KEGG   Panthera leo (lion): 122203952
Entry
122203952         CDS       T10741                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
plez  Panthera leo (lion)
Pathway
plez01521  EGFR tyrosine kinase inhibitor resistance
plez01522  Endocrine resistance
plez04010  MAPK signaling pathway
plez04012  ErbB signaling pathway
plez04014  Ras signaling pathway
plez04015  Rap1 signaling pathway
plez04022  cGMP-PKG signaling pathway
plez04024  cAMP signaling pathway
plez04062  Chemokine signaling pathway
plez04068  FoxO signaling pathway
plez04071  Sphingolipid signaling pathway
plez04072  Phospholipase D signaling pathway
plez04140  Autophagy - animal
plez04150  mTOR signaling pathway
plez04151  PI3K-Akt signaling pathway
plez04210  Apoptosis
plez04218  Cellular senescence
plez04270  Vascular smooth muscle contraction
plez04360  Axon guidance
plez04370  VEGF signaling pathway
plez04371  Apelin signaling pathway
plez04510  Focal adhesion
plez04540  Gap junction
plez04550  Signaling pathways regulating pluripotency of stem cells
plez04613  Neutrophil extracellular trap formation
plez04625  C-type lectin receptor signaling pathway
plez04630  JAK-STAT signaling pathway
plez04650  Natural killer cell mediated cytotoxicity
plez04660  T cell receptor signaling pathway
plez04662  B cell receptor signaling pathway
plez04664  Fc epsilon RI signaling pathway
plez04666  Fc gamma R-mediated phagocytosis
plez04720  Long-term potentiation
plez04722  Neurotrophin signaling pathway
plez04726  Serotonergic synapse
plez04730  Long-term depression
plez04810  Regulation of actin cytoskeleton
plez04910  Insulin signaling pathway
plez04912  GnRH signaling pathway
plez04914  Progesterone-mediated oocyte maturation
plez04915  Estrogen signaling pathway
plez04916  Melanogenesis
plez04917  Prolactin signaling pathway
plez04919  Thyroid hormone signaling pathway
plez04921  Oxytocin signaling pathway
plez04926  Relaxin signaling pathway
plez04928  Parathyroid hormone synthesis, secretion and action
plez04929  GnRH secretion
plez04935  Growth hormone synthesis, secretion and action
plez05010  Alzheimer disease
plez05022  Pathways of neurodegeneration - multiple diseases
plez05034  Alcoholism
plez05132  Salmonella infection
plez05152  Tuberculosis
plez05160  Hepatitis C
plez05161  Hepatitis B
plez05163  Human cytomegalovirus infection
plez05164  Influenza A
plez05165  Human papillomavirus infection
plez05167  Kaposi sarcoma-associated herpesvirus infection
plez05170  Human immunodeficiency virus 1 infection
plez05200  Pathways in cancer
plez05205  Proteoglycans in cancer
plez05206  MicroRNAs in cancer
plez05207  Chemical carcinogenesis - receptor activation
plez05208  Chemical carcinogenesis - reactive oxygen species
plez05210  Colorectal cancer
plez05211  Renal cell carcinoma
plez05212  Pancreatic cancer
plez05213  Endometrial cancer
plez05214  Glioma
plez05215  Prostate cancer
plez05218  Melanoma
plez05219  Bladder cancer
plez05220  Chronic myeloid leukemia
plez05221  Acute myeloid leukemia
plez05223  Non-small cell lung cancer
plez05224  Breast cancer
plez05225  Hepatocellular carcinoma
plez05226  Gastric cancer
plez05230  Central carbon metabolism in cancer
plez05231  Choline metabolism in cancer
plez05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:plez00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122203952 (RAF1)
   04012 ErbB signaling pathway
    122203952 (RAF1)
   04014 Ras signaling pathway
    122203952 (RAF1)
   04015 Rap1 signaling pathway
    122203952 (RAF1)
   04370 VEGF signaling pathway
    122203952 (RAF1)
   04371 Apelin signaling pathway
    122203952 (RAF1)
   04630 JAK-STAT signaling pathway
    122203952 (RAF1)
   04068 FoxO signaling pathway
    122203952 (RAF1)
   04072 Phospholipase D signaling pathway
    122203952 (RAF1)
   04071 Sphingolipid signaling pathway
    122203952 (RAF1)
   04024 cAMP signaling pathway
    122203952 (RAF1)
   04022 cGMP-PKG signaling pathway
    122203952 (RAF1)
   04151 PI3K-Akt signaling pathway
    122203952 (RAF1)
   04150 mTOR signaling pathway
    122203952 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122203952 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    122203952 (RAF1)
   04218 Cellular senescence
    122203952 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122203952 (RAF1)
   04540 Gap junction
    122203952 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    122203952 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122203952 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    122203952 (RAF1)
   04625 C-type lectin receptor signaling pathway
    122203952 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    122203952 (RAF1)
   04660 T cell receptor signaling pathway
    122203952 (RAF1)
   04662 B cell receptor signaling pathway
    122203952 (RAF1)
   04664 Fc epsilon RI signaling pathway
    122203952 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    122203952 (RAF1)
   04062 Chemokine signaling pathway
    122203952 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122203952 (RAF1)
   04929 GnRH secretion
    122203952 (RAF1)
   04912 GnRH signaling pathway
    122203952 (RAF1)
   04915 Estrogen signaling pathway
    122203952 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    122203952 (RAF1)
   04917 Prolactin signaling pathway
