Panthera leo (lion): 122210318 Help Entry 122210318         CDS       T10741                                  Symbol ADCY9 Name (RefSeq) adenylate cyclase type 9   KO K08049   adenylate cyclase 9 [EC:4.6.1.1] Organism plez  Panthera leo (lion) Pathway plez00230   Purine metabolism plez01100   Metabolic pathways plez01522   Endocrine resistance plez04015   Rap1 signaling pathway plez04020   Calcium signaling pathway plez04022   cGMP-PKG signaling pathway plez04024   cAMP signaling pathway plez04062   Chemokine signaling pathway plez04072   Phospholipase D signaling pathway plez04081   Hormone signaling plez04082   Neuroactive ligand signaling plez04114   Oocyte meiosis plez04211   Longevity regulating pathway plez04213   Longevity regulating pathway - multiple species plez04261   Adrenergic signaling in cardiomyocytes plez04270   Vascular smooth muscle contraction plez04371   Apelin signaling pathway plez04540   Gap junction plez04611   Platelet activation plez04713   Circadian entrainment plez04714   Thermogenesis plez04723   Retrograde endocannabinoid signaling plez04724   Glutamatergic synapse plez04725   Cholinergic synapse plez04727   GABAergic synapse plez04750   Inflammatory mediator regulation of TRP channels plez04911   Insulin secretion plez04912   GnRH signaling pathway plez04913   Ovarian steroidogenesis plez04914   Progesterone-mediated oocyte maturation plez04915   Estrogen signaling pathway plez04916   Melanogenesis plez04918   Thyroid hormone synthesis plez04921   Oxytocin signaling pathway plez04923   Regulation of lipolysis in adipocytes plez04925   Aldosterone synthesis and secretion plez04926   Relaxin signaling pathway plez04927   Cortisol synthesis and secretion plez04928   Parathyroid hormone synthesis, secretion and action plez04934   Cushing syndrome plez04935   Growth hormone synthesis, secretion and action plez04961   Endocrine and other factor-regulated calcium reabsorption plez04962   Vasopressin-regulated water reabsorption plez04970   Salivary secretion plez04971   Gastric acid secretion plez04972   Pancreatic secretion plez04976   Bile secretion plez05032   Morphine addiction plez05163   Human cytomegalovirus infection plez05166   Human T-cell leukemia virus 1 infection plez05200   Pathways in cancer plez05207   Chemical carcinogenesis - receptor activation plez05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:plez00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     122210318 (ADCY9)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     122210318 (ADCY9)    04371 Apelin signaling pathway     122210318 (ADCY9)    04020 Calcium signaling pathway     122210318 (ADCY9)    04072 Phospholipase D signaling pathway     122210318 (ADCY9)    04024 cAMP signaling pathway     122210318 (ADCY9)    04022 cGMP-PKG signaling pathway     122210318 (ADCY9)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     122210318 (ADCY9)    04081 Hormone signaling     122210318 (ADCY9)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     122210318 (ADCY9)   09144 Cellular community - eukaryotes    04540 Gap junction     122210318 (ADCY9)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     122210318 (ADCY9)    04062 Chemokine signaling pathway     122210318 (ADCY9)   09152 Endocrine system    04911 Insulin secretion     122210318 (ADCY9)    04923 Regulation of lipolysis in adipocytes     122210318 (ADCY9)    04912 GnRH signaling pathway     122210318 (ADCY9)    04913 Ovarian steroidogenesis     122210318 (ADCY9)    04915 Estrogen signaling pathway     122210318 (ADCY9)    04914 Progesterone-mediated oocyte maturation     122210318 (ADCY9)    04921 Oxytocin signaling pathway     122210318 (ADCY9)    04926 Relaxin signaling pathway     122210318 (ADCY9)    04935 Growth hormone synthesis, secretion and action     122210318 (ADCY9)    04918 Thyroid hormone synthesis     122210318 (ADCY9)    04928 Parathyroid hormone synthesis, secretion and action     