Panthera leo (lion): 122205840
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Entry
122205840 CDS
T10741
Symbol
TOP3A
Name
(RefSeq) DNA topoisomerase 3-alpha isoform X1
KO
K03165
DNA topoisomerase III [EC:
5.6.2.1
]
Organism
plez Panthera leo (lion)
Pathway
plez03440
Homologous recombination
plez03460
Fanconi anemia pathway
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09120 Genetic Information Processing
09124 Replication and repair
03440 Homologous recombination
122205840 (TOP3A)
03460 Fanconi anemia pathway
122205840 (TOP3A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
plez03032
]
122205840 (TOP3A)
03400 DNA repair and recombination proteins [BR:
plez03400
]
122205840 (TOP3A)
Enzymes [BR:
plez01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.1 DNA topoisomerase
122205840 (TOP3A)
DNA replication proteins [BR:
plez03032
]
Eukaryotic type
DNA Topoisomerases
122205840 (TOP3A)
DNA repair and recombination proteins [BR:
plez03400
]
Eukaryotic type
DSBR (double strand breaks repair)
HR (homologous recombination)
Bloom's syndrome complex (BTR)
122205840 (TOP3A)
FA (Fanconi anemia) pathway
122205840 (TOP3A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Topoisom_bac
Zn_ribbon_GRF
Toprim
Zn_ribbon_Top1
Zn_ribbon_GRF_2
zf-C2H2_10
Motif
Other DBs
NCBI-GeneID:
122205840
NCBI-ProteinID:
XP_042770375
UniProt:
A0A8C8XIQ1
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All DBs
Position
E1:10989762..11015861
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AA seq
988 aa
AA seq
DB search
MIFPVARCALRWLQRPGARTLSRAAMEVALRGVRKILCVAEKNDAAKGIADLLSNGRVRR
REGLSKFNKIYEFDYHLYGQNVTMIMTSVSGHLLAHDFQMQFRKWHSCNPLVLFEAEIEK
YCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCRAVKPSLPVLRARFSE
ITPRAVQTACENLTEPDPRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLIS
YGSCQFPTLGFVVERFKAIQAFVPEVFHKIKVTHDHKDGVVEFNWKRHRLFNHTACLVLY
QLCMEDPRATVVEVKSKAKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYI
SYPRTETNIFPKDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPT
KYTSSLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDV
YPYDRWSDKTLPVYERGSRFQPSTVEMVDGETSPPQLLTEADLIALMEKHGIGTDATHAE
HIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPNLRAELEADLKLICEGKK
DKLVVLRQQVQKYKQVFVEAVAKAKKLDEALSQYFGEGAEVAQQEAIYPAMPEPIKKCPQ
CNKDMVLKTKKSGGFYLSCTGFPECRSAMWFPDSVLEASRDGTVCPVCQPHPVYRLKFKF
KRGSLPPTMPLEFVGCVGGCDETLMELLDLRLSRGAPRASQPASQPSNHLQASQSLNRID
SAPRALPPPAATGESDSVTCNCGQEAVLLTVRKEGPNQGRQFYKCNGGGCNFFLWADSSP
PDAGGPPPSAPRPSGGAAGRPPGPGHRRGGFGRPGDDSGEGTSCLCSQPSVTRTVQKDGP
NKGRQFHTCAKPREQQCGFFQWADENVAPGSLGVQTWPRDRGRIQGPEARSKRARATSSD
TGSTAKKPRKCSVCHQPGHTRPFCPQNT
NT seq
2967 nt
NT seq
+upstream
nt +downstream
nt
atgatcttccctgtcgcccgctgcgctctccgctggctgcaacggccgggagccaggacc
ttgtcccgcgctgccatggaggtggccttgcgaggcgtgcggaaaattctctgtgtggcc
gagaaaaacgacgcggccaaggggatcgccgacctgctgtccaacggtcgcgtgaggcgg
