Panthera leo (lion): 122206411
Help
Entry
122206411 CDS
T10741
Symbol
ERBB2
Name
(RefSeq) receptor tyrosine-protein kinase erbB-2
KO
K05083
receptor tyrosine-protein kinase erbB-2 [EC:
2.7.10.1
]
Organism
plez Panthera leo (lion)
Pathway
plez01521
EGFR tyrosine kinase inhibitor resistance
plez01522
Endocrine resistance
plez01524
Platinum drug resistance
plez04010
MAPK signaling pathway
plez04012
ErbB signaling pathway
plez04020
Calcium signaling pathway
plez04066
HIF-1 signaling pathway
plez04151
PI3K-Akt signaling pathway
plez04510
Focal adhesion
plez04518
Integrin signaling
plez04520
Adherens junction
plez04530
Tight junction
plez05200
Pathways in cancer
plez05205
Proteoglycans in cancer
plez05206
MicroRNAs in cancer
plez05212
Pancreatic cancer
plez05213
Endometrial cancer
plez05215
Prostate cancer
plez05219
Bladder cancer
plez05223
Non-small cell lung cancer
plez05224
Breast cancer
plez05226
Gastric cancer
plez05230
Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
122206411 (ERBB2)
04012 ErbB signaling pathway
122206411 (ERBB2)
04066 HIF-1 signaling pathway
122206411 (ERBB2)
04020 Calcium signaling pathway
122206411 (ERBB2)
04151 PI3K-Akt signaling pathway
122206411 (ERBB2)
09133 Signaling molecules and interaction
04518 Integrin signaling
122206411 (ERBB2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
122206411 (ERBB2)
04520 Adherens junction
122206411 (ERBB2)
04530 Tight junction
122206411 (ERBB2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
122206411 (ERBB2)
05206 MicroRNAs in cancer
122206411 (ERBB2)
05205 Proteoglycans in cancer
122206411 (ERBB2)
05230 Central carbon metabolism in cancer
122206411 (ERBB2)
09162 Cancer: specific types
05212 Pancreatic cancer
122206411 (ERBB2)
05226 Gastric cancer
122206411 (ERBB2)
05219 Bladder cancer
122206411 (ERBB2)
05215 Prostate cancer
122206411 (ERBB2)
05213 Endometrial cancer
122206411 (ERBB2)
05224 Breast cancer
122206411 (ERBB2)
05223 Non-small cell lung cancer
122206411 (ERBB2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
122206411 (ERBB2)
01524 Platinum drug resistance
122206411 (ERBB2)
01522 Endocrine resistance
122206411 (ERBB2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
plez01001
]
122206411 (ERBB2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
plez04147
]
122206411 (ERBB2)
04090 CD molecules [BR:
plez04090
]
122206411 (ERBB2)
Enzymes [BR:
plez01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
122206411 (ERBB2)
Protein kinases [BR:
plez01001
]
Receptor tyrosine kinases (RTK)
EGFR family [OT]
122206411 (ERBB2)
Exosome [BR:
plez04147
]
Exosomal proteins
Exosomal proteins of breast cancer cells
122206411 (ERBB2)
CD molecules [BR:
plez04090
]
Proteins
122206411 (ERBB2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
GF_recep_IV
Pkinase
Furin-like
TM_ErbB1
ABC1
Haspin_kinase
Kinase-like
Motif
Other DBs
