Panthera leo (lion): 122218668
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Entry
122218668 CDS
T10741
Symbol
HTT
Name
(RefSeq) huntingtin
KO
K04533
huntingtin
Organism
plez Panthera leo (lion)
Pathway
plez05016
Huntington disease
plez05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05016 Huntington disease
122218668 (HTT)
05022 Pathways of neurodegeneration - multiple diseases
122218668 (HTT)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03019 Messenger RNA biogenesis [BR:
plez03019
]
122218668 (HTT)
04131 Membrane trafficking [BR:
plez04131
]
122218668 (HTT)
03029 Mitochondrial biogenesis [BR:
plez03029
]
122218668 (HTT)
Messenger RNA biogenesis [BR:
plez03019
]
Eukaryotic type
mRNA surveillance and transport factors
mRNA cycle factors
Common to processing body (P body) and stress granule
122218668 (HTT)
Membrane trafficking [BR:
plez04131
]
Endocytosis
Rab GTPases and associated proteins
Rab associated proteins
122218668 (HTT)
Mitochondrial biogenesis [BR:
plez03029
]
Mitochondrial quality control factors
Regulator of mitochondrial biogenesis
Other regulator of mitochondrial biogenesis
122218668 (HTT)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Htt_C-HEAT
Htt_N-HEAT
Htt_bridge
Htt_N-HEAT_1
HEAT
HEAT_GCN1
HEAT_2
HEAT_EF3_N
Rad26-like_helical_rpts
Motif
Other DBs
NCBI-GeneID:
122218668
NCBI-ProteinID:
XP_042792967
LinkDB
All DBs
Position
B1:complement(202593535..202741046)
Genome browser
AA seq
3129 aa
AA seq
DB search
MATLEKLMKAFESLKSFQQQQQQQQQQQQQPPPPPPPQPPQPLPQAQPPLPQPQPPPPPP
PPPPPGPAVAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSLRNSPEFQKLLGIAMEL
FLLCSDDAESDVRMVADECLNRVIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFA
ELAHLVRPQKCRPYLVNLLPCLTRISKRPEESVQETLAAAVPKIMASFGNFANDNEIKVL
LKAFIANLKSSSPTIRRTAAGSAVTICQHSRRTQYFYSWLLNVLLGLLVPVEDEHSTLLI
LGVLLTLRYLVPLLQQQVKDTSLKGSFGVTRKEMEVCPSTEQLIQVYELTLHYTQHQDHN
AVTGALELLQQLFRTPPPELLQALTAPGGGQRSGAQYGPGGRSRSGSIAELLAGGGSSCS
PVLSRKQKGKVLFGDAAALEDDSESRSEGSSPAFAASVKGEVGGELAASSGVSTPGDSVG
HDIITEQPRSQHTLQPDSVDLAGCGLASAATDGDEEDILSHSSSQISAVPSDPAMDLNDG
TQASSPVSDSSQTTTEGPDSAVTPSDSSEIVLDGADSQYSGMQIGQPQDEDEEAAGILPE
EDVDAFRNSAAALQQAHLLKSMGHSRRPSDSSVDTFVSRDEAAEAGDQENKPCRIKGDIG
QSTDDDSVPLVHCVRLLSASFLLTGEKNVLVPDRDVRVSVKALALSCVGAAVALHPESFF
SKLYKVPLDSVEYPEEPYVSDILNYIDHGDPQVRGATAVLCGTLISSTLSRSRFQVGDWM
GTVRALTGNTFSLEDCIPLLRKTLKDESSVTCKLACTAVRHCVMSLCSSSSSELGLQLIT
DVLSLRDSSYWLVRTELLETLAEIDFRLVSFLEAKAENLHRGAHHYTGLLKLQDRVLHDV
