Panthera leo (lion): 122201785 Help Entry 122201785         CDS       T10741                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism plez  Panthera leo (lion) Pathway plez04020   Calcium signaling pathway plez04024   cAMP signaling pathway plez04260   Cardiac muscle contraction plez04261   Adrenergic signaling in cardiomyocytes plez04371   Apelin signaling pathway plez04713   Circadian entrainment plez04911   Insulin secretion plez04921   Oxytocin signaling pathway plez04972   Pancreatic secretion plez05020   Prion disease plez05022   Pathways of neurodegeneration - multiple diseases plez05410   Hypertrophic cardiomyopathy plez05412   Arrhythmogenic right ventricular cardiomyopathy plez05414   Dilated cardiomyopathy plez05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:plez00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     122201785 (RYR2)    04020 Calcium signaling pathway     122201785 (RYR2)    04024 cAMP signaling pathway     122201785 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     122201785 (RYR2)    04921 Oxytocin signaling pathway     122201785 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     122201785 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     122201785 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     122201785 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     122201785 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     122201785 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     122201785 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     122201785 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     122201785 (RYR2)    05414 Dilated cardiomyopathy     122201785 (RYR2)    05415 Diabetic cardiomyopathy     122201785 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:plez04040]     122201785 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:plez04990]     122201785 (RYR2) Ion channels [BR:plez04040]  Voltage-gated cation channels   Ryanodine receptor    122201785 (RYR2) Domain-containing proteins not elsewhere classified [BR:plez04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    122201785 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 PI3_PI4_kinase Motif Other DBs NCBI-GeneID:  122201785 NCBI-ProteinID:  XP_042763717 LinkDB All DBs Position D2:complement(10936140..11701690) Genome browser AA seq 4970 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR SSVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREGGEAWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGAQNSTADIMFYRLSMPIECAEVFSKTVAG GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAAFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTEETKSITLFP DENKKHGLPGIGLSTSLRPRIQFSSPSFVSINNECYQYSPEFPLDILKAKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNDDLKHILQLIEPSVFKEAATPEED TEALEKEPSMEDSKPEGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK KKQAEKPIESGSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLETEEEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRVERTREGDSMALYNRSRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGSRSKAEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRTF LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI YSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSTQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTED TSDPEKTVERVLDIANVLFHLEQKSTSMHRRYYSLGSTVEHPQRSKKAVWHKLLSKQRKR AVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGADPPEEEEG TKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEK EMEKQKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATLKLGIAILNGGNSTVQQKM LDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTC DLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDV IDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMK LSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFF DMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENET LDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIE IMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTI FEMQLAAQISESDLNERSANKEESEKEKPEEQGPRMGFFSIVTVKSALFALRYNILTLMR MLSLKSLKKQMKKVKKMTMKDMVTAAFSSYWSIFMSLLHFVASVSRGFFRIICSLLLGGS LVEGAKKIRVAELLANMPDPTQDEVRGDGEEGDRRPMEAALPSEDLTDLKELTEESDLLS DIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPDVQEKFQEQKVKEEEKEEKEESKS EPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFAR NFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKEPPTRSSSGNAKVSSLDSGSPRIIAV HYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYI TEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAAL DFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSILGHYNNF FFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSE DGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVI LLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLAN YLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14913 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgaaggcgaggacgagatccagttcctgcgaactgacgatgaagtg gtcctgcagtgcaccgcgaccatccacaaagaacaacagaaactgtgcttggcagcggaa gggtttggcaacagactttgcttcctggagtctacttcaaattccaagaatgttccccca gacctctctatctgcacttttgtgctggaacagtctctctctgtccgggccctacaggag atgctggctaacacagtggagaaatcagaagggcaagttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggtggtcatcgaacactcctgtacggacatgccatattg ctacgccattcctatagtggcatgtatctgtgctgtctgtccacctcccggtcttcaact gataaactggcctttgacgttggcttgcaagaggacacaacaggtgaggcttgttggtgg accattcatcctgcctccaagcagaggtcggaaggagaaaaggtgcgcgttggagatgac ctcatcttagtcagtgtgtcctctgagaggtacctgcatttgtcttacggcaatggcagc ttacacgtggatgccgctttccagcagactctctggagcgtggccccaatcagctcagga agtgaagccgcccaagggtatctaattggtggtgacgtcctcaggttgctgcacggacac atggatgaatgcctcactgtcccttcaggagaacacggtgaagagcagcggagaactgtt cactatgaaggcggtgctgtatctgtccatgcacgttccctgtggagactagagacacta agagttgcgtggagtggaagccacataagatggggccagcccttccgactacgccatgtc acaacaggaaagtacttgagtctcatggaagacaaaaaccttctactcatggacaaagaa aaggctgatgtaaagtcaacagcatttaccttccgatcttccaaggaaaaattggatgta ggggtgagaaaagaagtcgatggcatgggaacatcagaaataaaatatggagactcagta tgctatattcaacatataaatactggcctgtggcttacttaccagtctgtggatgtgaaa tcagtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggtcacatggat gacggcttaaatctctctagatctcagcatgaagaatcacggaccgcacgagtcatccgg agctctgtcttccttttcaacaggtttataaggggccttgatgcgctcagcaaaaaagtg aaggcttccaccgtagacctccctatagaatctgtgagtctgagtctgcaggacctgatt ggttacttccatccccccgacgagcacttagagcatgaagacaaacagaacagattacgg gctctaaagaaccgtcagaatctcttccaggaagagggcatgatcaacctcgtgctcgag tgcatcgacaggctgcatgtctatagcagtgcggcgcatttcgcggacgtggcggggaga gaaggaggcgaggcttggaagtcgattctgaattctctctatgagttgctagcggctcta attagaggaaatcgtaaaaactgtgcccaattttctggctccctggactggttgatcagc cgattggaaagactggaagcttcttctggtattcttgaagttttgcactgtgtgttagta gaaagtccagaagccctaaatattatcaaagaaggacacattaaatccataatctccctt