Panthera leo (lion): 122213952
Help
Entry
122213952 CDS
T10741
Symbol
TYK2
Name
(RefSeq) non-receptor tyrosine-protein kinase TYK2 isoform X1
KO
K11219
non-receptor tyrosine-protein kinase TYK2 [EC:
2.7.10.2
]
Organism
plez Panthera leo (lion)
Pathway
plez04217
Necroptosis
plez04380
Osteoclast differentiation
plez04620
Toll-like receptor signaling pathway
plez04621
NOD-like receptor signaling pathway
plez04630
JAK-STAT signaling pathway
plez04658
Th1 and Th2 cell differentiation
plez04659
Th17 cell differentiation
plez05145
Toxoplasmosis
plez05160
Hepatitis C
plez05161
Hepatitis B
plez05162
Measles
plez05164
Influenza A
plez05165
Human papillomavirus infection
plez05167
Kaposi sarcoma-associated herpesvirus infection
plez05168
Herpes simplex virus 1 infection
plez05169
Epstein-Barr virus infection
plez05171
Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
122213952 (TYK2)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
122213952 (TYK2)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
122213952 (TYK2)
04621 NOD-like receptor signaling pathway
122213952 (TYK2)
04658 Th1 and Th2 cell differentiation
122213952 (TYK2)
04659 Th17 cell differentiation
122213952 (TYK2)
09158 Development and regeneration
04380 Osteoclast differentiation
122213952 (TYK2)
09160 Human Diseases
09172 Infectious disease: viral
05161 Hepatitis B
122213952 (TYK2)
05160 Hepatitis C
122213952 (TYK2)
05171 Coronavirus disease - COVID-19
122213952 (TYK2)
05164 Influenza A
122213952 (TYK2)
05162 Measles
122213952 (TYK2)
05168 Herpes simplex virus 1 infection
122213952 (TYK2)
05167 Kaposi sarcoma-associated herpesvirus infection
122213952 (TYK2)
05169 Epstein-Barr virus infection
122213952 (TYK2)
05165 Human papillomavirus infection
122213952 (TYK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
122213952 (TYK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
plez01001
]
122213952 (TYK2)
Enzymes [BR:
plez01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
122213952 (TYK2)
Protein kinases [BR:
plez01001
]
Non-receptor tyrosine kinases
JAK family [OT]
122213952 (TYK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
Jak1_Phl
FERM_F2
SH2_1
FERM_F1
Kinase-like
Kdo
FERM_C_FAK1
RIO1
ABC1
RA_2
Motif
Other DBs
NCBI-GeneID:
122213952
NCBI-ProteinID:
XP_042784328
LinkDB
All DBs
Position
A2:complement(7784796..7804495)
Genome browser
AA seq
1209 aa
AA seq
DB search
MSGRLRGRQVKVWGLMACLFPAKPAVKSMPLCRWGATTRDSRPDGDEAQPMVSRGGLKVL
LHWAGPDGGDPWVTFSEATLTAEEVCIHIAHKVGITPSCLNLFALFDAQAQVWLPPNHIL
EVSRDMNLTLYFRMRFYFRNWHSMNPQEPAVYRCGPTRAKSSSEQAEQGVQLLDPASFEY
LFEQGKHEFVNDVAPLWELSSEEEIHHFKNESLGMAFLHLCHLALCHGIPLEKVAKKISF
KDCIPRSFRLQLRRHNALTRLRLRRLFRRFVRAFQPGHVSQPVIMVKYLATLEQLAPRFG
TERVLVCRLEEQARAVGDPCYVQDGGQSPPEPGPELAPGPPTHEVLVTGTGGIRWRPVQA
EGPSGDGCSRNPRAGPSGKKSKAQEVGNQPVDRPQEAPWAYFCDFQDITHVVLKERHVSI
HCQDKCLELTLPSRAVALSLVSLVDGYFRLTADSSHYLCREVAPPRLVMSIRDGIHGPLL
EPFVLAKLRPEDGLYLIHWSTSHLNRLILTVAQRDQAPGGQQLHLRKFPIELRAGSFELE
GWDRSFPSVRELRTALQGCSLRVGDDCFSLRRCCLPRPGELSNLIIMRGSRASPGPLNLS
QLSFHRVCQDDITQLSHLGQGTRTNVYEGILRVGERGPKEGTADGGDPPTPSGDRGQELR
VVLKVLDPSHHDIALAFYETASLMSQVSHVHLAFVHGVCVHGSENIMVTEYVEHGPLDVW
LRRERGHVPVAWKVAVAQQLASALSYLEDKSLVHGNVCGRNILLARLGLAEGTSPFIKLS
DPGVGLGALSREERVERIPWTAPECLSGGASTLTTAADKWGFGVTLLEICFDGEAPLQGR
GPSEKECFYQKQHQLPQPSCPELATLTSQCLTYEPAQRPSFRTILRDLTQLQPQNLADIL
AVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAGGGP
QLRTGWRREIDILRTLYHKHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHNVGLA
QLLLFAQQICEGMAYLHAQHYVHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVR
EDGDSPVFWYAPECLKECKFYYASDVWSFGVTMYELLTYCDSSQSPPSKFIELIGLTQGQ
MTVLRLTELLERGERLPRPEKCPCEIYLLMKNCWEAEASFRPTFQNLIPILKTVQEKYQG
QAASVFNVC
NT seq
3630 nt
NT seq
+upstream
nt +downstream
nt
