Panthera leo (lion): 122210238 Help Entry 122210238         CDS       T10741                                  Symbol TSC2 Name (RefSeq) tuberin isoform X1   KO K07207   tuberous sclerosis 2 Organism plez  Panthera leo (lion) Pathway plez04072   Phospholipase D signaling pathway plez04115   p53 signaling pathway plez04140   Autophagy - animal plez04150   mTOR signaling pathway plez04151   PI3K-Akt signaling pathway plez04152   AMPK signaling pathway plez04211   Longevity regulating pathway plez04218   Cellular senescence plez04714   Thermogenesis plez04910   Insulin signaling pathway plez04919   Thyroid hormone signaling pathway plez05163   Human cytomegalovirus infection plez05165   Human papillomavirus infection plez05168   Herpes simplex virus 1 infection plez05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:plez00001]  09130 Environmental Information Processing   09132 Signal transduction    04072 Phospholipase D signaling pathway     122210238 (TSC2)    04151 PI3K-Akt signaling pathway     122210238 (TSC2)    04152 AMPK signaling pathway     122210238 (TSC2)    04150 mTOR signaling pathway     122210238 (TSC2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     122210238 (TSC2)   09143 Cell growth and death    04115 p53 signaling pathway     122210238 (TSC2)    04218 Cellular senescence     122210238 (TSC2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     122210238 (TSC2)    04919 Thyroid hormone signaling pathway     122210238 (TSC2)   09149 Aging    04211 Longevity regulating pathway     122210238 (TSC2)   09159 Environmental adaptation    04714 Thermogenesis     122210238 (TSC2)  09160 Human Diseases   09161 Cancer: overview    05231 Choline metabolism in cancer     122210238 (TSC2)   09172 Infectious disease: viral    05168 Herpes simplex virus 1 infection     122210238 (TSC2)    05163 Human cytomegalovirus infection     122210238 (TSC2)    05165 Human papillomavirus infection     122210238 (TSC2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:plez01009]     122210238 (TSC2) Protein phosphatases and associated proteins [BR:plez01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      122210238 (TSC2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Tuberin DUF3384 Rap_GAP HEAT Cnd1 Motif Other DBs NCBI-GeneID:  122210238 NCBI-ProteinID:  XP_042778752 LinkDB All DBs Position E3:complement(39458711..39494860) Genome browser AA seq 1824 aa AA seqDB search MAKPTSKDSGLKEKFRILFGLGTPRPNPRSAEGKQTEFIITAEILRELSVECGLNNRIRV IGQICEVAKTKKFEEHAVEALWKAVEDMLQPERPPEARHAVLALLKAIVQGQGDRLGVLR ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELAGFVLQWMDIGLSSEFLLVL VNLVKFNSCYLDEYIASMVHMICLLCVQTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFI VTLCRTVNVKELCEPCWKLMRNLLGTHLGHSAIYNMCRIMEDRAYMEDAPLLRGAVFFVG MALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSITRLIKKYRRELQAVTWDI LLNIIERLLRQLQSLDSPELRAIVHDLLTTVEELCDQNEFHGSHERYFELVERCADQRPE SSLLNLITYRAQSIHPAKDGWIHNLQLLMERFFRNESRSAVRIKVLDVLSFVLLINRQFY EEELISSVVISQLSHIPEDKDPQVRKLATQLLVDLAEGCHTHHFNSLLDIVEKVMARSLS APPELEERDVVAYSASLEDVKTAVLGLLVILQTKLYALPASHAVRVYETLVSHLQLHYKH GYALPIASSIRLQAFDFLLLLRADSLHRLGLPSKDGAVRFSPYCVCDSTEPERGSEKKAS GPLSPPTGPSGPAPAGPAVRLGSLPYSLLFRVLLQCLKQETDWKVLKLVLGKLPESLRFK VLIFTSPCSVDQLSSALCSMLSGPRTLERLRGTPEGFSRTDLHLAVVPVLTALISYHNYL DKTRQREMVYCLEQGLIYRCASQCVVALAVCSVEMPDIIIKALPVLVVKLTHISATASMA IPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC RLPFRKDFVPYITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS PPVREFQESSAADAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSMAQADDNLKNLHL ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL LGLDSGELQGSPELSSDPSAHVRQTKEAPAKLESQAGQQVCRGARDRVRSMSGGHGLRVG ALDAPATHCPGAQTTPASTSERASAAAQLPAQEKTSLAAYVPLLTQGWAEILVRRPTGNT SWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKERRDTALYKSLSVPAAGSAKPPPP PRSNTVASFSSLYQTSCQGELHRSISWADSAVVLEEGSPSETDLPGEPTELEDFEATLGP ERRCRRPEAYSRSSSSSSQEEKSFAAEEVAAGGLPIGRAVSAEGARPSAGLSFQPAQPLS KSSSSPELQTLQDTLGDPGDKADVGRLSPEAKARSQSGTLDGAGATWSTPGEASQGRGPA RPEGPSPSGCPRSPGGLRPRGYTISDSAPSRRGKRVERDAFKSRAGASNTEKVPGINPSF VFLQLYHSPFFGDESNKPILLPNESFERSVQLLDQIPSYDTHKIAVLYVGEGQSSSELAI LSNEHGSYRYTEFLTGLGKLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHI ATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIITPLDYECN LVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWI ARLRHIKRLRHRVGQIREEAHYSNPSLPLTQTHPPGHAKAPAPAEPMPTYETGQRKRLIS SVDDFTEFVRRGAWSHCSHQVPRP NT seq 5475 nt NT seq  +upstreamnt  +downstreamnt atggccaagccgacaagcaaggattcaggcttgaaggagaagttcaggattctgtttgga ctgggaaccccgcggccaaaccccaggtctgcagagggcaagcagacggaatttatcatc acggcggaaatcctgagagagctgagcgttgaatgtggcctcaacaatcgcatccgggtg atagggcagatctgtgaagttgcaaaaacgaagaagtttgaagagcatgcagtggaagcg ctctggaaggccgtcgaggacatgctgcagccagagcggccaccggaggcccggcatgcg gttctggctctgctgaaggccatcgtgcaggggcagggggaccgcttgggcgttctcagg gccctcttctttaaggtcatcaaggattacccctctaatgaagatctccacgaaagactg gaagttttcaaggccctcacagacaatgggagacacatcacatatttggaagaagaactg gctgggtttgtgctgcagtggatggacatcggcctgtcctcagagttccttctggtgctt gtgaacttggtcaaattcaacagctgttacctggatgaatacatcgcatcaatggtccac atgatctgcctgctgtgtgtccagactgtgtcctccgtggacatagaggtctctctgcag gtgctggacgccgtcgtctgctacaactgtctgccggctgagagcctgcccctgttcatt gtcactctctgtcgtaccgtcaacgtcaaggagctctgtgagccttgctggaagctgatg cgtaatcttctgggcacccacctgggtcacagtgccatctacaacatgtgccgcatcatg gaggacagagcctacatggaagatgccccgctgctgagaggggccgtgttctttgtgggc atggctctctggggggcgcaccgactctactcgctcaagaactccccgacatccgtgctg ccgtcgttttacgaggccatgacctgtccgaacgaggtggtgtcctatgaaatcgtcctg tctatcaccagactcatcaagaagtaccggagggagctccaggctgtgacgtgggatatc ctgctgaacatcatcgaacgtctgctgcggcagctccagagcctggacagcccggagctc agagccatcgtccatgacctgctgaccacagtggaggagctgtgtgaccagaatgagttc cacggctcgcacgagagatacttcgagctcgttgagagatgtgcagaccagaggccggag tcctccctcctaaacttaataacctacagggctcagtccatccatccggcaaaggacggc tggattcacaacctgcagttactgatggagagattcttccggaatgaatcccgcagtgct gtgcgcatcaaggtgctcgacgtcctgtcctttgtgctgctcatcaacaggcagttctat gaggaggagctgatcagctcggtggtcatctctcagctctcccacatcccggaggacaaa gacccccaagtccggaaactggccacccagttgctggtggacctggccgaaggctgtcac acccaccacttcaacagcctgctggacattgtggagaaggtgatggcccgctccctttcc gcaccccctgagctggaggaaagagatgtggtggcatattcagcctccttagaggatgtg aagactgccgtcttggggctcctggtgatccttcagaccaagctgtacgccttgcctgcc agccacgcggtgcgtgtgtacgagaccctcgtcagccacctgcagctccactacaagcac ggctatgccctgcccatcgccagtagcatccggctgcaggcctttgacttcctgctgctg ctgagggcggactccctgcaccgcctcggcctgcccagcaaggacggggctgtgaggttc agcccctactgcgtctgcgactccacggagccagagagaggctctgagaagaaggccagc ggccccctgtcgcctcccaccgggccatccggcccagcacctgccggtcccgctgtgcgg cttggctccctgccctactccctgctcttccgggtcctgctgcagtgcttgaagcaggag acggactggaaggtgctgaagcttgttctcggcaagctgcccgagtccctgcgcttcaag gtcctcatcttcacgtccccgtgcagcgtcgaccagctgtcttccgccctctgctccatg