KEGG   Panthera leo (lion): 122199586
Entry
122199586         CDS       T10741                                 
Symbol
HRAS
Name
(RefSeq) GTPase HRas isoform X1
  KO
K02833  GTPase HRas
Organism
plez  Panthera leo (lion)
Pathway
plez01521  EGFR tyrosine kinase inhibitor resistance
plez01522  Endocrine resistance
plez04010  MAPK signaling pathway
plez04012  ErbB signaling pathway
plez04014  Ras signaling pathway
plez04015  Rap1 signaling pathway
plez04062  Chemokine signaling pathway
plez04068  FoxO signaling pathway
plez04071  Sphingolipid signaling pathway
plez04072  Phospholipase D signaling pathway
plez04137  Mitophagy - animal
plez04140  Autophagy - animal
plez04144  Endocytosis
plez04150  mTOR signaling pathway
plez04151  PI3K-Akt signaling pathway
plez04210  Apoptosis
plez04211  Longevity regulating pathway
plez04213  Longevity regulating pathway - multiple species
plez04218  Cellular senescence
plez04360  Axon guidance
plez04370  VEGF signaling pathway
plez04371  Apelin signaling pathway
plez04510  Focal adhesion
plez04540  Gap junction
plez04550  Signaling pathways regulating pluripotency of stem cells
plez04625  C-type lectin receptor signaling pathway
plez04630  JAK-STAT signaling pathway
plez04650  Natural killer cell mediated cytotoxicity
plez04660  T cell receptor signaling pathway
plez04662  B cell receptor signaling pathway
plez04664  Fc epsilon RI signaling pathway
plez04714  Thermogenesis
plez04720  Long-term potentiation
plez04722  Neurotrophin signaling pathway
plez04725  Cholinergic synapse
plez04726  Serotonergic synapse
plez04730  Long-term depression
plez04810  Regulation of actin cytoskeleton
plez04910  Insulin signaling pathway
plez04912  GnRH signaling pathway
plez04915  Estrogen signaling pathway
plez04916  Melanogenesis
plez04917  Prolactin signaling pathway
plez04919  Thyroid hormone signaling pathway
plez04921  Oxytocin signaling pathway
plez04926  Relaxin signaling pathway
plez04929  GnRH secretion
plez04933  AGE-RAGE signaling pathway in diabetic complications
plez04935  Growth hormone synthesis, secretion and action
plez05010  Alzheimer disease
plez05022  Pathways of neurodegeneration - multiple diseases
plez05034  Alcoholism
plez05132  Salmonella infection
plez05160  Hepatitis C
plez05161  Hepatitis B
plez05163  Human cytomegalovirus infection
plez05165  Human papillomavirus infection
plez05166  Human T-cell leukemia virus 1 infection
plez05167  Kaposi sarcoma-associated herpesvirus infection
plez05170  Human immunodeficiency virus 1 infection
plez05200  Pathways in cancer
plez05203  Viral carcinogenesis
plez05205  Proteoglycans in cancer
plez05206  MicroRNAs in cancer
plez05207  Chemical carcinogenesis - receptor activation
plez05208  Chemical carcinogenesis - reactive oxygen species
plez05210  Colorectal cancer
plez05211  Renal cell carcinoma
plez05213  Endometrial cancer
plez05214  Glioma
plez05215  Prostate cancer
plez05216  Thyroid cancer
plez05218  Melanoma
plez05219  Bladder cancer
plez05220  Chronic myeloid leukemia
plez05221  Acute myeloid leukemia
plez05223  Non-small cell lung cancer
plez05224  Breast cancer
plez05225  Hepatocellular carcinoma
plez05226  Gastric cancer
plez05230  Central carbon metabolism in cancer
plez05231  Choline metabolism in cancer
plez05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
plez05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:plez00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122199586 (HRAS)
   04012 ErbB signaling pathway
    122199586 (HRAS)
   04014 Ras signaling pathway
    122199586 (HRAS)
   04015 Rap1 signaling pathway
    122199586 (HRAS)
   04370 VEGF signaling pathway
    122199586 (HRAS)
   04371 Apelin signaling pathway
    122199586 (HRAS)
   04630 JAK-STAT signaling pathway
    122199586 (HRAS)
   04068 FoxO signaling pathway
    122199586 (HRAS)
   04072 Phospholipase D signaling pathway
    122199586 (HRAS)
   04071 Sphingolipid signaling pathway
    122199586 (HRAS)
   04151 PI3K-Akt signaling pathway
    122199586 (HRAS)
   04150 mTOR signaling pathway
    122199586 (HRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    122199586 (HRAS)
   04140 Autophagy - animal
    122199586 (HRAS)
   04137 Mitophagy - animal
    122199586 (HRAS)
  09143 Cell growth and death
   04210 Apoptosis
    122199586 (HRAS)
   04218 Cellular senescence
    122199586 (HRAS)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122199586 (HRAS)
   04540 Gap junction
    122199586 (HRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    122199586 (HRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122199586 (HRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    122199586 (HRAS)
   04650 Natural killer cell mediated cytotoxicity
    122199586 (HRAS)
   04660 T cell receptor signaling pathway
    122199586 (HRAS)
   04662 B cell receptor signaling pathway
    122199586 (HRAS)
   04664 Fc epsilon RI signaling pathway
    122199586 (HRAS)
   04062 Chemokine signaling pathway
    122199586 (HRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122199586 (HRAS)