atgagtggaaggttgaggggacgtcaggtcaaggtctgggggctgatggcctgtctcttc
ccagccaagccagctgtcaagagcatgcctctgtgccgttggggtgccaccaccagggac
agcaggcctgatggggatgaggctcagcccatggtctccaggggaggcctaaaggtcctt
ctgcactgggctggccctgatggcggggacccctgggtcaccttcagcgaggccacactg
accgcagaggaggtctgcatccacatcgcacacaaagtcggcatcactccatcctgcctc
aatctcttcgccctctttgatgcccaggcccaggtgtggctgcccccaaaccacatcttg
gaggtctccagagacatgaacctgacattgtacttccgcatgaggttttatttccggaac
tggcacagcatgaatcctcaggagccggccgtgtaccgctgtgggcccaccagggccaag
tcttcctcggaacaggcagagcagggcgtgcaactcctggacccagcctcctttgagtac
ctctttgagcagggcaagcacgagtttgtgaatgatgtggcaccactgtgggagctgtcg
agcgaggaggagatccaccattttaagaacgagagcctgggcatggcctttctgcacctc
tgccacctcgccctttgccatggtatccccctggagaaggtggccaagaagatcagcttc
aaggactgcatcccgcgctccttccggctgcagctccggcggcacaacgcgttaacacgg
ctgcgcctacggagactcttccgcaggtttgtgcgggccttccagccgggccacgtctcc
cagccggtcatcatggtcaagtacctggccacgctggagcagctggcaccccgcttcggc
acggagcgcgtgctcgtgtgccggctggaggagcaggcccgggccgtgggggacccctgc
tacgtccaggacgggggccagtcccccccggagcctgggcctgaattggcccccggaccc
cctactcatgaggtgctggtgacaggcacgggtggcatccggtggcggccagtccaggca
gagggtcccagtggcgatggttgcagcaggaacccccgtgctggcccatcagggaagaaa
agcaaggcccaggaggtgggcaaccagccagtggacaggcctcaggaagcgccgtgggcc
tacttctgtgacttccaggacatcacccacgtggtgctgaaagagcgccacgtcagcatc
cactgtcaggacaagtgcctggagctcaccctgccttcccgggctgtggccctgtccttg
gtgtcgctggtggacggctatttccgcctgacggccgactcgagccactacctgtgccgg
gaggtggcccctccgcggctggtgatgagcatccgggatggcatccacgggcccttgctg
gagccattcgtgctggccaagctgcggcccgaagatggcctctacctcatccactggagc
accagccacctcaaccgtctcatcctcacggtggcccagcgtgaccaggcacctggcggg
cagcagctgcacctccgtaaattccccattgagctgcgggccgggagcttcgagctggag
ggctgggaccgctccttcccgagcgtgcgggagctgcgcaccgccctgcagggctgctcg
ctgcgggtcggggacgactgtttctccctgcgccgctgctgcctgccacggcccggagag
ctctccaacctcatcatcatgcgtgggtctcgggccagccctgggccactcaacctcagc
cagctcagcttccaccgcgtctgccaggatgacattactcagctgtctcacttgggccaa
ggcacgaggaccaatgtgtatgagggcatcttacgggtgggggaaagaggccccaaggag
ggcacggcagatggtggggacccccccacgcccagtggggaccgtggccaggagctacga
gtggtactcaaggtgctggatcccagtcaccacgacatcgccctggccttctacgagaca
gccagcctcatgagtcaggtctcccacgtgcacctggcctttgtgcacggcgtctgcgtg
cacggctctgagaacatcatggtgacagagtacgtggagcacggacccctggatgtgtgg
ctgcggcgggagaggggccacgtgcctgtggcctggaaggtggcagtggcccagcagctg
gccagcgctctcagctacctggaagacaagagcctggttcatggtaatgtgtgtggccgg
aacatcctgctggcacggctgggactggcggagggcaccagcccctttatcaagctgagc
gatcccggtgtgggcctgggtgccctttccagggaggagcgggtagagaggatcccctgg
acagcccccgagtgcctgtcaggtggggccagcaccctaaccactgcagctgacaaatgg
ggctttggtgtcaccctcctggagatctgcttcgacggggaggcccctctgcagggccgc
ggcccttccgagaaagagtgcttctaccagaagcagcaccagcttcctcagccctcatgc
ccggagctggccacactcaccagccagtgcctgacctatgaaccagctcagcggccctcc
ttccgcaccatcctgcgtgacctcactcagctgcagccccagaatcttgctgacatcttg
gctgtgaaccccgactcgcctgcgtcagaccccaccgttttccacaagcgctatttgaaa
aagatccgggatctgggcgagggtcatttcggcaaggtcagtctgtattgctacgacccg
actaacgacggcaccggcgagatggtggctgtgaaggccctcaaggcgggcgggggcccc
cagctccgcactggctggcggcgggagatcgacatcctgcgcacgctctaccacaagcac
atcgtcaaatacaagggatgctgtgaggaccaaggagagaagtcggtgcagctggttatg
gagtacgtgcctctgggcagcctccgggactaccttccccggcacaacgtcggactggcc
caactgctactcttcgcccagcagatctgtgagggcatggcctaccttcatgcacagcac
tacgtccaccgagacctggctgcccgcaacgtgctgctggacaacgacaggctggtcaaa
atcggggactttggcctagccaaggctgtgcctgaaggccatgagtactaccgcgtgcgc
gaagatggggacagccccgtattctggtatgctccagagtgcctgaaggagtgtaagttc
tactatgcatctgacgtctggtccttcggggtcaccatgtatgagctgctgacctactgt
gactccagccagagccccccttcgaaattcatcgagctcataggcctcacccaagggcag
atgacggtgctgaggctcactgagctgctggaacgaggggagaggctgccgcggccagag
aaatgcccttgcgagatctacctcctcatgaagaactgctgggaggcagaggcctcattc
cgccccactttccagaacctcatccccattctcaagacggtccaggagaaataccaaggc
caggccgcctcagtgttcaatgtgtgctga
DBGET
integrated database retrieval system
