Panthera leo (lion): 122205364
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Entry
122205364 CDS
T10741
Symbol
NOTCH1
Name
(RefSeq) neurogenic locus notch homolog protein 1 isoform X1
KO
K02599
Notch 1
Organism
plez
Panthera leo (lion)
Pathway
plez01522
Endocrine resistance
plez04330
Notch signaling pathway
plez04658
Th1 and Th2 cell differentiation
plez04919
Thyroid hormone signaling pathway
plez05020
Prion disease
plez05165
Human papillomavirus infection
plez05200
Pathways in cancer
plez05206
MicroRNAs in cancer
plez05224
Breast cancer
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
122205364 (NOTCH1)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
122205364 (NOTCH1)
09152 Endocrine system
04919 Thyroid hormone signaling pathway
122205364 (NOTCH1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
122205364 (NOTCH1)
05206 MicroRNAs in cancer
122205364 (NOTCH1)
09162 Cancer: specific types
05224 Breast cancer
122205364 (NOTCH1)
09172 Infectious disease: viral
05165 Human papillomavirus infection
122205364 (NOTCH1)
09164 Neurodegenerative disease
05020 Prion disease
122205364 (NOTCH1)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
122205364 (NOTCH1)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
EGF
hEGF
EGF_TEN
EGF_CA
EGF_2
Ank_2
Ank
Notch
NOD
NODP
Ank_5
Ank_4
Ank_3
EGF_3
EGF_DL_JAG
JAG1-like_EGF2
Motif
Other DBs
NCBI-GeneID:
122205364
NCBI-ProteinID:
XP_042769638
UniProt:
A0A8C8Y0E1
LinkDB
All DBs
Position
D4:92187054..92231314
Genome browser
AA seq
2536 aa
AA seq
DB search
MPPLLAPLLCLALLPALAARGLRCSQPSESCMNGGKCEVSPNGTEACVCSGAFAGRRCQA
PNPCLSAPCKNAGTCHAVDHGGPVDYACACRLGFSGPLCLTPRDNACLAKPCRNGGTCDL
LTLTEYKCRCPPGWSGKMCQQADPCASNPCANGGQCLPFEASYICRCPPGFHGPTCRQDV
NECGQSPGLCRNGGTCHNEVGSYRCTCRATHTGPHCELPYVPCSPSPCQNGGTCRPTGDT
THECACLPGFTGQNCEENIDDCPGNSCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDEC
QLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYC
ECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLG
ANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECISNPCQNDATCLDQIGEFQCICM
PGYEGVHCEVNTDECASSPCLQNGRCLDKINEFLCECPTGFTGHLCQFDVDECASTPCRN
GAKCLDGPNTYTCVCTEGYTGPHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHH
CETNVNECHSQPCRHGGTCQDRDNAYLCLCLKGTTGPNCETNLDDCASSPCDSGTCLDKI
DGYECSCEPGYTGSMCNVNIDECAGNPCHHGGTCEDGTNSFTCRCPEGYHGPTCLSEVNE
CSSNPCIHGACRDSLNGYTCDCDPGWSGAHCDINTNECESNPCANGGACRDMTSGYVCTC
