KEGG   Panthera leo (lion): 122221689
Entry
122221689         CDS       T10741                                 
Symbol
LRRK1
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 1 isoform X1
  KO
K08843  leucine-rich repeat kinase 1 [EC:2.7.11.1]
Organism
plez  Panthera leo (lion)
Brite
KEGG Orthology (KO) [BR:plez00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:plez01001]
    122221689 (LRRK1)
Enzymes [BR:plez01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     122221689 (LRRK1)
Protein kinases [BR:plez01001]
 Serine/threonine kinases: TKL group
  LRRK family
   122221689 (LRRK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr LRR_8 COR-B LRR_4 COR-A Roc Ank_2 Ank LRR_1 Arf LRR_14 LRR_EndoS Ank_KRIT1 Ras LRR_LRWD1 Ank_4 Beta-prop_LRRK2 PROPPIN MMR_HSR1 Gtr1_RagA TniB
Other DBs
NCBI-GeneID: 122221689
NCBI-ProteinID: XP_042797117
UniProt: A0A8C8WDQ6
LinkDB
Position
B3:19041671..19190588
AA seq 2017 aa
MAGMSRRPPSMYWCVGPEGSAVCPERAMETHNGAGDMGSKPSTPGSDPTARCPGTEGIHA
AYKQGDPSRARHLLREACDDSTSQLEKGRLLSISAAYGDLETVRYLLTERRVELPTEPTD
DNPAVVAAHFGHTDVVQELLESLPGACSPQRLLNWMLALACQRGHLGVVKLLVLTHGADP
ESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAFFCSYILLDSPDPSKHLLRKYF
IEASTLSSNCPGKMALRVKWSHLKLPWVDLDWLIDISCQITELDLSANCLSSLPSVIPWG
LINLRKLNLSNNHLGELPGVQSSDEIICSRLLEIDISSNKLPHLPPGFLHLLKLQKLTAS
KNYLEKLFEEESATNWIGLRKLQELDISNNKLTELPALFLHSFKSLSYLNVSRNNLKVFP
DAWACPLKCCRASKNALESLPDKMAVFWKNHLRDADFSENALKEVPLGLFQLDALMFLRL
QGNQLMVLPPQDKWTCRQLKTLDLSRNQFGKNEDGLKTKRISFFTTRGRQRSGTETAGVL
EFPAFLSESLEVLCLNDNHLDAVPPSVCLLKNLSELYLGNNPGLRELPPELGQLGNLWQL
DIEDLNISNVPTEIRKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQT
GRAPQVVHSEATIRTTKWELQRPAGSRAKVESVEFTVWDIGGPASMATVNQCFFTDKALY
VVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIETKFRVERIATLRAYVLA
LCRSPSGSRATGFPDITFKHLHELSCKSLEGQEGLRQLIFHVTCNMKDVGSTIGCQRLAG
RLIPRSYLSLQEAVLAEQQRRSLSDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFL
IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG
TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPKANTIQRVFKM
SFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRHRKVTIYSFTGNQRNRCSTFRVKR
NQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGIKIICQSEMRDFSAMAFITDHVNSL
IDQWFPALTATESDGTPLMEQYVPCPVCETSWAQHTDPSEKSEGVQYFDMEDCVLTAIEQ
DFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDESSVLGQGGSGTIIYRA
RYQGQPVAVKRFQIKKFKNFANAPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV
SLIGISIHPLCFALELAPLGSLNTVLSENARDSSFMPLGHMLTQKIAYQIASGLAYLHKK
NIIFCDLKSDNILVWSLDVKDHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIV
YDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFHRLQALMM
ECWDTKPEKRPLALSVVSQMKDPTFATFMYQLPCGKQTAFFSSQGQEYMVVFWDGKEESR
NYTVVNTEKGLMEVQRMSCAGMTLSCQLKVQNSLWTATEDQKIYIYSLKGMCPLNTPQRA
LDTPAVVTCLLAVPVIKKNSYLVLAGLADGLVAVFPVVRGAPDDSCSYLCSHTANRSKFS
IPDEDTRQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCVALEISRRLEPYSAPSVVTSVV
GSSECRGEEVVWCLDDRANSLVMYHAATYQLCARYFCGDPSPLRDMFPVCPLGPEPRGGH
TASPKEPKGDSIADVSIMYSEELGTQILTHQDSLTDYCSTSSSSSSPHRAPRSSSSLPCS
PASSASVPFAANYEDSDRLHEPTAGSDRSEHDLTPVDGEAFSQHLQAVRILAVKDVIWVP
RRGGDVIVIGLEKDAGGQRGRVIAVLKARELTPRGALVDAAVVAKDTVVCGFENENMEWC