ttagacaagcatggaagaaaccacaaggttctggacgtcttgtgctctctctgcgtctgc cacggagtagcagtccgttccaaccagcatctcatctgcgacaatctgctgccgggaaga gatctgcttctgcagacacgtcttgtaaaccacgttagcagcatgagacccaatattttt ctgggcgtcagtgaagggtccgcccagtataagaagtggtactacgagctgatggtggac cacacggagccgttcgtgactgccgaagccactcacctgagggtgggctgggcgtccacc gaagggtactctccctaccctggaggcggtgaggagtggggtggcaatggagtcggagac gatctcttctcctacggatttgatggccttcacctctggtcaggttgtattgcacgtact gtaagctcaccgaatcaacatctcttgagaactgacgatgtcatcagttgctgtttagat ctgagcgccccaagcatctcattccgaattaacgggcaacctgttcaaggaatgtttgag aatttcaacatcgatggcctcttctttccagttgttagtttctctgcaggaataaaggta cgctttctgcttggggggagacacggagaatttaaattccttcctccacctgggtatgct ccttgttacgaagctgttctgccaaaagagaagttgaaagtggaacacagcagagaatac aagcaagaaagaacttacacccgagacctgctgggccccacggtttccctgacgcaggcc gccttcacaccaatccctgtggacaccagccagattgtgttacctcctcacctggagaga ataagagaaaaactggcagagaatatccatgaactctgggttatgaataaaattgaactt ggctggcagtatggtccggttagagatgacaataagagacagcatccgtgtctggtggag ttctccaagctaccggagcaggaacgcaattacaatttgcagatgtcgcttgagaccctg aagactttgttggcattaggatgtcatgtgggaatagcagatgaacatgctgaagaaaag gtgaaaaaaatgaagctgcccaagaattaccagctgacaagtgggtataagcctgccccg atggacctgagcttcattaaactcacgccctctcaggaagcgatggtggacaagttggcg gagaacgcgcacaacgtgtgggcccgggatcgaatccggcagggctggacttacggcatc cagcaggatgtaaagaacagaagaaaccctcgcctggttccctacacccttctagatgac cgcaccaagaagtccaacaaggacagcctccgcgaggccgtgcgcacgctgctgggatat ggctatcatctggaggcgccagatcaagatcatgctgcccgagccgaagtgtgtagcggc accggggagaggttccgaatcttccgcgctgagaaaacctatgccgtcaaggcaggaagg tggtattttgaatttgaggctgtcactgctggagacatgagagttggatggagcaggcca ggttgtcaacctgaccaagagctgggctcagacgaacgtgcctttgcttttgatggcttc aaggcccagcggtggcaccagggcaacgaacactatgggcgctcttggcaagcgggcgat gtcgtgggatgcatggtggacatgacagagcacaccatgatgttcacactgaatggcgaa atccttctggacgactcgggctcggaactggcgttcaaggacttcgatgttggtgacgga ttcattcctgtctgtagccttggagtggctcaggtgggcaggatgaactttggaaaggat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggttacgaaccgtttgct gtgaacacaaacagggatattaccatgtggctaagcaagaggcttcctcagtttctccag gtcccttcaaaccatgagcacatcgaggtgaccagaatagatggcaccatcgacagttct ccgtgtttaaaagtcacccagaagtcctttggcgctcagaacagcactgccgacatcatg ttctatcgcctgagcatgccgatcgagtgtgccgaggttttctccaagacggtggcaggc gggctcccaggcgccggcctctttgggcccaagaatgatctggaggattacgatgcagat tctgactttgaggttctaatgaagacagctcatggccatctggtgccagaccgtgttgac aaagacaaggaagccacaaaaccagagtttaataaccacaaagactatgctcaggaaaag ccctctcgtctgaaacaaagatttttgcttagaagaacaaagccagattatagcacgagc cattctgcaaggctcaccgaagatgtccttgcagatgatcgggatgattatgattacttg atgcaaacgtccacgtactattactcagtgagaatctttcccggccaagaacctgctaac gtctgggtgggctggattacatcagatttccatcagtatgatacaggctttgacttggac agagttcgtacagtaaccgttactctaggagatgaaaagggaaaagtacacgaaagcatc aaacgcagcaactgctatatggtgtgcgcgggcgagagcatgagcccagggcaaggacgc aacaataatggcctggagatcgggtgcgtggtggatgctgccagtgggcttctcacattc accgccaacggcaaggagctgagcacctactaccaggtggagccaagtacgaaattattt cctgcagcttttgcccaagctacaagtcccaacgttttccagtttgagctgggaagaatc aagaatgtgatgcctctctccgcgggattattcaagagtgagcacaaaaaccctgtgcca cagtgtcccccgcgtctccacgtgcagtttctgtcccacgtcctgtggagcagaatgccc aaccagttcctgaaggtagatgtgtctcgaataagtgagcgccaaggctggctggtgcag tgtttggatcctctgcagttcatgtctctccatatcccggaggagaacagatctgtggac atactggagctgacagagcaggaagagctgctgaaattccactaccacacgctccggctt tactccgccgtctgcgccctcgggaaccaccgggtggcgcatgcgttgtgcagccacgtg