122210318 (ADCY9)    04916 Melanogenesis     122210318 (ADCY9)    04925 Aldosterone synthesis and secretion     122210318 (ADCY9)    04927 Cortisol synthesis and secretion     122210318 (ADCY9)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     122210318 (ADCY9)    04270 Vascular smooth muscle contraction     122210318 (ADCY9)   09154 Digestive system    04970 Salivary secretion     122210318 (ADCY9)    04971 Gastric acid secretion     122210318 (ADCY9)    04972 Pancreatic secretion     122210318 (ADCY9)    04976 Bile secretion     122210318 (ADCY9)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     122210318 (ADCY9)    04961 Endocrine and other factor-regulated calcium reabsorption     122210318 (ADCY9)   09156 Nervous system    04724 Glutamatergic synapse     122210318 (ADCY9)    04727 GABAergic synapse     122210318 (ADCY9)    04725 Cholinergic synapse     122210318 (ADCY9)    04723 Retrograde endocannabinoid signaling     122210318 (ADCY9)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     122210318 (ADCY9)   09149 Aging    04211 Longevity regulating pathway     122210318 (ADCY9)    04213 Longevity regulating pathway - multiple species     122210318 (ADCY9)   09159 Environmental adaptation    04713 Circadian entrainment     122210318 (ADCY9)    04714 Thermogenesis     122210318 (ADCY9)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     122210318 (ADCY9)    05207 Chemical carcinogenesis - receptor activation     122210318 (ADCY9)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     122210318 (ADCY9)    05163 Human cytomegalovirus infection     122210318 (ADCY9)   09165 Substance dependence    05032 Morphine addiction     122210318 (ADCY9)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     122210318 (ADCY9)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     122210318 (ADCY9)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     122210318 (ADCY9) Enzymes [BR:plez01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      122210318 (ADCY9) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom Motif Other DBs NCBI-GeneID:  122210318 NCBI-ProteinID:  XP_042778882 LinkDB All DBs Position E3:37775302..37895303 Genome browser AA seq 1352 aa AA seqDB search MASPPHQQLLRHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDS AGVPRRVGAGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACMERCFPQTRRRFRYAL FYIGFACLLWSIYFGVHMRSRLIVMVAPALCFLVVCGGFFLFTFTKVYARHYVWTSLVLT LLVFALTLAAQFQVLTPLSGRVDSSNHTLATKPTDTCLSQVGSFSMCIEVLFLLYTVMHL PLYLSLCLGVAYSVLFETFGYHFRDKDCFPPPEAGAPHWELLSRALLHVCIHAIGIHLFI MSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR HATSSPKNRKKKSSIQKAPIAFRPFKMQQIDEVSILFADIVGFTKMSANKSAHALVGLLN DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIRAIEQFCQEK KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD DRYEMEDGRVTERLGQSVVADQLKGLKTYLIAGQRAKESRCSCSEALLSGYEVIDGSRVS SGPRGQGTASPGSVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAVQNGCQEEHKN STKAPGAPNSKTQNGLLSPPHEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTF ASATFSSLLDVFLSTTVFLILSITCFLKYGAASMPPPPAALAVFGAALLLEVLSLVVSVR MVFFLEDVMACTKRLLERIAGWLPRHFIGAILVSLPALAVYSHITSEFDTDIHFTVFAGS AILTAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYISLCPDSSVVISHLDVGQNFSSKG NPCNSSLPRDGRAASLIGQEGVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKI QSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKEC YRVLNELIGDFDELLSRPGYGSIEKIKTIGATYMAASGLNGAQCRDGSHPQEHLQVLFEF AKEMMRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDSTG VECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDSGAVPQHQLSISPD IRVQVDGSIGRSPTDEIANLVPSVQSADKTPPGSENNVQARDAHLSSKRPWKEPVKAEER CRFGKAIEKSDCEDADAEEASELTRLNVSESV NT seq 4059 nt NT seq  +upstreamnt  +downstreamnt atggcttccccgccccaccagcagctgctgcggcaccacagcacggaggtgagctgtgac tccagcggagacagcaacagcgtgagggtcaaaatcaaccccaagcagctgtcctccaac agccaccccaagcactgcaaatacagcatctcctccagctgtagcagctctggggactcg gcgggcgtcccccggagagtgggcgctggaggccgcctgcgcaggcagaagaagctgccc