KEGG   Panthera leo (lion): 122210076
Entry
122210076         CDS       T10741                                 
Symbol
RAC1
Name
(RefSeq) ras-related C3 botulinum toxin substrate 1 isoform X1
  KO
K04392  Ras-related C3 botulinum toxin substrate 1
Organism
plez  Panthera leo (lion)
Pathway
plez04010  MAPK signaling pathway
plez04014  Ras signaling pathway
plez04015  Rap1 signaling pathway
plez04024  cAMP signaling pathway
plez04062  Chemokine signaling pathway
plez04071  Sphingolipid signaling pathway
plez04145  Phagosome
plez04148  Efferocytosis
plez04151  PI3K-Akt signaling pathway
plez04310  Wnt signaling pathway
plez04360  Axon guidance
plez04370  VEGF signaling pathway
plez04380  Osteoclast differentiation
plez04510  Focal adhesion
plez04520  Adherens junction
plez04530  Tight junction
plez04613  Neutrophil extracellular trap formation
plez04620  Toll-like receptor signaling pathway
plez04650  Natural killer cell mediated cytotoxicity
plez04662  B cell receptor signaling pathway
plez04664  Fc epsilon RI signaling pathway
plez04666  Fc gamma R-mediated phagocytosis
plez04670  Leukocyte transendothelial migration
plez04722  Neurotrophin signaling pathway
plez04810  Regulation of actin cytoskeleton
plez04932  Non-alcoholic fatty liver disease
plez04933  AGE-RAGE signaling pathway in diabetic complications
plez04972  Pancreatic secretion
plez05014  Amyotrophic lateral sclerosis
plez05020  Prion disease
plez05022  Pathways of neurodegeneration - multiple diseases
plez05100  Bacterial invasion of epithelial cells
plez05132  Salmonella infection
plez05135  Yersinia infection
plez05163  Human cytomegalovirus infection
plez05167  Kaposi sarcoma-associated herpesvirus infection
plez05169  Epstein-Barr virus infection
plez05170  Human immunodeficiency virus 1 infection
plez05200  Pathways in cancer
plez05203  Viral carcinogenesis
plez05205  Proteoglycans in cancer
plez05208  Chemical carcinogenesis - reactive oxygen species
plez05210  Colorectal cancer
plez05211  Renal cell carcinoma
plez05212  Pancreatic cancer
plez05231  Choline metabolism in cancer
plez05415  Diabetic cardiomyopathy
plez05416  Viral myocarditis
plez05417  Lipid and atherosclerosis
plez05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:plez00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122210076 (RAC1)
   04014 Ras signaling pathway
    122210076 (RAC1)
   04015 Rap1 signaling pathway
    122210076 (RAC1)
   04310 Wnt signaling pathway
    122210076 (RAC1)
   04370 VEGF signaling pathway
    122210076 (RAC1)
   04071 Sphingolipid signaling pathway
    122210076 (RAC1)
   04024 cAMP signaling pathway
    122210076 (RAC1)
   04151 PI3K-Akt signaling pathway
    122210076 (RAC1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    122210076 (RAC1)
   04148 Efferocytosis
    122210076 (RAC1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122210076 (RAC1)
   04520 Adherens junction
    122210076 (RAC1)
   04530 Tight junction
    122210076 (RAC1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122210076 (RAC1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    122210076 (RAC1)
   04620 Toll-like receptor signaling pathway
    122210076 (RAC1)
   04650 Natural killer cell mediated cytotoxicity
    122210076 (RAC1)
   04662 B cell receptor signaling pathway
    122210076 (RAC1)
   04664 Fc epsilon RI signaling pathway
    122210076 (RAC1)
   04666 Fc gamma R-mediated phagocytosis
    122210076 (RAC1)
   04670 Leukocyte transendothelial migration
    122210076 (RAC1)
   04062 Chemokine signaling pathway
    122210076 (RAC1)
  09154 Digestive system
   04972 Pancreatic secretion
    122210076 (RAC1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    122210076 (RAC1)
