KEGG   Panthera leo (lion): 122213878
Entry
122213878         CDS       T10741                                 
Symbol
MAP2K7
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 7 isoform X1
  KO
K04431  mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
Organism
plez  Panthera leo (lion)
Pathway
plez04010  MAPK signaling pathway
plez04012  ErbB signaling pathway
plez04141  Protein processing in endoplasmic reticulum
plez04380  Osteoclast differentiation
plez04530  Tight junction
plez04620  Toll-like receptor signaling pathway
plez04660  T cell receptor signaling pathway
plez04664  Fc epsilon RI signaling pathway
plez04668  TNF signaling pathway
plez04722  Neurotrophin signaling pathway
plez04912  GnRH signaling pathway
plez04926  Relaxin signaling pathway
plez04936  Alcoholic liver disease
plez05010  Alzheimer disease
plez05016  Huntington disease
plez05022  Pathways of neurodegeneration - multiple diseases
plez05132  Salmonella infection
plez05135  Yersinia infection
plez05161  Hepatitis B
plez05167  Kaposi sarcoma-associated herpesvirus infection
plez05169  Epstein-Barr virus infection
plez05170  Human immunodeficiency virus 1 infection
plez05208  Chemical carcinogenesis - reactive oxygen species
plez05417  Lipid and atherosclerosis
plez05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:plez00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    122213878 (MAP2K7)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122213878 (MAP2K7)
   04012 ErbB signaling pathway
    122213878 (MAP2K7)
   04668 TNF signaling pathway
    122213878 (MAP2K7)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    122213878 (MAP2K7)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    122213878 (MAP2K7)
   04660 T cell receptor signaling pathway
    122213878 (MAP2K7)
   04664 Fc epsilon RI signaling pathway
    122213878 (MAP2K7)
  09152 Endocrine system
   04912 GnRH signaling pathway
    122213878 (MAP2K7)
   04926 Relaxin signaling pathway
    122213878 (MAP2K7)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    122213878 (MAP2K7)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    122213878 (MAP2K7)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    122213878 (MAP2K7)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    122213878 (MAP2K7)
   05161 Hepatitis B
    122213878 (MAP2K7)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122213878 (MAP2K7)
   05169 Epstein-Barr virus infection
    122213878 (MAP2K7)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122213878 (MAP2K7)
   05135 Yersinia infection
    122213878 (MAP2K7)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122213878 (MAP2K7)
   05016 Huntington disease
    122213878 (MAP2K7)
   05022 Pathways of neurodegeneration - multiple diseases
    122213878 (MAP2K7)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122213878 (MAP2K7)
   05418 Fluid shear stress and atherosclerosis
    122213878 (MAP2K7)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    122213878 (MAP2K7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:plez01001]
    122213878 (MAP2K7)
Enzymes [BR:plez01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     122213878 (MAP2K7)
Protein kinases [BR:plez01001]
 Serine/threonine kinases: STE group
  STE7 family
   122213878 (MAP2K7)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 Seadorna_VP7 Pkinase_fungal Haspin_kinase APH RIO1
Other DBs
NCBI-GeneID: 122213878
NCBI-ProteinID: XP_042784170
UniProt: A0A8C8WD10
LinkDB
Position
A2:complement(5905425..5915115)
AA seq 435 aa
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPIIVITLSPAPAPSQRAALQ
LPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTG
YLTIGGQRYQAEIHDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL
MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRVQGPIPERILGKMTV
AIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYM
APERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLP
GHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYEMLEVDVASWFKDVMAKTESP
RTSGVLSQHHLPFFR
NT seq 1308 nt   +upstreamnt  +downstreamnt
atggcggcgtcctccctggagcagaagctgtcccgcctggaagcaaagctgaagcaggag
aaccgcgaggcccggcggaggatcgacctcaacctggatatcagcccccagcggcccagg
cccattattgtgatcactctaagccctgctcctgccccgtcccaacgagcagccctgcag
ctcccgctggccaatgatgggggcagccgctcaccgtcctccgagagctccccacagcac
cccacaccccctgcccggccccgccacatgctggggcttccgtcaaccttgttcacaccc
cgcagcatggagagtatcgagattgaccagaagctacaggagatcatgaagcagacgggc
tacctgaccatcgggggccagcggtaccaggcagaaatccatgatctggagaacctgggc
gagatgggcagcggcacttgcggccaggtgtggaagatgcgcttcaggaagacgggccac
gtcattgccgtcaagcaaatgcggcgctcggggaacaaggaggagaacaagcggatcctc
atggacctggatgtggtcctcaagagccatgactgcccctacatcgtgcagtgtttcggg
accttcattactaatacggatgttttcatcgccatggagctcatgggcacgtgcgctgag
aagctcaagaagcgggtgcagggccccattcccgagcggatcctgggcaagatgacggtg
gcgatcgtgaaggcgctgtactacctgaaggagaagcacggcgtgatccaccgtgacgtc
aagccctccaacatcctgctggacgagcggggccagatcaagctctgcgacttcggcatc
agcggccgtctcgtcgattctaaggccaagacgcgcagcgcgggctgtgccgcctacatg
gcacctgagcgcatagaccctccggaccccaccaagccagactacgacatccgggccgat
gtgtggagccttggcatctccttggtggagctggcgacgggacagtttccctacaagaac
tgcaagacagactttgaggtcctcaccaaagtcctgcaggaagagcccccgctcttgccc
ggtcacatgggcttctcgggggactttcagtccttcgtcaaagactgccttactaaggat
cacaggaagagaccaaagtataataagctacttgaacacagtttcatcaagcgctacgag
atgctggaggtagacgtggcatcctggttcaaggatgtcatggcgaagaccgagtcaccg
aggactagcggagtcctgagccagcaccacctgcccttcttcaggtag

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