Panthera leo (lion): 122206337 Help Entry 122206337         CDS       T10741                                  Symbol NF1 Name (RefSeq) neurofibromin isoform X1   KO K08052   neurofibromin 1 Organism plez  Panthera leo (lion) Pathway plez01521   EGFR tyrosine kinase inhibitor resistance plez04010   MAPK signaling pathway plez04014   Ras signaling pathway Brite KEGG Orthology (KO) [BR:plez00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     122206337 (NF1)    04014 Ras signaling pathway     122206337 (NF1)  09160 Human Diseases   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     122206337 (NF1) SSDB OrthologParalogGFIT Motif Pfam:  PH_NF1 RasGAP CRAL_TRIO_2 CRAL_TRIO MIF4G_like_2 Motif Other DBs NCBI-GeneID:  122206337 NCBI-ProteinID:  XP_042771339 UniProt:  A0A8C8XJC5 LinkDB All DBs Position E1:18976613..19294197 Genome browser AA seq 2841 aa AA seqDB search MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL REILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGATSQMSMDHEELIRTCTPGASL RKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEAD IRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWE DTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWI NMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRL LSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNT QFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQL VEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVS LLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRL ASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAE TVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLW NMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVS FEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLN KATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERG LKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSF ISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTH WSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQI NGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVY IYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLK VFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQ FTLTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIA LLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAAN EPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKL ITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVAL ASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAA HLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSL PKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMR DIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESC LKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALL EQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGY RHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHR KSLLLTDISMENVPMDTYPIHHGDPSYRTLKENQPWSSPKGSEGYLAATYPAVGQTSPRA RKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYE METQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRI LYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQY QTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTP TSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTSGHCNSGRTRHGSA SQVQKQRSAGSFKRNSIKKIV NT seq 8526 nt NT seq  +upstreamnt  +downstreamnt atggccgcgcacaggccggtggaatgggtccaggccgtggtcagccgcttcgacgagcag cttccaataaaaacaggacagcagaacacgcataccaaagtcagtactgaacacaacaag gaatgtcttattaatatttccaaatacaagttttctttggttatcagcggcctcaccact atcttaaagaatgttaacaatatgagaatatttggagaagctgctgaaaaaaatttatat ctctctcagttgattatattggatacactggaaaaatgtcttgctgggcaaccaaaggac acaatgcgattagatgaaacgatgctggtcaaacagttgctgccagaaatctgccatttt cttcacacctgtcgtgaaggaaaccaacatgcagctgaacttcggaattctgcatctggg gttttattttctctcagctgcaacaacttcaacgcagtgtttagtcgcatctctaccagg ttacaggaattgactgtttgttcagaagacaatgttgatgttcatgatatagaattgtta cagtatatcaatgtggattgtgcaaaattaaaacgactcctaaaggaaacagcatttaaa tttaaagccctaaagaaggttgcacagttagcagttataaatagcctggaaaaagcattt tggaactgggtagaaaattatccagatgaatttacaaagctgtaccagattccacagact gatatggctgagtgtgcagaaaaactgtttgacttggtggatggttttgccgaaagcacc aagcgtaaagcagcggtttggccactgcaaatcattctccttatcttgtgtccagaaatc attcaggatatctccaaggatgtggttgatgaaaacaacatgaataagaagttgtttctg gacagcctgcggaaagcacttgccggccatggaggaagcaggcagctgacggagagtgct gcaatagcctgtgtcaaactgtgcaaagcaagtacttatatcaactgggaagacaactct gtcattttcctcctagtccagtccatggtggttgatcttaagaacctgctttttaatcca agtaagccattctcaagaggcagtcagcccgcagatgtggatctgatgattgactgcctt gtctcttgctttcgtataagccctcacaacaaccaacactttaagatctgcctggctcag aattccccttctacatttcactatgtgctggtaaattcactccatcgaatcatcaccaat tctgcgttggattggtggcctaagatcgatgctgtatattgtcactcagtcgagcttcga aacatgtttggtgaaacgcttcataaagcagtgcagggttgtggagcacacccagcaata cgaatggcaccgagtcttacatttaaagaaaaagtaacaagccttaaatttaaagaaaaa cctacagacctggagacaagaagctataagtatcttctcctgtccatggtgaaactcatt catgcggatccaaagctcttgctttgtaatccaaggaaacaggggcctgaaacccaaggc agtacagcggaattaattacagggctcgtccagctggtccctcagtcacacatgccagag atcgcacaggaggcaatggaggctctgctggttcttcatcagttagatagcattgatttg tggaatcctgatgctcctgtggaaacattttgggaaattagctctcaaatgcttttttac atctgcaagaaattaactagccatcaaatgcttagtagcacagaaattctcaaatggttg cgggaaattttgatctgcaggaataaatttcttcttaaaaataagcaggcagatagaagt tcctgtcactttctcttcctttacggggtaggatgtgatgttccttcgagtggagctacc agtcagatgtccatggatcatgaagaattaatacgtacttgtacgcctggagcctctctt cggaagggaaaaggaaactcatccatggatagtgcagcagggtgcagcggcacaccgccg atatgccgacaggctcagaccaaactcgaagtggccctgtacatgtttctgtggagccct gacactgaagctgttctggttgccatgtcctgcttccgccacctctgtgaggaggcagat atccggtgtggggtggatgaagtgtcggtgcacaacttcttgcccaactataacacattc atggaatttgcctctgtcagcaatatgatgtcaacaggaagagcagcacttcagaaaaga gtgatggcactactcaggcgcatcgagcaccccactgcaggaaacacggaggcttgggaa gatacacatgcaaagtgggaacaagccacaaaactaatcctcaactatccaaaagctaaa atggaagatggccaggctgctgaaagccttcacaagaccattgttaagaggcgaatgtct catgtgagtggaggaggatccatagatttgtctgacacggactccctacaggaatggatc aacatgactggcttcctttgcgcccttgggggagtgtgcctgcagcaaagaagcaactct ggcttggcaacctatagcccccctatgggcccagtcagtgaacgcaagggttccatgatt tcggtgatgtcctcggagggaaatgcagatacacctgtcagcaaatttatggatcggctg