REGFSGPNCQTNINECASNPCLNQGSCIDDVAGYTCNCPLPYTGATCEVVLAPCAPGPCR
NGGECQESEDFESFSCVCPAGWQGQTCEVDINECVKNPCRHGASCQNTNGGYRCRCRAGY
TGHNCETDVDDCRPNPCHNGGSCTDGVNTAFCDCLPGFRGAFCEEDINECASNPCHHGAN
CTDCVDSYTCTCPTGFSGIHCENNTPDCTESSCFNGGTCVDGISSFTCLCPPGFTGSYCQ
HDVNECDSRPCLHGGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSSPCKNGGKCWQTNT
LYRCECHSGWTGLYCDVPNVSCEVAARRRDINVTHLCRNGGLCMDAGNTHHCRCQAGYTG
SYCEDQVDECSPSPCQNGATCTDYPGGYSCECVAGYHGVNCSEEINECLSHPCQNGGTCI
DLINTYKCSCPRGTQGVHCEVNVDDCSPLIDPVSRGPKCFNNGTCVDQVGGYSCACPPGF
VGERCEGDVNECLSNPCDARGTQNCVQRVNDFYCECRAGHTGRRCESVINGCKGRPCQNG
GTCAVASNTARGFICKCPAGFEGATCENDARACGSLRCLNGGTCISGPRSPTCLCLGPFT
GPECQFPAGSPCVGGNPCYNQGSCEPMPESPFYRCLCPAKFNGLLCHILDYSFGGGLGVD
IPPPQIEEACELPECREEAGNKVCSLGCNNHACGWDGGDCSLNFNDPWQNCSQSLQCWKY
FSDGRCDSQCNSAGCLFDGFDCQRADGQCNPLYDQYCKDHFGDGHCDQGCNSAECEWDGL
DCAEHVPERLAAGALVLVVLTPPAQLRNNSLHFLRELSRLLHTNVVFKRDAHGQPMVFPY
YGREEELRKHPIKRAVDGWAAPGALLDRVEAALLPGGGAGRRRRELDPMDIRGSIVYLEI
DNRQCVQSSSQCFQSATDVAAFLGALASLGSLNIPYKIEAVQSETVEPPPPPQLHFMYVA
VAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKNA
SDGALMDDSQHEWGDEDLEAKKFRFEEPVVLPDLDDQADHRQWTQQHLDAADLRVSAMAP
TPPQGEADADSMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGASL
HNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQIL
IRNRATDLDARMHDGTTPLILAARLAVEGMLEDLVNSHADVNAVDDLGKSALHWAAAVNN
VEAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDI
AQERMHHDIVRLLDEYSLARSPQLHGTALGGAPTLSPPLCSPGSYLGNLKPAVQGKKARK
PSTKGLACGGKEAKDLKARRKKPQDGKGCLLDSSSVLSPVDSLESPHGYLSDVASPPLLP
SPFQQSPAVPLNHLPGMPDTHLGVGHLSVAAKPEMAGLGGGGRLAFEAGPPRLSHLPAAS
STSTVLGTGGGVNFTVGGAAGLNGQCEWLSRLQNGLVPNQYNPLRGNVAPGTLSTQAPAL
QHSMMGPLHAGLSTAALSQMMSYQALPGTRLAGQPHLVQTQPPQQNLQMQPPNLQPQPPQ
PHLGVASAAGGHVGRSFLGGEPSQADVQPLGPGGLAVHTILPQDSQALPATLAPPMTTAQ
FLTPPSQHSYSSSPADNTPSHQLQVPEHPFLTPSPESPDQWSSSSPHSHVSDWSEGISSP
PTSTQSHIAHIPEALK
NT seq
7611 nt
NT seq
+upstream
nt +downstream
nt
atgccgccgctcctggcgcccctgctctgcctggcgctgctgcccgcgctcgccgcacga
ggactgcgatgttcccagcccagcgagagctgcatgaatggcgggaagtgtgaagtgtcc
cccaacggcacggaagcctgtgtctgtagcggtgccttcgcgggccggcgatgccaggcg
cccaacccctgcctcagcgccccctgcaagaacgcgggcacgtgccacgcggtggaccac
ggcggcccggtggactacgcctgtgcctgccgcctgggcttctccgggcccctctgcctg
acgccccgggacaacgcctgcctcgccaagccctgccgcaacggcggcacctgtgacctg
ctcacgctgaccgagtacaagtgccgctgcccccccggctggtcagggaagatgtgccag
caggccgacccgtgtgcctccaacccgtgtgccaatggcggccagtgcctgcccttcgag
gcctcgtacatctgccgctgcccgcccggcttccacggccccacctgcaggcaggacgtc
