KEGG   Panthera leo (lion): 122198690
Entry
122198690         CDS       T10741                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
plez  Panthera leo (lion)
Pathway
plez00562  Inositol phosphate metabolism
plez01100  Metabolic pathways
plez01521  EGFR tyrosine kinase inhibitor resistance
plez01522  Endocrine resistance
plez01524  Platinum drug resistance
plez04012  ErbB signaling pathway
plez04014  Ras signaling pathway
plez04015  Rap1 signaling pathway
plez04024  cAMP signaling pathway
plez04062  Chemokine signaling pathway
plez04066  HIF-1 signaling pathway
plez04068  FoxO signaling pathway
plez04070  Phosphatidylinositol signaling system
plez04071  Sphingolipid signaling pathway
plez04072  Phospholipase D signaling pathway
plez04081  Hormone signaling
plez04140  Autophagy - animal
plez04145  Phagocytosis
plez04150  mTOR signaling pathway
plez04151  PI3K-Akt signaling pathway
plez04152  AMPK signaling pathway
plez04210  Apoptosis
plez04211  Longevity regulating pathway
plez04213  Longevity regulating pathway - multiple species
plez04218  Cellular senescence
plez04360  Axon guidance
plez04370  VEGF signaling pathway
plez04380  Osteoclast differentiation
plez04510  Focal adhesion
plez04517  IgSF CAM signaling
plez04518  Integrin signaling
plez04550  Signaling pathways regulating pluripotency of stem cells
plez04611  Platelet activation
plez04613  Neutrophil extracellular trap formation
plez04620  Toll-like receptor signaling pathway
plez04625  C-type lectin receptor signaling pathway
plez04630  JAK-STAT signaling pathway
plez04650  Natural killer cell mediated cytotoxicity
plez04660  T cell receptor signaling pathway
plez04662  B cell receptor signaling pathway
plez04664  Fc epsilon RI signaling pathway
plez04666  Fc gamma R-mediated phagosome formation
plez04668  TNF signaling pathway
plez04670  Leukocyte transendothelial migration
plez04722  Neurotrophin signaling pathway
plez04725  Cholinergic synapse
plez04750  Inflammatory mediator regulation of TRP channels
plez04810  Regulation of actin cytoskeleton
plez04910  Insulin signaling pathway
plez04914  Progesterone-mediated oocyte maturation
plez04915  Estrogen signaling pathway
plez04917  Prolactin signaling pathway
plez04919  Thyroid hormone signaling pathway
plez04923  Regulation of lipolysis in adipocytes
plez04926  Relaxin signaling pathway
plez04929  GnRH secretion
plez04930  Type II diabetes mellitus
plez04931  Insulin resistance
plez04932  Non-alcoholic fatty liver disease
plez04933  AGE-RAGE signaling pathway in diabetic complications
plez04935  Growth hormone synthesis, secretion and action
plez04960  Aldosterone-regulated sodium reabsorption
plez04973  Carbohydrate digestion and absorption
plez05010  Alzheimer disease
plez05017  Spinocerebellar ataxia
plez05020  Prion disease
plez05100  Bacterial invasion of epithelial cells
plez05132  Salmonella infection
plez05135  Yersinia infection
plez05142  Chagas disease
plez05146  Amoebiasis
plez05160  Hepatitis C
plez05161  Hepatitis B
plez05162  Measles
plez05163  Human cytomegalovirus infection
plez05164  Influenza A
plez05165  Human papillomavirus infection
plez05166  Human T-cell leukemia virus 1 infection
plez05167  Kaposi sarcoma-associated herpesvirus infection
plez05168  Herpes simplex virus 1 infection
plez05169  Epstein-Barr virus infection
plez05170  Human immunodeficiency virus 1 infection
plez05171  Coronavirus disease
plez05200  Pathways in cancer
plez05203  Viral carcinogenesis
plez05205  Proteoglycans in cancer
plez05206  MicroRNAs in cancer
plez05207  Chemical carcinogenesis - receptor activation
plez05208  Chemical carcinogenesis - reactive oxygen species
plez05210  Colorectal cancer
plez05211  Renal cell carcinoma
plez05212  Pancreatic cancer
plez05213  Endometrial cancer
plez05214  Glioma
plez05215  Prostate cancer
plez05218  Melanoma
plez05220  Chronic myeloid leukemia
plez05221  Acute myeloid leukemia
plez05222  Small cell lung cancer
plez05223  Non-small cell lung cancer
plez05224  Breast cancer
plez05225  Hepatocellular carcinoma
plez05226  Gastric cancer
plez05230  Central carbon metabolism in cancer
plez05231  Choline metabolism in cancer
plez05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
plez05415  Diabetic cardiomyopathy
plez05417  Lipid and atherosclerosis
plez05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:plez00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    122198690 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    122198690 (PIK3CA)
   04014 Ras signaling pathway
    122198690 (PIK3CA)
   04015 Rap1 signaling pathway
    122198690 (PIK3CA)
   04370 VEGF signaling pathway
    122198690 (PIK3CA)
   04630 JAK-STAT signaling pathway
    122198690 (PIK3CA)
   04668 TNF signaling pathway
    122198690 (PIK3CA)
   04066 HIF-1 signaling pathway
    122198690 (PIK3CA)
   04068 FoxO signaling pathway
    122198690 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    122198690 (PIK3CA)
   04072 Phospholipase D signaling pathway
    122198690 (PIK3CA)
   04071 Sphingolipid signaling pathway
    122198690 (PIK3CA)
   04024 cAMP signaling pathway
    122198690 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    122198690 (PIK3CA)
   04152 AMPK signaling pathway
    122198690 (PIK3CA)
   04150 mTOR signaling pathway
    122198690 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    122198690 (PIK3CA)
   04517 IgSF CAM signaling
    122198690 (PIK3CA)
   04518 Integrin signaling
    122198690 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    122198690 (PIK3CA)
   04140 Autophagy - animal
    122198690 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    122198690 (PIK3CA)
   04218 Cellular senescence
    122198690 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122198690 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    122198690 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122198690 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122198690 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    122198690 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    122198690 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    122198690 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    122198690 (PIK3CA)
   04660 T cell receptor signaling pathway
    122198690 (PIK3CA)
   04662 B cell receptor signaling pathway
    122198690 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    122198690 (PIK3CA)
   04666 Fc gamma R-mediated phagosome formation