VIYLLGDEDPRVRHVAAAALMRLVPKLFYKCDQGQADPVVAVARDQSSVYLKLLMHETQP
PSHFSVSTITRIYRGYNLLPSMTDVTVENNLSRVIAAVSHELVTSTTRALTFGCCEALCL
LSTAFPVCVWSLGWHCGAPPLSVSGESRKSCTVGMATVILTLLSSAWFPLDLAAHQDALV
LAGNLLAASAPRSLRSSWTSEEEANPAAAKQEEVWPALGDRTLVPMVEQLFSHLLKVINI
CAHVLDDVAPGPAIKAALPSLTNPPSLSPIRRKGKEKEPGEQASAPLSPKKGSEASPASR
QSDASGPVTANKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSAEKFGGFLRSAL
DVLSQILELATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGL
SSNPSKSQGRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQAEQDHDASGWF
DVLQKVSTQLKTNLTSTTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQRQVLDL
LAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHS
KQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGANKADAGKELETQKEVV
VSMLLRLIQYHQVLEMFILVLQQCHKESEDKWKRLSRQIADVILPMLAKQQMHIDSHEAL
GVLNTLFEILAPSSLRPVDMLLRSMFVTPDTMAPVSTVQLWISGILAILRVLISQSTEDI
VLSRIQELSFSPYLISCPIINRLREGDSTSTPEEHNEGRQMKSLPEETFSRFLLQLVGIL
LEDIVTKQLKVEMSEQQHTFYCQELGTLLMCLIHIFKSGMFRRITAAASRLLTVDSSDSS
FYGLDRLNAQVRAMVPTHPALVLLWCQILLLVSHTDHRWWAEVQQTPRRRSLSSTKSLSP
QMSGEEGDSDAASKPGMCNREIVRRGALILFCDYVCQNLHDSEHLTWLIVNHIQDLINLS
HEPPVQDFISAVHRNSAASGLFIQAIQSRCENLSAPTTLKKTLQCLEGIHLSQSGAVLTL
YVDKLLCTPFRVLARMVDTLACRRVEMLLAANLQSSMAQLPVEELTRIQEYLQSSGLAQR
HQRLYSLLDRLRLATAPGSRGPSPPVTSHPLDGDGPLALETVIPDKDWYLRLVKSQCWTR
SDSALLEGAELVNRIPPSDMSTFMMNSEFNLSLLAPCLGLGVREVSGGQRSPLFEAARLA
TLDRVTGLVQQLPAAHHVFQPFLPTEPTAYWNKLNDLFGDAVLYRSLTTLARALAQYLLV
FSKLPGHLHLPPEKERDTVKFVVMTLEALSWHLIHEQIPLSLDLQAGLDCCCLALQLPSV
WSALSSPEMVTHACSLIHCVRFILEAIVVQPGDQLLSPDRRMNTPKAAREDEVDSNTQNP
AYITAACGMVAEMVEALPSVLALGHKRNSSTPAFLTSVLRNIIISLARLPLVNSYTRVPP
LVWKLGWSPKPGGDFGTAFPEIPVEFLQEKEVFKEFIYRINTLGWTSRTQFEETWATLLG
VLVTQPLVMEQEESPPEEDTERTQINVLAVQAITSLVLSAMTVPVAGNPAVSCLEQQPRN
KPLKALDTRFGRKLSIIRGIVEQEIQAMVSKRENVATHHLYQAWDPVPSLSPATTGALIG
HDKLLLQINPERELGNMSYKLGQVSIHSVWLGNSITPLREEEWEEEEEEEADVPTSASPP
TSPVNSRKHRAGVDIHSCSQFLLELYSRWILPSGSARRTPIILISEVVRSLLVVSDLFTE
RTQFEMMYLTLTELRRAHPAEDEILIQYLVPATCKAAAVLGMDKAVAEPVSRLLESTLRS
SHLPSRVGALHGALYVLECDLLDETAKQLVPVISDYLLCNLKGAAHCVNVHSQQHVLVMC
ATAFYLIENYPLDVGPEFSASVIQMCGVMLSGSEESTPSIIYHCVLRGLERLLLSEQLCR
LDAESLVKLSVDRVNVHSPHRAMAALGLMLTCMYTGKEKISPGRTSDPSPAAPDSESVIV
AMERVSVLFDRVRKGFPCEARVVARILPQFLDDFFPPQDVMNKVIGEFLSNQQPYPQFMA
TVVYKVFQTLHSSGQSSMVRDWVMLSLSNFTQRSPVAMAVWSLSCFFVSASTSPWVSAVL
PHVISRMGKLERVDVNLFCLVATDFYRHQIEEELDRRAFQSVFEVVAAPGNPYHRLLTCL
RNVHKVASC
NT seq
9390 nt
NT seq
+upstream