    122203952 (RAF1)
   04921 Oxytocin signaling pathway
    122203952 (RAF1)
   04926 Relaxin signaling pathway
    122203952 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    122203952 (RAF1)
   04919 Thyroid hormone signaling pathway
    122203952 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    122203952 (RAF1)
   04916 Melanogenesis
    122203952 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    122203952 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    122203952 (RAF1)
   04720 Long-term potentiation
    122203952 (RAF1)
   04730 Long-term depression
    122203952 (RAF1)
   04722 Neurotrophin signaling pathway
    122203952 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    122203952 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122203952 (RAF1)
   05206 MicroRNAs in cancer
    122203952 (RAF1)
   05205 Proteoglycans in cancer
    122203952 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    122203952 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    122203952 (RAF1)
   05230 Central carbon metabolism in cancer
    122203952 (RAF1)
   05231 Choline metabolism in cancer
    122203952 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122203952 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122203952 (RAF1)
   05212 Pancreatic cancer
    122203952 (RAF1)
   05225 Hepatocellular carcinoma
    122203952 (RAF1)
   05226 Gastric cancer
    122203952 (RAF1)
   05214 Glioma
    122203952 (RAF1)
   05221 Acute myeloid leukemia
    122203952 (RAF1)
   05220 Chronic myeloid leukemia
    122203952 (RAF1)
   05218 Melanoma
    122203952 (RAF1)
   05211 Renal cell carcinoma
    122203952 (RAF1)
   05219 Bladder cancer
    122203952 (RAF1)
   05215 Prostate cancer
    122203952 (RAF1)
   05213 Endometrial cancer
    122203952 (RAF1)
   05224 Breast cancer
    122203952 (RAF1)
   05223 Non-small cell lung cancer
    122203952 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    122203952 (RAF1)
   05161 Hepatitis B
    122203952 (RAF1)
   05160 Hepatitis C
    122203952 (RAF1)
   05164 Influenza A
    122203952 (RAF1)
   05163 Human cytomegalovirus infection
    122203952 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122203952 (RAF1)
   05165 Human papillomavirus infection
    122203952 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122203952 (RAF1)
   05152 Tuberculosis
    122203952 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122203952 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    122203952 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    122203952 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122203952 (RAF1)
   01522 Endocrine resistance
    122203952 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:plez01001]
    122203952 (RAF1)
Enzymes [BR:plez01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     122203952 (RAF1)
Protein kinases [BR:plez01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   122203952 (RAF1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 122203952
NCBI-ProteinID: XP_042767069
UniProt: A0A8C8WEV1
LinkDB
Position
A2:complement(53587434..53670452)
AA seq 648 aa
MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQPFGFQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDATS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSPIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NSSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacaaggggcctggaagacgatcagcaatggctttggattcaaagatgca
gtgtttgatggccccagctgcatctcccctacaatagttcagccatttggctttcagcgt
cgggcatcagatgatggcaaacttacggactcttctaagacaagcaacactatccgtgtt
ttcttgccaaacaagcaaagaacagtggtcaatgtgagaaatggaatgagcttgcatgat
tgccttatgaaagcactcaaggtgaggggcctgcagccggagtgctgtgcagtgttcaga
cttctccatgaacataaaggtaaaaaagcgcgtttagattggaatactgatgccacctcg
ttgattggagaagaacttcaagtagatttcctggatcatgttcccctcacaacacacaac
tttgctcggaagaccttcctgaaacttgccttctgtgacatctgtcagaagttcctgcta
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttattgttcccaaattctcct
attggtgatagtggggtcccagcactgccttctttgacaatgcgtcggatgcgagaatct
gtttcccggatgcctgttagttcccagcacagatactccacaccccacgccttcacgttc
aactcttccagcccttcctctgaaggttccctctcccagaggcagaggtcaacatccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagccacagtgaatcagcctcaccttcagccttgtccagcagccctaacaatctg
agcccaacgggctggtcacagcccaaaacccctgtgccagcacagagagagagggcacca
ggatccgggacccaggagaaaaacaaaatcaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagcgaagtgatgctttccactcggattggatcaggctcattt
ggaacggtgtataagggcaagtggcatggagatgttgcagtgaaaattctaaaagttgtc
gaccccacgccagagcagttccaggccttcaggaatgaggtggctgtcctacgcaaaaca
cggcacgtgaacatcctgctcttcatgggctacatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagactaagttc
cagatgttccagttgattgacatcgcccgccagactgctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctg
acggtgaaaattggagattttggtttggcaacagtaaagtcgcgctggagcggttctcag
caggtcgaacaacccactggctctgtcctgtggatggcccccgaggtgatccgaatgcag
gataataacccattcagcttccagtctgatgtctactcctacggcattgtgctctatgag
ctcatgacaggggagcttccttactcccacatcaataaccgcgaccagatcatcttcatg
gtgggccgagggtatgcctccccagacctcagtaagctatataagaactgccccaaagca
atgaagaggcttgtagctgactgtgtgaagaaggttaaggaagagaggcctctttttccc
cagatcctgtcttccatcgagcttctccaacactctctgccgaaaatcaaccggagtgct
tctgagccatccctgcaccgggcggcccacactgaggatatcaacgcctgcacgttgacc
acatcccctagactgcctgtcttctag

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