gacgaaccccagctgctctacgccatcgagaacaagtacatgcccggtttgctgcgggcc ggctactatgacctgctgattgacatccacctgagctcctacgccactgccaggctcatg atgaacagtgagttcatcgtgcccatgacggaggagaccaagagcatcaccctcttccct gatgagaacaaaaagcacggcctccccgggattggcctcagcacctccctcaggccacgg atacagttctcctcccccagttttgtgagcatcaataacgaatgctaccaatacagtcca gagttcccactggacatcctgaaggccaaaaccattcagatgctgacagaagctgttaaa gagggcagcctgcatgcccgggaccccgtggggggcaccactgaatttctctttgtacct ctcatcaagcttttctatactctgctcatcatggggatcttccacaatgacgacttaaaa cacatcttgcagctgatagagcccagtgtgttcaaggaagccgccactccggaagaagac actgaggctctggagaaagagccctccatggaagactccaagccagaaggagctggagaa gaagaagccaaagggggtaagaggcccaaggaaggactgctccaaatgaaactgcctgag ccagttaaattgcagatgtgtctgctgctccagtacctctgtgactgccaggtccgacac cggatagaagccatcgtggccttttcagatgactttgtagccaagctccaagacaatcag cgcttccgttacaacgaagttatgcaagctttaaacatgtcggccgcgctcactgccagg aagacaaaggaatttcgatccccacctcaggaacagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtcctgaagaaatccgagaccagctcttagattttcac gaagatttgatgacacattgtggaattgagctggatgaagatgggtctcttgatggaaac agtgacttaacaattagaggacgcctgctgtccttggtagaaaaggtgacatacctgaag aagaaacaagccgaaaaaccaattgagagtggctccaagaaatcctccactcttcagcag ttgatttctgagaccatggtccgatgggcgcaagagtctgtcattgaagaccctgaactg gtgagggccatgtttgtgttgctccatcgacagtacgatggcattgggggtctggtccgg gctctgccaaagacctacactataaatggtgtctccgtggaggataccatcaacctgctg gcatctctcggtcagattcgttctctgctgagtgtaagaatgggcaaagaagaagagaag cttatgattcgtggattaggggatatcatgaataataaagtattttaccagcaccctaat ctcatgagggcacttgggatgcacgagacggtgatggaggtcatggtgaatgtccttgga ggtggagagtccaaggaaatcacttttcccaagatggtggccaactgttgccgttttctt tgttacttctgtcgtataagtcggcagaatcaaaaagctatgtttgaccatctcagctat ttattggagaacagcagtgttggtcttgcctcaccagcaatgagaggttcaacaccgttg gatgtggcagccgcatcagtgatggataataatgaactggccttagctctgcgtgagcca gatttggaaaaggtagttcgatatttggctggttgtggactgcagagttgcccgatgctg gtatctaagggttacccagatattgggtggaatccagttgaaggagagagataccttgac tttctccgatttgctgtcttctgtaatggggagagtgtggaagagaatgctaatgttgtg gtgaggttgcttatccggaggcccgagtgtttcggtcctgctttgagaggggaaggtggg aacggtcttcttgcagcaatggaagaagccataaaaatagccgaggatccctctcgagat ggtccctcaccgactagcggatccagtaaaacacttgagacagaagaggaggaggatgac actatccacatggggaatgccatcatgacgttttatgcagctttgattgacctcttagga cgctgtgctcctgaaatgcatttgattcatgctggtaagggggaagccatcagaatccgg tcaattctgagatccctaattccactgggagatttggtgggagtaatcagcattgctttt cagatgccaacaatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttt tgcccagatcacaaggcagccatggttttgttccttgacagggtctatggcattgaggtt caagatttcctcctccatcttctcgaggttggctttctgcctgatctccgggctgctgct tctttagatacggctgctttgagtgccacagacatggccctggccctcaatcggtacctt tgcacagccgtgttgcctttgttaacaaggtgtgcccctctttttgcgggcacagaacac cacgcttctctcattgactcgttactgcacactgtgtacagactttcgaagggctgctca cttaccaaagctcagcgggattccatagaagtttgtttgctctccatttgtggccaattg agaccttctatgatgcagcacttgctccgaagattagtgtttgatgtcccattattaaat gaacatgcgaagatgcctcttaagttgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtgggggaacttcggagctgcctcagaagaagaacttcattta tcaagaaagttgttttggggcatttttgacgccctgtctcaaaagaaatatgaacaagaa cttttcaaactggcactgccttgcctgagtgccgttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaacccacaacctgttgatacctcaaacattacaattcctgagaagttggaatacttc attaacaaatatgctgaacattctcatgacaaatggtcaatggacaagttggcaaatgga tggatttatggagaaatatattcagactcgtctaaagttcagccgttaatgaagccatat aaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatctttaaaa accatgctggcatggggttggagggttgagagaacacgggagggagacagcatggccctc