Panthera leo (lion): 122208492
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Entry
122208492 CDS
T10741
Symbol
HSD17B2
Name
(RefSeq) 17-beta-hydroxysteroid dehydrogenase type 2
KO
K13368
17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:
1.1.1.62
1.1.1.239
]
Organism
plez Panthera leo (lion)
Pathway
plez00140
Steroid hormone biosynthesis
plez01100
Metabolic pathways
plez04913
Ovarian steroidogenesis
Module
plez_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
122208492 (HSD17B2)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
122208492 (HSD17B2)
Enzymes [BR:
plez01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.62 17beta-estradiol 17-dehydrogenase
122208492 (HSD17B2)
1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
122208492 (HSD17B2)
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Motif
Pfam:
adh_short
adh_short_C2
KR
Epimerase
DUF1776
Motif
Other DBs
NCBI-GeneID:
122208492
NCBI-ProteinID:
XP_042775549
UniProt:
A0A8C8Y970
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Position
E2:55101555..55191475
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AA seq
381 aa
AA seq
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MSTFSETAWLCLAVPAALGGIVLYKLKKSPGQVGGKVVCLAGLWAGAYLLSLSLFWGWVL
FPLSCFLMCAYLSGHEFLPVDQKAVLITGGDSGFGHALSKYLDELGFTVFVGVLNEKGPG
AEELRRTCSKRVSVLQMDITNPQQIKDAHSKVVEKVQNRGLWAVVNNAGIIGLPADGELI
PMTNYKQCMAVNFFGAVEVTKAFLPLLRKSKGRLVNISSMAGGVPIEKLAAYSSSKAALT
MFSAVMRQELSKWGVKVSVIQPGGFKTSIAGTSEMWNKLEQDILDNLTPEVLEDYGQDYI
LEQRDYLKFISGSTNTDMSPVLLDIRHAVSAKSPFAFYSPGPMAYPMLCFVSFSPTGVFD
YFSKKLHHFRGGMPKALTKQA
NT seq
1146 nt
NT seq
+upstream
nt +downstream
nt
atgagtaccttctctgagacagcatggctctgcctggctgtccccgcagcactgggagga
atagttctttacaaactcaagaagagcccggggcaggtgggggggaaggtggtctgcctg
gcgggcctctgggcaggggcttacctgctcagcctgtccctcttctggggctgggtcctc
ttccccctgtcctgtttcctcatgtgtgcttacttatctggccacgagtttttacctgtg
gatcaaaaggcggtgctgatcacaggtggtgattctggatttggccatgccctgtccaaa
tatctggatgagcttggcttcacggtatttgtcggagttctgaatgaaaagggaccagga
gcagaggaactgcgaagaacctgctccaagcgcgtctccgtgctccagatggacatcacc
aacccgcagcagataaaagacgcccacagcaaagtggtggaaaaggtgcagaacagagga
ctgtgggctgtggtcaacaatgctgggatcattggcttaccagcggatggggagctcatt
cccatgactaactacaaacaatgcatggccgtgaacttctttggggccgtggaggtcaca
aaggcatttttgcctcttcttaggaaatccaaggggaggctggtgaacatcagcagcatg
gcaggaggggtcccaatagagaagctggcagcctatagctcatccaaggcagctctgacc
atgttttcagcagtcatgagacaagagctttccaaatggggagttaaagtctctgtcatc
cagcctggaggcttcaaaacaagtatcgcgggcacgagtgaaatgtggaacaagctggag
caggacatcctggacaaccttacccccgaagtgctagaggactatgggcaggactatatc
cttgagcaacgggattatctcaagttcatcagcgggagtaccaacactgatatgtcccct
gtgctcctggacatccggcatgccgtgtctgctaagagcccctttgccttttactctcca
gggccaatggcttatccaatgctctgctttgtttcatttagtcctactggcgtatttgat
tattttagcaaaaagttgcatcactttagaggtggcatgcccaaggcgctaactaagcag
gcctaa
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