aacgagtgcggccagagccccgggctctgtcgcaacggaggtacctgccacaacgaggtc
ggctcctaccgctgcacctgccgcgccacccacaccggcccccactgcgagctgccctac
gtgccctgcagcccctcaccctgccagaacgggggcacctgccgccccacgggggacacc
acccacgagtgcgcctgcctgccaggcttcactggccagaactgcgaggagaatatcgac
gactgtcccggaaacagctgcaagaacggaggcgcctgcgtggacggcgtgaacacttac
aactgccgctgcccgcccgagtggacaggccagtactgcaccgaggacgtagacgagtgc
cagctgatgcccaacgcctgccagaacggcgggacctgccacaacacccacggcggctac
aactgcgtgtgcgtcaacggctggacgggggaagactgcagcgagaacatcgacgactgt
gccagcgccgcctgcttccacggggccacctgccacgaccgagtggcctccttctactgc
gagtgtcctcatggccgcaccggtctgctctgccatctaaacgacgcctgcatcagcaac
ccttgcaacgagggctccaactgtgacaccaaccccgtcaacggcaaggccatctgcacc
tgcccctccgggtacacgggcccggcctgcagccaggacgtggacgagtgctcgctgggc
gccaacccctgtgagcacgcgggcaagtgcatcaacacgctgggctctttcgagtgccag
tgtctgcagggctacacgggcccgcgctgcgagattgacgtcaacgagtgcatctcgaac
ccgtgtcagaatgacgccacctgcctggaccagatcggggagttccagtgcatctgcatg
ccgggctacgagggcgtgcactgtgaggtcaacacggacgagtgcgccagcagcccctgc
ctccagaacggccgctgcctggacaaaatcaacgagtttctgtgcgagtgccccacaggc
ttcaccgggcacctgtgtcagtttgacgtggacgagtgtgcaagcacgccttgcaggaac
ggcgccaagtgcctggacgggcccaacacctacacctgcgtgtgcacggaaggctacacg
gggccgcactgcgaggtggacattgacgagtgtgaccccgatccttgccactacgggtcg
tgcaaggatggtgttgccaccttcacctgcctgtgccggccgggctacacgggccaccac
tgcgagaccaacgtcaacgagtgtcacagccagccctgccgccacggcggcacctgccag
gaccgcgacaacgcctacctgtgcctctgcctcaaagggaccacaggacccaactgtgag
accaacctagatgactgtgccagcagcccctgtgactcaggcacgtgtctggacaagatc
gacggctacgagtgctcgtgcgagccgggctacacagggagcatgtgcaacgtcaacatc
gacgagtgtgcgggcaacccctgccaccacgggggcacctgcgaggacggcaccaacagc
ttcacctgccgctgccccgagggctaccacggccccacgtgcctgtccgaggtcaacgag
tgcagcagcaacccctgcatccacggggcctgccgggacagcctcaacgggtacacgtgt
gactgtgaccccgggtggagtggggctcactgtgacatcaacaccaacgagtgtgagtcc
aacccctgcgccaacgggggcgcctgtagagacatgaccagcggctacgtgtgcacctgc
cgcgagggcttcagtgggcccaattgccaaaccaacatcaacgagtgtgcgtctaacccg
tgcctgaaccagggctcgtgcatcgatgatgtggccggctacacgtgcaactgcccgctg
ccctacacaggagccacgtgtgaggtggtgctggccccgtgcgcccccggcccctgcagg
aacggtggcgagtgccaggagtccgaggacttcgagagcttctcgtgcgtctgtcctgca
ggctggcaaggacagacgtgcgaggtcgacatcaacgagtgtgtcaagaacccgtgccgc
cacggcgcctcctgccagaacaccaacggcggctaccgttgtcgctgccgcgccggctac
acggggcacaactgcgagacggacgtggatgactgccgacccaacccgtgccacaacggc
ggctcctgcacagacggcgttaacacggctttctgcgactgcctgcctggcttccggggg
gctttctgcgaggaggacatcaacgagtgcgccagcaacccctgccaccacggtgccaac
tgcaccgactgcgtggacagctacacctgcacctgccccacgggcttcagcggcatccac
