Panthera leo (lion): 122205362
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Entry
122205362 CDS
T10741
Symbol
JAK2
Name
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
KO
K04447
Janus kinase 2 [EC:
2.7.10.2
]
Organism
plez Panthera leo (lion)
Pathway
plez01521
EGFR tyrosine kinase inhibitor resistance
plez04062
Chemokine signaling pathway
plez04081
Hormone signaling
plez04148
Efferocytosis
plez04151
PI3K-Akt signaling pathway
plez04217
Necroptosis
plez04550
Signaling pathways regulating pluripotency of stem cells
plez04630
JAK-STAT signaling pathway
plez04658
Th1 and Th2 cell differentiation
plez04659
Th17 cell differentiation
plez04725
Cholinergic synapse
plez04917
Prolactin signaling pathway
plez04920
Adipocytokine signaling pathway
plez04933
AGE-RAGE signaling pathway in diabetic complications
plez04935
Growth hormone synthesis, secretion and action
plez05140
Leishmaniasis
plez05145
Toxoplasmosis
plez05152
Tuberculosis
plez05161
Hepatitis B
plez05164
Influenza A
plez05167
Kaposi sarcoma-associated herpesvirus infection
plez05168
Herpes simplex virus 1 infection
plez05200
Pathways in cancer
plez05207
Chemical carcinogenesis - receptor activation
plez05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
plez05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
122205362 (JAK2)
04151 PI3K-Akt signaling pathway
122205362 (JAK2)
09133 Signaling molecules and interaction
04081 Hormone signaling
122205362 (JAK2)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
122205362 (JAK2)
09143 Cell growth and death
04217 Necroptosis
122205362 (JAK2)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
122205362 (JAK2)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
122205362 (JAK2)
04659 Th17 cell differentiation
122205362 (JAK2)
04062 Chemokine signaling pathway
122205362 (JAK2)
09152 Endocrine system
04920 Adipocytokine signaling pathway
122205362 (JAK2)
04917 Prolactin signaling pathway
122205362 (JAK2)
04935 Growth hormone synthesis, secretion and action
122205362 (JAK2)
09156 Nervous system
04725 Cholinergic synapse
122205362 (JAK2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
122205362 (JAK2)
05207 Chemical carcinogenesis - receptor activation
122205362 (JAK2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
122205362 (JAK2)
09172 Infectious disease: viral
05161 Hepatitis B
122205362 (JAK2)
05164 Influenza A
122205362 (JAK2)
05168 Herpes simplex virus 1 infection
122205362 (JAK2)
05167 Kaposi sarcoma-associated herpesvirus infection
122205362 (JAK2)
09171 Infectious disease: bacterial
05152 Tuberculosis
122205362 (JAK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
122205362 (JAK2)
05140 Leishmaniasis
122205362 (JAK2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
122205362 (JAK2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
122205362 (JAK2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
122205362 (JAK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
plez01001
]
122205362 (JAK2)
Enzymes [BR:
plez01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
122205362 (JAK2)
Protein kinases [BR:
plez01001
]
Non-receptor tyrosine kinases
JAK family [OT]
122205362 (JAK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
FERM_F2
FERM_F1
SH2_1
Jak1_Phl
ABC1
FERM_C_FAK1
RIO1
Kinase-like
FERM_M
Motif
Other DBs
NCBI-GeneID:
122205362
NCBI-ProteinID:
XP_042769630
UniProt:
A0A8C8Y4B4
LinkDB
All DBs
Position
D4:complement(6588310..6705757)
Genome browser
AA seq
1131 aa
AA seq
DB search
MGMACLTMTEMEGVSVSPVHQNGDIPGNANSVKQIDPLLQVYLYHSLEKADGEYLNFPTG
EYVAEEICVAASKACGITPVYHSMFALMSETERTWYPPNHVFHVDESTRHNVLYRIRFYF
PYWYCNGSNRTYRHGVSRGAEAPLLDDFVMSYLFAQWRHDFLHGWIKIPVTHETQEECLG
MAVLDMMRLAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQF
SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIVITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDVTIKQGNQEGSNESRIVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERDNVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKLKDKSNLLVFRTNGVSDVPTSPTLQRHNNVNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGLRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSISILWKLEVAKQLAWA
MHFLEEKALIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNRIGTLGFSGAFEDRDP
TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEI
LKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQIC
KGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY
APESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIEL
LKNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
NT seq
3396 nt
NT seq
+upstream
nt +downstream
nt
atgggaatggcttgccttaccatgacggaaatggaaggagtatctgtatctcctgtacat
cagaatggtgatattcctggaaatgctaattctgtgaagcaaatagatccactcctacag
gtgtatctttatcattctcttgagaaggctgatggagaatatctgaattttccaactggg
gagtatgttgcagaagaaatttgtgttgctgcttctaaagcttgtggaatcacgcccgtg
tatcatagtatgtttgctttaatgagtgaaaccgaaaggacctggtatccgcccaaccat
gtcttccatgtagatgaatcaaccaggcacaacgtactctacagaataagattttacttt
ccttactggtattgtaatggcagcaacagaacctatcggcatggagtgtctcgaggtgct
gaagctcctcttcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat
tttttacatggatggataaaaataccggtgactcatgaaacgcaggaagaatgtcttgga
atggcagtgttagatatgatgagactagccaaagagaaggatcaaaccccattggacatc
tatagctctatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagac
tatcatattttgacaaggaagagaataaggtatagatttcgcagatttattgagcagttc
agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaaca
cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca
ggtgaggagatttttgcaaccattgtaataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgtgacttt
cctgatatcattgatgtgactattaaacaaggaaaccaagaaggctcaaatgaaagtaga
attgtaactatccataagcaagatggtaaaaatctggaaattgaactaagctcattaaga
gaagctttatcctttgtgtcattaattgatggctattacagattaaccgcggatgcacat
cattacctctgtaaagaagtagcacctccgatggtgcttgaaaatatacaaagcaactgt
catggcccaattttaatggattttgccatcagtaaactgaagaaagcaggtaatcagact
ggactctatgtacttcgatgcagtcctaaggactttaataaatattttctgacttttgct
gtcgagcgagataatgtcatcgaatataagcattgtttgattacaaaaaatgagaatgga
gaatacaacctcagcgggaccaagaagaacttcagtaatcttaaagatcttttgaattgc
taccagatggaaactgttcgctccgacagtataattttccagtttactaaatgctgcccc
ccaaagttgaaagataaatcaaatcttctagtctttagaaccaatggcgtttctgatgta
ccaacatcaccaacattacagaggcataataatgtgaaccaaatggtgtttcacaaaatc
agaaatgaagatttgatatttaatgaaagccttgggcaaggcacttttacaaaaattttt
aaaggtctaagaagagaagtaggagactatggtcaactgcatgaaacagaagttctttta
aaagttctggataaagcacacagaaactattcagagtctttctttgaagcagcaagcatg
atgagccagctttctcacaagcacctggttttaaattatggagtatgtgtctgtggagag
gaaaatattctggttcaggagtttgtaaaatttggatcattagatacatacctgaaaaag
aataaaaattctataagtatattatggaaacttgaagtggctaaacagttggcatgggcc
atgcattttctagaagaaaaagcccttattcatgggaatgtgtgtgccaaaaatattctg
cttatcagagaagaagacagaaagacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaaatctaaacttggcaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagacaagcctctgagtgctttggattctcaa
agaaagctccagttttatgaagataggcaccagcttcctgcaccaaagtggacagaatta
gcaaatcttattaataattgtatggattatgaaccagattttagaccttctttcagagcc
atcatacgagaccttaatagtttgtttactccagattacgagctattaacagaaaatgac
atgttgccaaataggataggcaccctcgggttttctggagcttttgaagaccgagacccg
acacagtttgaagagagacacttgaaatttctacagcagcttggcaagggcaattttggc
agtgtggagatgtgccggtatgaccctctacaagacaacactggggaggtggtggccgtg
aagaagctccagcacagtactgaggagcacctgagagactttgaaagagaaatcgaaatc
cttaaatccctgcagcatgacaacattgtcaagtacaagggagtgtgctacagtgctggc
cggcgtaatttaagattaattatggaatatttaccatatggaagtttacgagattatctc
caaaaacataaagaacggatagatcataaaaaacttctgcagtatacatctcagatatgc
aagggcatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaaggaat
atattggtggagaatgaaaacagggttaaaattggagattttggcttaaccaaagtcttg
ccacaagacaaagaatactacaaagtgaaagaacctggtgaaagtcccatattctggtat
gctccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagctttgga
gtggttctgtatgaacttttcacatacatcgagaagagtaaaagtccaccagcggaattt
atgcgtatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaactc
ctaaagaataatggaagattaccaagaccagatggatgcccagatgagatttatttgatt
atgactgaatgctggaacaataatgtaaatcagcgcccctcttttagagacctagctctt
cgagttgatcaaataagggacaacatggctggatga
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