KEGG   Panthera leo (lion): 122202777
Entry
122202777         CDS       T10741                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
plez  Panthera leo (lion)
Pathway
plez01522  Endocrine resistance
plez04010  MAPK signaling pathway
plez04012  ErbB signaling pathway
plez04014  Ras signaling pathway
plez04024  cAMP signaling pathway
plez04068  FoxO signaling pathway
plez04071  Sphingolipid signaling pathway
plez04137  Mitophagy - animal
plez04140  Autophagy - animal
plez04141  Protein processing in endoplasmic reticulum
plez04210  Apoptosis
plez04215  Apoptosis - multiple species
plez04217  Necroptosis
plez04310  Wnt signaling pathway
plez04380  Osteoclast differentiation
plez04510  Focal adhesion
plez04530  Tight junction
plez04620  Toll-like receptor signaling pathway
plez04621  NOD-like receptor signaling pathway
plez04622  RIG-I-like receptor signaling pathway
plez04625  C-type lectin receptor signaling pathway
plez04657  IL-17 signaling pathway
plez04658  Th1 and Th2 cell differentiation
plez04659  Th17 cell differentiation
plez04660  T cell receptor signaling pathway
plez04664  Fc epsilon RI signaling pathway
plez04668  TNF signaling pathway
plez04722  Neurotrophin signaling pathway
plez04723  Retrograde endocannabinoid signaling
plez04728  Dopaminergic synapse
plez04750  Inflammatory mediator regulation of TRP channels
plez04910  Insulin signaling pathway
plez04912  GnRH signaling pathway
plez04914  Progesterone-mediated oocyte maturation
plez04917  Prolactin signaling pathway
plez04920  Adipocytokine signaling pathway
plez04926  Relaxin signaling pathway
plez04930  Type II diabetes mellitus
plez04931  Insulin resistance
plez04932  Non-alcoholic fatty liver disease
plez04933  AGE-RAGE signaling pathway in diabetic complications
plez04935  Growth hormone synthesis, secretion and action
plez04936  Alcoholic liver disease
plez05010  Alzheimer disease
plez05012  Parkinson disease
plez05016  Huntington disease
plez05017  Spinocerebellar ataxia
plez05020  Prion disease
plez05022  Pathways of neurodegeneration - multiple diseases
plez05132  Salmonella infection
plez05133  Pertussis
plez05135  Yersinia infection
plez05142  Chagas disease
plez05145  Toxoplasmosis
plez05152  Tuberculosis
plez05161  Hepatitis B
plez05162  Measles
plez05166  Human T-cell leukemia virus 1 infection
plez05167  Kaposi sarcoma-associated herpesvirus infection
plez05169  Epstein-Barr virus infection
plez05170  Human immunodeficiency virus 1 infection
plez05171  Coronavirus disease - COVID-19
plez05200  Pathways in cancer
plez05208  Chemical carcinogenesis - reactive oxygen species
plez05210  Colorectal cancer
plez05212  Pancreatic cancer
plez05231  Choline metabolism in cancer
plez05415  Diabetic cardiomyopathy
plez05417  Lipid and atherosclerosis
plez05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:plez00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    122202777 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122202777 (MAPK8)
   04012 ErbB signaling pathway
    122202777 (MAPK8)
   04014 Ras signaling pathway
    122202777 (MAPK8)
   04310 Wnt signaling pathway
    122202777 (MAPK8)
   04668 TNF signaling pathway
    122202777 (MAPK8)
   04068 FoxO signaling pathway
    122202777 (MAPK8)
   04071 Sphingolipid signaling pathway
    122202777 (MAPK8)
   04024 cAMP signaling pathway
    122202777 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122202777 (MAPK8)
   04137 Mitophagy - animal
    122202777 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    122202777 (MAPK8)
   04215 Apoptosis - multiple species
    122202777 (MAPK8)
   04217 Necroptosis
    122202777 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122202777 (MAPK8)
   04530 Tight junction
    122202777 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    122202777 (MAPK8)
   04621 NOD-like receptor signaling pathway
    122202777 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    122202777 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    122202777 (MAPK8)
   04660 T cell receptor signaling pathway
    122202777 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    122202777 (MAPK8)
   04659 Th17 cell differentiation
    122202777 (MAPK8)
   04657 IL-17 signaling pathway
    122202777 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    122202777 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122202777 (MAPK8)