tgcgagaacaacacgcccgactgcacagagagctcctgtttcaacggcggcacctgcgtg
gacggcatcagctccttcacctgtctgtgtccgcctggcttcacgggcagctactgccag
cacgacgtcaacgagtgtgattctcggccctgcctgcacggcggcacctgccaggacagc
tacgggacctacaagtgcacctgcccacagggctacacgggcctcaactgccagaacctc
gtgcgctggtgcgactcctcaccgtgtaagaacggcggcaagtgctggcagaccaacacc
ctgtaccgctgcgagtgccacagcggctggaccggcctctactgcgacgtgcccaacgtg
tcctgcgaggtggccgcacggcgccgagacatcaacgtcacccacctgtgccggaacggg
gggctctgcatggacgcgggcaacacgcaccactgtcgctgccaggccggctacacgggc
agctactgcgaggaccaggtggacgagtgctcgcccagcccctgccagaatggggccacc
tgcaccgactaccctggcggctactcctgcgagtgcgtggccgggtaccacggggtgaac
tgctctgaggagatcaacgagtgtctgtcccacccatgccaaaacgggggcacctgcatc
gacctcatcaacacctacaagtgttcctgtccccggggcacacagggtgtgcactgtgag
gtcaacgtggacgactgcagtcccctcatcgaccccgtctcccggggccccaagtgcttt
aacaacggcacctgtgtggaccaggtcggcggctacagctgcgcctgcccacccggcttc
gtgggcgagcgctgtgagggagacgtgaacgagtgcctgtccaacccctgcgacgcccgt
ggcacccagaactgcgtgcagcgcgtcaacgacttctactgcgagtgccgcgcgggccat
acaggacgccgctgtgagtcggtcatcaacggctgtaagggcaggccctgccagaacggg
ggcacttgcgccgtggcctccaacactgcccgcgggttcatctgcaagtgcccggcgggc
ttcgagggcgccacgtgcgagaacgacgcgcgcgcctgcgggagcctgcgctgcctcaac
ggcggcacgtgcatctcgggcccgcgcagccccacctgcctgtgcctgggccccttcacg
ggccccgagtgccagttcccggccggcagcccctgcgtgggcggcaacccctgctacaac
cagggcagctgcgagccgatgcccgagagccccttctaccgctgcctgtgccccgccaag
ttcaacgggctcctgtgccacatcctggactacagcttcgggggcggcctgggcgtcgac
atccccccgccgcagatcgaggaggcgtgcgagctgcccgagtgccgcgaggaggcgggc
aacaaggtgtgcagcctgggctgcaacaaccacgcgtgcggctgggacggcggcgactgc
tccctcaacttcaacgacccctggcagaactgctcgcagtcgctgcagtgctggaagtac
ttcagcgacggccgctgcgacagccagtgcaactcggccgggtgcctgttcgacggcttc
gactgccagcgcgcggacggccagtgcaaccccctgtacgaccagtactgcaaggaccac
ttcggtgacgggcactgcgaccagggctgcaacagcgccgagtgcgagtgggacgggctg
gactgcgcggagcacgtgcccgagcggctggcggccggcgcgctggtgctggtggtgctg
acgccgcccgcgcagctgcgcaacaactccctgcacttcctgcgggagctcagccgcctg
ctgcacaccaacgtggtcttcaagcgcgacgcgcacggccagcccatggtcttcccctac
tacggccgcgaggaggagctgcgcaaacaccccatcaagcgcgccgtggacggctgggcc
gcgcccggggccctgctcgaccgggtggaggccgccctgctcccgggcggcggggccggc
cgccggcgccgggagctggaccccatggacatccgcggatccattgtctacctggagatt
gacaaccggcagtgtgtccagtcgtcctcacaatgcttccagagtgccacggacgtggcc
gccttcctgggcgccctcgcctcgctgggcagcctcaacatcccctacaagatcgaggcc
gtgcagagtgagaccgtggagccgcccccgcccccgcagctgcacttcatgtacgtggcc
gtggccgccttcgtgctcctcttctttgtgggctgcggggtgctgctgtcccgcaagcgt
