KEGG   Panthera leo (lion): 122219824
Entry
122219824         CDS       T10741                                 
Symbol
MAPK14
Name
(RefSeq) mitogen-activated protein kinase 14 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
plez  Panthera leo (lion)
Pathway
plez01522  Endocrine resistance
plez04010  MAPK signaling pathway
plez04015  Rap1 signaling pathway
plez04068  FoxO signaling pathway
plez04071  Sphingolipid signaling pathway
plez04114  Oocyte meiosis
plez04148  Efferocytosis
plez04218  Cellular senescence
plez04261  Adrenergic signaling in cardiomyocytes
plez04370  VEGF signaling pathway
plez04380  Osteoclast differentiation
plez04517  IgSF CAM signaling
plez04550  Signaling pathways regulating pluripotency of stem cells
plez04611  Platelet activation
plez04613  Neutrophil extracellular trap formation
plez04620  Toll-like receptor signaling pathway
plez04621  NOD-like receptor signaling pathway
plez04622  RIG-I-like receptor signaling pathway
plez04625  C-type lectin receptor signaling pathway
plez04657  IL-17 signaling pathway
plez04658  Th1 and Th2 cell differentiation
plez04659  Th17 cell differentiation
plez04660  T cell receptor signaling pathway
plez04664  Fc epsilon RI signaling pathway
plez04668  TNF signaling pathway
plez04670  Leukocyte transendothelial migration
plez04714  Thermogenesis
plez04722  Neurotrophin signaling pathway
plez04723  Retrograde endocannabinoid signaling
plez04728  Dopaminergic synapse
plez04750  Inflammatory mediator regulation of TRP channels
plez04912  GnRH signaling pathway
plez04914  Progesterone-mediated oocyte maturation
plez04917  Prolactin signaling pathway
plez04926  Relaxin signaling pathway
plez04932  Non-alcoholic fatty liver disease
plez04933  AGE-RAGE signaling pathway in diabetic complications
plez04935  Growth hormone synthesis, secretion and action
plez04936  Alcoholic liver disease
plez05014  Amyotrophic lateral sclerosis
plez05020  Prion disease
plez05022  Pathways of neurodegeneration - multiple diseases
plez05132  Salmonella infection
plez05133  Pertussis
plez05135  Yersinia infection
plez05140  Leishmaniasis
plez05142  Chagas disease
plez05145  Toxoplasmosis
plez05152  Tuberculosis
plez05161  Hepatitis B
plez05163  Human cytomegalovirus infection
plez05167  Kaposi sarcoma-associated herpesvirus infection
plez05169  Epstein-Barr virus infection
plez05170  Human immunodeficiency virus 1 infection
plez05171  Coronavirus disease - COVID-19
plez05205  Proteoglycans in cancer
plez05208  Chemical carcinogenesis - reactive oxygen species
plez05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
plez05415  Diabetic cardiomyopathy
plez05417  Lipid and atherosclerosis
plez05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:plez00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122219824 (MAPK14)
   04015 Rap1 signaling pathway
    122219824 (MAPK14)
   04370 VEGF signaling pathway
    122219824 (MAPK14)
   04668 TNF signaling pathway
    122219824 (MAPK14)
   04068 FoxO signaling pathway
    122219824 (MAPK14)
   04071 Sphingolipid signaling pathway
    122219824 (MAPK14)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    122219824 (MAPK14)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    122219824 (MAPK14)
  09143 Cell growth and death
   04114 Oocyte meiosis
    122219824 (MAPK14)
   04218 Cellular senescence
    122219824 (MAPK14)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    122219824 (MAPK14)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122219824 (MAPK14)
   04613 Neutrophil extracellular trap formation
    122219824 (MAPK14)
   04620 Toll-like receptor signaling pathway
    122219824 (MAPK14)
   04621 NOD-like receptor signaling pathway
    122219824 (MAPK14)
   04622 RIG-I-like receptor signaling pathway
    122219824 (MAPK14)
   04625 C-type lectin receptor signaling pathway
    122219824 (MAPK14)
   04660 T cell receptor signaling pathway
    122219824 (MAPK14)
   04658 Th1 and Th2 cell differentiation
    122219824 (MAPK14)
   04659 Th17 cell differentiation
    122219824 (MAPK14)
   04657 IL-17 signaling pathway
    122219824 (MAPK14)
   04664 Fc epsilon RI signaling pathway
    122219824 (MAPK14)
   04670 Leukocyte transendothelial migration
    122219824 (MAPK14)
  09152 Endocrine system
   04912 GnRH signaling pathway
