Panthera leo (lion): 122206556
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Entry
122206556 CDS
T10741
Symbol
SHMT1
Name
(RefSeq) serine hydroxymethyltransferase, cytosolic
KO
K00600
glycine hydroxymethyltransferase [EC:
2.1.2.1
]
Organism
plez Panthera leo (lion)
Pathway
plez00260
Glycine, serine and threonine metabolism
plez00630
Glyoxylate and dicarboxylate metabolism
plez00670
One carbon pool by folate
plez01100
Metabolic pathways
plez01200
Carbon metabolism
plez01230
Biosynthesis of amino acids
plez01240
Biosynthesis of cofactors
plez01523
Antifolate resistance
plez04981
Folate transport and metabolism
Module
plez_M00141
C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00630 Glyoxylate and dicarboxylate metabolism
122206556 (SHMT1)
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
122206556 (SHMT1)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
122206556 (SHMT1)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
122206556 (SHMT1)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
122206556 (SHMT1)
Enzymes [BR:
plez01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.1 glycine hydroxymethyltransferase
122206556 (SHMT1)
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Gene cluster
GFIT
Motif
Pfam:
SHMT
DegT_DnrJ_EryC1
Motif
Other DBs
NCBI-GeneID:
122206556
NCBI-ProteinID:
XP_042771792
UniProt:
A0A8C9D7K8
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Position
E1:10949112..10976052
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AA seq
484 aa
AA seq
DB search
MTTQVNGAHKDADLWSSHEKMLAQPLKDCDTEVYDIIKKESNRQRVGLELIASENFASRA
VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELEILCQKRALQVYDLDPQCWGVNVQPYSG
SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
INYDQLEENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGV
VPSPFEHCHVVSTTTHKTLRGCRAGMIFYRRGVRSVDPKTGKETLYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTPEFRVYQRQVVANCRALAETLMELGYKVVTGGSDNHLIL
VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGFLEKEFQK
VAQFIHRGIELTLQIQDDVGARATLKEFKEKLAGDEKHQRAIRALREEVESFASLFPLPG
LPAF
NT seq
1455 nt
NT seq
+upstream
nt +downstream
nt
atgacaactcaagtcaacggggctcacaaggatgccgacctgtggtcctcacatgagaag
atgttggcacagcccctcaaagactgcgacaccgaggtttacgacatcatcaagaaggag
agtaaccggcagagggttgggctggagctgatcgcctcagagaatttcgccagccgagca
gttctggaggctctgggctcttgcttaaataacaagtactctgaagggtacccagggcag
aggtattatggcgggaccgagttcatcgatgagctggagatcctctgtcagaagcgggcg
ctacaggtctatgatctggacccccaatgctggggggtcaatgtccagccctactcaggc
tccccggcaaacttcgccgtgtataccgcgctggtggaaccccacgggcgcatcatgggc
ctggacctgcccgacgggggccacctgacccacgggttcatgacagacaagaagaaaatc
tctgctacgtccatcttttttgagtctatgccctataaggtgaacccagacactggctac
atcaactatgaccaactggaggaaaatgcccgcctcttccacccgaagctgattattgca
gggaccagctgctactcccgaaacctggattacgctcgactgaggaggatcgcagatgac
aacggggcctatctcatggccgacatggcgcacatcagcgggctggtggctgccggcgtg
gtgccttccccctttgagcactgccacgtagtgtccaccaccacccacaaaaccctgcga
ggctgccgcgccggcatgatcttctacaggagaggagtgcgcagcgtggatcccaagacc
ggcaaagagacgctgtacaacctggagtcgctcatcaactctgccgtgttcccgggcctg
cagggaggtccccacaaccacgccattgctggggtcgccgtggccctgaaacaagccatg
actccggaattccgggtgtaccagcgccaggtggtggccaactgcagggctctggctgag
accttgatggagctgggctacaaagtggtaacaggtggttctgacaaccatttgatcctc
gtggatctccgttccaaaggcacggatggtggcagggccgagaaggtactagaagcctgc
tctatagcctgcaacaagaacacctgtccaggtgacaaaagcgcactgcgccccagcgga
ctgcgtctggggactccggcactgacatcccgcggatttttggaaaaagagttccaaaaa
gtggcccagtttattcacagagggatagaactgactctgcagattcaggacgacgttggt
gccagagccaccctgaaggagttcaaggagaaactggccggggacgagaagcaccaaagg
gccatcagggctctcagggaggaagtggagagcttcgcgtctctcttccctctgcctggc
ctgcctgccttttag
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