ttatccttaatggtgtgtaaccatgagaaagtgggacttcaaatacggaccaacgttaag gatctggtgggtctagaattgagtcctgctctttatccaatgctatttaacaaattgaag aataccatcagcaagttttttgactcgcaaggacaggttttattgaccgacaccaatact cagtttgtggagcaaaccatagctataatgaagaacttactagataatcataccgaaggc agctccgaacatctggggcaagctagcattgaaacaatgatgttaaatctagtcagatat gttcgagtgcttgggaacatggtccatgcaattcaaataaaaacgaagctgtgtcagtta gtcgaggtaatgatggcaaggagagatgacctctcattttgtcaagagatgaaatttagg aataaaatggtagaatacctgacagactgggtcatgggaacatcaaaccaagcagcagat gatgatgtaaaatgtcttacaagagacttggaccaggcgagcatggaagccgttgtttca ctcctggctggtcttccactgcagcctgaggaaggagatggtgtggaattgatggaagcc aagtcacagttatttctgaagtatttcacattgtttatgaaccttttgaatgactgtagt gaagttgaagatgaaaatgcacaaacaggtggcaggaaacgtggcatgtcccggaggctg gcatcactgaggcactgcacagtccttgcaatgtccaacttactcaatgctaatgtggac agtggcctcatgcactccataggtttaggttatcacaaagatcttcagacaagagctaca tttatggaagttctgacaaaaatcctccagcaaggcacagaatttgacacgcttgcagaa acggtgctggccgaccggtttgagaggctggtggagttggtcacaatgatgggagaccag ggagagctcccaatagccatggctttggccaacgtggtcccgtgttctcagtgggatgaa ctagctcgagttctagtgactctgtttgattctcggcatttgctctaccaactgctctgg aacatgttttctaaggaagtagaattggcagactccatgcagactcttttccgaggaaac agcttagccagtaaaataatgaccttctgtttcaaggtatatggtgctacctacctacaa aaactcctggatccgttattacgaatcgtgatcacatcctctgactggcaacatgttagc tttgaagtggatcctaccaggttagaacaatcagagagccttgaggaaaaccaacggaac cttctgcagatgactgaaaagttcttccatgccatcatcagttcctcctcagaattcccc cctcagcttcgaagtgtgtgccactgtttataccaggcaacttgccactccctactgaat aaagctacagtaaaagaaaaaaaggaaaacaaaaaatcagtggttagccagcgtttccct cagaacagcatcggtgcggtgggaagtgccatgttcctcagatttatcaatcctgccatt gtctcaccgtatgaagcagggattttagataaaaagccgccacctagaattgaaaggggc ttgaagttaatgtcaaagatacttcagagcattgccaatcatgttctcttcacaaaagaa gagcatatgcggccttttaatgattttgtgaaaagcaactttgatgcagcgcggaggttt ttccttgatatagcatctgattgtcctaccagtgatgcagtaaatcatagtctctccttc atcagtgatggcaatgtgcttgctttacatcgtctactctggaacaatcaagagaaaatt ggccagtatctttccagtaacagggatcacaaagctgttggaagacgaccttttgataag atggcaacacttcttgcgtacttgggtcctccagagcacaaacctgtggccgatacacat tggtccagccttaaccttaccagttcaaagtttgaggaatttatgactaggcatcaagta catgaaaaagaagagttcaaggctttgaaaacattaagtattttctaccaagctgggact tccaaagctgggaatcctatattttattatgttgcacggaggtttaaaactggccaaatc aatggcgatttgctgatataccacgtcttgctgactttaaagccatattatgcaaagcca tatgaaattgtagtggaccttacccataccgggcctagcaatcgctttaaaacagacttt ctctccaagtggtttgttgtttttcctggctttgcttatgacaatgtctctgcagtctat atctataactgcaactcctgggtcagagagtataccaagtatcacgaacggctactgact ggcctcaaaggcagcaagaggctcattttcatcgactgtcctggcaaactggctgagcac atagagcatgaacaacagaaactgcctgctgccacactggctttagaagaggacctgaag gtattccacaatgctctcaagctagctcacaaagacaccaaggtttctattaaagttggt tctactgctgttcaagtaacctcagcagagcgaacaaaagtcctaggacagtcggtcttt ctaaatgatatctattatgcttcggaaattgaagagatctgcctggtggatgagaaccag tttaccttaaccattgcaaaccagggcacaccgctcaccttcatgcaccaggagtgcgaa gccattgtccagtctatcattcacatccggacacgctgggagctgtcgcagcccgactcc atcccccagcacaccaagattcggccaaaagatgtccctgggacactactcaatattgca ttacttaatttaggcagttccgaccctagtttacggtcagctgcctataatcttctctgt