Panthera leo (lion): 122221567
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Entry
122221567 CDS
T10741
Symbol
PDE8A
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
plez Panthera leo (lion)
Pathway
plez00230
Purine metabolism
plez01100
Metabolic pathways
plez04927
Cortisol synthesis and secretion
plez04934
Cushing syndrome
plez05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
122221567 (PDE8A)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
122221567 (PDE8A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
122221567 (PDE8A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
122221567 (PDE8A)
Enzymes [BR:
plez01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
122221567 (PDE8A)
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Ortholog
Paralog
GFIT
Motif
Pfam:
PDEase_I
PDE8A_N
PAS
PAS_9
PDE8
PAS_4
PDE8_3rd
PAS_3
DUF5894
PAS_8
Sina_ZnF
Response_reg
Motif
Other DBs
NCBI-GeneID:
122221567
NCBI-ProteinID:
XP_042796840
LinkDB
All DBs
Position
B3:complement(4336735..4493050)
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AA seq
836 aa
AA seq
DB search
MGCAPSIHISEGRTAYSGGKEAEDAPGAAAAPPPPAGPRLPPGPKTTASPGARGAGLAES
EPRDGSGRKVAIADVQFGPMRFHPDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEA
QAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTIIIGVVRRTDREESSVM
PLIAAGFTRRYVENPSLMACYNELLQLEFGEVRSQLKLRACNSIFTALEKSQEAVEITSE
DRVIQYANPAFETTMGYQAGELIGKELAEVPVNEKKAELLDTINSCIRIGKEWQGIYHAK
KKNGDNVQQNVKIVPVVGQGGKIRHYVSIIRVCNGNNKAEKRTESVQSDPHTDNQSGKHK
DRRKSSLDVRAVASRASEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPVPVTE
ALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKSLQQAPG
SVVTPISLHDVPPRIARAMENEEYWDFDIFELEAATHKRPLIYLGLKMFARFGICEFLNC
SEATLRSWLQIIEANYHSCNPYHNSTHSADVLHATAYFLCKERIKQTLDPVDEVAALIAA
TIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTRDDKCNIFKNMERND
YRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLAALEENEETNKDEEAINTMLRTPEN
RTLIKRMLIKCADVSNPCRPLEQCIEWAARISEEYFSQTDEEKQQDLPVVMPVFDRNTCS
IPKSQISFIDYFITDMFDAWDAFVDLPELMQHLDNNFKYWKGLDEMQLRSLRPPPE
NT seq
2511 nt
NT seq
+upstream
nt +downstream
nt
atgggctgcgcaccgagcatccacatttccgagggccggacggcgtacagcggcggcaag
gaggccgaggacgcgccgggcgccgccgccgcgccgccgccgcccgccgggccgcgcctc
ccacccggcccgaagaccaccgcctcgcccggggcccgcggtgccggcctcgcggagtcc
gagcctcgcgacggcagcggcaggaaggtagccattgctgacgtgcagtttggccccatg
agatttcatccagatcaactccaggtacttttagtgtttaccaaagaagataaccagtgt
aatggattctgcagggcgtgtgaaaaagcagggtttaagtgcacagttaccaaggaggcc
caggctgtccttgcctgtttcctggacaagcatcacgacatcatcatcatagaccacaga
aacccccgacagctggacgcggaggccctgtgcaggtctatcaggtcatcaaaactctct
gaaaacacaattatcattggtgtagtacgcaggacggatagagaagagtcctctgtgatg
cccctcattgctgctggctttacaaggaggtatgtggaaaaccccagcctcatggcctgt
tacaacgaactgctccagctggagttcggagaggtgcggtcccagctgaaactcagggct
tgtaactcaatattcactgcactggagaaaagtcaagaagcagttgaaattacaagtgaa
gaccgtgttatacagtatgcaaatcctgcgtttgaaacaaccatgggctatcaagcaggc
gaactaataggcaaggagttagcggaagtgcctgtaaatgaaaaaaaggctgagttgctc
gataccataaattcatgcatcaggataggcaaggagtggcaaggaatttaccacgccaaa
aagaaaaatggggacaacgtacaacagaacgtgaagatagtacctgtcgtcggacaggga
ggaaaaattagacactatgtgtccattatcagagtgtgcaatggcaacaataaggccgag
aaaagaactgaaagtgttcagtctgaccctcacacagataatcagtcaggcaaacacaaa
gacagaaggaaaagctcgctcgatgtcagagctgttgcctctcgagcaagtgaagtcagc
agccagagacggcactcctccatggcccggatacattccatgacgatcgaggcgcccatc
accaaggtaatcaacattatcaacgccgcccaggaaagcagccccgtgcctgtgacggaa
gccttagaccgtgtgctggagattctgagaaccactgaattgtattcgccgcagttcggt
gctaaggacgatgatcctcatgccaatgaccttgttggaggcttaatgtctgatggtttg
cgaagactatccgggaatgaatatgttctttcaacaaaaagcctgcagcaggcgcccggc
agtgttgtcacccccatctcccttcacgacgtccctccccggatagctcgggccatggaa
aatgaggagtactgggactttgatatttttgaactggaggccgccacacataaaaggcct
ttgatctatctcggtctcaaaatgtttgcgcgctttggaatctgtgaattcttgaactgc
tctgaggcgacgctgagatcgtggctgcaaattattgaagccaattaccattcttgtaac
ccctaccacaattccacgcactctgccgacgtgcttcatgccactgcctatttcctctgc
aaagagaggataaagcaaacgttagatccagttgacgaggtcgctgccctcattgcagcc
accatccacgacgtggaccaccccgggaggaccaactccttcctgtgcaatgccggcagc
gagctggccatcctgtacaacgacactgccgtgctggagagccaccacgcggccctggcc
ttccagctgaccacccgcgatgacaaatgcaatatcttcaaaaacatggagaggaatgac
tatcggacgctgcgccagggtattatcgatatggtcttggccacggaaatgacaaaacac
ttcgagcatgtcaacaaatttgtcaacagcatcaacaagcccctggcggcactagaagaa
aacgaggaaacgaataaagatgaagaagccataaacactatgctccggactccagagaac
cggactctgattaaacggatgctcatcaagtgtgcggacgtgtccaatccctgccggccg
ctggagcagtgcatcgagtgggccgcacgcatatcagaagaatatttttctcagacggat
gaggagaagcagcaggacttgcccgtggtgatgccggtttttgacagaaacacctgcagc
atccccaaatcccagatctctttcattgactacttcatcacggacatgtttgatgcctgg
gacgcctttgtcgacctgcctgagctaatgcagcatcttgacaacaacttcaaatactgg
aaaggactggacgagatgcagctgcggagcctccggccgccccctgaatag
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