LAVWRGWGTREFDVFYHSYEELGRLEACMRKRRVLCS
NT seq 6054 nt   +upstreamnt  +downstreamnt
atggctggcatgtctcggcgaccgcccagcatgtactggtgtgtgggtccagagggctca
gctgtgtgtccagaacgtgccatggagacccataatggtgctggggacatgggcagcaaa
ccgtccacaccaggcagtgaccccacagcgcggtgcccggggacggagggcattcacgct
gcatacaagcaaggagaccccagcagggcccggcacttgctccgggaggcttgtgatgac
agcacatcccagctggagaagggccggctcctgagcatctcagcggcctatggggatctg
gagactgtccgataccttctcaccgagagacgggtggagctgcccacggagcccaccgat
gacaacccagctgtggtggcagcgcattttgggcacactgacgtggtgcaggaattgctt
gaatctttgccaggtgcctgcagcccccagaggctgctgaactggatgctggccttggct
tgccaaagagggcatctgggggtggtgaagctcctggtcctgacacacggggccgacccg
gaaagctacgctgtcaggaagaacgagtttcctgtcattgtgcgcttgcccctctatgca
gccatcaagtcaggaaatgaagacatcgccatattcctgcttcggcatggggccttcttc
tgttcctacatcttattggacagtcctgaccccagcaaacatctcctcaggaagtacttc
attgaggctagcaccttgtccagcaactgtccgggaaaaatggcgctgcgtgtgaaatgg
tcccatctcaagttgccctgggtggatctagactggctcatagacatctcctgccagatc
acagagctggacctttctgccaattgcctgtcttccctcccctccgtcatcccctgggga
ctcatcaacctccggaagctgaacctctccaacaaccacctgggggagctgcctggcgtg
cagtcatcggatgaaatcatctgttccaggctcctggaaattgacatttccagcaataaa
ttgccccatctcccaccaggattcttgcacctcttaaaacttcaaaaattgacagcttca
aaaaactacttggaaaagttgtttgaagaagaaagtgccactaactggatcggtttgcgg
aagctgcaggaactcgacatctctaacaataaattgacggaactccctgccctttttctt
cattctttcaagtcactcagttatctgaatgtctccagaaataacctgaaggtgtttcca
gatgcctgggcctgccctttgaaatgttgtagagcatccaaaaatgccctggaatctcta
ccagacaaaatggctgtcttttggaaaaaccacctcagggatgcggatttctcagaaaac
gctctcaaagaagtccccctggggcttttccagctcgatgccctcatgttcctgaggtta
caggggaaccagctcatggtgctgccacctcaagataagtggacctgtagacaacttaaa
accctggatctctccagaaaccaatttggcaaaaatgaagacggacttaaaacaaagcgt
atttcctttttcaccaccagagggcgccagcgttctgggacggagacagccggtgtgctg
gaatttccggccttcctaagtgagtctttggaggtcctttgtctgaacgacaatcatctg
gatgcagtccctccctcggtttgcctactgaagaacttatcagaactctacttgggaaac
aatcctggcctccgagaactccctcctgagctggggcagctgggcaacctttggcagttg
gacattgaagacctgaacatcagcaacgtgcccacggagatcagaaaggaaggccccaaa
gcgatgttgtcttacctgcgcgctcagctgcggaaagcagagaagtgcaagctgatgaaa
atgatcatcgtgggtcctccgcgccagggcaagtccaccctcctggagatcttacagacg
gggagggccccccaggtggtgcacagcgaggccaccatcaggaccaccaagtgggagctc
cagaggccagctggctcgagagccaaggttgagtccgtggaattcaccgtctgggacatc
ggtggccccgccagcatggccactgtcaatcagtgcttcttcacagacaaggccctgtat
gtggtggtctggaacctagcactgggggaggaggccgtggccaacctccagttctggctg
ctcaacatcgaggccaaggcccccaacgctgtggtgctggtggttggaacacacctggac
ttaatcgaaaccaaattccgagtggagagaatcgcaaccctgcgcgcctatgtgctggcg
ttgtgccgttcgccctccgggtccagggccacgggcttcccggacatcaccttcaaacac
ttacacgaactctcctgcaagagtctggaaggccaggaagggctacggcagctgatcttc
cacgtcacgtgcaacatgaaggatgtgggcagcaccataggctgccagagactcgcgggg
aggctgatccccaggagctacctgagcctccaggaggcagtgctggctgagcagcagcgc
cgaagcctgagcgacgacgtgcagtacctgacggacaggcagctggagcagctggtggag
cagacaccagacaacgacatcaaagactatgaggacctgcagtccgccatcagcttcctc
atagagaccggcacactgctgcacttcccggacaccagccacggcctgaggaacctctac
ttcctcgaccccatttggctgtccgaatgtctgcagaggatcttcaacatcaagggctcc
cgctcagtggccaagaacggggtgatccgggccgaggacctcaggatgctgctggtgggg
accggcttcacacagcagacagaggagcagtacttccagttcctggccaagttcgagatc
gccctgccggtggccaacgacagctatcttctgccacacctccttccgtccaaacccggc