   04920 Adipocytokine signaling pathway
    122202777 (MAPK8)
   04912 GnRH signaling pathway
    122202777 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    122202777 (MAPK8)
   04917 Prolactin signaling pathway
    122202777 (MAPK8)
   04926 Relaxin signaling pathway
    122202777 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    122202777 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    122202777 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    122202777 (MAPK8)
   04722 Neurotrophin signaling pathway
    122202777 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122202777 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    122202777 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122202777 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    122202777 (MAPK8)
   05231 Choline metabolism in cancer
    122202777 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122202777 (MAPK8)
   05212 Pancreatic cancer
    122202777 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122202777 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    122202777 (MAPK8)
   05161 Hepatitis B
    122202777 (MAPK8)
   05171 Coronavirus disease - COVID-19
    122202777 (MAPK8)
   05162 Measles
    122202777 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122202777 (MAPK8)
   05169 Epstein-Barr virus infection
    122202777 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122202777 (MAPK8)
   05135 Yersinia infection
    122202777 (MAPK8)
   05133 Pertussis
    122202777 (MAPK8)
   05152 Tuberculosis
    122202777 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    122202777 (MAPK8)
   05142 Chagas disease
    122202777 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122202777 (MAPK8)
   05012 Parkinson disease
    122202777 (MAPK8)
   05016 Huntington disease
    122202777 (MAPK8)
   05017 Spinocerebellar ataxia
    122202777 (MAPK8)
   05020 Prion disease
    122202777 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    122202777 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122202777 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    122202777 (MAPK8)
   05415 Diabetic cardiomyopathy
    122202777 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    122202777 (MAPK8)
   04936 Alcoholic liver disease
    122202777 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    122202777 (MAPK8)
   04931 Insulin resistance
    122202777 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122202777 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    122202777 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:plez01001]
    122202777 (MAPK8)
Enzymes [BR:plez01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     122202777 (MAPK8)
Protein kinases [BR:plez01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   122202777 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH DUF530
Other DBs
NCBI-GeneID: 122202777
NCBI-ProteinID: XP_042765233
UniProt: A0A8C8Y9D9
LinkDB
Position
D2:45813804..45912533
AA seq 427 aa
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacagcaatttttatagtgtagagattggagattctacattt
acagttttgaaacgatatcagaatttaaaacctataggctcaggagctcaaggaattgta
tgtgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaagctgagccggccg
tttcagaatcagactcatgctaaacgggcttacagagagctagttctaatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggaactagatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcccagtaatatagtggtaaaa
tcagactgcactttgaagattcttgactttggactggccaggactgcaggaactagtttt
atgatgacgccttacgtagtgactcgctactacagagcacctgaggtcatcctagggatg
ggctacaaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccatgccctgaattcatgaagaaactacaaccaacagtaaggacttacgtt
gaaaacagacctaaatatgctggatatagctttgagaaactcttccccgatgtacttttc
ccagctgactcggaacacaacaaacttaaagccagtcaggcaagggacttgttatccaaa
atgctggtaattgatgcatctaaaaggatctctgtagatgaagccctccagcatccatat
atcaatgtctggtatgatccttctgaagcagaagctccaccacccaagatacctgacaag
caattagatgaaagggaacatacaatagaagagtggaaagagttgatatacaaagaagtt
atggacttggaggagagaaccaagaatggagttatacgggggcagccctctcctttaggt
gcagcagtgatcaatggctctcagcatccatcgtcatcatcgtctgtcaatgatgtgtct
tcaatgtcaacagatccgactttggcctcagatacagatagcagtctggaagcatcagct
ggacctctgggctgttgtagatga

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