tacaaccgttctcgtcgtatttctcagacaagccaggtttctgttgatgctgcgcatggt tatagcccccgagccattgatatgagcaatgtcacactgtccagagacctgcacgctatg gcagaaatgatggctgaaaactaccataatatatgggcaaagaaaaagaaaatggagctg gagtccaaaggaggtggaaaccatcccctgctggtaccctatgatacactgacagccaaa gagaaagccaaggatagggaaaaagcacaggacatcctcaagttcttgcagatcaatgga tatgctgtatccaggggattcaaggacctggaattggacacaccttccattgagaaacga tttgcctatagtttccttcagcaactcattcgctatgtggatgaagcccatcagtatatc ctggagtttgatggtggcagcagaagcaaggcggaacattttccttacgagcaagaaatc aagttctttgctaaagttgtgcttcctttaattgatcagtatttcaaaaaccatcgttta tacttcttatctgcagcaagcagacccctctgttctggaggacatgcgtcaaacaaggag aaagaaatggtgacgagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttggaaatgatgccacatcaattgtcaactgtcttcatattttgggtcagactttg gatgcaaggaccgtcatgaagactggcctggagagcgttaaaagtgcgctcagaacgttt ctggacaatgcggcggaggatctggagaagacgatggagaatctcaagcagggccagttc acccacacccgaaaccaacccaaaggtgttactcagattatcaattataccacggtggct ctgttgccaatgctgtcatcattatttgagcatattggccagcatcagttcggagaagat ctaatattggaagatgtacaggtgtcatgttatagaattctgactagcttatatgctttg ggaaccagcaaaagtatttatgtggaaaggcaacgctctgcattaggagaatgtcttgct gcttttgctggtgcctttcctgtcgcatttttggaaactcatctcgacaaacataacatc tactctatctacaataccaagtcatcgcgagaaagagcagctctgaatttgccaactaac gtggaagatgtgtgcccaaatataccgtctttggagaaactcatggaagaaattgtggaa ttagcggagtccggcattcgctacacgcagatgccacacgtcatggaagtcatactgccc atgctttgcagctacatgtctcgttggtgggagcacggacctgaaaataatccagaaagg gctgaaatgtgctgtaccgccctgaactccgagcacatgaacacgctcttggggaatata ttgaaaatcatatataataacctgggaattgatgagggagcctggatgaagaggttagca gtattttcacagcccattataaataaagtgaaacctcagctcctgaaaactcatttcttg ccattaatggagaaactcaagaaaaaagcagcgatggtggtgtcggaggaggaccatctg aaagctgaggccaggggggatatgtccgaggcagagcttctcattctcgatgagttcacc actctggccagggacctctatgccttctacccgctcttgattagatttgtggactataac agggcaaagtggctaaaagaacctaacccagaagcagaggaccttttccgcatggtggct gaagtgtttatctactggtcaaaatcccacaatttcaaaagagaagagcagaactttgtg gtacagaatgaaatcaacaatatgtctttccttattacggacaccaagtcaaagatgtca aaggccgctgtctctgatcaggaaaggaagaagatgaagcgcaaaggagatcggtactcc acgcagacctctctcattgtggcagctctgaagcggttgctgcccattgggttgaacatc tgtgcccctggggaccaggagctcatcgctctggccaaaaaccgatttagtatgaaagac actgaggatgaagtacgagatataatccgcagtaatattcatttacaaggcaagttggag gatcctgctatcagatggcaaatggctctttacaaagacttaccgaacaggactgaagat acatcagatccagagaagaccgtagagagagtattagatatagcaaatgtgctttttcat cttgagcagaaatctacatctatgcaccggagatattacagtctgggaagtacagtggag cacccacagagatcgaagaaagctgtatggcacaaacttctgtccaagcagaggaagagg gcagtggtggcctgcttccgaatggctcctttatataatctgccaaggcaccgggccgtt aacctctttcttcagggatacgaaaagtcttggattgaaacagaagaacactactttgaa gataagctgatagaagatttagcaaaacctggagcagaccctccagaggaagaggaaggc acgaagagagtcgaccccctccatcagctcatccttctgtttagtcgaacagctttaaca gagaaatgcaaactggaggaagattttttatatatggcttatgcagatattatggcaaag agttgtcatgatgaggaagatgatgatggtgaagaagaagtgaagagttttgaagaaaaa gaaatggagaagcagaagcttctgtaccagcaagccaggctccatgaccgcggggctgct gagatggtgctacagaccatcagtgccagcaaaggtgatactggaccaatggtagcggcg actttgaaacttggaattgcaatcttaaatggcgggaactccacagttcagcagaaaatg cttgactatctcaaggagaagaaggacgtgggtttctttcagagccttgccggcctgatg cagtcgtgcagcgtcctcgacctaaatgcatttgagcggcagaacaaagctgaaggactt ggaatggtcacggaagaaggatcaggagaaaaggttctccaagatgacgagttcacgtgt gacctcttccgtttcctccagctgctttgtgagggacacaactcagattttcaaaattat ctgagaactcagactggcaataacacaactgtcaacatcatcatctctaccgtagactac ctactcagagtccaggaatccattagtgatttctattggtattactctgggaaagatgtt