cggcggcagcatggacagctctggttcccggagggcttcaaggtgtcagaggccagcaag
aagaagcggcgggagcccctcggcgaggactccgtgggcctcaagcccctgaagaacgcg
tcggatggtgctctcatggacgacagccagcacgagtggggtgacgaggatctggaggcc
aagaagttccggttcgaggagccagtggttctccccgacctggatgaccaggcagatcac
cggcagtggacccagcagcacctggacgctgccgacctgcgtgtgtccgccatggccccc
acgccaccccagggcgaggccgacgccgacagcatggatgtgaacgtccgagggccggac
ggcttcacgcccctcatgatcgcctcctgcagcggagggggcctggagacgggcaacagc
gaggaggaggaggacgcgcccgccgtcatctccgacttcatctatcagggcgccagtctg
cacaaccagacggaccgcactggcgagaccgccctgcacctggctgcccgctactcgcgc
tccgacgcggccaagcgcctgctggaagccagcgccgacgccaacatccaggacaacatg
ggccgcaccccgctgcacgcagccgtgtctgccgacgcgcagggcgtcttccagatcctg
atccggaaccgagccacggacctggacgcgcgcatgcacgatggcacgacgccgctgatc
ctggccgcccgcctggcggtggagggcatgctggaagatctcgtcaactcgcatgccgac
gtcaacgccgtggacgacctgggcaagtccgcgctgcactgggccgccgccgtgaacaac
gtggaggcggctgtcgtgctcctgaagaacggggccaacaaggacatgcaaaacaacaag
gaggagacgcccctgttcctggccgctcgggagggcagctacgagaccgccaaggtgctg
ctggaccacttcgccaaccgggacatcacagaccacatggaccgcctgccccgtgacatc
gcccaggagcgcatgcatcacgacatcgtgcggctgttggacgagtacagcctggcgcgc
agcccccagctgcacggcacggccctgggtggcgcgcccacgctgtccccgccgctctgc
tcccccggcagctacctgggcaacctcaagcccgccgtgcagggcaagaaggcccgcaag
cccagcaccaagggcctggcctgcggcggcaaggaggccaaagacctcaaggcacgcagg
aagaagccccaggacggcaagggctgcctgctggacagctcgagcgtgctgtcgcccgtg
gactccctcgagtcgccgcatggctacctgtcggacgtggcctcgccgccgctcctgcct
tctccgttccagcagtccccggccgtgcccctcaaccacctgcccggcatgcctgacacc
cacctgggcgtcggccacctgagcgtggccgccaagcccgagatggcagggctgggcggg
ggcggccggctggccttcgaggcgggacccccgaggctctcccacctgcccgcggcctcc
agcaccagcacggtcctgggcactggcggcggcgtgaatttcaccgtgggtggggccgcg
ggcttgaacggccagtgcgagtggctgtcccggctgcagaacggcctggtgcccaaccag
tacaacccgctgcgagggaacgtggcgccgggcaccctgagcacgcaggccccggccctc
cagcacagcatgatgggcccgctgcacgccggcctgtccacggccgccctgtcccagatg
atgagctaccaggccctgcccggcacgcgcctggctggccagcctcacctggtgcagacc
cagccgccgcagcagaacttacagatgcagccgcccaacctgcagccccagccgccccag
ccacacctcggcgtggcctcggccgccggtggccacgtgggccggagcttcctgggcggg
gagccgagccaggcagacgtgcagccgctgggccccggcggcctggccgtgcacaccatc
ctgccgcaggacagccaggccctgcccgccacgctggccccgcccatgaccaccgcgcag
ttcctgaccccgccctcgcagcatagctactcctcctcgcccgcggacaacacccccagc
caccagctgcaggtgcctgagcaccccttcctcaccccgtcccccgagtcccccgaccag
tggtccagctcgtcaccgcattcccacgtctctgactggtccgagggcatctccagcccg
cccaccagcacgcagtcccacatcgcccacattccagaggcgctcaagtaa
DBGET
integrated database retrieval system
