Panthera leo (lion): 122221672
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Entry
122221672 CDS
T10741
Symbol
IGF1R
Name
(RefSeq) insulin-like growth factor 1 receptor isoform X1
KO
K05087
insulin-like growth factor 1 receptor [EC:
2.7.10.1
]
Organism
plez Panthera leo (lion)
Pathway
plez01521
EGFR tyrosine kinase inhibitor resistance
plez01522
Endocrine resistance
plez04010
MAPK signaling pathway
plez04014
Ras signaling pathway
plez04015
Rap1 signaling pathway
plez04066
HIF-1 signaling pathway
plez04068
FoxO signaling pathway
plez04081
Hormone signaling
plez04114
Oocyte meiosis
plez04140
Autophagy - animal
plez04144
Endocytosis
plez04150
mTOR signaling pathway
plez04151
PI3K-Akt signaling pathway
plez04152
AMPK signaling pathway
plez04211
Longevity regulating pathway
plez04213
Longevity regulating pathway - multiple species
plez04510
Focal adhesion
plez04520
Adherens junction
plez04550
Signaling pathways regulating pluripotency of stem cells
plez04730
Long-term depression
plez04913
Ovarian steroidogenesis
plez04914
Progesterone-mediated oocyte maturation
plez05200
Pathways in cancer
plez05202
Transcriptional misregulation in cancer
plez05205
Proteoglycans in cancer
plez05214
Glioma
plez05215
Prostate cancer
plez05218
Melanoma
plez05224
Breast cancer
plez05225
Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
122221672 (IGF1R)
04014 Ras signaling pathway
122221672 (IGF1R)
04015 Rap1 signaling pathway
122221672 (IGF1R)
04066 HIF-1 signaling pathway
122221672 (IGF1R)
04068 FoxO signaling pathway
122221672 (IGF1R)
04151 PI3K-Akt signaling pathway
122221672 (IGF1R)
04152 AMPK signaling pathway
122221672 (IGF1R)
04150 mTOR signaling pathway
122221672 (IGF1R)
09133 Signaling molecules and interaction
04081 Hormone signaling
122221672 (IGF1R)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
122221672 (IGF1R)
04140 Autophagy - animal
122221672 (IGF1R)
09143 Cell growth and death
04114 Oocyte meiosis
122221672 (IGF1R)
09144 Cellular community - eukaryotes
04510 Focal adhesion
122221672 (IGF1R)
04520 Adherens junction
122221672 (IGF1R)
04550 Signaling pathways regulating pluripotency of stem cells
122221672 (IGF1R)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
122221672 (IGF1R)
04914 Progesterone-mediated oocyte maturation
122221672 (IGF1R)
09156 Nervous system
04730 Long-term depression
122221672 (IGF1R)
09149 Aging
04211 Longevity regulating pathway
122221672 (IGF1R)
04213 Longevity regulating pathway - multiple species
122221672 (IGF1R)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
122221672 (IGF1R)
05202 Transcriptional misregulation in cancer
122221672 (IGF1R)
05205 Proteoglycans in cancer
122221672 (IGF1R)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
122221672 (IGF1R)
05214 Glioma
122221672 (IGF1R)
05218 Melanoma
122221672 (IGF1R)
05215 Prostate cancer
122221672 (IGF1R)
05224 Breast cancer
122221672 (IGF1R)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
122221672 (IGF1R)
01522 Endocrine resistance
122221672 (IGF1R)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
plez01001
]