attgatgaacaaggacaacggaatttctccaaagcaattcaagtagcaaaacaagtcttt aacacgctcacagagtatattcagggtccttgcactgggaatcagcagagcttggcccac agcaggctatgggacgcagttgtgggcttccttcacgtattcgcccacatgcagatgaag ctgtctcaggattccagtcaaatcgagctattaaaagaattaatggatcttcagaaggat atggtggtcatgttgctgtccatgctagaaggtaatgttgtcaatggaaccattggcaaa cagatggtcgatatgcttgtggagtcttccaacaacgtggagatgattctcaagtttttt gacatgttcttaaaactaaaggatttgacctcttctgacacatttaaagaatacgaccct gacggcaagggagtcatttccaagagggacttccataaagcgatggagagccataaacac tacacgcaatcagaaaccgagtttcttctgtcctgtgcagagacggatgaaaacgaaacc ctggactatgaagagtttgtcaaaaggtttcacgagcccgcaaaggacatcggcttcaac gtggccgttcttctgaccaacctttcggagcacatgcccaatgatacgcgactgcagact ttcctggagttggcagagagcgtgctgaattacttccagccctttctgggccgcatcgag atcatgggaagtgccaaacgcatcgagagggtgtattttgaaatcagtgagtccagccga acccagtgggagaagccccaggtcaaggagtccaaaaggcagttcatatttgacgtggtc aacgaagggggagaaaaggagaaaatggaactttttgtcaacttctgtgaggacaccata ttcgaaatgcagctggcagcgcagatctcagagtcggatttgaatgagaggtcagcgaat aaagaagagagtgagaaggagaagccagaagagcaggggcccagaatgggtttcttttcc atcgtgacggtcaagtcggccctgtttgctctcaggtataatatcttgaccctcatgaga atgctcagcctgaagagcctgaagaaacagatgaaaaaggtgaagaagatgacgatgaag gatatggtcacggccgccttttcgtcctactggagtattttcatgagcctcctgcacttt gtggccagcgtttccagaggcttcttccgcatcatttgcagcctgctgcttggcgggagc ctagtagaaggagcaaaaaagatccgagtggcagaactcttagccaacatgccagacccc actcaggatgaggtgagaggggatggagaagagggggacaggaggcccatggaggccgcc ctgccctcggaagatctgacagacctgaaggaactgacagaggaaagcgaccttctttcg gacatatttggcttggatctgaagagagaaggaggacagtacaaacttattcctcataat ccaaacgctggcctcagcgatctaatgagcaacccggtccctatccctgacgtgcaagaa aaatttcaggaacagaaggtgaaagaggaagaaaaggaggagaaagaagaaagcaaatct gaacctgaaaaggccgagggagaagatggagaaaaagaagaaaaagccaaagaagataag ggtaaacagaagttgaggcagctccacacacacagatacggagagccagaagttcccgag tcggcattctggaagaaaatcatcgcatatcaacagaaacttctaaactattttgctcgc aacttttacaacatgagaatgttagccttattcgtcgcgtttgcaatcaatttcatcttg ctcttttataaggtctccacttcttctgtggttgaaggaaaggagccccccactcgcagt tcaagtggaaatgccaaagttagcagcctggacagtggctcgcctagaatcatcgcggtt cattacgtcctggaggagagcagcggctacatggagcccacgctgcggatcttagccatt cttcacacggtcatttctttcttctgcatcatcggctactactgcttgaaagtcccattg gttatttttaagcgagaaaaggaagtagctcgaaaattggaatttgatgggctttatatt acagaacagccttcagaagatgatattaaaggccagtgggatagactcgtaatcaacaca cagtcatttcccaacaactactgggacaaatttgttaaaagaaaggttatggataaatat ggggagttctatggccgggacagaatcagcgagctccttggtatggacaaagccgcccta gatttcagcgatgcccgggaaaagaagaagccaaagaaagacagctccctgtcagccgta ctgaactctattgatgtgaagtatcagatgtggaaactaggagtcgtcttcacggacaac tctttcctctacctggcctggtatatgactatgtccattctgggacactataacaacttt ttttttgctgctcatcttcttgacattgccatgggattcaagacactgagaaccatcttg tcatcggtaactcacaatggcaagcagcttgtattaactgttggcttgttagctgttgtt gtatacctatatactgttgtggcattcaactttttccgaaaattctacaataaaagtgaa gatggtgacacaccggatatgaaatgtgatgatatgctaacgtgctacatgttccacatg tacgtcggggtacgtgccggagggggtatcggcgatgaaatcgaagacccagcaggcgac gaatatgagatctatcgaatcatctttgacatcaccttcttcttcttcgtgattgtcatc ctcttggccataattcaaggtttaattattgatgcttttggagagctaagagaccaacag gagcaagtcaaagaagacatggagaccaaatgtttcatctgtgggataggcaacgattac ttcgacacagtgccacatggctttgaaacccacactttacaggaacacaacctggccaat tacctgttttttctgatgtatctcataaacaaagatgaaacagagcacacgggacaggaa tcttatgtctggaagatgtatcaagaaagatgctgggaattcttcccagcaggggattgt ttccggaaacagtatgaagaccagctaaattaa

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