nt +downstream
nt
atggcgactctggaaaagctgatgaaggccttcgaatccctcaagtctttccagcagcag
cagcagcaacagcagcagcagcagcagcagccgccgccgccgccgccgcctcagcctcct
cagccgctgccgcaggcgcagccgccgctgcctcagcctcagccgccgcccccgccgccg
cccccgccgccccccggcccggccgtggccgaggagccgcttcaccgaccaaagaaagaa
ctctcagccaccaagaaagaccgtgtgaatcactgtctgacgatatgtgagaacatagtg
gcacagtcactcagaaattctccagaatttcagaaacttctgggcatcgctatggagctc
ttcctgctgtgcagtgatgatgcagagtcggatgtcaggatggtggctgacgagtgcctc
aacagagtcataaaagcgctgatggactcgaatcttccgcggttacagcttgaactctat
aaggaaatcaaaaagaatggcgctccccggagcctgcgtgctgccctgtggaggtttgcg
gagctggctcacctggttcggcctcagaaatgcaggccttacttggtaaaccttttgcct
tgcctgactcgaataagcaagagacccgaggaatctgttcaggagaccttggctgcagct
gtccctaaaattatggcttcttttggcaattttgcaaatgacaatgaaattaaggttctg
ttgaaggctttcatagcgaatctgaagtcaagctcgcctaccattcggcgtactgcagct
ggctcagcagtgaccatctgccagcactccagaaggacgcagtacttctatagctggcta
ctgaacgtgctcctgggcttgctggttcctgttgaggacgaacactctaccctcctgatt
ctcggagtgctgctcacgttgaggtatttggtgcccttgctgcagcagcaggtcaaggac
acgagcctgaaaggcagctttggggtgacacggaaagaaatggaagtctgtccctcaact
gagcagctcatccaggtttacgaactgaccttgcattacactcagcaccaagaccacaac
gccgtgactggggcgctggagctcctgcaacagctcttcaggacgcccccgcccgagctc
ctgcaggccttgaccgcgccgggcggcgggcagcggagcggcgcgcagtatgggcccggc
ggccggagccgcagcggcagcatcgcggagctcctagccggagggggttcttcatgcagc
cctgtcctttcaagaaaacaaaaagggaaagtgctcttcggagacgcagcagccttggag
gatgactccgagtccaggtcggagggcagcagccccgccttcgcagcctcagtcaagggt
gaggttggtggtgagctggcggcctcttctggggtctccactcctggcgactccgtgggg
cacgacatcatcaccgagcagccccgctcacagcacacgctgcagcccgactcggtggat
ctggccggctgtggcttggcgagtgctgccaccgacggggatgaggaggacatcctgagc
cacagctcgagccagatcagcgccgtcccgtctgacccagccatggacctgaacgatggc
acccaggcctcctccccagtcagtgacagctcccagaccaccaccgaagggcccgattca
gctgtgaccccttcagacagttctgaaatcgtgttagatggggccgacagccagtattcg
gggatgcagatcggacagccacaggacgaggatgaggaggccgcgggcattcttccggag
gaagacgtggatgctttccgaaactccgcagctgcccttcagcaagcacatttattgaaa
agcatgggccacagccggcggccctccgacagcagtgtggatacgtttgtctcaagagac
gaagctgccgaagcaggagaccaagaaaacaagccttgccggatcaaaggtgacatagga
cagtctaccgatgacgattctgttcctcttgtccactgtgtccgccttctgtcggcttcg
tttttgctgactggggagaagaatgtgttggttccggacagggacgtgagggtcagcgtg
aaggcgctggcactgagctgtgtgggagccgctgtggcccttcatcctgagtctttcttc
agcaaactttacaaagtacctcttgactccgtggagtaccctgaggagccatatgtgtca
gacatcctgaactacatcgatcatggagacccccaggtcagaggagccacggccgttctc
tgtgggaccctcatctcctccaccctgagcaggtcccgcttccaagtgggagactggatg