NCBI-GeneID:
122206411
NCBI-ProteinID:
XP_042771484
LinkDB
All DBs
Position
E1:38444032..38467946
Genome browser
AA seq
1327 aa
AA seq
DB search
MSTLAPNHGRRRRWRRRAALRKYKNEVVELKSPLRRAPRAEQSSQAAARPFAARSSPSHG
AGAAVSTMELAAWCRWGLLLALLPSGATGTQVCTGTDMKLRLPASPETHLDMLRHLYQGC
QVVQGNLELTYLHANASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYA
LAVLDNGDPLDSGTPATGAALGGLRELQLRSLTEILKGGVLIQRNPQLCHQDTILWKDIF
HKNNQLALMLIDTNRSRACQPCSPACKDSHCWGASSGDCQSLTRTVCAGGCARCKGPQPT
DCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGA
SCVTACPYNYLSTDVGSCTLVCPLNNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREA
RAVTSANIQEFVGCKKIFGSLAFLPESFEGDPASNTAPLQPEQLRVFEALEEITGYLYIS
AWPDSLPNLSVFQNLRVIRGRVLHDGAYSLTLQGLGISWLGLRSLRELGSGLALIHRNSR
LCFVHTVPWDQLFRNPHQALLHSANRPEDECAGEGLACYPLCAHGHCWGPGPTQCVNCSQ
FLRGQECVEECRVLQGLPREYVKDRFCLPCHPECQPQNGSVTCLGSEADQCVACAHYKDP
PFCVARCPSGVKPDLSFMPIWKFADEEGTCQPCPINCTHSCADLDEKGCPAEQRASPVTS
IIAAVVGILLVVVVGLVLGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMR
ILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYV
MAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGM
SYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALES
ILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYM
IMVKCWMIDSECRPRFRELVAEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDED
MGDLVDAEEYLVPQQGFFCPDPAPGAGGTAHRRHRSSSTRSGGGELTLGLEPSEEEPPKS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLSPQDPSPLQRYSEDPTVPLPPETDGYVAPLTC
SPQPEYVNQPEVWPKPPSPLEGPLPPSRPAGATLERPKTLSPKTLSPGKNGVVKDVFAFG
GAVENPEYLAPRGRAAPQPHPPPAFSPAFDNLYYWDQDTSERGSPPSTFEGTPTAENPEY
LGLDVPV
NT seq
3984 nt
NT seq
+upstream
nt +downstream
nt
atgagcacgctcgctcccaatcacgggaggaggaggaggtggaggaggagggctgccttg
aggaagtacaagaatgaagttgtggagctgaagagtcccctgcgtcgtgccccgagagcc
gagcagagctcccaggcagccgcccggcccttcgcagcccggtccagcccgagccatggg
gccggagccgcagtgagcaccatggagctggcggcctggtgccgctgggggctcctcctc
gccctcctgccctccggagccacgggcacccaagtgtgcaccggcacagacatgaagctg
cggctcccagccagtcccgagacccacctggacatgctccgccacctctaccagggctgt
caagtggtacagggtaacctggagctcacctacctgcatgccaatgccagcctctccttc
ctgcaggatatccaggaggtgcaaggctatgtgctcattgcccacaaccaagtgagacag
gtcccactgcagaggctacgaatcgtgcgaggcacccagctctttgaggacaactacgcc
ctggccgtgctggacaacggagacccactggacagtggcacccctgctacaggggctgcc
ctaggagggctgcgggagctgcagctccgaagcctcacagagatcctgaagggaggggtc
ctcattcagcggaatccgcagctctgccaccaggacacgattctgtggaaggacatcttc
cacaagaacaaccagctggccctcatgctgatagacaccaaccgctctcgggcctgccaa
ccctgttctccagcttgtaaagactcccactgctggggagcaagttccggggactgtcag
agcttgactcgaactgtctgtgctggtggctgtgcccgctgcaagggcccgcagcccacc
gactgctgccacgagcagtgtgctgctggctgcacgggccccaagcattctgactgcctg
gcctgcctccacttcaaccacagtggcatctgtgagctgcactgcccagccctggtcacc
tacaacacggacaccttcgaatccatgcccaaccctgagggccgttataccttcggtgcc
agctgtgtgactgcctgtccctacaactacctgtctacggacgtgggatcctgcaccctg
gtctgtcccctgaacaaccaagaggtgacagctgaggatggaacacagcggtgtgagaaa
