Panthera leo (lion): 122199529
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Entry
122199529 CDS
T10741
Symbol
PDE3B
Name
(RefSeq) cGMP-inhibited 3',5'-cyclic phosphodiesterase B
KO
K13296
cGMP-inhibited 3',5'-cyclic phosphodiesterase B [EC:
3.1.4.17
]
Organism
plez Panthera leo (lion)
Pathway
plez00230
Purine metabolism
plez01100
Metabolic pathways
plez04022
cGMP-PKG signaling pathway
plez04024
cAMP signaling pathway
plez04371
Apelin signaling pathway
plez04910
Insulin signaling pathway
plez04914
Progesterone-mediated oocyte maturation
plez04922
Glucagon signaling pathway
plez04923
Regulation of lipolysis in adipocytes
plez04924
Renin secretion
plez05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
122199529 (PDE3B)
09130 Environmental Information Processing
09132 Signal transduction
04371 Apelin signaling pathway
122199529 (PDE3B)
04024 cAMP signaling pathway
122199529 (PDE3B)
04022 cGMP-PKG signaling pathway
122199529 (PDE3B)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
122199529 (PDE3B)
04922 Glucagon signaling pathway
122199529 (PDE3B)
04923 Regulation of lipolysis in adipocytes
122199529 (PDE3B)
04914 Progesterone-mediated oocyte maturation
122199529 (PDE3B)
04924 Renin secretion
122199529 (PDE3B)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
122199529 (PDE3B)
Enzymes [BR:
plez01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase
122199529 (PDE3B)
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Motif
Pfam:
PDEase_I
DUF1129
Motif
Other DBs
NCBI-GeneID:
122199529
NCBI-ProteinID:
XP_042760602
UniProt:
A0A8C8X7E6
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Position
D1:70812551..70987108
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AA seq
1121 aa
AA seq
DB search
MRRDERDAKAMRCPQAPDGAGPPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELL
LPPPASPQQPRRGSPSARARLSLGALAAFVLALLLGSGPGSWAAGAARLRTVLSVCSHSL
SPLFSIACAFFFLTCFLTRSKRGPGPGRSGGGGGAWWLLALPACCYLGDFLAWQAWTWAW
GPPAAAQHTPPAVAGRLFSALSCVGLLTLAHPARLRHGILVLLFSSFVWWVSFTGLGSLP
AALRPLLACLVGDAGCLLALGLDHFFQIREAPHHPRLASTAEDKVPVIRPRRRSSCVSFG
ETSAGYSGSSKMFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGSGVDLSVLNEARN
MVSDLLIDPTLPPQVISSLRSISSLMGAFSGSCRPRINPLTPFPGFYPCSEVEDPAEKGD
RKLHKGLHSRNSLPTPQLRRSPGTSGLPPIEQSSSRWERSNGKRPHQEFGISSQGSYLNG
PLSSNLLTMTKQRSSSVSLTHHIGLRRAAAFPSLSPVNSPSHGLVSAGSLMNRSLVEFPA
TASSLTKPSVILHRSLGSAPNSPDFYQHVRNSDSSLCNSCGHQILKYVSTSESESGIDCH
SGKSGDEDNTVSSKQSFSLTEVQHEVETENTECRKLFLEGDTHLTEEAQNEQQPNIEQEA
SLDLILIEDYDSLIEKMSNWNFQIFEVVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPT
LQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPIPGLQQIHNDHATGNETDSDG
RMNPGQIAYISSRSCSIPDESYGCLSANIPALELMALYVAAAMHDYDHPGRTNAFLVATN
APQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLNLDHVEFKRFRFLVIEAILATDLKK
HFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVN
EFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGEWIEAE
EDEDAESCYDEEDGEELDTDDEEIEDNLNPKPRRRKGRRRIFCQLMHHLTENHKIWKEII
EEEEKCKADGNKLQVENSSLPQADDIQVIEEADEEEERQFE
NT seq
3366 nt
NT seq
+upstream
nt +downstream
nt
atgaggagggacgagcgagacgccaaagccatgcggtgcccgcaggcgccggacggggcc
ggcccgccccccgagagtctgaggaacggctacgtgaagagctgcgtgagccccctgcgg
caggaccctccgcgtggcttcttcttccacctctgccgcttctgcaacgtggagctgctg
ctgccgccgccggcctccccccagcagccgcgccgcggctccccctccgcccgggcgcgc