ggcactgttagagctctgacaggaaatacattttctctggaggactgcattcctttgctg
cggaaaactttgaaggatgaatcttctgtcacttgcaagttggcctgcacagctgtgagg
cactgtgtcatgagtctgtgcagcagtagctccagtgaactgggactgcagctgatcacc
gatgtactgagcctgagggacagctcctactggctggtgaggacagagcttttggagacg
ctcgcagagattgactttaggttggtgagctttttggaggcaaaagcagaaaatctacac
agaggggcccatcattacacagggcttttaaaactgcaggaccgagtgctccatgacgtc
gtcatctacttgcttggggacgaagaccccagggtgcgacacgttgccgcagctgcactg
atgaggcttgtcccgaagctgttttataaatgtgaccaaggacaagccgacccagtggtg
gctgtggcaagagaccaaagcagcgtttacctgaaacttctcatgcacgagactcagccc
ccatctcacttctccgtcagcaccataaccagaatatacagaggctataacctactgccg
agcatgacagacgtcactgtggaaaataacctctcgagagtcattgcggcagtttcccac
gagctggtcacgtcgaccacccgagcacttacattcggatgctgcgaggctttgtgtctt
ctttccactgcctttccagtctgcgtttggagtttaggctggcactgtggggcacccccg
ctgagcgtgtccggtgagtccaggaagagctgtactgttggcatggccacggtcatcctc
accttgctctcgtcagcttggttcccgctggacctcgcagcgcaccaggatgcactggtg
ctggccggaaacctgctcgcagccagtgcccccaggtctctgagaagttcgtggacctct
gaggaagaggccaacccagcagccgccaagcaggaagaggtctggccggctctgggtgac
cggaccctggtgcccatggtggagcagctcttctcccacctgctgaaggtgattaatatc
tgcgcacacgtgctggacgatgtggctcctggaccggcaataaaggcagccctgccgtcc
ctaacgaaccctccttctctaagtccgatccgccggaagggaaaggagaaagagccggga
gagcaggcctctgcgcccttgagccccaagaaaggcagcgaagccagtccagcctctcga
caatccgacgcctcagggcctgttacagcaaataagtcctcatcactggggagtttctac
caccttccttcatacctcaaattgcacgatgtcctgaaagctactcacgctaactataag
gttaccttggaccttcagaacagtgctgaaaagtttgggggctttctgcgttctgccttg
gatgtgctctctcagatcctagaattggcaaccctgcaggacatcgggaagtgtgtcgag
gagatcctaggctacctgaaatcctgtttcagtcgagaaccgatgatggcaactgtttgt
gttcagcagttgctgaagactctctttgggacaaacttggcctcccagtttgatggcttg
tcttccaaccccagcaagtcccagggccgagcgcagcgtctgggctcctccagcgtgagg
ccgggcttgtaccactactgcttcatggctccctacacccacttcacccaggccttagcc
gacgccagcctgaggaacatggtgcaggcagagcaggaccacgacgcctcagggtggttc
gacgtgcttcagaaagtgtctacccagttgaagacgaacctcaccagcaccactaagaac
cgcgcagataagaacgctattcataatcacattcgtttgttcgagcctctggttataaaa
gctttaaagcagtacacaaccacaacgtctgtgcagctacagaggcaggtcttagatttg
ctggcacagctggttcagttacgggtcaattactgtcttctggattcagatcaggtgttc
attggatttgtgctgaagcagttcgaatacattgaagtaggccagttcagggaatcagag
gcaattattccaaacatctttttcttcctggtattactgtcttacgagcgctatcattca
aaacagatcattggaatccctaaaatcattcagctctgtgacggcatcatggccagcggg
aggaaggctgtgacacatgccataccggctctacagccgatagtccatgacctgttcgta
ctgagaggagccaataaagccgatgcaggaaaagagcttgaaacccagaaagaagtggtg
gtgtccatgctgctgagactcatccagtaccatcaggtgctggagatgttcatcctggtc
