KEGG   Panthera leo (lion): 122206866
Entry
122206866         CDS       T10741                                 
Symbol
GNAI1
Name
(RefSeq) guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1
  KO
K04630  guanine nucleotide-binding protein G(i) subunit alpha
Organism
plez  Panthera leo (lion)
Pathway
plez04015  Rap1 signaling pathway
plez04022  cGMP-PKG signaling pathway
plez04024  cAMP signaling pathway
plez04062  Chemokine signaling pathway
plez04071  Sphingolipid signaling pathway
plez04081  Hormone signaling
plez04082  Neuroactive ligand signaling
plez04261  Adrenergic signaling in cardiomyocytes
plez04360  Axon guidance
plez04371  Apelin signaling pathway
plez04540  Gap junction
plez04611  Platelet activation
plez04670  Leukocyte transendothelial migration
plez04713  Circadian entrainment
plez04723  Retrograde endocannabinoid signaling
plez04724  Glutamatergic synapse
plez04725  Cholinergic synapse
plez04726  Serotonergic synapse
plez04727  GABAergic synapse
plez04728  Dopaminergic synapse
plez04730  Long-term depression
plez04914  Progesterone-mediated oocyte maturation
plez04915  Estrogen signaling pathway
plez04916  Melanogenesis
plez04921  Oxytocin signaling pathway
plez04923  Regulation of lipolysis in adipocytes
plez04924  Renin secretion
plez04926  Relaxin signaling pathway
plez04928  Parathyroid hormone synthesis, secretion and action
plez04934  Cushing syndrome
plez04935  Growth hormone synthesis, secretion and action
plez04971  Gastric acid secretion
plez05012  Parkinson disease
plez05030  Cocaine addiction
plez05032  Morphine addiction
plez05034  Alcoholism
plez05133  Pertussis
plez05142  Chagas disease
plez05145  Toxoplasmosis
plez05163  Human cytomegalovirus infection
plez05170  Human immunodeficiency virus 1 infection
plez05200  Pathways in cancer
plez05207  Chemical carcinogenesis - receptor activation
Brite
KEGG Orthology (KO) [BR:plez00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    122206866 (GNAI1)
   04371 Apelin signaling pathway
    122206866 (GNAI1)
   04071 Sphingolipid signaling pathway
    122206866 (GNAI1)
   04024 cAMP signaling pathway
    122206866 (GNAI1)
   04022 cGMP-PKG signaling pathway
    122206866 (GNAI1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    122206866 (GNAI1)
   04081 Hormone signaling
    122206866 (GNAI1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    122206866 (GNAI1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122206866 (GNAI1)
   04670 Leukocyte transendothelial migration
    122206866 (GNAI1)
   04062 Chemokine signaling pathway
    122206866 (GNAI1)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    122206866 (GNAI1)
   04915 Estrogen signaling pathway
    122206866 (GNAI1)
   04914 Progesterone-mediated oocyte maturation
    122206866 (GNAI1)
   04921 Oxytocin signaling pathway
    122206866 (GNAI1)
   04926 Relaxin signaling pathway
    122206866 (GNAI1)
   04935 Growth hormone synthesis, secretion and action
    122206866 (GNAI1)
   04928 Parathyroid hormone synthesis, secretion and action
    122206866 (GNAI1)
   04916 Melanogenesis
    122206866 (GNAI1)
   04924 Renin secretion
    122206866 (GNAI1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    122206866 (GNAI1)
  09154 Digestive system
   04971 Gastric acid secretion
    122206866 (GNAI1)
  09156 Nervous system
   04724 Glutamatergic synapse
    122206866 (GNAI1)
   04727 GABAergic synapse
    122206866 (GNAI1)
   04725 Cholinergic synapse
    122206866 (GNAI1)
   04728 Dopaminergic synapse
    122206866 (GNAI1)
   04726 Serotonergic synapse
    122206866 (GNAI1)
   04730 Long-term depression
    122206866 (GNAI1)
   04723 Retrograde endocannabinoid signaling
    122206866 (GNAI1)
  09158 Development and regeneration
   04360 Axon guidance
    122206866 (GNAI1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    122206866 (GNAI1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122206866 (GNAI1)
   05207 Chemical carcinogenesis - receptor activation
    122206866 (GNAI1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    122206866 (GNAI1)
   05163 Human cytomegalovirus infection
    122206866 (GNAI1)
  09171 Infectious disease: bacterial
   05133 Pertussis
    122206866 (GNAI1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    122206866 (GNAI1)
   05142 Chagas disease
    122206866 (GNAI1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    122206866 (GNAI1)
  09165 Substance dependence
   05030 Cocaine addiction
    122206866 (GNAI1)
   05032 Morphine addiction
    122206866 (GNAI1)
   05034 Alcoholism
    122206866 (GNAI1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    122206866 (GNAI1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:plez04147]
    122206866 (GNAI1)
   04031 GTP-binding proteins [BR:plez04031]
    122206866 (GNAI1)
Exosome [BR:plez04147]
 Exosomal proteins
  Proteins found in most exosomes
   122206866 (GNAI1)
GTP-binding proteins [BR:plez04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 1 (Gi/o) [OT]
    122206866 (GNAI1)
SSDB
Motif
Pfam: G-alpha Arf Gtr1_RagA TniB FtsK_SpoIIIE AAA_29
Other DBs
NCBI-GeneID: 122206866
NCBI-ProteinID: XP_042772403
UniProt: A0A8C8XG40
LinkDB
Position
A2:83416133..83501254
AA seq 354 aa
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAG
YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMT
AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVK
TTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAA
AYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
NT seq 1065 nt   +upstreamnt  +downstreamnt
atgggctgtacgctgagcgccgaggacaaggcggcggtggagcggagtaagatgatcgac
cggaacctccgcgaggatggcgagaaggcggcgcgcgaggtcaagctgctgctgctcggt
gctggtgaatctgggaaaagcacaattgtgaagcaaatgaaaattatccatgaagctggt
tattcggaggaggaatgtaaacagtacaaagcggtggtctacagcaacaccatccaatca
attattgctatcattagggccatggggaggttgaagatagacttcggtgactcagctcgg
gcggatgatgcccgccaactgtttgtgcttgctggagccgctgaagaaggctttatgact
gcagaacttgccggagttataaagagactgtggaaagatagtggtgtacaagcctgtttc
aacagatcccgagagtaccagcttaatgattccgcagcatactatttgaatgacttggac
agaatagcacaaccaaactacattccaactcaacaagatgttctcagaactagagtgaaa
actacaggaattgttgaaacccattttactttcaaagatcttcattttaaaatgtttgat
gtgggaggacagagatctgagcggaagaagtggattcattgcttcgaaggagtgaccgcc
atcatcttctgtgtggctctgagtgactatgacctggttctagccgaagatgaggaaatg
aatcgaatgcatgaaagcatgaagttgtttgacagcatatgtaacaacaaatggtttaca
gacacgtctattatactttttctaaacaagaaggatctctttgaagaaaaaatcaaaaag
agccctctcactatatgctatccagaatacgcaggctcaaacacatatgaagaggcagct
gcgtatattcagtgtcagtttgaagacctcaataaaagaaaggacacaaaggaaatatac
acccacttcacatgtgccacagatacgaagaatgtgcagtttgtttttgatgctgtaaca
gatgtcatcataaaaaataatctaaaagattgtggtctcttctaa

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