agggaaggattgtctaaattcaacaagatctatgaatttgattatcatctgtacggccag
aatgttaccatgataatgacttcggtttctggacatttgctggctcatgatttccagatg
cagttccgcaaatggcacagctgcaatccccttgtcctctttgaagcagaaattgaaaag
tactgcccagagaattttgtagacatcaagaaaactctggaacgagagacccggcagtgc
caggccctggtgatctggaccgactgcgatagagaaggggaaaatatcgggttcgagatt
atccacgtgtgcagggctgtgaagcccagtctgccggtgctgagagcccgtttctctgag
atcaccccccgagccgtccagacggcctgtgagaacctgaccgagcccgatccgagagtg
agcgatgctgtggacgtgaggcaggagctggacctgaggatcggagctgccttcactagg
ttccagaccctgaggctgcagaggatttttcccgaggtgttagcggagcagctgatcagt
tacggcagctgccagttcccaaccctggggttcgtggtagagaggttcaaagccattcag
gcttttgtgccagaagtcttccacaaaattaaagtaactcatgaccacaaagatggtgtc
gtagaattcaactggaaaaggcatcgcctctttaaccacacagcttgtcttgtcctctat
cagctgtgcatggaggatcccagggcaaccgtggtagaggtcaagtctaaggcaaagagc
aagtggaggcctcaagcattggacactgtggagcttgagaagctggcttctcgaaagttg
agaataaatgctaaagaaaccatgaggattgccgaaaagctctacactcaagggtacatc
agctatcctcgaactgagacaaacatcttccccaaagacttaaacctgacggtgctcgta
gagcagcagaccccggatccacgttggggggcctttgcccagagcattctagaacggggc
ggccctactccacgcaatgggaacaagtctgaccaagctcaccctcccatccaccccacc
aaatacactagcagcttgcagggagatgagcagcgactgtatgagttcatcgttcgtcat
ttcctggcttgctgctcccaggatgctcaggggcaggagaccactgtggagatcgacatc
gctcaggaacgcttcgtggcccacggcctcatgattctggcccgaaactacctggatgtg
tacccatatgaccgctggagtgacaagaccctccccgtctacgagagaggctcccgcttt
cagcccagcactgtggagatggtggacggagagaccagtcccccccagctgctcaccgaa
gccgacctcatcgccctcatggaaaagcacggcattggtactgatgccactcatgcggag
cacatcgagaccatcaaagcccggatgtacgtcgggctcaccccggacaagcggtttctg
cccgggcatctaggcatggggcttgtggaaggctatgactccatgggctatgagatgtcc
aagcccaacctccgggctgagctggaagctgatctgaagctgatctgtgaggggaagaag
gacaagttggtggttctgaggcagcaagtccagaaatacaaacaggttttcgttgaagca
gtggccaaagcaaagaaattggacgaggccttatcccagtactttggggaaggggcagag
gtggcccagcaagaagccatctacccagccatgccagagcccatcaagaagtgcccgcag
tgcaacaaggacatggtcctcaagaccaagaagagtggcgggttctacctcagctgcacc
ggtttcccagaatgccgatcggccatgtggttccctgactctgtgctggaggccagcagg
gatgggactgtgtgtccggtttgtcagccgcaccctgtttacaggttgaagttcaagttt
aaacgtggcagccttcccccgaccatgcctctggagtttgtgggctgcgtcggaggatgt
gatgagaccctgatggagctcctggacctaagactctcacggggcgcccccagagccagc
cagccagccagccagccctctaaccacctgcaggctagccagtccctgaacagaatcgac
agcgccccccgggccctgccaccacccgctgccactggtgaaagtgactctgtgacctgc
aactgtggccaggaggccgtgctgctcaccgtccggaaagagggtcccaaccagggccgg
cagttttataagtgcaacggtggcggctgcaacttcttcctgtgggccgacagcagcccc
ccggatgcaggggggccccccccctcggcaccaagaccctcaggtggcgcggcaggacgc
ccgcctggcccggggcatcgccggggtgggtttggcagacccggcgatgacagcggagag
ggcacgtcgtgcctgtgcagccagcccagcgtcacccggacggtgcagaaggacgggccc
aacaaggggcgccagttccacacatgcgccaagccaagagagcagcagtgcggcttcttc
cagtgggcggacgagaacgtggccccagggagtctcggagtccagacctggccaagagac
aggggcagaatccaggggccagaggccagaagcaaaagagcccgggccacttcctcagac
acgggctccacggccaagaagccccggaaatgcagcgtttgccaccagcctggacacacc
cgtcccttctgtcctcagaacacatga
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