ctgcagcaatgccacaaggagagcgaggacaagtggaagcggctgtcccggcagatcgcc
gacgtcatcctcccgatgttggccaagcagcagatgcacattgattctcacgaagccctt
ggcgtgttaaatactttatttgagattctggccccttcctccctccgtcccgtggacatg
cttttacggagtatgttcgtcactccagacacaatggcacctgtgagcactgttcagctg
tggatatcaggaatcctagccattttgagggttctcatttcccagtcaactgaagacatt
gttctttctcgtattcaggagctctctttctctccatatttaatctcctgtccaataatt
aataggctaagagagggggacagtacttcgacaccagaagaacacaatgaagggagacaa
atgaagagcttgccggaagaaacgttttcaagatttctactacaactagttggcattctt
ttggaggatattgttacaaagcagctcaaagtggaaatgagtgaacagcaacatactttc
tactgccaagaactgggcactctgctgatgtgtctcatccacatcttcaagtctggaatg
ttccgtaggatcacagcagccgcctccagactcctcacggtggacagcagcgacagcagc
ttctacggcctggacaggctgaacgcgcaggtgcgcgccatggtgcccacgcatccggcg
ctcgtgctgctctggtgccagatcctgctgctcgtcagccacaccgaccaccgctggtgg
gcagaggtgcagcagacccccaggagacgtagtctgtccagtacgaagtcactcagcccc
cagatgtccggagaggagggggactccgacgcggccagtaaacccggaatgtgcaacaga
gaaatagtgcggcggggagctctcattctcttctgcgattatgtctgtcagaacctacat
gattcagagcacttaacgtggctcatcgtgaatcatattcaggacctgatcaatctgtcc
catgagcctcccgtgcaggatttcattagtgctgttcaccggaactccgccgccagcggc
ctcttcatccaggcaattcagtctcgttgtgagaacctttcagcccccaccaccctgaag
aagacgcttcagtgcttggaagggatccacctcagccagtcgggcgccgtgttaacactg
tatgtggacaagcttttgtgcaccccgttccgagtgctggctcgcatggtcgacaccctt
gcctgtcgccgcgtggagatgcttttggccgcaaatttgcagagcagcatggcccagttg
ccggtggaggaactaaccagaatccaggaataccttcagagcagcgggctggctcagaga
caccagaggctgtactccctgctggacaggcttcgtcttgctaccgcaccgggctcccgt
ggcccttctcctccagtcacgtcccacccgctggacggggatgggcccctggcactggag
acagtcattccagacaaagactggtacctacgtctagtcaaatcccagtgctggactagg
tcagattctgcgctgctggaaggggcagaactggtgaatcggattcctcccagtgacatg
agcacgttcatgatgaactcggaattcaacttaagcctgttggcgccgtgcctgggcctt
ggcgtgcgcgaagtctccggaggccagaggagtccacttttcgaagcagctcgcctggcg
actctggaccgtgtgaccggcctggtgcagcagctccctgccgcccaccacgttttccag
ccgttcctgcccacagagcccaccgcctactggaacaagttgaatgatctgtttggggat
gctgtgttgtatcgctccttgaccactctggcccgggctctggcccagtacctgctggta
ttctccaaacttcccggccacttgcaccttcctcctgagaaggagagggacacggtgaag
tttgtggtcatgaccctcgaggccctgtcgtggcatttgatccatgagcagatcccgctg
agtctggaccttcaggcgggcctggactgctgttgcctggccctgcagctgcccagcgtc
tggagcgcactctcctccccagagatggtgacccacgcctgttctctcatccactgtgtc
cgcttcatcctggaagccattgtggtgcagcctggggaccagcttcttagtccagaccga
aggatgaacaccccaaaggctgccagagaggacgaagtagattcaaacacacaaaacccg
gcctatattaccgcagcctgtgggatggtggcagaaatggtggaggctttgccgtcggtg
