Panthera leo (lion): 122217071
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Entry
122217071 CDS
T10741
Symbol
PDHA2
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
plez Panthera leo (lion)
Pathway
plez00010
Glycolysis / Gluconeogenesis
plez00020
Citrate cycle (TCA cycle)
plez00620
Pyruvate metabolism
plez00785
Lipoic acid metabolism
plez01100
Metabolic pathways
plez01200
Carbon metabolism
plez01210
2-Oxocarboxylic acid metabolism
plez04066
HIF-1 signaling pathway
plez04922
Glucagon signaling pathway
plez05230
Central carbon metabolism in cancer
plez05415
Diabetic cardiomyopathy
Module
plez_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
122217071 (PDHA2)
00020 Citrate cycle (TCA cycle)
122217071 (PDHA2)
00620 Pyruvate metabolism
122217071 (PDHA2)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
122217071 (PDHA2)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
122217071 (PDHA2)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
122217071 (PDHA2)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
122217071 (PDHA2)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
122217071 (PDHA2)
Enzymes [BR:
plez01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
122217071 (PDHA2)
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Motif
Pfam:
E1_dh
DXP_synthase_N
Motif
Other DBs
NCBI-GeneID:
122217071
NCBI-ProteinID:
XP_042789899
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Position
B1:complement(125079350..125080800)
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AA seq
391 aa
AA seq
DB search
MRKMLAAAVSRVLSGVTQKPTSRVLVASCNYSNDAMFAIKKCDLYRLEEGPPVTTVLTRE
DGLKYYRMMQTVRRMELKADQLYKQKFIRGFCHLCDGQEACSVGLEAGINPTDHVITSYR
AHGLCYTRGLSVRSILAELTGRRGGCAKGKGGSMHMYVKNFYGGNGIVGAQGPLGAGIAL
ACKYKGNKEVCLTLYGDGAANQGQIAEAHNMAALWKLPCVFICENNLYGMGTPVERASAS
TDYYKRGNFIPGLRVDGMDVLGVREATKFVADYCRSGKGPIVMELQTYRYHGHSMSDPGI
SYRTREEVQNVRKKSDPIMLLKDRMVNSELATVEELKDIDVEVRKEVEDAAQFAMTDPEP
PLEELAHHIYCNTPAFEVRGANQWIKFKSLS
NT seq
1176 nt
NT seq
+upstream
nt +downstream
nt
atgaggaagatgctcgctgccgctgtctcccgcgtgttgtccggggtcacgcagaagccc
actagcagagtgctggtggcatcctgtaactattcaaatgatgcgatgtttgcaattaag
aaatgtgatctttatcgcttagaagagggtccccctgtcacaacagtgctcacccgggag
gatgggctcaaatactacaggatgatgcagactgttcgccgaatggagctgaaggcagat
cagctgtataaacaaaaatttatccgtgggttctgtcacttgtgcgatggtcaggaagct
tgttctgtgggcctggaggccgggataaatcccaccgaccatgtcatcacctcctatcgg
gctcatggcttgtgctatactcgtggactctctgtccgatcaattcttgcagagctgaca
ggacgaaggggaggctgtgctaaaggaaaaggaggatcgatgcatatgtatgtcaagaat
ttctatgggggcaatggcattgttggcgcacaggggcccctgggagctggtattgctctg
gcctgtaaatacaagggaaacaaggaggtctgtttgactctttatggggatggtgctgcg
aatcagggtcagatagctgaagctcacaatatggcagctttgtggaaattaccctgtgtt
ttcatctgtgagaataacctctatggaatgggaacccctgttgagagagcatcagccagc
accgattactataagagaggaaattttatccctggactaagggtagacggaatggatgtt
ctaggtgttcgggaggcaactaagtttgtagctgactactgtagatctggaaaggggccc
atagtgatggagctgcagacctaccggtatcatggacacagtatgagtgaccctggaatc
agttatcgtacccgagaagaagttcagaatgtgagaaagaagagcgatcctattatgctt
ctcaaagacagaatggtaaacagtgagcttgccactgttgaggaactaaaggatattgat
gttgaagtgaggaaagaagtggaggatgcagcccagtttgctatgactgatcctgaacca
cctttggaagaattagctcatcacatctactgcaatactccagcttttgaagttcgtggt
gcaaaccagtggattaagttcaagtccctcagttaa
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