   04929 GnRH secretion
    122199586 (HRAS)
   04912 GnRH signaling pathway
    122199586 (HRAS)
   04915 Estrogen signaling pathway
    122199586 (HRAS)
   04917 Prolactin signaling pathway
    122199586 (HRAS)
   04921 Oxytocin signaling pathway
    122199586 (HRAS)
   04926 Relaxin signaling pathway
    122199586 (HRAS)
   04935 Growth hormone synthesis, secretion and action
    122199586 (HRAS)
   04919 Thyroid hormone signaling pathway
    122199586 (HRAS)
   04916 Melanogenesis
    122199586 (HRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    122199586 (HRAS)
   04726 Serotonergic synapse
    122199586 (HRAS)
   04720 Long-term potentiation
    122199586 (HRAS)
   04730 Long-term depression
    122199586 (HRAS)
   04722 Neurotrophin signaling pathway
    122199586 (HRAS)
  09158 Development and regeneration
   04360 Axon guidance
    122199586 (HRAS)
  09149 Aging
   04211 Longevity regulating pathway
    122199586 (HRAS)
   04213 Longevity regulating pathway - multiple species
    122199586 (HRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    122199586 (HRAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122199586 (HRAS)
   05206 MicroRNAs in cancer
    122199586 (HRAS)
   05205 Proteoglycans in cancer
    122199586 (HRAS)
   05207 Chemical carcinogenesis - receptor activation
    122199586 (HRAS)
   05208 Chemical carcinogenesis - reactive oxygen species
    122199586 (HRAS)
   05203 Viral carcinogenesis
    122199586 (HRAS)
   05230 Central carbon metabolism in cancer
    122199586 (HRAS)
   05231 Choline metabolism in cancer
    122199586 (HRAS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122199586 (HRAS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122199586 (HRAS)
   05225 Hepatocellular carcinoma
    122199586 (HRAS)
   05226 Gastric cancer
    122199586 (HRAS)
   05214 Glioma
    122199586 (HRAS)
   05216 Thyroid cancer
    122199586 (HRAS)
   05221 Acute myeloid leukemia
    122199586 (HRAS)
   05220 Chronic myeloid leukemia
    122199586 (HRAS)
   05218 Melanoma
    122199586 (HRAS)
   05211 Renal cell carcinoma
    122199586 (HRAS)
   05219 Bladder cancer
    122199586 (HRAS)
   05215 Prostate cancer
    122199586 (HRAS)
   05213 Endometrial cancer
    122199586 (HRAS)
   05224 Breast cancer
    122199586 (HRAS)
   05223 Non-small cell lung cancer
    122199586 (HRAS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122199586 (HRAS)
   05170 Human immunodeficiency virus 1 infection
    122199586 (HRAS)
   05161 Hepatitis B
    122199586 (HRAS)
   05160 Hepatitis C
    122199586 (HRAS)
   05163 Human cytomegalovirus infection
    122199586 (HRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122199586 (HRAS)
   05165 Human papillomavirus infection
    122199586 (HRAS)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122199586 (HRAS)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122199586 (HRAS)
   05022 Pathways of neurodegeneration - multiple diseases
    122199586 (HRAS)
  09165 Substance dependence
   05034 Alcoholism
    122199586 (HRAS)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122199586 (HRAS)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    122199586 (HRAS)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122199586 (HRAS)
   01522 Endocrine resistance
    122199586 (HRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:plez04131]
    122199586 (HRAS)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:plez04147]
    122199586 (HRAS)
   04031 GTP-binding proteins [BR:plez04031]
    122199586 (HRAS)
Membrane trafficking [BR:plez04131]
 Exocytosis
  Small GTPases and associated proteins
   Other small GTPases and associated proteins
    122199586 (HRAS)
 Endocytosis
  Macropinocytosis
   Ras GTPases
    122199586 (HRAS)
Exosome [BR:plez04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   122199586 (HRAS)
  Exosomal proteins of colorectal cancer cells
   122199586 (HRAS)
GTP-binding proteins [BR:plez04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    122199586 (HRAS)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU MMR_HSR1 RsgA_GTPase FeoB_N ATP_bind_1 Septin Ldh_1_N DUF6974
Other DBs
NCBI-GeneID: 122199586
NCBI-ProteinID: XP_042760682
UniProt: A0A8C9DB09
LinkDB
Position
D1:114976457..114981444
AA seq 189 aa
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKVRKLSPPDEGGPG
CMSCKCLLS
NT seq 570 nt   +upstreamnt  +downstreamnt
atgacggaatataagctcgtggtggtgggcgctggaggtgtggggaagagtgccctgacc
atccagctcatccagaaccacttcgtggacgagtatgaccccaccatcgaggactcctat
cggaagcaagtggttattgatggcgagacgtgcctactggacattttggacacggcgggc
caggaggagtatagcgccatgcgggaccagtacatgcgcactggggaaggcttcctctgt
gtgtttgccatcaacaataccaagtcctttgaggacatccaccagtacagggagcaaatc
aagcgagtgaaggactccgatgacgtgcccatggtgctggtggggaacaagtgcgacctg
gccgcgcgcaccgtggagtcccggcaggcgcaggacctcgcccgcagctacggcatcccg
tacatcgagacgtcggccaagactcgccagggcgtggaggacgccttctacacgctggtc
cgagagatccggcaacacaaggtgcggaagctgagcccgcccgacgagggtggccccggc
tgcatgagctgcaagtgcctgctctcctga

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