Panthera leo (lion): 122214502
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Entry
122214502 CDS
T10741
Symbol
PDHB
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit beta, mitochondrial
KO
K00162
pyruvate dehydrogenase E1 component subunit beta [EC:
1.2.4.1
]
Organism
plez Panthera leo (lion)
Pathway
plez00010
Glycolysis / Gluconeogenesis
plez00020
Citrate cycle (TCA cycle)
plez00620
Pyruvate metabolism
plez00785
Lipoic acid metabolism
plez01100
Metabolic pathways
plez01200
Carbon metabolism
plez01210
2-Oxocarboxylic acid metabolism
plez04066
HIF-1 signaling pathway
plez04922
Glucagon signaling pathway
plez05230
Central carbon metabolism in cancer
plez05415
Diabetic cardiomyopathy
Module
plez_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
122214502 (PDHB)
00020 Citrate cycle (TCA cycle)
122214502 (PDHB)
00620 Pyruvate metabolism
122214502 (PDHB)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
122214502 (PDHB)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
122214502 (PDHB)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
122214502 (PDHB)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
122214502 (PDHB)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
122214502 (PDHB)
Enzymes [BR:
plez01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
122214502 (PDHB)
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Paralog
GFIT
Motif
Pfam:
Transket_pyr
Transketolase_C
Motif
Other DBs
NCBI-GeneID:
122214502
NCBI-ProteinID:
XP_042785744
UniProt:
A0A8C8X2I1
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All DBs
Position
A2:complement(26133677..26139686)
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AA seq
359 aa
AA seq
DB search
MAAVSGLVRRPLEQVSGLLRRRFHRTAPAALQVTVREAINQGMDEELERDEKVFLLGEEV
AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI
DQVINSAAKTYYMSGGFQSVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNS
EDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPSEAQSKDFLIPIGKAKIERQGTHITVV
SHSRPVGHCLEAATVLSKEGIECEVINMRTIRPMDIETIEASVMKTNHLITVEGGWPQFG
VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSVPQVKDIIFAIKKTLNI
NT seq
1080 nt
NT seq
+upstream
nt +downstream
nt
atggcggctgtgtctgggctggtgcggagaccccttgaacaggtctccgggctgctgagg
aggcgcttccaccgaacggcgccggcggcgctgcaggtgacagttcgtgaagctataaac
caaggtatggatgaggagctggaaagagatgagaaggtgtttctgcttggggaagaagtt
gcccagtatgatggggcatataaggttagtcgaggcctgtggaagaaatacggagataag
aggatcatagacactcccatatctgagatgggctttgctggaattgccgtgggtgcggcc
atggctgggttgaggcccatttgtgaatttatgaccttcaatttctcaatgcaagccatt
gaccaggttataaactcagctgccaagacctactacatgtcagggggctttcagtctgtg
cccatagtcttcagggggcccaatggcgcctcagcaggcgtggctgcccagcactcacag
tgctttgctgcctggtatgggcactgcccaggcttaaaggtggtcagcccctggaattca
gaggatgcaaaaggacttattaaatcagccattcgggataacaacccagtggtggtgcta
gagaacgaactgatgtatggagttccttttgaatttccctcagaagctcaatcaaaagat
tttctgattcccattggaaaggccaaaatagaaaggcaagggacacacataactgtagtt
tcccattcaagacccgtgggccactgcttagaagctgcaacggtgctatccaaagaagga
attgaatgtgaggtgataaatatgcgaaccatcagaccaatggacattgaaacaatagaa
gccagtgtcatgaagaccaatcatctgataactgtggaaggaggctggccacagtttgga
gtaggagctgaaatttgtgccaggatcatggaaggccctgcattcaatttcctggatgct
cctgcagttcgcgtcactggtgctgatgtccctatgccttatgcaaagattctagaagac
aactcggtacctcaggttaaagacatcatatttgcaataaagaaaacattaaatatctag
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