagacaaaagccagatggaagaggagaagacagagatgatccgg
tcctacatccaggaggtggtgcagtacatcaagaggttagaggaagcacagagtaaaaga
caagaaaaactcgtggagaaacacaaggaggtccgccagcagatcctagatgaaaagccc
aagctgcagatggagctggagcaagagtaccaagacaagttcaagagactgcccctggag
attctggagtttgtacaggaggccatgaaagggaaaatcagtgaagacagcaatcacggg
tctgcccctccctccctggcctcagagcctggaaaggtgaaccacaagtctccctccagt
gaggaagtagaaggagagaacccaggaagagagtttgatactcctctgtga |