ctctcgctgggcgccctggccgcctttgtcctcgccctgctgctcggctcggggcccggg
agctgggctgccggggccgcccggctgcggaccgtgctgagcgtgtgctcgcacagcctc
agccccctgttcagcatcgcctgtgccttcttcttcctcacctgcttcctgacccggagc
aagcggggccccgggccgggccggagcggcggcggcggcggcgcctggtggctgctggcg
ctgccagcctgctgttacctgggggacttcttggcgtggcaggcgtggacttgggcttgg
gggccccccgccgcggcccagcacacgccccccgcggtggcgggcaggttgttctcggcg
ctgagctgcgtgggcttgctgacgctcgcgcacccggccaggctccggcacggcatcctg
gtgctgctcttctccagcttcgtctggtgggtctccttcaccgggctcgggtcgctgccc
gccgccctcaggccgctgctcgcctgcctggtcggggacgccggctgcctgctggccctg
ggcttggatcacttcttccagatcagggaagcccctcatcaccctcgcttggccagtacc
gccgaggacaaagtgcctgtgatcagaccccgcaggaggtccagctgcgtgtcgttcgga
gaaacttcggccggttactccggcagttccaagatgttcaggagaccttcgttgccttgc
atttcccgcgaacagatgattctttgggactgggacttaaagcaatggtataaacctcat
tatcagaattctggaggtggaagtggagttgatctttcagtgctaaatgaggctcgcaat
atggtgtcagaccttctgattgatccaacccttcccccacaagtcatttcttccctgcgg
agtatcagttccttgatgggtgctttctcaggttcctgtaggccaaggattaatcccctc
acaccatttcctggattttacccctgctcggaagtagaggacccagctgagaaaggagat
cgaaaacttcacaagggactacacagtaggaatagcttaccaactccccagctgaggagg
agccccggaacttccggtctgccacctattgaacaatcgtcatcccggtgggaacgcagt
aatggcaaaaggccacaccaagagtttggcatttcaagtcaaggatcctatctaaatgga
cctttaagttcaaatctactgacaatgacgaagcaaaggtcatcttccgtatccctaact
caccatataggtctaagaagagctgctgctttccccagcctgagtcctgtgaattctccc
agccatggactagtctccgctggctctctaatgaatcgatcacttgtagaatttcctgcc
actgccagttctcttactaagccaagtgttattttacaccgatctctgggcagtgcaccc
aattcaccagatttttatcagcatgttagaaattctgatagcagtttatgtaacagctgt
ggacatcaaatattgaaatatgtttcaacatctgaatccgaatctggtatagactgccac
agtggaaagtcaggtgatgaagacaacaccgtttcctcaaaacaatcattcagcctcaca
gaagtgcaacatgaagtggaaacagagaacacagagtgcagaaaattatttttggaaggt
gatactcacctaacagaagaggcacagaatgaacagcaaccaaatattgaacaggaagca
tcactggacctgattttaatagaagattatgattccttaatagagaagatgagcaactgg
aattttcaaatatttgaagttgttgaaaaaatgggagagaaatcaggaaggatccttagt
caggttatgtataccttatttcaagacactggtttattggaaatatttaaaattcccact
ctacagttcatgaactattttcgtgcattagaaaatggctaccgagacattccttatcac
aatcgtatacatgccacagacgtcctgcatgcagtttggtatctgacaacccggccaatt
cctggtttacagcagatccacaatgatcatgcaacaggaaacgaaacagattcggatggt
agaatgaaccctgggcaaattgcctacatttcttcgaggagctgctctattccagatgag
agctatgggtgcctttctgcaaacattcctgcactggaattgatggctctctacgtggca
gctgccatgcatgattatgatcacccagggcggacaaatgcatttctagtggctactaat
gcccctcaggcagttttgtacaacgacagatctgttctagaaaatcatcatgccgcatca
gcttggaatctatatctttctcgcccagagtacaacttccttcttaatcttgatcacgtg
gaattcaagcgctttcgttttttagtcattgaagcaatccttgccacagatcttaaaaag
cattttgatttccttgctgaattcaatgccaaggccaatgatgtaaacagtaacggtata
gaatggagcaatgaaaatgatcgcctcttggtatgccaggtgtgtatcaaactggcagat
ataaatggcccagcgaaagttcgggacttgcatttgaaatggacagaaggcatcgtcaat
gaattttatgagcagggagatgaagaagctaatcttggtttgcccatcagtcccttcatg
gatcgttcttcacctcaactagcaaaactccaagaatctttcatcacccacatagtgggg
cctctgtgtaactcctacgatgctgccggcttgctgccgggtgagtggatagaagcagaa
gaggatgaagatgccgaaagttgttatgatgaagaagatggcgaagaattagatacagat
gatgaagaaatagaagacaacttaaatcctaaaccacgaaggaggaagggcagacggcga
atattttgtcagctaatgcaccacctcaccgaaaaccacaagatatggaaggaaatcatc
gaggaagaagagaaatgtaaagctgatgggaataaactgcaggtggagaattcttcctta
cctcaagcagatgacattcaggtcattgaagaagcagatgaagaggaggagagacagttt
gaataa
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