cagctgttcgagagggcctccagccggtggtgggaccccaagttcgactcggtgaacctg gaggaggcttgcatggagcgctgcttcccgcagacccggcgccgcttccggtatgcgctc ttctacatcggcttcgcctgccttctgtggagcatctattttggggtccacatgcggtcc cgcctgattgtcatggtagcccctgctctgtgcttcctcgtcgtgtgtgggggctttttt ctgtttaccttcaccaaggtgtatgcccggcattacgtgtggacctctctggttctcacc ctcctggtgtttgccctgaccctggctgcccagtttcaggttctgacgcctctctcagga cgtgttgacagctccaatcacaccctcgccaccaagcccacggacacttgtttgtctcaa gtggggagcttttccatgtgcatcgaagtgctctttttgctctacaccgtcatgcactta cctttgtacttgagcttgtgtttgggagtggcctattctgttctctttgagacctttggc tatcacttccgagacaaagactgctttcccccacccgaagcaggggccccacactgggag ctgctgagcagagccctgctccacgtctgcattcacgccattgggatccacctcttcatc atgtcccaggtgagatccaggagcacctttctcaaggtgggacagtcaattatgcacgga aaggatctggaagtggaaaaagccctgaaagagaggatgattcattctgtgatgccaaga atcatagctgatgacttgatgaaacagggggatgaggagagcgagaattctgtcaaaagg cacgccacctccagccccaagaacaggaagaaaaagtcttccatacagaaagcccctata gcgttccgcccttttaaaatgcagcagatcgatgaagtcagtattttatttgcagatatc gtgggcttcaccaagatgagtgccaataagtccgctcacgccctggtgggtctcctcaac gatctgttcggtcgctttgaccggttgtgtgaagagaccaagtgtgagaaaatcagcacc ctgggagactgctactattgcgtggcagggtgtccagagccccgggctgaccatgcctac tgctgcattgagatgggcttgggcatgatcagagccatcgagcagttctgccaggagaag aaagagatggtgaacatgcgtgtcggggttcacacggggaccgtcttgtgtggcattttg ggcatgaggaggttcaaattcgatgtgtggtccaatgatgtgaacttggccaatctcatg gagcagctgggagttgccggcaaggttcacatttctgaggccactgcaaaatacctagat gatcggtacgaaatggaagacgggagggtgactgaacggctcggccagagcgttgttgct gatcagctgaaaggtttgaagacatacctgatagcgggtcagagagcgaaggagtctcgt tgcagctgttcagaggccttgctttctggctatgaggtcattgacggctcacgggtgtcc tcaggccctaggggacaggggacagcatcgccagggagtgtcagtgacttggcgcagact gtcaaaacctttgataaccttaagacctgcccttcgtgcggaatcacgttcgcccccaaa tcggaagctggtgcggaaggaggagcggtccaaaacggctgtcaagaggagcataaaaac agcaccaaggctcccggagctcctaattccaaaactcaaaatggacttctgagtcctccc catgaggagaagctcaccaacagtcagacctccctgtgtgagatcttacaggaaaaggga aggtgggcaggagtgagcttggaccagtcagctctccttccgctgagattcaagaacatc cgggagaaaacagacgcccattttgttgatgttatcaaagaagacagcctgatgaaggat tattttttcaagccacccatcaatcagttcagcttgaacttcctggatcaggagctagag cgatcctatcggaccagctatcaagaagaggttataaagaattctcccgtgaagactttt gccagcgccaccttcagctccctcctggatgtgtttctgtcgacgacagtgtttctgatt ctgtccatcacctgcttcctgaagtacggggctgcctccatgcctcccccgcccgccgcc ctggctgtcttcggtgccgccctgctgctggaggtgctgtccctcgtggtctccgtcagg atggtgtttttcctggaggatgtgatggcttgtaccaagcgcctgctggagcggatagcc ggctggctcccgcgccatttcattggggccatcctggtgtcactccctgctctcgccgtc tattcacatatcacctctgaatttgacaccgacatacacttcaccgtgtttgcgggctcc gccatcctgaccgctgtcgtgcactactgtaacttctgccagctcagctcctggatgagg tcctccttagccaccgtcgtcggggctgggccgctgctcctgctctacatctccctttgc ccggacagttccgtagtaatttcacacctggatgtgggacagaatttcagttccaagggg aatccgtgcaacagttccttgccgcgtgacggcagagcagccagcctgattggccaggag ggggttcttgtcttctttctcctgctcttgttggtctggttcctgaatcgagaattcgag gtcagctaccgcctgcactaccacggggatgtggaggcggacctccaccgcaccaagatc cagagcatgagggaccaagctgactggctgctgagaaacatcatcccctaccacgtggct gagcagctgaaggtctcccagacctactccaagaaccatgacagcgggggcgtcatcttt gccagcatcgtcaacttcagcgagttctacgaggagaactacgaggggggcaaggagtgc taccgcgtcctcaacgagctcatcggggacttcgacgagctcctgagcaggccgggctac ggcagcatcgagaagatcaagaccatcggagccacgtacatggctgcgtcagggctgaac ggcgcgcagtgccgggacggcagccacccgcaggagcacctgcaggtcctgtttgagttc gccaaggagatgatgcgcgtggtggacgacttcaacagcaacatgctgtggttcaacttc aagctcagggtgggcttcaaccacgggccgctcacggcgggggtcatcggcaccaccaag ctgctctatgacatctggggcgacaccgtcaacatcgccagcaggatggacagcacgggg gtggagtgccggatccaggtgagcgaggagagctaccgcgtcctgagcaagatgggctat gacttcgactaccgagggacggtgaacgtcaagggcaagggccagatgaagacctacctg tacccaaagtgcacggacagcggggccgtgccgcagcaccagctgtccatctccccggac atccgagtccaggtggacggcagcatcgggcggtctcccacggacgagatcgccaacctg gtgccttctgtccagagtgcggacaagacgcctccgggttccgaaaacaacgtgcaggcc agggatgctcacctgtcctctaagaggccctggaaggagcctgtcaaagccgaagaaagg tgtcgatttggcaaagccatagagaaaagcgactgtgaagacgcggacgctgaagaagcc agcgagctcaccaggctcaacgtttctgagagcgtgtga

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