  09158 Development and regeneration
   04360 Axon guidance
    122210076 (RAC1)
   04380 Osteoclast differentiation
    122210076 (RAC1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122210076 (RAC1)
   05205 Proteoglycans in cancer
    122210076 (RAC1)
   05208 Chemical carcinogenesis - reactive oxygen species
    122210076 (RAC1)
   05203 Viral carcinogenesis
    122210076 (RAC1)
   05231 Choline metabolism in cancer
    122210076 (RAC1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122210076 (RAC1)
   05212 Pancreatic cancer
    122210076 (RAC1)
   05211 Renal cell carcinoma
    122210076 (RAC1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    122210076 (RAC1)
   05163 Human cytomegalovirus infection
    122210076 (RAC1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122210076 (RAC1)
   05169 Epstein-Barr virus infection
    122210076 (RAC1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122210076 (RAC1)
   05135 Yersinia infection
    122210076 (RAC1)
   05100 Bacterial invasion of epithelial cells
    122210076 (RAC1)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    122210076 (RAC1)
   05020 Prion disease
    122210076 (RAC1)
   05022 Pathways of neurodegeneration - multiple diseases
    122210076 (RAC1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122210076 (RAC1)
   05418 Fluid shear stress and atherosclerosis
    122210076 (RAC1)
   05415 Diabetic cardiomyopathy
    122210076 (RAC1)
   05416 Viral myocarditis
    122210076 (RAC1)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    122210076 (RAC1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122210076 (RAC1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:plez04131]
    122210076 (RAC1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:plez04147]
    122210076 (RAC1)
   04031 GTP-binding proteins [BR:plez04031]
    122210076 (RAC1)
Membrane trafficking [BR:plez04131]
 Exocytosis
  Small GTPases and associated proteins
   Rho GTPases
    122210076 (RAC1)
 Endocytosis
  Lipid raft mediated endocytosis
   Arf6-dependent endocytosis
    122210076 (RAC1)
  Macropinocytosis
   Ras GTPases
    122210076 (RAC1)
 Others
  NADPH oxidases (Nox) and associated proteins
   Nox associated proteins
    122210076 (RAC1)
Exosome [BR:plez04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   122210076 (RAC1)
  Exosomal proteins of other body fluids (saliva and urine)
   122210076 (RAC1)
  Exosomal proteins of colorectal cancer cells
   122210076 (RAC1)
  Exosomal proteins of bladder cancer cells
   122210076 (RAC1)
GTP-binding proteins [BR:plez04031]
 Small (monomeric) G-proteins
  Rho Family
   Rac/Cdc42 [OT]
    122210076 (RAC1)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU CagD
Other DBs
NCBI-GeneID: 122210076
NCBI-ProteinID: XP_042778463
UniProt: A0A8C8XFZ1
LinkDB
Position
E3:complement(4749724..4773332)
AA seq 192 aa
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG
QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR
DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP
PVKKRKRKCLLL
NT seq 579 nt   +upstreamnt  +downstreamnt
atgcaggccatcaagtgtgtggtggtgggagacggagccgtaggtaaaacgtgcctactg
atcagttacacaaccaatgcgtttcctggagaatatatccccactgtctttgacaactac
tctgccaatgttatggtggatggaaaaccggtgaatctgggcttatgggatacagctgga
caagaagattatgacagattacgtcccttatcctatccgcaaacagatgtattcttaatt
tgcttttctcttgtgagtcctgcgtcatttgaaaatgttcgagcaaagtggtaccctgaa
gtgcgacaccactgtcccaacacccccatcatcttagtgggaactaaacttgacctcagg
gacgacaaagacacgattgagaaactgaaggagaaaaagctgactcccatcacctacccg
cagggtttggccatggcgaaggagatcggtgctgtaaaatacctggagtgctcggcgctc
acgcagcgaggcctcaagacagtgtttgatgaagctattcgagcggttctctgcccccct
cccgtcaagaagaggaagagaaaatgcctgctgttgtaa

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