    122198690 (PIK3CA)
   04670 Leukocyte transendothelial migration
    122198690 (PIK3CA)
   04062 Chemokine signaling pathway
    122198690 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122198690 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    122198690 (PIK3CA)
   04929 GnRH secretion
    122198690 (PIK3CA)
   04915 Estrogen signaling pathway
    122198690 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    122198690 (PIK3CA)
   04917 Prolactin signaling pathway
    122198690 (PIK3CA)
   04926 Relaxin signaling pathway
    122198690 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    122198690 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    122198690 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    122198690 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    122198690 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    122198690 (PIK3CA)
   04722 Neurotrophin signaling pathway
    122198690 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122198690 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    122198690 (PIK3CA)
   04380 Osteoclast differentiation
    122198690 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    122198690 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    122198690 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122198690 (PIK3CA)
   05206 MicroRNAs in cancer
    122198690 (PIK3CA)
   05205 Proteoglycans in cancer
    122198690 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    122198690 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    122198690 (PIK3CA)
   05203 Viral carcinogenesis
    122198690 (PIK3CA)
   05230 Central carbon metabolism in cancer
    122198690 (PIK3CA)
   05231 Choline metabolism in cancer
    122198690 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122198690 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122198690 (PIK3CA)
   05212 Pancreatic cancer
    122198690 (PIK3CA)
   05225 Hepatocellular carcinoma
    122198690 (PIK3CA)
   05226 Gastric cancer
    122198690 (PIK3CA)
   05214 Glioma
    122198690 (PIK3CA)
   05221 Acute myeloid leukemia
    122198690 (PIK3CA)
   05220 Chronic myeloid leukemia
    122198690 (PIK3CA)
   05218 Melanoma
    122198690 (PIK3CA)
   05211 Renal cell carcinoma
    122198690 (PIK3CA)
   05215 Prostate cancer
    122198690 (PIK3CA)
   05213 Endometrial cancer
    122198690 (PIK3CA)
   05224 Breast cancer
    122198690 (PIK3CA)
   05222 Small cell lung cancer
    122198690 (PIK3CA)
   05223 Non-small cell lung cancer
    122198690 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122198690 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    122198690 (PIK3CA)
   05161 Hepatitis B
    122198690 (PIK3CA)
   05160 Hepatitis C
    122198690 (PIK3CA)
   05171 Coronavirus disease
    122198690 (PIK3CA)
   05164 Influenza A
    122198690 (PIK3CA)
   05162 Measles
    122198690 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    122198690 (PIK3CA)
   05163 Human cytomegalovirus infection
    122198690 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122198690 (PIK3CA)
   05169 Epstein-Barr virus infection
    122198690 (PIK3CA)
   05165 Human papillomavirus infection
    122198690 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122198690 (PIK3CA)
   05135 Yersinia infection
    122198690 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    122198690 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    122198690 (PIK3CA)
   05142 Chagas disease
    122198690 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122198690 (PIK3CA)
   05017 Spinocerebellar ataxia
    122198690 (PIK3CA)
   05020 Prion disease
    122198690 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122198690 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    122198690 (PIK3CA)
   05415 Diabetic cardiomyopathy
    122198690 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    122198690 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    122198690 (PIK3CA)
   04931 Insulin resistance
    122198690 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122198690 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122198690 (PIK3CA)
   01524 Platinum drug resistance
    122198690 (PIK3CA)
   01522 Endocrine resistance
    122198690 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:plez04131]
    122198690 (PIK3CA)
Enzymes [BR:plez01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     122198690 (PIK3CA)
Membrane trafficking [BR:plez04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    122198690 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 122198690
NCBI-ProteinID: XP_042759336
UniProt: A0A8C8XKM4
LinkDB
Position
C2:complement(87504401..87590749)
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaaatatcctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaactagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaataccagggcaagtatattttaaaagtatgtggatgtgatgaatac
ttccttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggccaaagaaagcctttactcccaactgccaatggac
tgtttcacaatgccatcttattccagacgtatctccacagctacaccatatatgaatgga
gaaacatctacaaagtccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcaacctatgtgaatgtaaatattcgagacatcgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttctaat
cccaggtggaatgaatggctaaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtctgtg
tctcgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaggcaatggag
cttctggattgtaattacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaatacttaacagatgacaagctttctcagtacttaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcgtattgtcgtgcatgtgggatgtatttgaag
cacctaaatagacaagttgaagctatggaaaagctcattaacttaactgacattctcaaa
caagaaaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
agaccagatttcatggatgctctacagggttttctgtctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgttaacactgcagatcattcgcattatg
gaaaatatctggcaaaatcaaggccttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcagatt
caatgcaaaggtggcctgaaaggcgcactgcagttcaacagccacacactacaccagtgg
ctcaaagacaagaacaaaggcgaaatatacgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctaccttcatactgggaatcggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactatttcatatagattttggacactttttggatcat
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaattcgaaaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
ctcttctcaatgatgcttggctctggaatgccagaactgcaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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