ttggccttgggccataagaggaatagcagcaccccagcgtttctcacgtcggtgctcagg
aacatcatcatcagcctggctcgcttacccctcgtcaacagctacacgcgcgtccccccc
ctggtttggaaacttggatggtcacccaaaccgggaggggattttggtacagcgtttcct
gagatcccagtggagttcctccaggagaaggaggtctttaaagagttcatctatcgcatc
aacactctagggtggaccagccgcacccagtttgaggaaacgtgggccaccctcctcggt
gtcctggtgactcagcccctcgtgatggagcaggaggagagcccgccggaagaagacacg
gagaggacccagatcaacgtcctggccgtgcaggccatcacctcgctggtgctgagtgcg
atgactgtgcccgtggccggcaacccggccgtgagctgcctggagcagcagccccggaac
aagcccctgaaagctctcgacaccaggtttgggaggaagctgagcattatcagaggaatt
gtggagcaagagatccaagcgatggtttcgaagagagagaatgtcgccacccatcacttg
taccaagcgtgggaccccgtcccttctctctctccagctactacaggtgccctcatcggc
cacgacaagcttctgctgcagatcaaccctgagcgggagctggggaacatgagctacaag
ctcggccaggtgtccattcactccgtgtggctggggaacagcatcacgcccctgagagag
gaagagtgggaggaggaggaggaggaggaggccgacgtccccacgtctgcatcaccaccc
acatcgccggtcaactccaggaagcaccgggctggagtcgatatccattcctgttcccag
tttttgcttgaattgtatagtcgctggatcctgccgtcagggtcagccagaaggaccccc
atcatcctgatcagcgaagtggtccgatctctcctagtggtctcagacttgttcactgag
cgcacccagtttgagatgatgtatctgacgctgaccgagctgaggagggcgcaccctgca
gaagacgagattctcattcagtacctggtgcctgccacctgcaaggcggctgccgtcctc
ggaatggacaaggccgtggccgagcccgtcagccggctgctggagagcacactgaggagc
agccacctgcccagcagggtcggggccctgcatggcgccctctacgtgctggagtgtgac
ctcctggatgagacggcgaagcagctcgtccctgtcatcagcgactacctcctgtgcaac
ctcaaaggggcagcccactgcgtgaatgttcacagccagcagcacgtgctggtgatgtgt
gccaccgccttctacctgattgagaactatcccctggacgtaggcccagaattctccgcg
tcagtaattcagatgtgtggggtgatgctgtccgggagtgaggagtccactccgtccatc
atttaccactgcgtcctgcggggcctggagcgtcttctgctctccgaacagctgtgccgg
ctggatgctgagtccctggtcaagctgagtgtggacagagtgaacgtgcacagcccgcac
cgggccatggctgccctgggcctgatgctcacctgcatgtacacagggaaggagaaaatc
agcccaggcagaacctcagaccccagccccgccgccccagacagcgagtccgtgatcgtg
gctatggagcgtgtgtccgttcttttcgacagggtcaggaaaggattcccctgtgaagcc
agagtggtggcacggatccttcctcagtttttagatgacttcttcccaccccaggatgtc
atgaacaaagtcattggggaatttctgtccaaccagcagccatacccacagttcatggcc
accgttgtgtacaaggttttccagaccctgcacagcagtgggcagtcgtccatggtccgg
gactgggtcatgctgtccctctccaacttcacccagaggagcccggtggccatggctgtg
tggagcctctcctgcttcttcgtcagtgcttccactagcccctgggtctccgccgtcctt
ccccacgtcatcagcaggatgggcaagctggagcgagtggacgttaacctcttctgcctg
gtggccacagacttttacagacaccagatagaggaggagctggaccgccgggccttccag
tccgtgttcgaggtggtcgcggctccgggaaacccataccatcgactgttgacttgtttg
cggaacgtccacaaagtcgcctcgtgctga
DBGET
integrated database retrieval system