tgcagcaagccctgtgcccgagtgtgctacggcctaggcatggagcacctgcgggaggcg
agggcagtcaccagtgccaacatccaagaatttgtcggctgcaagaagatctttgggagc
ctggcgtttctgccagagagctttgagggggacccagcctccaacactgcccccctgcag
cctgagcagctcagagtgtttgaggctctggaggagattacaggttacctgtacatctca
gcgtggccggacagcttgcctaacctcagtgtcttccagaacctcagagtgatccggggc
cgagttctgcatgacggtgcttactcgctgacccttcaagggctgggcatcagctggctg
gggctgcgttcgctgcgggagctgggcagtgggctggccctcatccaccgcaactctcgc
ctctgcttcgtacacacggtgccctgggaccagctcttccggaacccccaccaggctctg
ctccacagcgccaaccggccagaggacgagtgcgcgggtgagggcctggcctgctacccg
ctgtgtgcccacgggcactgctggggtccgggacccacccagtgtgtcaactgcagccag
ttccttcgaggccaggagtgtgtggaggaatgccgagtactgcaggggcttccccgggag
tatgtgaaggataggttctgtctgccatgccacccagagtgtcagccccagaatggctca
gtgacctgcttgggctcggaagctgaccagtgtgtggcctgtgcccactacaaggaccct
cctttctgtgtggctcgctgccccagtggggtgaaacctgacctctccttcatgcccatc
tggaagtttgcagatgaggagggcacgtgccagccatgccccatcaactgcacccactcc
tgtgcggacctggacgagaagggctgccccgccgagcagagagccagccctgtgacatcc
atcattgctgctgtggtgggcattctgctggtcgtggttgtggggctggtccttggcatc
ctaatcaagcgaaggcggcagaagatccggaagtacacgatgcggaggctgctgcaggag
acggagctggtggagcccctgacgcctagtggagccatgcccaaccaggctcagatgcga
atcctgaaagaaacagagctgaggaaggtgaaggtgcttggatccggagcttttggcact
gtctacaagggcatctggatccctgatggggaaaatgtgaaaatcccagtggccatcaaa
gtgttgagggaaaatacatctcccaaagccaacaaagaaatcttggacgaagcgtatgtg
atggctggcgtgggctccccatatgtgtctcgccttctgggcatctgtctgacatccacc
gtgcagttggtgacacagcttatgccttatggctgcctcttagaccatgtccgagaacac
cgtgggcgcctaggctcccaggacctgctgaactggtgtgtgcagattgccaaggggatg
agctacttggaggatgttcggctcgtgcacagggacctggctgcccggaacgtgctggtc
aagagtcccaaccacgtcaagattacagattttgggctggctcggctgctggacattgac
gagacagagtaccatgccgatgggggcaaggtgcccatcaagtggatggcgctggagtcc
attctccgccggcggttcacccatcagagtgacgtgtggagctacggtgtgactgtatgg
gaactgatgacttttggggccaaaccttatgatgggatcccagcccgggagattcctgac
ctgctggagaagggagaacggctgccccagccccccatctgcaccattgatgtctacatg
atcatggtcaaatgttggatgatagactctgaatgtcggccacgtttccgggagttggtg
gctgaattctcccggatggccagggacccccagcgctttgtggtcatccagaatgaggac
ttgggcccagccagtcccttggacagcactttctaccgttcactgctggaggatgaggac
atgggagacctggtggacgctgaggagtacctggtaccccagcagggtttcttctgccca
gaccctgccccaggcgccgggggcacagcccaccgcagacaccgcagctcatccaccagg
agtggcggtggtgagctgacactggggctggagccctccgaggaagagcctcccaagtct
ccactggcaccctcagaaggggctggctctgatgtgtttgatggcgacctgggaatgggg
gcagccaaggggctgcagagcctttccccacaggaccccagccctctacagcggtacagt
gaggatcctaccgtacccctaccccctgagactgatggctacgttgcccccctgacctgc
agtccccagcctgaatacgtgaaccagccagaggtttggccaaagcccccatcgccctta
gaaggccctctgcctccttctcgacctgccggtgccactctggaaaggcccaagactctg
tcccccaagactctttcccccggcaagaatggggttgtcaaagacgtttttgcctttggg
ggtgctgtggagaaccccgagtacttggcaccccggggcagggctgcccctcagccccac
cctcctccagccttcagcccagcctttgacaacctctattactgggaccaggacacatct
gagcggggctctccacccagcacctttgaagggacccctacagcagagaaccccgaatac
ctgggcctggatgtgccagtgtga
DBGET
integrated database retrieval system