122221672 (IGF1R)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
plez04090
]
122221672 (IGF1R)
Enzymes [BR:
plez01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
122221672 (IGF1R)
Protein kinases [BR:
plez01001
]
Receptor tyrosine kinases (RTK)
INSR family [OT]
122221672 (IGF1R)
CD molecules [BR:
plez04090
]
Proteins
122221672 (IGF1R)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
Furin-like
Pkinase
fn3
Ig_DSCAM-DSCAML_C
Kinase-like
Motif
Other DBs
NCBI-GeneID:
122221672
NCBI-ProteinID:
XP_042797043
UniProt:
A0A8C8WBC4
LinkDB
All DBs
Position
B3:complement(17004218..17304990)
Genome browser
AA seq
1367 aa
AA seq
DB search
MKSGSGGGSPTSLWGLLFFSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH
ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPLCEKTTINNEYNYRCWTTNRCQKMCPSACGKRACTDSNECCHPECLGSCS
APDNDTACVACRHYYYAGVCVPTCPPNTYRFEGWRCVDRDFCANIPSAESSDSEGFVIHD
GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRQILGEEQLEGNYSF
YVLDNQNLQQLWDWGHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR
NNGERASCESDVLHFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE
ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDSYLYRH
NYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK
VFENFLHNSIFVPRPERKRRDVTQVTNTTMSSRSRNITVADTYNITDPEELETEYPFFES
RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW
ESRPENSIFLKWPEPENPNGLILMYEIKYGSQIEDQRECVSRQEYRKYGGAKLNRLNPGN
YTARIQATSLSGNGSWTDPVFFYVPAKITYENFIHLIIALPVAVLLIVGGLVIMLYVFHR
KRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKG
VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIME
LMTRGDLKSYLRSLRPEIENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARN
CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGV
VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL
EIISSIKDEMEPGFREVSFYYSEENKPPEPEELDLEPEDMESVPLDPSASSSSLPLPDRH
SGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
NT seq
4104 nt
NT seq
+upstream
nt +downstream
nt
atgaagtctggctccggaggagggtccccgacctcgctgtgggggctcctgtttttctcc
gccgcgctctcgctctggccgacgagtggagaaatctgcgggccgggcatcgatatccgt
aacgactatcagcagctgaagcgcctggagaactgcacggtgatcgagggctacctccac
atcctgctcatctccaaggcagaggactaccgcagctaccgcttccccaagctcacggtc
atcaccgagtacttgctgctgttccgcgtggccggcctcgagagcctcggggacctcttc
ccgaacctcacggtcatccgcggctggaaactcttctacaactacgccctggtcatcttt
gagatgaccaatctcaaggatattgggctttacaatctgaggaacattacccggggggcc
atcaggattgagaaaaacgctgacctctgttacctctccacggtggactggtccctaatc
ctggatgcggtgtctaataactacatcgtgggaaacaagcccccaaaggaatgcggggac
ctgtgtccggggacgatggaggagaagcccttgtgcgagaagacgaccatcaacaatgaa
tacaactaccgctgctggacgaccaaccgctgccagaaaatgtgcccgagcgcgtgcggg
aagcgggcttgcacggacagcaacgagtgctgtcaccccgagtgcctgggcagctgcagc
gcgccggacaacgacacggcctgcgtggcctgcaggcattactactacgccggcgtctgc
gtgcccacctgcccgcccaacacctaccgctttgagggctggcgctgcgtggaccgcgac
ttctgcgccaacatccccagcgccgagagcagcgactccgaggggttcgtgatccatgac
ggcgagtgcatgcaggagtgcccctcagggttcatccggaacgggagtcagagcatgtac
tgcatcccttgtgaaggtccttgccccaaggtctgcgaggaggagaagaaaacaaagacc
attgattctgttacctctgctcaaatgctccaaggatgcaccatcttcaagggcaatctg
ctcattaatatccgccgaggcaataacattgcctcggagctggagaacttcatgggactc