ctttcaggtcccagaactctggagcggctccgaggcaccccggaaggtttctccaggacc gacctgcacctggctgtggttcctgtgctgacggcgttaatctcttaccataactatttg gacaaaaccagacagcgggagatggtatactgcctggagcaaggcctgatctaccgctgt gccagccagtgcgtggtggccctggccgtgtgcagcgtcgaaatgcccgacatcatcatc aaggcgctgcctgtcttggtcgtgaagctcacacacatttcggccacagccagcatggcc attccactcctcgaattcctgtcaactctggccaggctgcctcacctctacaggaacttt gccgctgagcagtacgcgagtgtgttcgccatctccctgccgtacaccaacccctccaag tttaatcagtacatcgtgtgcctggcccatcacgtcatagccatgtggttcattagatgc cgtctgccttttcggaaggattttgttccttatatcactaagggcctgcgctccaatgtc ctcctgtcttttgatgacaccccggagaaggacagcttcagagcgcggagcaccagtctg aacgagaggcccaagagtttgaggatagccagaccccccaaacaaggcttgaataactcc ccacccgtgagagaattccaggagagctctgcagccgacgccttccggtgccgcagcatc agtgtgtctgaacatgtggtccgcagcaggatccagacgtccctcacgagtgccagcttg gggtctgcggacgagaactcaatggcccaggctgacgacaacttgaaaaatctccacctg gagctcacggagacttgtctggacatgatggccagatacgtgttctccaacttcacggcg gtccccaagaggtcccccgtgggggagttcctcttggctggtggcaggaccaagacctgg ctggttggaaacaagctcgtcactgtgacgacgagcgtggggaccgggacccggtcactg ctgggcttggactcaggagagctgcagggcagcccagagctgagctctgaccccagtgcg cacgtgaggcagacaaaggaggcgcctgccaagttggagtcccaggctgggcagcaggtg tgccgtggggcccgggaccgcgtccgctccatgtctgggggccacggccttcgtgttggt gccttggacgctccagccacccactgcccaggcgcacagaccacaccggccagcacgtcc gagagggcctcggctgccgcccagctcccggcgcaggagaagacgagcctggcggcctac gtacccctgctgacccagggctgggcggagatcttggtccggaggcccacggggaacacc agctggctgatgagtctggagaaccccctcagccccttctcctcggacatcaacaacatg cccctgcaggagctgtccaacgccctcatggccgccgagcgcttcaaggagcgtcgtgac acggccctgtacaagtcactttcggtgccggcggccggctccgccaagccccctccgccc ccacgttctaacacagtggcctctttctcctccctgtaccagaccagttgccaaggagag ctgcacaggagcatttcctgggcagactccgcggtggttctggaggagggaagtcccagc gagactgatttgccaggcgagcccaccgagctggaggactttgaggccaccctgggccca gagaggcgctgtcggcgccctgaagcctacagtagatcgtcttccagctccagccaagag gagaagtctttcgccgcagaggaggtggctgccggagggctccccatcgggcgggctgtg tctgccgagggagcccggccctctgcggggctctccttccagcccgcccagcccctcagc aagtctagctcctcgccagagctgcagaccctgcaggatacactcggggaccctggggac aaggccgacgttgggcggctgagccccgaggccaaggcccgctcacagtccgggactctg gatggggcaggtgccacctggtcgaccccaggtgaagcgagtcagggccggggccctgcg aggcccgagggtccctcgccttctggctgtccccgttcccccggtggcctgcgtcccaga ggctacaccatttcggattcagccccgtcacgcagaggcaagagggtagagcgggacgcc ttcaagagcagagctggggcctccaatactgagaaggtgccgggcatcaaccccagcttc gtgttcctgcagctctaccactctcctttctttggcgacgagtccaacaagccgatcctt ctgcctaacgagtccttcgagcggtcggtgcagctcctcgaccagatcccgtcctacgac acacacaagatcgctgtcctgtacgtgggagaaggccagagcagcagcgagctcgccatc ctgtccaacgagcacggctcgtaccggtacacagagttcctgacgggcctgggcaagctc atcgagcttaaggactgccagccggataaggtgtacctgggcggtctggacgtgtgcggg gaggacggccagttcacttactgctggcacgatgacatcatgcaggctgtcttccatatc gccaccctgatgcccaccaaggacgtggacaagcaccgctgtgacaagaagcgccatctg ggcaacgactttgtgtccattgtctataatgactccggcgaggacttcaaactgggcacc attaaaggccagttcaacttcgtccacgtgatcatcacccccctggactacgagtgcaac ctggtgtccctacagtgcaggaaggacatggagggcctcgtggacaccagcgtggccaag atcgtgtctgatcgcaacctgcccttcgtggcccgtcagatggctctgcacgccaacatg gcctcccaggtgcaccacagccgctctaaccccacggatatctacccgtccaagtggatc gccaggctccgtcacatcaagcggctgcgccaccgggtagggcagatccgcgaggaagcc cactactccaaccccagcctgccactgacgcagacgcaccctccgggccacgccaaggcc ccggccccggccgagcccatgcccacgtacgagacgggccagcggaagcgcctcatctcc tctgtggatgacttcaccgagttcgtgagacggggggcatggagccactgcagccaccag gtccctcggccctaa

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