Panthera leo (lion): 122209407
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Entry
122209407 CDS
T10741
Symbol
ATP2A1
Name
(RefSeq) sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1
KO
K05853
P-type Ca2+ transporter type 2A [EC:
7.2.2.10
]
Organism
plez Panthera leo (lion)
Pathway
plez04020
Calcium signaling pathway
plez04022
cGMP-PKG signaling pathway
plez04024
cAMP signaling pathway
plez04148
Efferocytosis
plez04260
Cardiac muscle contraction
plez04261
Adrenergic signaling in cardiomyocytes
plez04380
Osteoclast differentiation
plez04919
Thyroid hormone signaling pathway
plez04972
Pancreatic secretion
plez05010
Alzheimer disease
plez05017
Spinocerebellar ataxia
plez05022
Pathways of neurodegeneration - multiple diseases
plez05410
Hypertrophic cardiomyopathy
plez05412
Arrhythmogenic right ventricular cardiomyopathy
plez05414
Dilated cardiomyopathy
plez05415
Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09130 Environmental Information Processing
09132 Signal transduction
04020 Calcium signaling pathway
122209407 (ATP2A1)
04024 cAMP signaling pathway
122209407 (ATP2A1)
04022 cGMP-PKG signaling pathway
122209407 (ATP2A1)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
122209407 (ATP2A1)
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
122209407 (ATP2A1)
09153 Circulatory system
04260 Cardiac muscle contraction
122209407 (ATP2A1)
04261 Adrenergic signaling in cardiomyocytes
122209407 (ATP2A1)
09154 Digestive system
04972 Pancreatic secretion
122209407 (ATP2A1)
09158 Development and regeneration
04380 Osteoclast differentiation
122209407 (ATP2A1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
122209407 (ATP2A1)
05017 Spinocerebellar ataxia
122209407 (ATP2A1)
05022 Pathways of neurodegeneration - multiple diseases
122209407 (ATP2A1)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
122209407 (ATP2A1)
05412 Arrhythmogenic right ventricular cardiomyopathy
122209407 (ATP2A1)
05414 Dilated cardiomyopathy
122209407 (ATP2A1)
05415 Diabetic cardiomyopathy
122209407 (ATP2A1)
Enzymes [BR:
plez01000
]
7. Translocases
7.2 Catalysing the translocation of inorganic cations
7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
7.2.2.10 P-type Ca2+ transporter
122209407 (ATP2A1)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
E1-E2_ATPase
Cation_ATPase_C
Cation_ATPase
Cation_ATPase_N
Hydrolase
Hydrolase_3
HAD
Motif
Other DBs
NCBI-GeneID:
122209407
NCBI-ProteinID:
XP_042777152
UniProt:
A0A8C8XAF3
LinkDB
All DBs
Position
E3:18819743..18835206
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AA seq
1000 aa
AA seq
DB search
MEAAHSKTTEECLAYFGVSETTGLTPDQVKRHLEKYGLNELPAEEGKSLWELVIEQFEDL
LVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALK
EYEPEMGKVYRADRKTVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVDQSIL
TGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMA
ATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWLRGAIYYFKIAV
ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCKMFIIDKVDGNICVLNEFSITGSTYAPEGEVLKNDKPVRSGQYDGLVELATICALC
NDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVFSTDVRSLSKVERANACNSVIRQLMK
KEFTLEFSRDRKSMSVYCSPAKSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPITGPV
KDKILSVIKEWGTGRDTLRCLALATRDTPPKREEMILDDSARFMEYETDLTFVGVVGMLD
PPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDDL
PLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMG
SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAAL
GLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIG
GYVGAATVGAAAWWFLYADDGPHVTYSQLTHFMQCNEENPDFEGVDCEVFEAPQPMTMAL
SVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRA
LDCTQWLMVLKISFPVILLDELLKFIARNYLEDPEDERRK
NT seq
3003 nt
NT seq
+upstream
nt +downstream
nt
atggaggctgcacactccaagaccacagaagaatgtctggcctattttggggtgagcgag
actacaggcctgacgccggaccaagtgaagcggcacctagagaaatacggcctcaatgag
ctccctgctgaggaagggaagtccctgtgggagttggtgatagagcagtttgaagacctc
ctggtgcggatccttctcctggccgcctgcatttccttcgtgctggcctggttcgaggaa
ggtgaagagaccatcactgcctttgttgaaccctttgtcatcctcttgatcctcatcgcc
aatgccatcgtgggggtttggcaggagcgtaatgcagagaatgccattgaggctctgaag
gaatatgaacccgagatggggaaagtctaccgggctgaccgcaagacagtacagaggatc
aaggctcgggacattgtccccggggacattgtggaggtggctgtgggcgacaaagtgcct
gcagatatccggatcctgtccatcaaatccaccaccctccgggttgaccagtccatcctg
acgggcgagtccgtatctgtcatcaagcacacagaccctgttcctgacccccgagctgtc
aaccaggataagaagaacatgcttttctcgggtaccaacatcgcagctggcaaggcctta
ggcatcgtggccactactggtgtgagcaccgagattgggaagatccgtgaccagatggct
gccacggaacaggacaaaacccctctgcagcagaagctggatgagtttggggagcagctc
tccaaggtcatctccctcatctgtgtggccgtctggctcatcaacatcggccatttcaac
gatcccgtccacggcggctcctggttgcggggtgccatctactactttaagattgccgtg
gccctggctgtggccgcaatcccagaaggccttcctgcggtcatcaccacctgcctggcc
ttgggcacccggcggatggcaaagaaaaatgcaattgtgaggagcctgccctccgtggag
actctgggctgcacctccgtcatctgttccgacaagacgggcaccctcaccaccaaccag
atgtctgtctgcaagatgtttattatcgacaaggtggacggaaacatctgtgtcctgaac
gagttctccatcactggttccacttacgctccagaaggagaggtcttgaagaatgataag
ccagtccgctcagggcagtatgatgggctggtggagttggccaccatttgtgccctctgc
aatgactcctccttggacttcaacgaggccaaaggtgtttacgagaaggtgggtgaggca
acagagacggcgctcaccaccctggtggagaagatgaatgtgttcagcacagacgtgagg
agcctctcaaaagtggagcgggccaacgcctgcaactcagtgatccgccagctaatgaag
aaggaatttaccctggagttctcccgagaccggaagtccatgtctgtctattgctccccg
gccaaatcccgggctgccgtgggcaacaagatgtttgtcaagggtgcccctgagggggtc
atcgaccgctgtaactacgtgcgagttggcaccacccgcgtgccgattacagggccggtg
aaggacaagatcctgtccgtgatcaaggagtggggcaccggccgggataccctgcgctgc
ctggccctggccacccgggacacccccccgaagcgagaggagatgatcctggatgactct
gccaggtttatggagtacgagacggacctgacatttgtcggcgtggtgggcatgctggac
ccaccccgcaaggaggtcacgggctctattcagctgtgccgggatgccggaatccgagtc
atcatgatcaccggggacaacaaaggcacagccattgccatctgccgacgaatcggcatc
tttggggagaacgaggaggtggccgaccgagcctacaccggccgggagtttgacgacctg
cccctggcggagcagcgggaggcctgccgtcgcgcctgctgcttcgcccgcgtggagccc
tcccataagtcgaagatcgtggagtatctgcagtcctacgatgagatcacggccatgacg
ggtgatggtgtcaacgatgcccccgccctgaagaaggccgagatcggcatcgccatggga
tccggcaccgccgtggccaagaccgcttctgagatggtgctggccgacgacaacttctcc
accatcgtggctgcggtggaggagggccgcgccatctacaacaacatgaagcagttcatc
cgctacctcatctcctccaacgtgggcgaggtggtctgcatcttcctgaccgccgcctta
ggactgcctgaggccctgatccctgtgcagctgctgtgggtgaacttggtgacagatggg
ctcccggccacagccctgggcttcaacccaccagacctggacatcatggaccggcctccc
cggagccccaaggagcccctcatcagtggctggctcttcttccgctacatggcaatcggg
ggctacgtgggtgcggccactgtgggagcggctgcctggtggttcctgtatgcagatgac
gggcctcatgtcacttacagccagctgactcacttcatgcagtgcaacgaggaaaacccc
gactttgagggcgtggactgcgaggtctttgaggccccccagcccatgaccatggccttg
tctgtgctggttaccattgaaatgtgcaacgctctcaacagcctgtctgagaaccagtcc
cttctgcggatgccgccctgggtgaacatctggctgctgggctccatctgcctgtccatg
tccctgcacttcctcatcctctatgtcgaccctctgccgatgatcttcaagctccgggcc
ctggactgcacccagtggctcatggtcctcaagatctcatttccggtcatcctgctcgat
gagctcctcaagttcattgctcggaactacctagaggatccagaagatgaaagaaggaag
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