    122219824 (MAPK14)
   04914 Progesterone-mediated oocyte maturation
    122219824 (MAPK14)
   04917 Prolactin signaling pathway
    122219824 (MAPK14)
   04926 Relaxin signaling pathway
    122219824 (MAPK14)
   04935 Growth hormone synthesis, secretion and action
    122219824 (MAPK14)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    122219824 (MAPK14)
  09156 Nervous system
   04728 Dopaminergic synapse
    122219824 (MAPK14)
   04723 Retrograde endocannabinoid signaling
    122219824 (MAPK14)
   04722 Neurotrophin signaling pathway
    122219824 (MAPK14)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122219824 (MAPK14)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    122219824 (MAPK14)
  09159 Environmental adaptation
   04714 Thermogenesis
    122219824 (MAPK14)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    122219824 (MAPK14)
   05208 Chemical carcinogenesis - reactive oxygen species
    122219824 (MAPK14)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122219824 (MAPK14)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    122219824 (MAPK14)
   05161 Hepatitis B
    122219824 (MAPK14)
   05171 Coronavirus disease - COVID-19
    122219824 (MAPK14)
   05163 Human cytomegalovirus infection
    122219824 (MAPK14)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122219824 (MAPK14)
   05169 Epstein-Barr virus infection
    122219824 (MAPK14)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122219824 (MAPK14)
   05135 Yersinia infection
    122219824 (MAPK14)
   05133 Pertussis
    122219824 (MAPK14)
   05152 Tuberculosis
    122219824 (MAPK14)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    122219824 (MAPK14)
   05140 Leishmaniasis
    122219824 (MAPK14)
   05142 Chagas disease
    122219824 (MAPK14)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    122219824 (MAPK14)
   05020 Prion disease
    122219824 (MAPK14)
   05022 Pathways of neurodegeneration - multiple diseases
    122219824 (MAPK14)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122219824 (MAPK14)
   05418 Fluid shear stress and atherosclerosis
    122219824 (MAPK14)
   05415 Diabetic cardiomyopathy
    122219824 (MAPK14)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    122219824 (MAPK14)
   04932 Non-alcoholic fatty liver disease
    122219824 (MAPK14)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122219824 (MAPK14)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    122219824 (MAPK14)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:plez01001]
    122219824 (MAPK14)
Enzymes [BR:plez01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     122219824 (MAPK14)
Protein kinases [BR:plez01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   122219824 (MAPK14)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Kdo APH NAD_binding_8
Other DBs
NCBI-GeneID: 122219824
NCBI-ProteinID: XP_042794494
UniProt: A0A8C8XR21
LinkDB
Position
B2:34407997..34482682
AA seq 360 aa
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGADLLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
NT seq 1083 nt   +upstreamnt  +downstreamnt
atgtctcaggagaggcccacgttctaccggcaggagctgaacaagacaatctgggaggtg
ccggagcgttaccagaacctgtccccggtgggctccggtgcctatggctccgtgtgtgct
gcctttgacacaaaaactgggttacgtgtggcagtgaagaagctctccagaccgtttcag
tccatcattcatgccaaaaggacctacagagaactgcggttacttaaacatatgaaacat
gaaaatgtgattggtctgttggatgtttttacacctgcaaggtctctggaggaattcaat
gatgtgtatctggtgacccatctcatgggagcagatctgaacaacattgtgaaatgtcag
aagcttacggatgaccatgttcagttccttatctaccagattctccgaggtctcaagtat
atacattcagctgacataattcacagggacctgaagcctagtaatctagctgtgaatgaa
gactgtgagctgaagatcttggattttggactggctcgacatacagatgatgaaatgaca
ggctatgtggccactaggtggtacagggctcctgagatcatgctgaactggatgcattac
aaccagacagttgatatttggtcagtgggatgcataatggccgagctgttgactggaaga
acgttgtttcctggtacagaccatattgatcagttgaagctcattttaagactcgttgga
accccaggggctgatcttttgaagaaaatctcctcagagtctgcaagaaactacattcag
tccttgacccagatgccgaaaatgaactttgcaaatgtatttattggtgccaatcccttg
gcggtggacttgctggagaagatgcttgtactggactcagacaagagaatcacagcggcc
caagcacttgcacacgcctactttgcccagtaccatgatcctgatgatgaaccagtggcc
gatccttatgatcagtcctttgaaagcagggacctccttatagatgaatggaagagcctg
acctacgatgaagtcatcagctttgtgcccccaccccttgaccaagaagagatggaatcc
tga

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