gccttaacttgtacctttaatttaaaaatcgagggccagctactagagacgtcaggttta tgcatccctgccaacaacaccctctttattgtctctattagtaagacactggcggccaat gagccacatctcaccttagaatttttggaagagtgtatttctggatttagcaaatctagt attgaattgaaacacctttgtttggaatacatgactccatggctgtcaaacctagtccgt ttttgtaagcacaatgatgatgccaaacgacaaagagttaccgccattctcgataagctg ataacaatgaccataaatgagaaacagatgtacccatctattcaagccaaaatatggggg agccttgggcagattacagatctccttgacgttgtactagacagtttcatcaaaaccagt gcgacaggtggcttgggatcaataaaagccgaggtgatggcagatactgccgtagctttg gcttctggaaatgtgaaattggtttccagcaaggttattggaaggatgtgcaaaataatt gacaagacatgcttgtctccaactcctaccttagagcagcatctcatgtgggacgacatt gccatcctcgcacgctacatgctgatgctgtccttcaacaattcccttgacgtggcagct catctcccctacctcttccatgttgttactttcttagtagccacggggccgctctccctt agagcttccacacacggattggtcattaatatcattcactctctgtgtacttgttcacag ctgcattttagtgaagagaccaagcaagttttgagactcagtttgacagagttctcgtta cccaagttttacttgctgtttggcattagcaaagtcaagtcagctgccgtcattgccttc cgctccagttaccgggacaggtcgttctctcctggctcctatgagagggagacttttgct ttgacatccttggaaacagtcacagaggctttgttggagataatggaggcatgtatgaga gatattccaacatgcaagtggctggaccagtggacggaactagctcaaagattcgcattc caatataatccatccctgcaaccgagagctcttgttgtctttggctgtattagcaagcga gtgtctcatgggcagataaagcagattatccgtattcttagcaaggcacttgagagttgc ttaaaaggacctgatacttacaacagtcaagttctgatagaagccacagtaatagcgcta accaaattacagccgctcctcaataaggactcccctctgcacaaagccctcttttgggta gctgtggctgtgctacagctcgatgaggtcaacttgtattcagcaggcaccgcacttctt gaacaaaacctgcacaccttagacagtctgcggatattcaacgacaagagtccagaggaa gtatttatggcaatccggaaccctctggaatggcactgcaagcagatggatcattttgtt ggactcaatttcaactctaactttaacttcgcgctggttggacacctcttaaaagggtac aggcatccttcacctgccattgttgcaagaacggtcagaattctgcatacactactgact ctggtcaacaaacatagaaactgtgacaaatttgaggtgaacacacagagcgtggcttac ttggcagccttactcacagtgtctgaggaggttcgaagtcgctgtagcctaaaacataga aagtctcttcttcttactgatatttcaatggaaaatgttcctatggatacatatcccatc catcatggcgaccccagctataggacgctaaaggagaaccagccgtggtcatctcccaaa ggttctgaggggtaccttgcagccacctatccagccgtgggccagaccagtccccgggcc aggaagtccatgagcttggacatggggcagccttctcaggccaacacgaagaagttgctg ggaacaaggaaaagttttgatcacttgatatcagacacaaaggctcctaaaaggcaagaa atggaatcagggatcacaacaccccccaaaatgaggagagtagcagaaactgattatgaa atggaaactcagaggatttcctcatcacaacaacacccgcatttgcgtaaagtttcggtg tctgaatcaaatgttctcttggatgaagaagtacttactgatccaaagatccaagcactt cttcttaccgttctggctacgctggtaaaatataccacggatgagtttgatcagcgaatc ctttatgaatacttagcggaagccagtgttgttttccccaaggtttttccagtcgtacac aatttgttggactctaagatcaacaccctattgtcattgtgccaagatccaaatttgtta aatccaattcatggaattgtgcagagtgtggtgtaccatgaagaatctccaccacagtac cagacatcatacctgcaaagttttggttttaatggcttgtggcggtttgcaggacccttt tcaaagcaaacccaaatcccagactatgctgagcttattgttaagtttcttgatgccttg attgacacgtatttgcctggaattgatgaagaaaccagtgaggagtccctcctgacaccc acttctccttatcctcctgcagtgcagagccagcttagtatcactgctaaccttaacctt tctaattccatgacctcactcgcaacttcccagcattccccagggatcgacaaggagaac gttgaactctcccccacctctggccactgtaacagtggacgcactcgccatggatccgca agccaggtgcagaagcaaagaagcgctggcagtttcaaacgtaatagcattaagaagatc gtgtga

DBGET integrated database retrieval system