ctggacactcacggcatgcgacaccccaaggccaataccattcagagagtgtttaagatg
agcttcgttcctgttggcttctggcaaaggtttatagcacggatgctgatcagcctggcg
gagatggacctccagctttttgaaaacaagaagaatactaaaagcagacacaggaaagtc
accatttatagttttacaggaaaccagagaaatcgctgcagtacgttcagagtgaaaaga
aatcagaccatctattggcaggaagggctcctggtcacttttgatgggggctacctcagt
gtggaatcctcggacgtgaactggaaaaagaaaaaaagtggaggaataaaaatcatttgc
cagtcagaaatgagggacttctctgcaatggcttttatcacagaccatgtcaattccttg
atcgatcagtggtttcctgccctgacagccacagaaagcgacgggaccccactcatggag
cagtacgtcccctgcccagtctgcgagacctcctgggcccagcacaccgacccaagtgag
aaatcagagggcgtacagtacttcgacatggaagactgcgtgctgacagccattgagcag
gacttcatctcctgccccagacaccctgacctccccgtgcctctccaggagctggttcct
gagctgttcatgactgacttcccggccaggctcttcctggagaacagcaagttggagcac
agcgaggatgagagcagtgtcctgggtcaaggtgggagcggcaccatcatctaccgggcc
cggtaccaaggccagcccgtggcagtgaagcgattccagatcaagaaattcaagaacttt
gccaacgccccagcagacaccatgctgaggcacctgcgggccacggacgccatgaagaac
ttctcggagttccggcaagaggccagcatgctacacgccctgcagcacccctgtattgtg
tccctcatcggcatcagcatccacccgctctgcttcgccctggagctcgccccactgggt
agcctcaacaccgtgctgtcagagaatgccagagattcttcctttatgcccctgggacac
atgctcacccaaaaaatagcctaccagattgcctctggcctggcctacctgcacaagaaa
aacatcatcttctgtgacctgaagtcagacaacattctggtctggtctctggacgtcaag
gaccacatcaatatcaagctgtcggactacgggatctcacggcagtcatttcatgagggt
gccctcggcgtggagggcacacccggctaccaggccccagagatccgtcctcgcattgtg
tatgacgagaaggtagacatgttctcctatggaatggtgctctacgagttgctgtcgggg
cagcggccagcgctgggccaccaccagcttcagatcgccaagaagctgtccaagggcatc
cgtcctgttctggggcagcccgaggaggtgcagttccatcgcctgcaggcactcatgatg
gagtgctgggacacaaagcccgagaagcgcccactggccctgtcggtggtgagccagatg
aaggacccaacctttgcaacgttcatgtaccagctaccctgtgggaagcagacggccttc
ttctcatcccagggccaggagtacatggtggtgttctgggatgggaaagaggagtccagg
aactacacggtggtgaacacggagaagggcctcatggaggtgcagcggatgagctgtgcg
ggaatgacactaagctgccagctcaaggtccagaactctctgtggacggccactgaggac
cagaagatctacatctatagcctcaagggcatgtgcccgttaaacacaccccaacgggct
ttggacaccccggctgtcgtcacctgcttattggcagtgcctgttattaaaaagaattcc
tacctggtgttggcaggcctggccgacgggcttgtggcagtgtttcccgtggtgcggggt
gccccggacgacagctgctcctacctgtgctcacacacagccaacaggtccaagtttagc
atcccagatgaagacacacggcagaacccctaccccgtgaaggccatggaggtggtcaac
agcggctccgaggtctggtacagcaacgggcccggcctgctggtcatcgactgtgtggcc
ctggagatcagcaggaggctggagccctactcggccccttcggtggtcacctcggtcgtg
ggcagctccgagtgcaggggggaggaggtcgtctggtgcctggacgacagggccaactcc
ttggtgatgtaccatgcagctacctaccagctgtgcgcccggtacttctgcggggacccc
agcccgctcagagacatgtttcccgtgtgcccgttgggtccagagccccgtggcggccac
acagccagccccaaagagcccaagggggactccatcgcggacgtgagcatcatgtacagc
gaggagctgggcacgcagatcctgacccaccaggactcgctgactgactactgctccacg
tcctcctcctcatcctccccccaccgggcccccaggtcgtcctcaagcctgccctgctcc
ccggcaagctctgccagcgtgcctttcgccgccaactacgaggactccgacaggctgcac
gagcccaccgcgggctccgacaggtctgagcatgacctgacccccgtggacggggaggct
ttcagccagcacctgcaggccgtgaggatcctagctgtgaaagacgtcatctgggtcccc
aggcgcggcggcgatgttatcgtcatcggcctggagaaggacgccggaggccagcggggc
cgtgtcatcgccgtcttaaaagcccgcgagctgactccgcgtggggcgcttgtggatgcg
gccgtggtggcaaaggacacggttgtgtgtggctttgagaacgaaaacatggagtggtgc
ctggctgtctggaggggctggggcaccagagagtttgatgttttctaccactcctacgaa
gagctgggccggctggaggcttgcatgcggaagagaagggtcctctgctcctga

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