atcgaggtggtgacaggctacgtgaagatccgccattcccacgccttggtctccttgtcc
ttcctcaaaaaccttcgccagatcttaggagaggagcagctggaggggaactactctttc
tatgtcctcgacaaccagaacctgcagcagctctgggactggggccatcgcaacctgacc
atcaaagctgggaagatgtactttgctttcaaccccaagttgtgcgtctccgaaatttac
cgcatggaggaggtgaccgggactaaggggcgccagagcaaaggggacatcaatacgagg
aacaacggagagcgagcctcctgtgaaagtgacgtcctgcacttcacctctacgaccacg
tggaagaaccgcatcatcataacctggcaccggtaccggccccctgactacagggacctc
atcagcttcaccgtctactacaaggaggcaccttttaaaaacgtcacggagtatgatggc
caggatgcctgtggctccaacagctggaacatggtagatgtggacctccctcccaacaag
gacgtcgagcctggcattttactgcatggactaaagccttggacgcagtatgctgtttac
gtcaaggcggtgaccctcaccatggtggagaatgaccatatccgcggggccaagagtgaa
atcttgtacattcgcaccaatgcttcagttccttccattcccctggatgttctttcggca
tcaaactcctcttctcagctcatcgtgaagtggaacccgccgtccctgcccaacggcaac
ctgagttactacatcgtgaggtggcagcggcagccccaggacagctacctttaccgccac
aactactgctccaaagacaaaatccccatcaggaagtatgccgatggcaccattgacgtc
gaggaggtgaccgagaaccccaagaccgaagtgtgcggcggagagaaggggccttgctgt
gcctgccccaaaaccgaggccgagaagcaggcggagaaggaggaggctgagtaccgcaaa
gtcttcgagaacttcctgcacaactccatctttgtgcccagacctgaaaggaagcggaga
gatgtcacacaagtcaccaacaccaccatgtccagccgaagcaggaacatcacggtggca
gacacctataatatcacagaccccgaagagctcgagacagaataccctttctttgagagc
agagtggataacaaggagagaactgtgatctccaacctccggcctttcactttgtaccgc
attgacatccacagctgtaaccacgaggctgagaagctgggctgcagcgcctccaacttt
gtctttgcaagaaccatgcctgcagaaggagcagacgacattcctgggccggtgacctgg
gagtcaaggcctgaaaactccatctttttaaagtggccggaacctgagaatcccaatgga
ctgattctaatgtatgaaataaaatatggatcacaaatcgaggatcagcgggaatgtgta
tccagacaggagtaccggaagtatggaggcgccaagcttaaccggctcaacccggggaac
tatacggcccggatccaggccacctctctctctggaaatgggtcgtggacggatcccgtg
ttcttctacgtccccgccaaaataacatatgaaaatttcatccacctgatcatcgctctg
cctgttgccgtcctgctgatagtggggggactggttatcatgttgtacgtcttccacaga
aaaagaaataacagcaggctggggaatggagtgctgtatgcttcggtgaacccagagtac
ttcagtgccgcagatgtgtatgtacctgatgagtgggaggttgctcgggagaaaatcacc
atgagccgagagctggggcagggctcgttcgggatggtctacgaaggagttgccaaaggc
gtggttaaagatgagcccgaaaccagggtggccatcaaaacggtgaacgaggccgcgagc
atgcgtgaaaggattgaatttctcaacgaggcttcagtgatgaaggagttcaattgtcac
catgtggtgcggttgctgggcgtggtgtcccagggccagccgacgctggtcatcatggaa
ctgatgacgcggggcgatctcaaaagttatctcaggtctctgaggccagaaatagagaat
aatccagtcctagcacctccaagcctaagcaagatgatccagatggctggagagattgca
gacggcatggcatacctcaacgccaacaagtttgtccacagggaccttgctgcccggaac
tgcatggtggctgaagatttcacggtcaaaatcggagatttcggtatgacgagagatatc
tacgagacagactattaccggaaaggagggaaggggctgctgcctgtgcgctggatgtca
cccgagtccctcaaggatggggtcttcaccactcactctgacgtctggtccttcggggtc
gttctctgggagatcgccacgctggccgagcagccgtaccagggcttgtccaacgagcaa
gtccttcgcttcgtcatggagggcggccttctggacaagccggacaactgccccgacatg
ctgtttgaactgatgcgcatgtgctggcagtacaaccccaagatgaggccttccttcctg
gagatcatcagcagcatcaaggacgagatggaacctggcttccgggaggtctccttctac
tacagcgaggagaacaagccgcccgagccggaggagctggatctggagccggaggacatg
gagagcgtccccctggacccctccgcctcctcgtcctccctgccgctgcccgacagacac
tcaggacacaaggccgagaacggcccgggccccggcgtgctggttctccgagccagcttc
gacgagagacagccttacgcgcacatgaacgggggacgcaagaacgagagggccttgcct
ctgccccagtcttcgacctgctga
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integrated database retrieval system
